[go: up one dir, main page]

AU2001278098A1 - Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms - Google Patents

Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms

Info

Publication number
AU2001278098A1
AU2001278098A1 AU2001278098A AU7809801A AU2001278098A1 AU 2001278098 A1 AU2001278098 A1 AU 2001278098A1 AU 2001278098 A AU2001278098 A AU 2001278098A AU 7809801 A AU7809801 A AU 7809801A AU 2001278098 A1 AU2001278098 A1 AU 2001278098A1
Authority
AU
Australia
Prior art keywords
mevalonate
genes
manipulation
transgenic organisms
create novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001278098A
Inventor
Frederick M. Hahn
Adelheid R. Kuehnle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of AU2001278098A1 publication Critical patent/AU2001278098A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P9/00Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90Isomerases (5.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8209Selection, visualisation of transformants, reporter constructs, e.g. antibiotic resistance markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8214Plastid transformation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Nutrition Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Enzymes And Modification Thereof (AREA)
AU2001278098A 2000-07-31 2001-07-31 Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms Abandoned AU2001278098A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22170300P 2000-07-31 2000-07-31
US60/221,703 2000-07-31
PCT/US2001/024037 WO2002010398A2 (en) 2000-07-31 2001-07-31 Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms

Publications (1)

Publication Number Publication Date
AU2001278098A1 true AU2001278098A1 (en) 2002-02-13

Family

ID=22828972

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001278098A Abandoned AU2001278098A1 (en) 2000-07-31 2001-07-31 Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms

Country Status (4)

