AU2001284697A1 - Method of synthesizing diketopiperazines - Google Patents
Method of synthesizing diketopiperazinesInfo
- Publication number
- AU2001284697A1 AU2001284697A1 AU2001284697A AU8469701A AU2001284697A1 AU 2001284697 A1 AU2001284697 A1 AU 2001284697A1 AU 2001284697 A AU2001284697 A AU 2001284697A AU 8469701 A AU8469701 A AU 8469701A AU 2001284697 A1 AU2001284697 A1 AU 2001284697A1
- Authority
- AU
- Australia
- Prior art keywords
- synthesizing diketopiperazines
- diketopiperazines
- synthesizing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 230000002194 synthesizing effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22307500P | 2000-08-04 | 2000-08-04 | |
| US60223075 | 2000-08-04 | ||
| PCT/US2001/024281 WO2002012201A1 (en) | 2000-08-04 | 2001-08-02 | Method of synthesizing diketopiperazines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2001284697A1 true AU2001284697A1 (en) | 2002-02-18 |
Family
ID=22834911
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001284697A Abandoned AU2001284697A1 (en) | 2000-08-04 | 2001-08-02 | Method of synthesizing diketopiperazines |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US6967202B2 (en) |
| AU (1) | AU2001284697A1 (en) |
| GB (1) | GB2382346B (en) |
| WO (1) | WO2002012201A1 (en) |
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| CN100553636C (en) | 2000-08-04 | 2009-10-28 | Dmi生物科学公司 | Methods of use of diketopiperazines and compositions containing them |
| WO2003080117A1 (en) * | 2002-03-19 | 2003-10-02 | Abgenix, Inc. | Methods for treating chronic obstructive pulmonary disease (copd) |
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| PE20120332A1 (en) | 2008-12-19 | 2012-04-14 | Univ Indiana Res & Tech Corp | PEPTIDE PROPHARS FROM THE GLUCAGON SUPERFAMILY BASED ON AMIDA |
| JP5755566B2 (en) | 2008-12-19 | 2015-07-29 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | Amide insulin prodrug |
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| US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| EP2862854A1 (en) * | 2008-12-29 | 2015-04-22 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| DK2405963T3 (en) | 2009-03-11 | 2013-12-16 | Mannkind Corp | DEVICE, SYSTEM AND PROCEDURE FOR MEASURING RESISTANCE IN AN INHALATOR |
| US8551528B2 (en) | 2009-06-12 | 2013-10-08 | Mannkind Corporation | Diketopiperazine microparticles with defined specific surface areas |
| US9016147B2 (en) | 2009-11-03 | 2015-04-28 | Mannkind Corporation | Apparatus and method for simulating inhalation efforts |
| CA2802485C (en) | 2010-06-16 | 2019-09-17 | Indiana University Research And Technology Corporation | Single chain insulin agonists exhibiting high activity at the insulin receptor |
| EP2582421A1 (en) | 2010-06-21 | 2013-04-24 | MannKind Corporation | Dry powder drug delivery system and methods |
| MX2012014576A (en) | 2010-06-24 | 2013-02-21 | Univ Indiana Res & Tech Corp | Amide based glucagon superfamily peptide prodrugs. |
| JP5912112B2 (en) | 2010-06-24 | 2016-04-27 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | Amide insulin prodrug |
| WO2012033792A2 (en) | 2010-09-07 | 2012-03-15 | Dmi Acquisition Corp. | Treatment of diseases |
| WO2012135765A2 (en) | 2011-04-01 | 2012-10-04 | Mannkind Corporation | Blister package for pharmaceutical cartridges |
| WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
| BR112014007657A2 (en) | 2011-10-10 | 2017-04-11 | Ampio Pharmaceuticals Inc | Implantable medical devices with improved immune tolerance and methods for production and implantation |
| MX362164B (en) | 2011-10-10 | 2019-01-07 | Ampio Pharmaceuticals Inc | Treatment of degenerative joint disease. |
| JP6018640B2 (en) | 2011-10-24 | 2016-11-02 | マンカインド コーポレイション | Analgesic composition effective for alleviating pain, and dry powder and dry powder drug delivery system comprising the composition |
| SG11201400283RA (en) | 2011-10-28 | 2014-03-28 | Ampio Pharmaceuticals Inc | Treatment of rhinitis |
| US9573987B2 (en) | 2011-12-20 | 2017-02-21 | Indiana University Research And Technology Corporation | CTP-based insulin analogs for treatment of diabetes |
| ES2624294T3 (en) | 2012-07-12 | 2017-07-13 | Mannkind Corporation | Dry powder drug delivery systems |
| CA2886228A1 (en) | 2012-09-26 | 2014-04-03 | Indiana University Research And Technology Corporation | Insulin analog dimers |
| WO2014066856A1 (en) | 2012-10-26 | 2014-05-01 | Mannkind Corporation | Inhalable influenza vaccine compositions and methods |
| EP2970511B1 (en) | 2013-03-14 | 2020-09-30 | Indiana University Research and Technology Corporation | Insulin-incretin conjugates |
| WO2014144895A1 (en) | 2013-03-15 | 2014-09-18 | Mannkind Corporation | Microcrystalline diketopiperazine compositions and methods |
