[go: up one dir, main page]

AU2001278010A1 - Therapeutic angiogenesis by bone marrow-derived cell transplantation in myocardial ischemic tissue and skeletal muscle ischemic tissue - Google Patents

Therapeutic angiogenesis by bone marrow-derived cell transplantation in myocardial ischemic tissue and skeletal muscle ischemic tissue

Info

Publication number
AU2001278010A1
AU2001278010A1 AU2001278010A AU7801001A AU2001278010A1 AU 2001278010 A1 AU2001278010 A1 AU 2001278010A1 AU 2001278010 A AU2001278010 A AU 2001278010A AU 7801001 A AU7801001 A AU 7801001A AU 2001278010 A1 AU2001278010 A1 AU 2001278010A1
Authority
AU
Australia
Prior art keywords
ischemic tissue
bone marrow
skeletal muscle
cell transplantation
derived cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001278010A
Inventor
Sam Baldwin
Nicolas A. F. Chronos
Toyoaki Murohara
Maria Palasis
Keith Allen Robinson
Takafumi Ueno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Scientific Scimed Inc
Original Assignee
Scimed Life Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22825164&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2001278010(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Scimed Life Systems Inc filed Critical Scimed Life Systems Inc
Publication of AU2001278010A1 publication Critical patent/AU2001278010A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • C12N5/0663Bone marrow mesenchymal stem cells (BM-MSC)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/069Vascular Endothelial cells
    • C12N5/0692Stem cells; Progenitor cells; Precursor cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/70Undefined extracts
    • C12N2500/80Undefined extracts from animals
    • C12N2500/84Undefined extracts from animals from mammals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50Cell markers; Cell surface determinants
    • C12N2501/58Adhesion molecules, e.g. ICAM, VCAM, CD18 (ligand), CD11 (ligand), CD49 (ligand)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/90Polysaccharides
    • C12N2501/91Heparin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C12N2506/1353Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from bone marrow mesenchymal stem cells (BM-MSC)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2001278010A 2000-07-26 2001-07-26 Therapeutic angiogenesis by bone marrow-derived cell transplantation in myocardial ischemic tissue and skeletal muscle ischemic tissue Abandoned AU2001278010A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22083400P 2000-07-26 2000-07-26
US60/220,834 2000-07-26
PCT/US2001/023438 WO2002008389A2 (en) 2000-07-26 2001-07-26 Therapeutic angiogenesis by bone marrow-derived cell transplantation in myocardial ischemic tissue and skeletal muscle ischemic tissue

Publications (1)

Publication Number Publication Date
AU2001278010A1 true AU2001278010A1 (en) 2002-02-05

Family

ID=22825164

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001278010A Abandoned AU2001278010A1 (en) 2000-07-26 2001-07-26 Therapeutic angiogenesis by bone marrow-derived cell transplantation in myocardial ischemic tissue and skeletal muscle ischemic tissue

Country Status (6)

