AU2001288229A1 - An advantageous carrier solution for vitrifiable concentrations of cryoprotectants, and compatible cryoprotectant mixtures - Google Patents
An advantageous carrier solution for vitrifiable concentrations of cryoprotectants, and compatible cryoprotectant mixturesInfo
- Publication number
- AU2001288229A1 AU2001288229A1 AU2001288229A AU8822901A AU2001288229A1 AU 2001288229 A1 AU2001288229 A1 AU 2001288229A1 AU 2001288229 A AU2001288229 A AU 2001288229A AU 8822901 A AU8822901 A AU 8822901A AU 2001288229 A1 AU2001288229 A1 AU 2001288229A1
- Authority
- AU
- Australia
- Prior art keywords
- solutions
- cryoprotectants
- carrier solution
- compatible
- vitrification
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000002577 cryoprotective agent Substances 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 2
- 238000004017 vitrification Methods 0.000 abstract 3
- 239000008365 aqueous carrier Substances 0.000 abstract 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 abstract 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 abstract 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 1
- 229930195725 Mannitol Natural products 0.000 abstract 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 abstract 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 239000008101 lactose Substances 0.000 abstract 1
- 239000000594 mannitol Substances 0.000 abstract 1
- 235000010355 mannitol Nutrition 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/125—Freeze protecting agents, e.g. cryoprotectants or osmolarity regulators
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- External Artificial Organs (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
Abstract
Disclosed herein are aqueous carrier solutions for cryoprotectants that are useful for a variety of cryoprotectant solutions for use with cells, tissues, and whole organs, said aqueous carrier solutions permitting antinucleators to be fully effective in vitrification solutions, thereby allowing vitrification solutions to attain extreme effectiveness, and compatible vitrification solution compositions for use with these carrier solutions. The carrier solutions comprise lactose, mannitol or trehalose, and glucose in combination with other beneficial ingredients.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22169100P | 2000-07-31 | 2000-07-31 | |
| US60221691 | 2000-07-31 | ||
| PCT/US2001/023853 WO2002009516A2 (en) | 2000-07-31 | 2001-07-30 | Carrier solution for vitrifiable concentrations of cryoprotectants, and cryoprotectant mixtures |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2001288229A1 true AU2001288229A1 (en) | 2002-02-13 |
Family
ID=22828916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001288229A Abandoned AU2001288229A1 (en) | 2000-07-31 | 2001-07-30 | An advantageous carrier solution for vitrifiable concentrations of cryoprotectants, and compatible cryoprotectant mixtures |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6869757B2 (en) |
| EP (1) | EP1311155B1 (en) |
| AT (1) | ATE311104T1 (en) |
| AU (1) | AU2001288229A1 (en) |
| CA (1) | CA2388544C (en) |
| DE (1) | DE60115461T2 (en) |
| WO (1) | WO2002009516A2 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6949335B2 (en) * | 1999-11-30 | 2005-09-27 | 21St Century Medicine, Inc. | Polyglycerol and lactose compositions for the protection of living systems from states of reduced metabolism |
| US6869757B2 (en) * | 2000-07-31 | 2005-03-22 | 21St Century Medicine, Inc. | Advantageous carrier solution for vitrifiable concentrations of cryoprotectants, and compatible cryoprotectant mixtures |