| SG10201707619RA (en) | 2013-03-15 | 2017-10-30 | Ampio Pharmaceuticals Inc | Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same |
| AU2014290438B2 (en) | 2013-07-18 | 2019-11-07 | Mannkind Corporation | Heat-stable dry powder pharmaceutical compositions and methods |
| WO2015021064A1 (en) | 2013-08-05 | 2015-02-12 | Mannkind Corporation | Insufflation apparatus and methods |
| WO2015148905A1 (en) | 2014-03-28 | 2015-10-01 | Mannkind Corporation | Use of ultrarapid acting insulin |
| EP3183240A4 (en) | 2014-08-18 | 2018-06-27 | Ampio Pharmaceuticals, Inc. | Treatment of joint conditions |
| ES2947409T3 (en) | 2014-09-24 | 2023-08-08 | Univ Indiana Res & Tech Corp | Lipid amide-based insulin prodrugs |
| JP6657230B2 (en) | 2014-09-24 | 2020-03-04 | インディアナ ユニヴァーシティ リサーチ アンド テクノロジー コーポレイション | Incretin-insulin conjugate |
| US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
| HK1246669A1 (en) | 2015-06-22 | 2018-09-14 | Ampio Pharmaceuticals, Inc. | Use of low molecular weight fractions of human serum albumin in treating diseases |
| CN111875668B (en) * | 2020-07-29 | 2022-05-27 | 陕西慧康生物科技有限责任公司 | Synthetic method of cyclic dipeptide containing glutamine or asparagine |
| CN112321515A (en) * | 2020-10-21 | 2021-02-05 | 上海馨远医药科技有限公司 | Preparation method of chiral 1-tert-butyl-3-methyl-6-methylpiperazine-1, 3-diformate |
| CN116043230A (en) * | 2023-02-08 | 2023-05-02 | 福建工程学院 | A kind of aqueous phase modification method of amino acid corrosion inhibitor |
| CN116375654B (en) * | 2023-03-22 | 2024-12-31 | 湖北三峡实验室 | Method for preparing 2, 5-diketopiperazine from diglycolamine |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3928330A (en) | 1973-12-19 | 1975-12-23 | Ciba Geigy Corp | Substituted piperazinedione carboxylic acids and metal salts thereof |
| DE2940654A1 (en) | 1979-10-06 | 1981-04-16 | Bayer Ag, 5090 Leverkusen | DIMERES KETEN OF 1,2 ,, - TRIAZOL-3-CARBONIC ACID |
| US4331595A (en) | 1980-06-23 | 1982-05-25 | Ortho Pharmaceutical Corporation | Immunoregulatory diketopiperazine compounds |
| US4289759A (en) | 1980-06-23 | 1981-09-15 | Ortho Pharmaceutical Corporation | Immunoregulatory diketopiperazine compounds |
| US4694061A (en) | 1983-10-12 | 1987-09-15 | Ciba-Geigy Corporation | Radiation-sensitive polycondensates, processes for their preparation coated material and its use |
| US4806538A (en) | 1984-11-02 | 1989-02-21 | Fujisawa Pharmaceutical Co., Ltd. | Piperazine compound as PAF-antagonist |
| US5047401A (en) | 1985-09-09 | 1991-09-10 | Board Of Regents, The University Of Texas System | Use of dipeptide alkyl esters to treat GVHD |
| US4694081A (en) | 1985-09-23 | 1987-09-15 | Monsanto Company | Process to prepare 2,5-diketopiperazines |
| US4992552A (en) | 1988-08-31 | 1991-02-12 | Eastman Kodak Company | Process for preparation of amino acids |
| AU628257B2 (en) | 1990-03-15 | 1992-09-10 | Nutrasweet Company, The | Process for manufacturing aspartame from a diketopiperazine and novel intermediates and derivatives therefor |
| JPH04234374A (en) | 1990-12-27 | 1992-08-24 | Ajinomoto Co Inc | Production of diketopiperazine derivative |
| US5817751A (en) | 1994-06-23 | 1998-10-06 | Affymax Technologies N.V. | Method for synthesis of diketopiperazine and diketomorpholine derivatives |
| AU2871195A (en) | 1994-06-23 | 1996-01-19 | Affymax Technologies N.V. | Methods for the synthesis of diketopiperazines |
| US5990112A (en) | 1996-06-18 | 1999-11-23 | Affymax Technologies N.V. | Inhibitors of metalloproteases pharmaceutical compositions comprising same and methods of their use |
| AU715667B2 (en) | 1996-04-03 | 2000-02-10 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US5932579A (en) * | 1996-06-18 | 1999-08-03 | Affymax Technologies N.V. | Collagenase-1 and stromelysin-1 inhibitors, pharmaceutical compositions comprising same and methods of their use |
| US7202279B1 (en) | 1998-02-11 | 2007-04-10 | Georgetown University | Cyclic dipeptides and azetidinone compounds and their use in treating CNS injury and neurodegenerative disorders |
| CN100553636C (en) * | 2000-08-04 | 2009-10-28 | Dmi生物科学公司 | Methods of use of diketopiperazines and compositions containing them |
-
2001
- 2001-08-02 WO PCT/US2001/024281 patent/WO2002012201A1/en not_active Ceased
- 2001-08-02 US US09/922,604 patent/US6967202B2/en not_active Expired - Lifetime
- 2001-08-02 GB GB0301542A patent/GB2382346B/en not_active Expired - Fee Related
- 2001-08-02 AU AU2001284697A patent/AU2001284697A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| GB2382346A (en) | 2003-05-28 |
| WO2002012201A1 (en) | 2002-02-14 |
| GB0301542D0 (en) | 2003-02-26 |
| GB2382346B (en) | 2004-08-11 |
| US6967202B2 (en) | 2005-11-22 |
| US20020038026A1 (en) | 2002-03-28 |
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