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AU2001282115A1 - Method and device for the measurement of chemical and/or biological samples - Google Patents

Method and device for the measurement of chemical and/or biological samples

Info

Publication number
AU2001282115A1
AU2001282115A1 AU2001282115A AU8211501A AU2001282115A1 AU 2001282115 A1 AU2001282115 A1 AU 2001282115A1 AU 2001282115 A AU2001282115 A AU 2001282115A AU 8211501 A AU8211501 A AU 8211501A AU 2001282115 A1 AU2001282115 A1 AU 2001282115A1
Authority
AU
Australia
Prior art keywords
unit
irradiation
sample
measurement
chemical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001282115A
Inventor
Leif Brand
Christian Eggeling
Karsten Gall
Rolf Gunther
Claus Seidel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evotec OAI AG
Original Assignee
Evotec OAI AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10040988A external-priority patent/DE10040988A1/en
Priority claimed from DE2001102218 external-priority patent/DE10102218A1/en
Application filed by Evotec OAI AG filed Critical Evotec OAI AG
Publication of AU2001282115A1 publication Critical patent/AU2001282115A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6419—Excitation at two or more wavelengths

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

A device for the measurement of chemical and/or biological samples, in particular by means of luminescence spectroscopy, comprises an irradiation unit (12), a sample receiver (10), at least one optical unit (30) and a detector unit (40). Electromagnetic radiation of various wavelength ranges and/or polarisations are led to the sample (10) from the irradiation unit (12). The colour marker in the sample (10), which contains at least one colour marker, is stimulated into producing luminescence and gives off light. The emitted light is led by means of an optical unit in the direction of an optical unit. The light emitted by the colour markers is detected by detectors (42,44,46, 48) in the detector unit. According to the invention, the measurement results may be improved on the irradiation unit (12) generating a pulsed irradiation. The irradiation unit is thus preferably controlled by a control unit (18) in such a way that the irradiation pulses impinge on the sample (10) in a temporal sequence.
AU2001282115A 2000-08-22 2001-08-22 Method and device for the measurement of chemical and/or biological samples Abandoned AU2001282115A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE10040988A DE10040988A1 (en) 2000-08-22 2000-08-22 Measurement of chemical and/or biological samples, useful for screening interactions between two bio-molecules, comprises excitement of a marker with electromagnetic radiation of one wavelength or polarization from a pulsed transmitter
DE10040988 2000-08-22
DE10102218 2001-01-19
DE2001102218 DE10102218A1 (en) 2001-01-19 2001-01-19 Measurement of chemical and/or biological samples, useful for screening interactions between two bio-molecules, comprises excitement of a marker with electromagnetic radiation of one wavelength or polarization from a pulsed transmitter
PCT/EP2001/009680 WO2002016911A1 (en) 2000-08-22 2001-08-22 Method and device for the measurement of chemical and/or biological samples

Publications (1)

Publication Number Publication Date
AU2001282115A1 true AU2001282115A1 (en) 2002-03-04

Family

ID=26006770

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001282115A Abandoned AU2001282115A1 (en) 2000-08-22 2001-08-22 Method and device for the measurement of chemical and/or biological samples

Country Status (6)

Country Link
EP (1) EP1311829B1 (en)
AT (1) ATE399989T1 (en)
AU (1) AU2001282115A1 (en)
DE (1) DE50114075D1 (en)
DK (1) DK1311829T3 (en)
WO (1) WO2002016911A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6552794B2 (en) * 2001-04-04 2003-04-22 Applied Spectral Imaging Ltd. Optical detection method for improved sensitivity
DE10221564A1 (en) * 2002-05-15 2003-11-27 Evotec Ag Photoluminescence analyzer for chemical and biological sample screening uses a high intensity homogeneous line image as illumination source, and has multiple sensor scanning of the image
WO2004065944A2 (en) * 2003-01-21 2004-08-05 Evotec Technologies Gmbh Method for analyzing the luminescence of chemical and/or biological samples
EP2453240B1 (en) 2005-05-23 2016-12-28 Harald F. Hess Optical microscopy with phototransformable optical labels
GB0715168D0 (en) * 2007-08-03 2007-09-12 Enigma Diagnostics Ltd Illumination apparatus for use in fluorescence-based detection
DE102010047237B4 (en) 2010-08-13 2021-07-01 Leica Microsystems Cms Gmbh Method for separating detection signals in the beam path of an optical device

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0679251T3 (en) * 1993-01-18 1999-01-25 Evotec Biosystems Aktiengesell Process and apparatus for assessing the fitness of biopolymers
FI101829B1 (en) * 1995-03-07 1998-08-31 Erkki Juhani Soini Biospecific assay method
US5784157A (en) * 1995-11-21 1998-07-21 The Research Foundation Of State University Of New York Method and apparatus for identifying fluorophores
DE19634873A1 (en) * 1996-08-29 1998-03-12 Boehringer Mannheim Gmbh System for the differentiation of fluorescent groups of molecules by time-resolved fluorescence measurement
DE19718016A1 (en) * 1997-04-29 1998-11-05 Drexhage Karl Heinz Method for the optical detection of analyte molecules in a natural biological medium

Also Published As

Publication number Publication date
DK1311829T3 (en) 2008-10-27
WO2002016911A1 (en) 2002-02-28
DE50114075D1 (en) 2008-08-14
EP1311829B1 (en) 2008-07-02
EP1311829A1 (en) 2003-05-21
ATE399989T1 (en) 2008-07-15

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