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AU2001279641A1 - Method for the production of artificial oxygen carriers from covalently cross linking haemoglobin with improved functional properties of haemoglobin by cross-linking in the presence of chemically non-reacting effectors of the oxygen affinity of the haemoglobin - Google Patents

Method for the production of artificial oxygen carriers from covalently cross linking haemoglobin with improved functional properties of haemoglobin by cross-linking in the presence of chemically non-reacting effectors of the oxygen affinity of the haemoglobin

Info

Publication number
AU2001279641A1
AU2001279641A1 AU2001279641A AU7964101A AU2001279641A1 AU 2001279641 A1 AU2001279641 A1 AU 2001279641A1 AU 2001279641 A AU2001279641 A AU 2001279641A AU 7964101 A AU7964101 A AU 7964101A AU 2001279641 A1 AU2001279641 A1 AU 2001279641A1
Authority
AU
Australia
Prior art keywords
haemoglobin
linking
cross
effectors
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001279641A
Other languages
English (en)
Inventor
Wolfgang Barnikol
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanguibiotech AG
Original Assignee
Sanguibiotech AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanguibiotech AG filed Critical Sanguibiotech AG
Publication of AU2001279641A1 publication Critical patent/AU2001279641A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
AU2001279641A 2000-06-29 2001-06-02 Method for the production of artificial oxygen carriers from covalently cross linking haemoglobin with improved functional properties of haemoglobin by cross-linking in the presence of chemically non-reacting effectors of the oxygen affinity of the haemoglobin Abandoned AU2001279641A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10031742 2000-06-29
DE10031742A DE10031742A1 (de) 2000-06-29 2000-06-29 Verfahren zur Herstellung künstlicher Sauerstoffträger aus kovalent vernetzten Hämoglobinen mit verbesserten funktionellen Eigenschaften durch Vernetzung in Anwesenheit chemisch nicht reagierender Effektoren der Sauerstoffaffinität der Hämoglobine
PCT/EP2001/006329 WO2002000229A1 (de) 2000-06-29 2001-06-02 Verfahren zur herstellung künstlicher sauerstoffträger aus kovalent vernetzten hämoglobinen mit verbesserten funktionellen eigenschaften durch vernetzung in anwesenheit chemisch nicht reagierender effektoren der sauerstoffaffinität der hämoglobine

Publications (1)

Publication Number Publication Date
AU2001279641A1 true AU2001279641A1 (en) 2002-01-08

Family

ID=7647246

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001279641A Abandoned AU2001279641A1 (en) 2000-06-29 2001-06-02 Method for the production of artificial oxygen carriers from covalently cross linking haemoglobin with improved functional properties of haemoglobin by cross-linking in the presence of chemically non-reacting effectors of the oxygen affinity of the haemoglobin

Country Status (7)