Country Link
US (2) US6878371B2 (en)
EP (1) EP1303588B1 (en)
JP (1) JP2004516242A (en)
AU (1) AU2001278010A1 (en)
CA (1) CA2429502A1 (en)
WO (1) WO2002008389A2 (en)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8075880B2 (en) * 1999-01-11 2011-12-13 Steward St. Elizabeth's Medical Center Of Boston, Inc. Compositions and methods for regulating angiogenesis
US7125714B2 (en) 1997-02-05 2006-10-24 Licentia Ltd. Progenitor cell materials and methods
US6290728B1 (en) 1998-09-10 2001-09-18 Percardia, Inc. Designs for left ventricular conduit
WO2001020999A1 (en) * 1999-09-23 2001-03-29 Trimedyne, Inc. Materials and methods for inducing angiogenesis and the repair of mammalian tissue
EP1303588B1 (en) * 2000-07-26 2012-10-24 Boston Scientific Limited Therapeutic angiogenesis by bone marrow-derived cell transplantation in myocardial ischemic tissue and skeletal muscle ischemic tissue
FR2830936B1 (en) * 2001-10-16 2004-08-27 Agronomique Inst Nat Rech METHOD FOR MEASURING THE STATE OF TENSION OF A MATERIAL AND APPLICATIONS OF THIS METHOD
US6977162B2 (en) 2002-03-01 2005-12-20 Ravgen, Inc. Rapid analysis of variations in a genome
AU2003247135A1 (en) * 2002-07-23 2004-02-09 Nanodiagnostics, Inc. Embryonic stem cell markers and uses thereof
WO2007116408A2 (en) * 2006-04-11 2007-10-18 Nanodiagnostics Israel Ltd. Pluripotent stem cells characterized by expression of germline specific genes
US7326219B2 (en) 2002-09-09 2008-02-05 Wilk Patent Development Device for placing transmyocardial implant
JP2006505380A (en) * 2002-11-05 2006-02-16 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド Mesenchymal stem cells and methods of use thereof
US20040258670A1 (en) * 2002-12-05 2004-12-23 Case Western Reserve University Cell-based therapies for ischemia
US7470538B2 (en) * 2002-12-05 2008-12-30 Case Western Reserve University Cell-based therapies for ischemia
CA2516486A1 (en) * 2003-02-19 2004-09-02 Dnavec Research Inc. Method of treating ischemic disease
EP1469064A1 (en) * 2003-04-15 2004-10-20 DRK-Blutspendedienst Baden-Württemberg-Hessen gGmbH Expression of proteins in endothelial cells derived from precursor cells from cord blood
US7195598B2 (en) * 2003-05-23 2007-03-27 Siemens Aktiengesellschaft Method for determining the effectiveness of a medical therapy by analysis of collateral vessels
WO2005078073A2 (en) 2004-02-09 2005-08-25 Indiana University Research And Technology Corporation Isolation, expansion and of clonogenic endothelial progenitor cells
US20080095749A1 (en) * 2004-03-22 2008-04-24 Sudeepta Aggarwal Mesenchymal stem cells and uses therefor
WO2005093044A1 (en) * 2004-03-22 2005-10-06 Osiris Therapeutics, Inc. Mesenchymal stem cells and uses therefor
EP1745125A1 (en) * 2004-05-14 2007-01-24 Becton, Dickinson and Company Cell culture environments for the serum-free expansion of mesenchymal stem cells
US7364657B2 (en) * 2005-03-31 2008-04-29 Abbott Cardiovascular Systems Inc. Integrated system for on-site cell acquisition, processing, and delivery
CN1928111B (en) * 2005-09-09 2011-04-20 中国科学院上海生命科学研究院 Correlation analysis of circulation endothelium progenitor cell and coronary artery pathological changes
US7736346B2 (en) * 2005-10-18 2010-06-15 Biocardia, Inc. Bio-interventional therapeutic treatments for cardiovascular diseases
PT2441461E (en) * 2005-11-07 2014-08-26 Amorcyte Inc Compositions and methods of vascular injury repair
EP2010193A4 (en) * 2006-04-17 2012-07-25 Hepacore Ltd Methods for bone regeneration using endothelial progenitor cell preparations
WO2007136424A2 (en) * 2006-05-17 2007-11-29 Cognate Therapeutics, Inc. Isolation and purification of hematopoietic stem cells from post-liposuction lipoaspirates
CA2913024A1 (en) 2006-11-03 2008-05-08 Aastrom Biosciences, Inc. Mixed cell populations for tissue repair and separation technique for cell processing
WO2008085229A2 (en) * 2006-11-15 2008-07-17 Arteriocyte Inc. Cell-based therapies for treating liver disease
WO2008101100A2 (en) * 2007-02-14 2008-08-21 Indiana University Research And Technology Corporation Composition for stimulating formation of vascular structures