Country Link
US (8) US20030033626A1 (en)
EP (3) EP1360300A2 (en)
AU (1) AU2001278098A1 (en)
WO (1) WO2002010398A2 (en)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020086380A1 (en) * 1996-03-29 2002-07-04 Francis X. Cunningham Jr Genes encoding epsilon lycopene cyclase and method for producing bicyclic carotene
EP2305825B1 (en) * 1998-07-06 2015-01-14 DCV Inc. doing business as Bio-Technical Resourses Method of vitamin production
US20030033626A1 (en) * 2000-07-31 2003-02-13 Hahn Frederick M. Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms
US20120094385A1 (en) * 2000-07-31 2012-04-19 Kuehnle Agrosystems, Inc. Gene positioning system for plastidic transformation and products thereof
US7172886B2 (en) 2001-12-06 2007-02-06 The Regents Of The University Of California Biosynthesis of isopentenyl pyrophosphate
US7192751B2 (en) 2001-12-06 2007-03-20 The Regents Of The University Of California Biosynthesis of amorpha-4,11-diene
DK1589807T3 (en) * 2002-12-06 2012-02-13 Del Monte Fresh Produce Company Transgenic pineapple plants with modified carotenoid levels and methods for their preparation
US7663021B2 (en) 2002-12-06 2010-02-16 Del Monte Fresh Produce Company Transgenic pineapple plants with modified carotenoid levels and methods of their production
ATE414781T1 (en) * 2003-07-08 2008-12-15 Dsm Ip Assets Bv IMPROVED PROCESS FOR PRODUCING COENZYME Q-10
US7723569B2 (en) * 2004-04-30 2010-05-25 National Institute Of Agrobiological Sciences Method for producing ubiquinone-10 in plant
BRPI0510115B1 (en) * 2004-05-21 2022-09-27 The Regents Of The University Of California METHOD FOR PRODUCING AN ISOPRENOID OR ISOPRENOID PRECURSOR THROUGH A MEVALONATE PATHWAY IN ESCHERICHIA COLI AND THE GENETICALLY MODIFIED HOST CELL THAT PRODUCES THEM
JP5590769B2 (en) 2004-07-27 2014-09-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Genetically modified host cells and methods of using the host cells for producing isoprenoid compounds
WO2006102342A2 (en) 2005-03-18 2006-09-28 Microbia, Inc. Production of carotenoids in oleaginous yeast and fungi
US20090053797A1 (en) * 2005-08-19 2009-02-26 Yoichiro Shiba Genetically modified host cells and use of same for producing isoprenoid compounds
EP1931770A4 (en) * 2005-10-07 2009-11-25 Univ California NUCLEIC ACIDS ENCODING MODIFIED P450 CYTOCHROME ENZYMES AND METHODS OF USE THEREOF
US20090047722A1 (en) * 2005-12-09 2009-02-19 Bionavitas, Inc. Systems, devices, and methods for biomass production
WO2007136847A2 (en) * 2006-05-19 2007-11-29 The Regents Of The University Of California Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels
WO2008042338A2 (en) 2006-09-28 2008-04-10 Microbia, Inc. Production of carotenoids in oleaginous yeast and fungi
US20100035321A1 (en) * 2007-04-20 2010-02-11 Bionavitas, Inc. Systems, devices, and, methods for releasing biomass cell components
US8609385B2 (en) 2007-05-01 2013-12-17 Zuvachem, Inc. Methods for the direct conversion of carbon dioxide into a hydrocarbon using a metabolically engineered photosynthetic microorganism
MX2009012839A (en) * 2007-06-01 2010-02-24 Sapphire Energy High throughput screening of genetically modified photosynthetic organisms.
WO2009006386A2 (en) 2007-06-29 2009-01-08 The Regents Of The University Of California Host cells and methods for producing isoprenyl alkanoates
WO2009006429A1 (en) * 2007-06-29 2009-01-08 Regents Of The University Of California Host cells and methods for producing 3-methyl-2-buten-1-ol, 3-methyl-3-buten-1-ol, and 3-methyl-butan-1-ol
CA2700008A1 (en) * 2007-08-01 2009-02-05 Bioglow Inc. Bioluminescent plants comprising bacterial lux operon and methods of making same
WO2009018498A2 (en) * 2007-08-01 2009-02-05 Bionavitas, Inc. Illumination systems, devices, and methods for biomass production
WO2009028854A1 (en) 2007-08-24 2009-03-05 Lg Electronics Inc. Digital broadcasting system and method of processing data in digital broadcasting system
AR073437A1 (en) * 2007-09-11 2010-11-10 Sapphire Energy Inc ISOPRENOID PRODUCTION THROUGH PHOTOSYNTHETIC ORGANISMS
WO2009036087A1 (en) * 2007-09-11 2009-03-19 Sapphire Energy, Inc. Methods of producing organic products with photosynthetic organisms and products and compositions thereof
EP3354740A1 (en) 2007-12-13 2018-08-01 Danisco US Inc. Compositions and methods for producing isoprene
US8173410B2 (en) 2008-04-23 2012-05-08 Danisco Us Inc. Isoprene synthase variants for improved microbial production of isoprene
CA2759700A1 (en) 2009-04-23 2010-10-28 Danisco Us Inc. Three-dimensional structure of isoprene synthase and its use thereof for generating variants
TWI427149B (en) * 2009-06-17 2014-02-21 Danisco Us Inc Improved isoprene production using the dxp and mva pathway