| US7250292B2 (en) * | 2000-01-26 | 2007-07-31 | 21St Century Medicine | Hypertonic reduction of chilling injury |
| CA2539274C (en) | 2003-09-16 | 2016-03-15 | 21St Century Medicine, Inc. | Methods and compositions for the cryopreservation of organs |
| US20150017628A1 (en) * | 2012-02-08 | 2015-01-15 | University Of Warwick | Cryopreservation of cells in absence of vitrification inducing agents |
| US12453805B2 (en) | 2020-09-24 | 2025-10-28 | Everest Medical Innovation GmbH | Cryoprotective compositions, surgical kits, and methods for protection of a surgical site during cryosurgery |
| US12426594B2 (en) | 2020-09-24 | 2025-09-30 | Everest Medical Innovation GmbH | Cryoprotective compositions and methods for protection of a surgical site during cryosurgery |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01106826A (en) * | 1987-10-21 | 1989-04-24 | Terumo Corp | Blood preserving solution composition |
| CA2051092C (en) * | 1990-09-12 | 2002-07-23 | Stephen A. Livesey | Method and apparatus for cryopreparation, dry stabilization and rehydration of biological suspensions |
| IL104470A0 (en) * | 1992-01-21 | 1993-05-13 | Cryopharm Corp | Process for freezing cells and cell like materials and compositions prepared thereby |
| AU3290097A (en) * | 1996-05-29 | 1998-01-05 | Universal Preservation Technologies, Inc. | Loading and unloading of permeating protectants for cell, tissue, and organ cryopreservation by vitrification |
| US5879875A (en) * | 1996-06-14 | 1999-03-09 | Biostore New Zealand | Compositions and methods for the preservation of living tissues |
| WO1997047192A1 (en) * | 1996-06-14 | 1997-12-18 | Biostore New Zealand Limited | Compositions and methods for the preservation of living tissues |
| WO1999060849A1 (en) * | 1998-05-26 | 1999-12-02 | Lifecell Corporation | Cryopreservation of human red blood cells |
| DE69929071T2 (en) * | 1998-09-21 | 2006-08-17 | 21St Century Medicine Inc., Cucamonga | IMPROVED COOLING PROTECTION SOLUTIONS |
| US6194137B1 (en) * | 1999-04-13 | 2001-02-27 | Organ Recovery Systems, Inc. | Method of cryopreservation of blood vessels by vitrification |
| US6616858B2 (en) * | 1999-11-30 | 2003-09-09 | Greg Fahy | Prevention of ice nucleation by polyglycerol |
| US6869757B2 (en) * | 2000-07-31 | 2005-03-22 | 21St Century Medicine, Inc. | Advantageous carrier solution for vitrifiable concentrations of cryoprotectants, and compatible cryoprotectant mixtures |
| US20020045156A1 (en) * | 2000-05-16 | 2002-04-18 | Mehmet Toner | Microinjection of cryoprotectants for preservation of cells |
-
2001
- 2001-07-27 US US09/916,396 patent/US6869757B2/en not_active Expired - Lifetime
- 2001-07-30 AU AU2001288229A patent/AU2001288229A1/en not_active Abandoned
- 2001-07-30 CA CA2388544A patent/CA2388544C/en not_active Expired - Lifetime
- 2001-07-30 EP EP01967949A patent/EP1311155B1/en not_active Expired - Lifetime
- 2001-07-30 DE DE60115461T patent/DE60115461T2/en not_active Expired - Lifetime
- 2001-07-30 WO PCT/US2001/023853 patent/WO2002009516A2/en not_active Ceased
- 2001-07-30 AT AT01967949T patent/ATE311104T1/en not_active IP Right Cessation
-
2005
- 2005-03-11 US US11/078,214 patent/US7741018B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE60115461T2 (en) | 2006-06-08 |
| ATE311104T1 (en) | 2005-12-15 |
| US20050153272A1 (en) | 2005-07-14 |
| EP1311155B1 (en) | 2005-11-30 |
| WO2002009516A3 (en) | 2002-06-13 |
| EP1311155A2 (en) | 2003-05-21 |
| US6869757B2 (en) | 2005-03-22 |
| DE60115461D1 (en) | 2006-01-05 |
| US7741018B2 (en) | 2010-06-22 |
| CA2388544C (en) | 2011-02-22 |
| US20020076687A1 (en) | 2002-06-20 |
| WO2002009516A2 (en) | 2002-02-07 |
| CA2388544A1 (en) | 2002-02-07 |
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