AU2001287639A1 - Trp8, trp9 and trp10, markers for cancer - Google Patents
Trp8, trp9 and trp10, markers for cancerInfo
- Publication number
- AU2001287639A1 AU2001287639A1 AU2001287639A AU8763901A AU2001287639A1 AU 2001287639 A1 AU2001287639 A1 AU 2001287639A1 AU 2001287639 A AU2001287639 A AU 2001287639A AU 8763901 A AU8763901 A AU 8763901A AU 2001287639 A1 AU2001287639 A1 AU 2001287639A1
- Authority
- AU
- Australia
- Prior art keywords
- trp10
- trp8
- trp9
- cancer
- markers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G01N33/575—
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The present invention relates to gene expression in normal cells and cells of malignant tumors and particularly to novel markers associated with cancer, Trp8, Trp9 and Trp10, and the genes encoding Trp8, Trp9 and Trp10. Also provided are vectors, host cells, antibodies, and recombinant methods for producing these human proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating a tumor.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22151300P | 2000-07-28 | 2000-07-28 | |
| US60/221,513 | 2000-07-28 | ||
| PCT/EP2001/008309 WO2002010382A2 (en) | 2000-07-28 | 2001-07-18 | Trp8, trp9 and trp10, markers for cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2001287639A1 true AU2001287639A1 (en) | 2002-02-13 |
Family
ID=22828139
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001287639A Abandoned AU2001287639A1 (en) | 2000-07-28 | 2001-07-18 | Trp8, trp9 and trp10, markers for cancer |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7205108B2 (en) |
| EP (1) | EP1366158B1 (en) |
| JP (1) | JP2004505617A (en) |
| AT (1) | ATE396266T1 (en) |
| AU (1) | AU2001287639A1 (en) |
| CA (1) | CA2417671A1 (en) |
| DE (1) | DE60134178D1 (en) |
| WO (1) | WO2002010382A2 (en) |
Families Citing this family (84)
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| US7364867B2 (en) | 2000-04-17 | 2008-04-29 | The Mount Sinai School Of Medicine | Method of identifying bitter compounds by employing TRP8, a transient receptor potential channel expressed in taste receptor cells |
| DE10215321A1 (en) * | 2002-04-02 | 2003-10-23 | Metagen Pharmaceuticals Gmbh | New nucleic acid encoding Trpp8 splice variants, useful for diagnosis of prostatic cancer, and to screen for diagnostic or therapeutic agents, also related proteins |
| US20050176010A1 (en) * | 2002-04-16 | 2005-08-11 | Bayer Healthcare Ag | Regulation of human transient receptor potential channel |
| WO2003089596A2 (en) * | 2002-04-19 | 2003-10-30 | Schering Aktiengesellschaft | Novel prostate tumor-specific promoter |
| CA2512392A1 (en) * | 2003-01-08 | 2004-07-29 | Toudai Tlo, Ltd. | Human calcium transporter 1 gene, screening method of calcium absorption regulating factor, and calcium absorption regulating factor |
| NZ547633A (en) | 2003-11-06 | 2010-08-27 | Seattle Genetics Inc | Monomethylvaline compounds capable of conjugation to ligands |
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| US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
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| EP1948687A2 (en) * | 2005-10-31 | 2008-07-30 | Janssen Pharmaceutica N.V. | A polypeptide complex of trpm8 and calmodulin and its uses thereof |
| EP2268665B1 (en) * | 2008-03-19 | 2014-11-12 | Soricimed Biopharma Inc. | Peptide composition for cancer treatment by inhibiting trpv6 calcium channel activity |
| MX2012000086A (en) | 2009-06-26 | 2012-06-12 | Soricimed Biopharma Inc | Soricidin derived peptides and methods for the detection of trpv-6 cancers and drug delivery. |
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| CN103313990B (en) | 2010-11-17 | 2016-07-20 | 基因泰克公司 | Alanyl maytansinol antibody coupling matter |
| CN103608684B (en) | 2011-05-12 | 2016-05-04 | 基因泰克公司 | A Multiple Reaction Monitoring LC-MS/MS Method for the Detection of Therapeutic Antibodies in Animal Samples Using Framework Signature Peptides |
| RS54446B1 (en) | 2011-10-14 | 2016-06-30 | Medimmune Limited | PIROLOBENZIDIAZEPINE AND ITS CONJUGATES |
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| CA2887895C (en) | 2012-10-12 | 2019-10-29 | Adc Therapeutics Sarl | Pyrrolobenzodiazepine-anti-cd19 antibody conjugates |
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| EP2906297B1 (en) | 2012-10-12 | 2017-12-06 | ADC Therapeutics SA | Pyrrolobenzodiazepine-antibody conjugates |
| JP6270859B2 (en) | 2012-10-12 | 2018-01-31 | エイディーシー・セラピューティクス・エス・アー・エール・エルAdc Therapeutics Sarl | Pyrrolobenzodiazepine-antibody conjugate |