EP2292741A1 (en) * 2009-08-26 2011-03-09 OrganoBalance GmbH Genetically modified organisms for the production of lipids
US8937214B2 (en) * 2009-10-23 2015-01-20 Monsanto Technology Llc Methods and compositions for expression of transgenes in plants
MY167872A (en) 2010-06-02 2018-09-26 Evolva Inc Recombinant production of steviol glycosides
CN103443271A (en) 2010-10-27 2013-12-11 丹尼斯科美国公司 Isoprene synthase variants for improved production of isoprene
CA2822467A1 (en) 2010-12-22 2012-06-28 Danisco Us Inc. Compositions and methods for improved isoprene production using two types of ispg enzymes
WO2012088450A1 (en) 2010-12-22 2012-06-28 Danisco Us Inc. Biological production of pentose sugars using recombinant cells
WO2012156976A1 (en) 2011-05-16 2012-11-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods of producing artemisinin in non-host plants and vectors for use in same
US9631215B2 (en) 2011-08-08 2017-04-25 Evolva Sa Recombinant production of steviol glycosides
CA2851265A1 (en) 2011-10-07 2013-05-10 Danisco Us Inc. Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene
HK1201554A1 (en) 2011-10-27 2015-09-04 Danisco Us Inc. Isoprene synthase variants with improved solubility for production of isoprene
US20140182011A1 (en) 2011-11-03 2014-06-26 The University Of Hong Kong Methods Using Acyl-Coenzyme A-Binding Proteins to Enchance Drought Tolerance in Genetically Modified Plants
US9163263B2 (en) 2012-05-02 2015-10-20 The Goodyear Tire & Rubber Company Identification of isoprene synthase variants with improved properties for the production of isoprene
JP5827601B2 (en) * 2012-07-04 2015-12-02 住友ゴム工業株式会社 Method for adjusting expression of specific protein by light-responsive transcription factor, isoprenoid-producing plant introduced with gene encoding light-responsive transcription factor, and method for producing polyisoprenoid using the isoprenoid-producing plant
SG11201505597SA (en) 2013-02-06 2015-08-28 Evolva Sa Methods for improved production of rebaudioside d and rebaudioside m
CA2900882A1 (en) 2013-02-11 2014-08-14 Evolva Sa Efficient production of steviol glycosides in recombinants hosts
US9523097B2 (en) * 2013-03-15 2016-12-20 The United States Of America, As Represented By The Secretary Of Agriculture Engineering rubber production in plants
US20140380524A1 (en) 2013-06-19 2014-12-25 The University Of Hong Kong Methods of using 3-hydroxy-3-methylglutaryl-coa synthase to enhance growth and/or seed yield of genetically modified plants
CN106572688B (en) 2014-08-11 2022-01-25 埃沃尔瓦公司 Production of steviol glycosides in recombinant hosts
EP3190905B1 (en) 2014-09-09 2025-03-12 Danstar Ferment AG Production of steviol glycosides in recombinant hosts
JP2018503388A (en) 2015-01-30 2018-02-08 エヴォルヴァ エスアー.Evolva Sa. Production of steviol glycosides in recombinant hosts
EP3271457B1 (en) 2015-03-16 2021-01-20 DSM IP Assets B.V. Udp-glycosyltransferases
CA2995067A1 (en) 2015-08-07 2017-02-16 Evolva Sa Production of steviol glycosides in recombinant hosts
CN109195457A (en) 2016-04-13 2019-01-11 埃沃尔瓦公司 Steviol glycoside is generated in the recombination host
EP3458599A1 (en) 2016-05-16 2019-03-27 Evolva SA Production of steviol glycosides in recombinant hosts
CA3028227A1 (en) 2016-06-30 2018-01-04 Kuehnle Agrosystems, Inc. Improved heterotrophic production methods for microbial biomass and bioproducts
WO2018083338A1 (en) 2016-11-07 2018-05-11 Evolva Sa Production of steviol glycosides in recombinant hosts
EP3615667B1 (en) 2017-04-27 2021-08-11 The Regents of The University of California Microorganisms and methods for producing cannabinoids and cannabinoid derivatives
US20180327770A1 (en) 2017-05-11 2018-11-15 The United States Of America, As Represented By The Secretary Of Agriculture Guayule with increased rubber production and yield
CN107475121A (en) * 2017-09-19 2017-12-15 新奥科技发展有限公司 The prevention and controls of harmful bacteria in a kind of microalga cultivation process
US10961541B2 (en) 2017-09-19 2021-03-30 The United States Of America As Represented By The Secretary Of Agriculture Genetically altered guayule having increased rubber production and methods thereof
JP2021505154A (en) 2017-12-07 2021-02-18 ザイマージェン インコーポレイテッド Designed biosynthetic pathway for producing (6E) -8-hydroxygeraniol by fermentation
WO2019126778A1 (en) 2017-12-21 2019-06-27 Zymergen Inc. Nepetalactol oxidoreductases, nepetalactol synthases, and microbes capable of producing nepetalactone
US11377675B2 (en) 2019-01-16 2022-07-05 Kuehnle Agrosystems, Inc. Subterranean microalgae for production of microbial biomass, substances, and compositions

