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AU2001278638A1 - Thioether-sulphamate steroids as steroid sulphatase inhibitors and anti-cancer compounds - Google Patents

Thioether-sulphamate steroids as steroid sulphatase inhibitors and anti-cancer compounds

Info

Publication number
AU2001278638A1
AU2001278638A1 AU2001278638A AU7863801A AU2001278638A1 AU 2001278638 A1 AU2001278638 A1 AU 2001278638A1 AU 2001278638 A AU2001278638 A AU 2001278638A AU 7863801 A AU7863801 A AU 7863801A AU 2001278638 A1 AU2001278638 A1 AU 2001278638A1
Authority
AU
Australia
Prior art keywords
group
sulphamate
modulator
steroid sulphatase
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001278638A
Inventor
Matthew Paul Leese
Barry Victor Lloyd Potter
Michael John Reed
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sterix Ltd
Original Assignee
Sterix Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterix Ltd filed Critical Sterix Ltd
Publication of AU2001278638A1 publication Critical patent/AU2001278638A1/en
Abandoned legal-status Critical Current

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    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
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Abstract

There is provided a compound of Formula I wherein X is a ring system; R 1 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; R 2 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; wherein when X is a steroidal structure and both of R 1 and R 2 are sulphamate groups, the steroidal ring system (X) represents an oestrogen; and wherein said compound is capable of inhibiting steroid sulphatase (STS) activity and/or is capable of acting as a modulator of cell cycling and/or as a modulator of apoptosis and/or as a modulator of cell growth. There is also provided a compound of Formula VIII wherein R 2 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; and wherein said compound is capable of inhibiting steroid sulphatase (STS) activity and/or is capable of acting as a modulator of cell cycling and/or as a modulator of apoptosis and/or as a modulator of cell growth.
AU2001278638A 2000-08-18 2001-08-17 Thioether-sulphamate steroids as steroid sulphatase inhibitors and anti-cancer compounds Abandoned AU2001278638A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0020498.2A GB0020498D0 (en) 2000-08-18 2000-08-18 Compound
GB0020498 2000-08-18
PCT/GB2001/003705 WO2002016394A1 (en) 2000-08-18 2001-08-17 Thioether-sulphamate steroids as steroid sulphatase inhibitors and anti-cancer compounds

Publications (1)

Publication Number Publication Date
AU2001278638A1 true AU2001278638A1 (en) 2002-03-04

Family

ID=9897954

Family Applications (3)

Application Number Title Priority Date Filing Date
AU2001278638A Abandoned AU2001278638A1 (en) 2000-08-18 2001-08-17 Thioether-sulphamate steroids as steroid sulphatase inhibitors and anti-cancer compounds
AU2001278629A Abandoned AU2001278629A1 (en) 2000-08-18 2001-08-17 Oestrogen-17-sulphamates as inhibitors of steroid sulphatase
AU2001278631A Abandoned AU2001278631A1 (en) 2000-08-18 2001-08-17 17-aryl-linker derivatised estrogen 3-sulphamates as inhibitors of steroid sulphatase

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2001278629A Abandoned AU2001278629A1 (en) 2000-08-18 2001-08-17 Oestrogen-17-sulphamates as inhibitors of steroid sulphatase
AU2001278631A Abandoned AU2001278631A1 (en) 2000-08-18 2001-08-17 17-aryl-linker derivatised estrogen 3-sulphamates as inhibitors of steroid sulphatase

Country Status (12)

Country Link
US (3) US7067503B2 (en)
EP (4) EP2202240A1 (en)
JP (3) JP5191079B2 (en)
AT (1) ATE428720T1 (en)
AU (3) AU2001278638A1 (en)
CY (1) CY1109130T1 (en)
DE (1) DE60138390D1 (en)
DK (1) DK1311532T3 (en)
ES (1) ES2323630T3 (en)
GB (1) GB0020498D0 (en)
PT (1) PT1311532E (en)
WO (3) WO2002016394A1 (en)

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GB0306717D0 (en) * 2003-03-24 2003-04-30 Sterix Ltd Compound
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DK1608671T3 (en) * 2003-03-24 2010-05-10 Sterix Ltd Estrogen derivatives as inhibitors of steroid sulfatase
GB0505541D0 (en) * 2005-03-17 2005-04-27 Novartis Ag Organic compounds
GB0702446D0 (en) * 2007-02-08 2007-03-21 Sterix Ltd Composition
US9284345B2 (en) * 2007-04-12 2016-03-15 Endorecherche, Inc. 17alpha-substituted steroids as systemic antiandrogens and selective androgen receptor modulators
US20100204146A1 (en) 2007-09-17 2010-08-12 Preglem S.A. Treatment of Oestrogen Dependant Conditions in Pre-menopausal Women
WO2014124412A2 (en) * 2013-02-11 2014-08-14 President And Fellows Of Harvard College Methods and compounds for the inhibition of cellular proliferation
ES2514140B1 (en) * 2013-03-26 2015-08-03 Universidad Pablo De Olavide Use of the STX64 steroid sulfatase inhibitor for the treatment of aging
AU2017208970A1 (en) 2016-01-18 2018-08-02 Arisan Therapeutics Adamatane derivatives for the treatment of filovirus infection
US11548893B2 (en) 2017-07-15 2023-01-10 Arisan Therapeutics Inc. Enantiomerically pure adamantane carboxamides for the treatment of filovirus infection
EP3988096A1 (en) * 2020-10-26 2022-04-27 Universidad Pablo de Olavide OTRI Sulfated c19 steroid hormones to treat and/or prevent proteotoxicity in protein-aggregation diseases

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