| EA032986B1 (en) | 2012-12-21 | 2019-08-30 | Медимьюн Лимитед | Pyrrolobenzodiazepines |
| CA2894961C (en) | 2012-12-21 | 2020-09-15 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
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| JP6878287B2 (en) | 2014-11-25 | 2021-05-26 | アーデーセー セラピューティクス ソシエテ アノニム | Pyrrolobenzodiazepine-antibody conjugate |
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| GB201506402D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
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| KR102890251B1 (en) | 2019-03-15 | 2025-11-25 | 메드임뮨 리미티드 | Azetidobenzodiazepine dimers and conjugates comprising the same for use in the treatment of cancer |
| GB2597532A (en) | 2020-07-28 | 2022-02-02 | Femtogenix Ltd | Cytotoxic compounds |
| EP4426727A2 (en) | 2021-11-03 | 2024-09-11 | Hangzhou Dac Biotech Co., Ltd. | Specific conjugation of an antibody |
| TW202432187A (en) | 2022-12-23 | 2024-08-16 | 美商建南德克公司 | Cereblon degrader conjugates, and uses thereof |
| CN121263210A (en) | 2023-04-17 | 2026-01-02 | 沛科生物公司 | Antibodies and antibody-drug conjugates, as well as their usage, synthesis processes, and intermediates |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5885776A (en) * | 1997-01-30 | 1999-03-23 | University Of Iowa Research Foundation | Glaucoma compositions and therapeutic and diagnositic uses therefor |
| US5919638A (en) | 1996-10-08 | 1999-07-06 | Abbott Laboratories | Reagents and methods useful for detecting prostate tumors |
| US6262245B1 (en) | 1997-02-25 | 2001-07-17 | Corixa Corporation | Compounds for immunotherapy of prostate cancer and methods for their use |
| US6194152B1 (en) | 1997-08-20 | 2001-02-27 | Dendreon Corporation | Prostate tumor polynucleotide compositions and methods of detection thereof |
| CA2360396A1 (en) * | 1998-12-30 | 2000-07-13 | Andrew M. Scharenberg | Characterization of a calcium channel family |
| US6534642B1 (en) | 1999-07-09 | 2003-03-18 | Matthias A. Hediger | Compositions corresponding to a calcium transporter and methods of making and using same |
| WO2001014423A1 (en) | 1999-08-19 | 2001-03-01 | Smithkline Beecham P.L.C. | Identification of three putative calcium channel vanilrep peptides |
| WO2001042467A2 (en) | 1999-12-08 | 2001-06-14 | Millennium Pharmaceuticals, Inc. | Genes, compositions, kits, and methods for identification, assessment, prevention, and therapy of cervical cancer |
| CN1436234A (en) | 2000-01-14 | 2003-08-13 | 科里克萨有限公司 | Composition and methods for therapy and diagnosis of prostate cancer |
| US20020072101A1 (en) | 2000-01-21 | 2002-06-13 | Gaughan Glen T. | Novel human nucleic acid molecules and polypeptides encoding cation channels |
| US20020142377A1 (en) | 2000-02-22 | 2002-10-03 | Glucksmann Maria Alexandra | 18607, a novel human calcium channel |
| US20020156253A1 (en) | 2000-06-26 | 2002-10-24 | Curtis Rory A.J. | 48000 and 52920, novel human calcium channels and uses thereof |
| WO2001068857A2 (en) | 2000-03-15 | 2001-09-20 | Millennium Pharmaceuticals, Inc. | 18615 and 48003, human ion channels and uses therefor |
| AU2001285018A1 (en) * | 2000-08-17 | 2002-02-25 | Agensys, Inc. | Nucleic acids and corresponding proteins entitled 83p2h3 and catrf2e11 useful in treatment and detection of cancer |
| AU2002215345A1 (en) | 2000-10-13 | 2002-04-22 | Eos Biotechnology, Inc. | Methods of diagnosis of prostate cancer, compositions and methods of screening for modulators of prostate cancer |
-
2001
- 2001-07-18 DE DE60134178T patent/DE60134178D1/en not_active Expired - Lifetime
- 2001-07-18 WO PCT/EP2001/008309 patent/WO2002010382A2/en not_active Ceased
- 2001-07-18 AT AT01967204T patent/ATE396266T1/en not_active IP Right Cessation
- 2001-07-18 AU AU2001287639A patent/AU2001287639A1/en not_active Abandoned
- 2001-07-18 US US10/343,114 patent/US7205108B2/en not_active Expired - Fee Related
- 2001-07-18 EP EP01967204A patent/EP1366158B1/en not_active Expired - Lifetime
- 2001-07-18 CA CA002417671A patent/CA2417671A1/en not_active Abandoned
- 2001-07-18 JP JP2002516300A patent/JP2004505617A/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE60134178D1 (en) | 2008-07-03 |
| WO2002010382A2 (en) | 2002-02-07 |
| WO2002010382A9 (en) | 2002-09-19 |
| EP1366158B1 (en) | 2008-05-21 |
| US7205108B2 (en) | 2007-04-17 |
| JP2004505617A (en) | 2004-02-26 |
| CA2417671A1 (en) | 2002-02-07 |
| US20040072998A1 (en) | 2004-04-15 |
| EP1366158A2 (en) | 2003-12-03 |
| WO2002010382A3 (en) | 2003-10-09 |
| ATE396266T1 (en) | 2008-06-15 |
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