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5380831A (en) 1986-04-04 1995-01-10 Mycogen Plant Science, Inc. Synthetic insecticidal crystal protein gene
DE3700397A1 (en) * 1986-01-10 1987-07-16 Canon Kk RECORDING DEVICE
US4846872A (en) 1986-08-11 1989-07-11 Fujisawa Pharmaceutical Co., Ltd. Herbicide
US5436301A (en) * 1988-05-09 1995-07-25 Teijin Limited Epoxy resin-impregnated prepreg
US5545816A (en) * 1990-03-02 1996-08-13 Amoco Corporation Phytoene biosynthesis in genetically engineered hosts
US5877402A (en) * 1990-05-01 1999-03-02 Rutgers, The State University Of New Jersey DNA constructs and methods for stably transforming plastids of multicellular plants and expressing recombinant proteins therein
US5306862A (en) 1990-10-12 1994-04-26 Amoco Corporation Method and composition for increasing sterol accumulation in higher plants
TW261517B (en) 1991-11-29 1995-11-01 Mitsubishi Shozi Kk
US6395959B1 (en) * 1992-05-05 2002-05-28 Institut Pasteur Nucleotide sequence encoding the enzyme I SceI and the use thereof
US5340126A (en) * 1992-12-21 1994-08-23 Dana Corporation Flangeless fire ring holder
US6291745B1 (en) 1993-04-02 2001-09-18 Pioneer Hi-Bred International, Inc. Limonene and other downstream metabolites of geranyl pyrophosphate for insect control in plants
US5824774A (en) 1996-04-12 1998-10-20 Board Of Trustees Of The University Of Kentucky Chimeric isoprenoid synthases and uses thereof
WO1997038571A1 (en) 1996-04-15 1997-10-23 Washington State University Research Foundation Compositions and methods for taxol biosynthesis
JP2002513283A (en) * 1997-01-17 2002-05-08 ザ スクリップス リサーチ インスティテュート RNA binding proteins and binding sites useful for expression of recombinant molecules
CA2302873C (en) 1997-09-02 2005-01-25 Washington State University Research Foundation Nucleic and amino acid sequences for a novel transketolase from (mentha piperita)
CN1295336C (en) 1998-04-14 2007-01-17 协和发酵工业株式会社 Method for producing isoprenoid compound using microorganisms and method for detecting compound having antibacterial or herbicidal activity
TWI250210B (en) 1998-05-06 2006-03-01 Dsm Ip Assets Bv An isolated DNA sequence coding for an enzyme involved in the mevalonate pathway or the pathway from isopentenyl pyrophosphate to farnesyl pyrophosphate
EP0955363A3 (en) 1998-05-06 2004-01-28 F. Hoffmann-La Roche Ag Dna sequences encoding enzymes involved in production of isoprenoids
EP1947189B1 (en) 1998-07-06 2010-12-01 DCV Inc. doing business as Bio-Technical Resourses Method of vitamin production
EP1095033A1 (en) * 1998-07-06 2001-05-02 Eastman Chemical Company Method of producing vitamin e
EP2305825B1 (en) 1998-07-06 2015-01-14 DCV Inc. doing business as Bio-Technical Resourses Method of vitamin production
AR022383A1 (en) 1998-09-18 2002-09-04 Univ Kentucky Res Found SYNTHESES
US6916972B2 (en) 1998-11-05 2005-07-12 E. I. Du Pont De Nemours And Company Mevalonate synthesis enzymes
US6306633B1 (en) 1999-02-01 2001-10-23 Smithkline Beecham Corporation Polynucleotides encoding mevalonate kinase from Streptococcus pneumoniae
US6281017B1 (en) 1999-02-03 2001-08-28 Washington State University Research Foundation 1-deoxy-d-xylulose-5-phosphate reductoisomerases and method of use
EP1260590B1 (en) * 2000-03-02 2007-02-14 TOUDAI TLO, Ltd. Method of screening substance specifically inhibiting non-mevalonate pathway
US20030033626A1 (en) * 2000-07-31 2003-02-13 Hahn Frederick M. Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms
US20040063182A1 (en) 2000-12-28 2004-04-01 Chikara Ohto Process for producing prenyl alcohol
JP3838033B2 (en) 2000-12-28 2006-10-25 トヨタ自動車株式会社 Method for producing prenyl alcohol
US6989257B2 (en) 2001-06-06 2006-01-24 Dsm Ip Assets B.V. Isoprenoid production
US7192751B2 (en) * 2001-12-06 2007-03-20 The Regents Of The University Of California Biosynthesis of amorpha-4,11-diene
US7172886B2 (en) * 2001-12-06 2007-02-06 The Regents Of The University Of California Biosynthesis of isopentenyl pyrophosphate
US7216238B2 (en) 2003-06-30 2007-05-08 Symbol Technologies, Inc. System and method for controlling usage of software on computing devices
BRPI0510115B1 (en) * 2004-05-21 2022-09-27 The Regents Of The University Of California METHOD FOR PRODUCING AN ISOPRENOID OR ISOPRENOID PRECURSOR THROUGH A MEVALONATE PATHWAY IN ESCHERICHIA COLI AND THE GENETICALLY MODIFIED HOST CELL THAT PRODUCES THEM