Country Link
US (1) US20040023851A1 (de)
EP (1) EP1294385B1 (de)
AT (1) ATE358494T1 (de)
AU (1) AU2001279641A1 (de)
DE (2) DE10031742A1 (de)
ES (1) ES2284670T3 (de)
WO (1) WO2002000229A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6306166B1 (en) * 1997-08-13 2001-10-23 Scimed Life Systems, Inc. Loading and release of water-insoluble drugs
DE10031744A1 (de) * 2000-06-29 2002-01-17 Sanguibio Tech Ag Mit Blutplasma verträgliche, vernetzte und mit Polyalkylenoxiden konjugierte Säugetierhämoglobine als künstliche medizinische Sauerstoffträger, ihre Herstellung und ihre Verwendung
DE10220992A1 (de) * 2002-05-11 2003-12-04 Sanguibiotech Ag Verwendung eines oder mehrerer Sauerstoffträger, ausgewählt aus Hämoglobin, Myoglobin und Derivaten hiervon zur Behandlung einer Organfunktionsstörung infolge eines akuten Versorgungsmangels und zur Behandlung/Vermeidung einer Gewebeschädigung infolge einer solchen Störung
EP1469011B1 (de) * 2003-04-17 2007-11-07 Ezio Panzeri Hemoglobin Konjugate
US7235639B2 (en) * 2003-04-23 2007-06-26 Ezio Panzeri Hemoglobin conjugates
DE10352692A1 (de) 2003-11-12 2005-06-23 Sanguibiotech Gmbh Verwendung hypo-onkotischer Lösungen in das Blut addierbarer, hyperpolymerer Hämoglobine zur Behandlung eines Lungenödems
EP2491962A1 (de) 2007-01-21 2012-08-29 Hemoteq AG Medizinprodukt zur Behandlung von Verschlüssen von Körperdurchgängen und zur Prävention drohender Wiederverschlüsse
US9192697B2 (en) * 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
JP2012532670A (ja) 2009-07-10 2012-12-20 ボストン サイエンティフィック サイムド，インコーポレイテッド 薬剤搬送バルーンのためのナノ結晶の使用
WO2011008393A2 (en) * 2009-07-17 2011-01-20 Boston Scientific Scimed, Inc. Nucleation of drug delivery balloons to provide improved crystal size and density
WO2011081712A1 (en) * 2009-12-31 2011-07-07 Boston Scientific Scimed, Inc. Cryo activated drug delivery and cutting balloons
US8889211B2 (en) 2010-09-02 2014-11-18 Boston Scientific Scimed, Inc. Coating process for drug delivery balloons using heat-induced rewrap memory
EP2550973B1 (de) 2011-07-23 2013-08-28 SastoMed GmbH Wundspray
US8669360B2 (en) 2011-08-05 2014-03-11 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
US9056152B2 (en) 2011-08-25 2015-06-16 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
EP2614833A1 (de) 2012-01-13 2013-07-17 SastoMed GmbH Narbenbildung verringernde Wundbehandlung
RU2504387C2 (ru) * 2012-04-12 2014-01-20 Учреждение Российской академии наук Институт высокомолекулярных соединений РАН Способ получения полимерного модифицированного гемоглобина
DE102013014651A1 (de) 2013-09-03 2015-03-05 Sanguibiotech Gmbh Zubereitungen zur verbesserten Gewebe-Oxygenierung durch peritoneale Beatmung
EP3421044A1 (de) 2017-06-26 2019-01-02 SastoMed GmbH Sauerstoffträger zur behandlung von hautindispositionen
AU2018304174B2 (en) 2017-07-18 2025-07-10 VirTech Bio, Inc. Blood substitutes comprising hemoglobin and methods of making

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4001200A (en) * 1975-02-27 1977-01-04 Alza Corporation Novel polymerized, cross-linked, stromal-free hemoglobin
US4001401A (en) * 1975-02-02 1977-01-04 Alza Corporation Blood substitute and blood plasma expander comprising polyhemoglobin
US4179637A (en) * 1978-04-14 1979-12-18 Santora James V Incandescent light bulb with multiple filaments providing multiple lives
US4600531A (en) * 1984-06-27 1986-07-15 University Of Iowa Research Foundation Production of alpha-alpha cross-linked hemoglobins in high yield
GB8710598D0 (en) * 1987-05-05 1987-06-10 Star Medical Diagnostics Ltd Hemoglobin based blood substitute
US5234903A (en) * 1989-11-22 1993-08-10 Enzon, Inc. Chemically modified hemoglobin as an effective, stable non-immunogenic red blood cell substitute
US5386014A (en) * 1989-11-22 1995-01-31 Enzon, Inc. Chemically modified hemoglobin as an effective, stable, non-immunogenic red blood cell substitute
US5312808A (en) * 1989-11-22 1994-05-17 Enzon, Inc. Fractionation of polyalkylene oxide-conjugated hemoglobin solutions
US5439882A (en) * 1989-12-29 1995-08-08 Texas Tech University Health Sciences Center Blood substitute
US5250665A (en) * 1991-05-31 1993-10-05 The University Of Toronto Innovations Foundation Specifically β-β cross-linked hemoglobins and method of preparation
US5387672A (en) * 1993-03-02 1995-02-07 The University Of Maryland At Baltimore Hemoglobin intramolecularly cross-linked withlong chain divalent reagents
WO1994021682A1 (en) * 1993-03-16 1994-09-29 Hemosol Inc. Selective crosslinking of hemoglobins by oxidized, ring-opened saccharides

Also Published As

Publication number Publication date
DE10031742A1 (de) 2002-01-17
EP1294385A1 (de) 2003-03-26
EP1294385B1 (de) 2007-04-04
ATE358494T1 (de) 2007-04-15
ES2284670T3 (es) 2007-11-16
WO2002000229A1 (de) 2002-01-03
US20040023851A1 (en) 2004-02-05
DE50112296D1 (de) 2007-05-16

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