[go: up one dir, main page]

AU2001282410A1 - N-benzylindole-3-acetic acid derivatives for use in the treatment of drug resistan cancer - Google Patents

N-benzylindole-3-acetic acid derivatives for use in the treatment of drug resistan cancer

Info

Publication number
AU2001282410A1
AU2001282410A1 AU2001282410A AU8241001A AU2001282410A1 AU 2001282410 A1 AU2001282410 A1 AU 2001282410A1 AU 2001282410 A AU2001282410 A AU 2001282410A AU 8241001 A AU8241001 A AU 8241001A AU 2001282410 A1 AU2001282410 A1 AU 2001282410A1
Authority
AU
Australia
Prior art keywords
benzylindole
resistan
cancer
drug
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001282410A
Inventor
Anita Rose Maguire
Michael Clynes Martin
Robert Andrew O'Connor
Stephen James Plunkett
Samantha Mary Touhey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University College Cork
Dublin City University
Original Assignee
University College Cork
Dublin City University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University College Cork, Dublin City University filed Critical University College Cork
Publication of AU2001282410A1 publication Critical patent/AU2001282410A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572Five-membered rings
    • C07F9/5728Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • A61K31/405Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/22Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
AU2001282410A 2000-08-24 2001-08-24 N-benzylindole-3-acetic acid derivatives for use in the treatment of drug resistan cancer Abandoned AU2001282410A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00650115 2000-08-24
EP00650115 2000-08-24
PCT/IE2001/000109 WO2002020478A1 (en) 2000-08-24 2001-08-24 N-benzylindole-3-acetic acid derivatives for use in the treatment of drug resistan cancer

Publications (1)

Publication Number Publication Date
AU2001282410A1 true AU2001282410A1 (en) 2002-03-22

Family

ID=8174468

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001282410A Abandoned AU2001282410A1 (en) 2000-08-24 2001-08-24 N-benzylindole-3-acetic acid derivatives for use in the treatment of drug resistan cancer

Country Status (3)

Country Link
AU (1) AU2001282410A1 (en)
IE (1) IE20010784A1 (en)
WO (1) WO2002020478A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005112921A2 (en) * 2004-04-26 2005-12-01 Vanderbilt University Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity
CN101528222A (en) 2006-06-19 2009-09-09 范德比尔特大学 Methods and compositions for diagnostic and therapeutic targeting of COX-2
WO2013059245A1 (en) 2011-10-17 2013-04-25 Vanderbilt University Indomethacin analogs for the treatment of castrate-resistant prostate cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT95692A (en) * 1989-10-27 1991-09-13 American Home Prod PROCESS FOR THE PREPARATION OF INDOLE-, INDENO-, PYRANOINDOLE- AND TETRA-HYDROCARBAZOLE-ALCANOIC ACID DERIVATIVES, OR WHICH ARE USEFUL AS PLA2 INHIBITORS AND LIPOXIGENASE
IL109311A0 (en) * 1993-04-16 1994-07-31 Lilly Co Eli 1H-indole-3-acetamide sPla2 inhibitors
IL115582A0 (en) * 1994-10-14 1996-01-19 Lilly Co Eli Methods for treating resistant tumors
IE960761A1 (en) * 1996-10-31 1998-05-06 Univ Dublin City Combinations for use in increasing the potency of a¹substrate for multidrug resistance related protein
US5811425A (en) * 1997-03-04 1998-09-22 Abbott Laboratories Heterocyclic compounds as COX-2 inhibitors

Also Published As

Publication number Publication date
IE20010784A1 (en) 2003-04-16
WO2002020478A1 (en) 2002-03-14

Similar Documents

Publication Publication Date Title
PL370029A1 (en) 2-amino-4-heteroarylaminopyrimidine derivatives for use in the treatment of cancer
AU3021001A (en) Thiazolidine carboxylic acid derivatives and their use in the treatment of cancer
AU2002213357A1 (en) Variant igg3 rituxan r and therapeutic use thereof
AU2002246152A1 (en) Utilization of pyrazoline derivatives in the preparation of a medicament for the prevention and/or treatment of proliferative cell diseases
WO2001028494A3 (en) Nordihydroguaiaretic derivatives for use in treatment of tumors
AU2002252227A1 (en) Heterocyclic derivatives for the treatment of cancer and other proliferative diseases
AU2922600A (en) Pyridopyranoazepine derivatives, preparation and therapeutic use
AU4373499A (en) Use of drug-loaded nanoparticles for the treatment of cancers
HUP0300848A3 (en) A composition comprising camptothecin and a pyrimidine derivative for the treatment of cancer
AU6062900A (en) Substituted indole compounds and their use for the treatment of cancer
AU2002220735A1 (en) Substituted derivatives of aminofuran-2-yl-acetic acid and aminothien-2-yl-acetic acid and the use thereof for treating migraines and pain
AU4770800A (en) Body treatment product
AU2001235437A1 (en) Isothiazolecarboxylic acid derivatives and their use as microbicides
AU2001243515A1 (en) Combination drug therapy
AU3913900A (en) Radioenhanced cancer treatment using orally administered camptothecin derivatives
AU2670600A (en) Pharmaceutical composition containing desoxypeganine for the treatment of nicotine dependence
AU6038601A (en) Amino acid derivatives and their use as medicines
AU2001214116A1 (en) Novel paclitaxel derivatives for the treatment of cancer
AU1243101A (en) High dose folic acid for the treatment of hyperhomocysteinemia
AU2002212489A1 (en) Veterinary composition for the topical treatment of traumatized or inflamed skin
AU2001282410A1 (en) N-benzylindole-3-acetic acid derivatives for use in the treatment of drug resistan cancer
AU7653600A (en) Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives for the treatment of multiple sclerosis
AUPQ367699A0 (en) Treatment of cancer
AU5552400A (en) Treatment of cancer
AU2002308105A1 (en) Benzoaxathiepin derivatives and their use as medicines