Also Published As

Publication number Publication date
US8999682B2 (en) 2015-04-07
EP2281890A1 (en) 2011-02-09
EP1360300A2 (en) 2003-11-12
US20060263863A1 (en) 2006-11-23
US20080261280A1 (en) 2008-10-23
US7618819B2 (en) 2009-11-17
WO2002010398A3 (en) 2003-06-26
EP2292776A1 (en) 2011-03-09
US7129392B2 (en) 2006-10-31
US20140106416A1 (en) 2014-04-17
US20120083020A1 (en) 2012-04-05
WO2002010398A2 (en) 2002-02-07
US20130203132A1 (en) 2013-08-08
US20040194162A1 (en) 2004-09-30
US20050241017A1 (en) 2005-10-27
US20030033626A1 (en) 2003-02-13

Similar Documents

Publication Publication Date Title
AU2001278098A1 (en) Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms
AU2635201A (en) Direct manipulation of displayed content
AU2001292842A1 (en) Compositions and methods relating to prostate specific genes and proteins
AU2001241474A1 (en) Biosensor compositions and methods of use
AU2002222610A1 (en) Transgenic animal expressing hla-a24 and utilization thereof
AU2001255797A1 (en) Enhanced gene expression in plants using transcription factors
AU2002219988A1 (en) Compositions and methods relating to breast specific genes and proteins
AU2002245031A1 (en) Compositions and methods relating to prostate specific genes and proteins
AU2001244892A1 (en) Improvements in and relating to honey based products
AU2001286810A1 (en) Compositions and methods relating to lung specific genes
AU2002220009A1 (en) Compositions and methods relating to lung specific genes and proteins
AU2001297741A1 (en) Compositions and methods relating to breast specific genes and proteins
AU2002239409A1 (en) Compositions and methods relating to colon specific genes and proteins
AU2001240814A1 (en) Improvements in and relating to investigating corrosion
AU2001274808A1 (en) Combined two-shoe tree and organizer
AU2002217991A1 (en) Compositions and methods relating to prostate specific genes and proteins
AU2400401A (en) Novel phosphodiesterases and genes thereof
AU2001277937A1 (en) Compositions and methods relating to lung specific genes
AU2002213458A1 (en) Methods and compositions relating to the generation of partially transgenic organisms
AU2002241557A1 (en) Compositions and methods relating to prostate specific genes and proteins
AU2002236579A1 (en) Compositions and methods relating to prostate specific genes and proteins
AU2001297804A1 (en) Compositions and methods relating to breast specific genes and proteins
AU2001284265A1 (en) Genetic study
AU2001241622A1 (en) Novel defense induced genes and uses thereof
AU2001278887A1 (en) Methods for maximizing expression of transgenic traits in autopolyploid plants