EP2134438A1 (en) 2007-03-02 2009-12-23 Smith&Nephew PLC Apparatus and method for filter cleaning by ultrasound, backwashing and filter movement during the filtration of biological samples
US8496926B2 (en) * 2007-04-16 2013-07-30 Biocardia, Inc. Treatment for chronic myocardial infarction
WO2008132722A1 (en) 2007-04-26 2008-11-06 Ramot At Tel-Aviv University Ltd. Pluripotent autologous stem cells from oral mucosa and methods of use
US20080300642A1 (en) * 2007-05-30 2008-12-04 Japan As Represented By President Of National Cardiovascular Center Regeneration treatment apparatus, operating method thereof, and regeneration treatment method
CN102105226B (en) 2008-07-25 2015-01-21 史密夫及内修公开有限公司 Controller for an acoustic standing wave generation device in order to prevent clogging of a filter
WO2010017378A2 (en) * 2008-08-08 2010-02-11 Indiana University Research And Technology Corporation Methods and compositions for vasculogenic potential determination
WO2011121036A2 (en) 2010-03-30 2011-10-06 Vib Vzw Induction of arteriogenesis using specific factors or by cell therapy with polarized myeloid cells
CN101940592B (en) * 2010-08-27 2014-06-25 上海士腾生物技术有限公司 Preparation for treating ischemic cerebrovascular disease and preparation method thereof
WO2012048099A2 (en) 2010-10-08 2012-04-12 Osiris Therapeutics, Inc. Nanoparticle-loaded cells
WO2012048275A2 (en) 2010-10-08 2012-04-12 Caridianbct, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
CN105142650B (en) * 2013-01-12 2019-08-27 西斯卡治疗学有限公司 Rapid infusion of autologous bone marrow-derived stem cells
WO2015057813A1 (en) * 2013-10-16 2015-04-23 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Compositions and methods for promoting the mineralization of biological tissue
JP6612227B2 (en) 2013-11-16 2019-11-27 テルモ ビーシーティー、インコーポレーテッド Cell growth in bioreactors
EP3122866B1 (en) 2014-03-25 2019-11-20 Terumo BCT, Inc. Passive replacement of media
EP3198006B1 (en) 2014-09-26 2021-03-24 Terumo BCT, Inc. Scheduled feed
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
JP7034949B2 (en) 2016-05-25 2022-03-14 テルモ ビーシーティー、インコーポレーテッド Cell proliferation
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
WO2018184028A2 (en) 2017-03-31 2018-10-04 Terumo Bct, Inc. Cell expansion
US12234441B2 (en) 2017-03-31 2025-02-25 Terumo Bct, Inc. Cell expansion
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
KR102503086B1 (en) * 2017-09-08 2023-02-23 가부시키가이샤 오츠카 세이야쿠 고죠 Young pig-derived stem cells and method for producing the same
BR112020010079A2 (en) 2017-11-22 2020-11-03 Mesoblast International Sàrl cell compositions and treatment methods i
US12043823B2 (en) 2021-03-23 2024-07-23 Terumo Bct, Inc. Cell capture and expansion
US12152699B2 (en) 2022-02-28 2024-11-26 Terumo Bct, Inc. Multiple-tube pinch valve assembly
USD1099116S1 (en) 2022-09-01 2025-10-21 Terumo Bct, Inc. Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5980887A (en) * 1996-11-08 1999-11-09 St. Elizabeth's Medical Center Of Boston Methods for enhancing angiogenesis with endothelial progenitor cells
US20030125615A1 (en) * 1998-02-05 2003-07-03 Yitzhack Schwartz Homing of autologous cells to a target zone in tissue using active therapeutics or substances
DE69937888T2 (en) * 1998-07-31 2009-01-02 Genzyme Corp., Cambridge Process for the preparation of mesenchymal stem cells
ES2284489T3 (en) * 1999-03-30 2007-11-16 Ran Kornowski INTRAMIOCARDIC INJECTION OF AUTOMATIC OSEA MEDULA.
US7097832B1 (en) * 1999-03-30 2006-08-29 Myocardial Therapeutics, Inc. Intramyocardial injection of autologous bone marrow
WO2001020999A1 (en) * 1999-09-23 2001-03-29 Trimedyne, Inc. Materials and methods for inducing angiogenesis and the repair of mammalian tissue
AU7500400A (en) * 1999-09-30 2001-04-30 Mcgill University Autologous marrow stem cell (msc) transplantation for myocardial regeneration
JP2002020298A (en) * 2000-07-10 2002-01-23 Junkanki Kenkyusho:Kk Neovascularization promoter
EP1303588B1 (en) * 2000-07-26 2012-10-24 Boston Scientific Limited Therapeutic angiogenesis by bone marrow-derived cell transplantation in myocardial ischemic tissue and skeletal muscle ischemic tissue
US7138144B2 (en) * 2001-09-07 2006-11-21 Nadir Askenasy Method of inducing immune tolerance via blood/lymph flow-restricted bone marrow transplantation

Also Published As

Publication number Publication date
EP1303588A2 (en) 2003-04-23
US20020037278A1 (en) 2002-03-28
WO2002008389A2 (en) 2002-01-31
JP2004516242A (en) 2004-06-03
CA2429502A1 (en) 2002-01-31
WO2002008389A9 (en) 2003-06-12
US7799349B2 (en) 2010-09-21
EP1303588B1 (en) 2012-10-24
US20050147597A1 (en) 2005-07-07
WO2002008389A3 (en) 2002-10-10
US6878371B2 (en) 2005-04-12

Similar Documents

Publication Publication Date Title
AU2001278010A1 (en) Therapeutic angiogenesis by bone marrow-derived cell transplantation in myocardial ischemic tissue and skeletal muscle ischemic tissue
AU2001275339A1 (en) Identification and use of human bone marrow-derived endothelial progenitor cells to improve myocardial function after ischemic injury
IL159895A0 (en) Methods of generating human cardiac cells and tissues and uses thereof
AU2002224003A1 (en) Process of decellularizing biological matrices and acellular biological matrices useful in tissue engineering
IL183853A0 (en) New oxabispidine compounds useful in the treatment of cardiac arrhythmias
AU8880701A (en) Cardiac arrhythmia treatment methods
EP1217970A4 (en) Improved tissue injectable composition
PT1066838E (en) Bone tissue regenerating composition
IL150389A0 (en) Skin moisturizing composition
AU7852600A (en) Iontophoretic delivery to heart tissue
AU2001238363A1 (en) Compositions for preventing cellulite in mammalian skin
IL154802A0 (en) New oxabispidine compound useful in the treatment of cardiac arrhythmias
EP1200133A4 (en) Manipulation of tissue or organ type using the notch pathway
AU2002224471A1 (en) In vivo stimulation of angiogenic activity
HUP0200551A2 (en) Cosmetic stick composition
AU2001269803A1 (en) Compositions and methods for modulating muscle cell and tissue contractility
AU5134600A (en) Full-length molecules expressed in human tissues
IL153485A0 (en) New bispidine compounds and their use in the treatment of cardiac arrhythmias
AU2002210961A1 (en) Novel gene overexpressed in heart and skeletal muscle and use tehreof
IL146752A0 (en) New bispidine compounds useful in the treatment of cardiac arrhythmias
PL354032A1 (en) New bispidine compounds useful in the treatment of cardiac arrhythmias
PL353155A1 (en) New bispidine compounds useful in the treatment of cardiac arrhythmias
PL357102A1 (en) New bispidine compounds useful in the treatment of cardiac arrhythmias
WO2001007605A8 (en) Immunosuppression by cell surface expression of recombinant cd154
TW389038U (en) Structure of multi-functional walking stick