AU2001270204A1 - Modulation of beta-amyloid levels by beta-secretase bace2 - Google Patents
Modulation of beta-amyloid levels by beta-secretase bace2Info
- Publication number
- AU2001270204A1 AU2001270204A1 AU2001270204A AU7020401A AU2001270204A1 AU 2001270204 A1 AU2001270204 A1 AU 2001270204A1 AU 2001270204 A AU2001270204 A AU 2001270204A AU 7020401 A AU7020401 A AU 7020401A AU 2001270204 A1 AU2001270204 A1 AU 2001270204A1
- Authority
- AU
- Australia
- Prior art keywords
- beta
- bace2
- secretase
- modulation
- amyloid levels
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21572900P | 2000-06-28 | 2000-06-28 | |
| US60/215,729 | 2000-06-28 | ||
| PCT/US2001/020465 WO2002000913A2 (en) | 2000-06-28 | 2001-06-27 | MODULATION OF β-AMYLOID LEVELS BY β-SECRETASE BACE2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2001270204A1 true AU2001270204A1 (en) | 2002-01-08 |
Family
ID=22804142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001270204A Abandoned AU2001270204A1 (en) | 2000-06-28 | 2001-06-27 | Modulation of beta-amyloid levels by beta-secretase bace2 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US6713276B2 (en) |
| EP (2) | EP1315516A2 (en) |
| JP (1) | JP2004501652A (en) |
| AU (1) | AU2001270204A1 (en) |
| CA (1) | CA2413209A1 (en) |
| WO (1) | WO2002000913A2 (en) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6844148B1 (en) | 1998-09-24 | 2005-01-18 | Pharmacia & Upjohn Company | Alzheimer's disease secretase, APP substrates therefor, and uses therefor |
| JP5138851B2 (en) * | 1999-06-28 | 2013-02-06 | オクラホマ メディカル リサーチ ファウンデーション | Catalytically active recombinant memapsin and methods of use thereof |
| US6713276B2 (en) * | 2000-06-28 | 2004-03-30 | Scios, Inc. | Modulation of Aβ levels by β-secretase BACE2 |
| US7763609B2 (en) * | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| US7592348B2 (en) | 2003-12-15 | 2009-09-22 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| US7700603B2 (en) * | 2003-12-15 | 2010-04-20 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| US7341991B2 (en) * | 2003-12-31 | 2008-03-11 | Posco | Inhibitors of amyloid precursor protein processing |
| US20060223849A1 (en) * | 2005-03-14 | 2006-10-05 | Mjalli Adnan M | Benzazole derivatives, compositions, and methods of use as beta-secretase inhibitors |
| US20070092517A1 (en) * | 2005-08-10 | 2007-04-26 | Oklahoma Medical Research Foundation | Truncated memapsin 2 compositions and treatments |
| AU2006307314C1 (en) | 2005-10-25 | 2011-08-25 | Shionogi & Co., Ltd. | Aminodihydrothiazine derivative |
| CN101437933B (en) | 2005-12-28 | 2013-11-06 | 斯克里普斯研究所 | Natural antisense and non-coding RNA transcripts as drug targets |
| JP5379692B2 (en) | 2006-11-09 | 2013-12-25 | プロビオドルグ エージー | 3-Hydroxy-1,5-dihydro-pyrrol-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcers, cancer and other diseases |
| EP2091948B1 (en) | 2006-11-30 | 2012-04-18 | Probiodrug AG | Novel inhibitors of glutaminyl cyclase |
| EP2061771A1 (en) * | 2006-12-12 | 2009-05-27 | Schering Corporation | Aspartyl protease inhibitors containing a tricyclic ring system |
| CN101668751A (en) | 2006-12-12 | 2010-03-10 | 先灵公司 | aspartyl protease inhibitors |
| AU2008220785B2 (en) | 2007-03-01 | 2013-02-21 | Vivoryon Therapeutics N.V. | New use of glutaminyl cyclase inhibitors |
| WO2008128985A1 (en) | 2007-04-18 | 2008-10-30 | Probiodrug Ag | Thiourea derivatives as glutaminyl cyclase inhibitors |
| EP2147914B1 (en) * | 2007-04-24 | 2014-06-04 | Shionogi&Co., Ltd. | Aminodihydrothiazine derivatives substituted with cyclic groups |
| WO2008133273A1 (en) * | 2007-04-24 | 2008-11-06 | Shionogi & Co., Ltd. | Pharmaceutical composition for treatment of alzheimer's disease |
| US20110098309A1 (en) * | 2007-07-12 | 2011-04-28 | Acumen Pharmaceuticals, Inc. | Methods of inhibiting the formation of amyloid-beta diffusable ligands using acylhydrazide compounds |
| US8962677B2 (en) * | 2007-07-12 | 2015-02-24 | Acumen Pharmaceuticals, Inc. | Methods of restoring cognitive ability using non-peptidic compounds |
| US9006283B2 (en) | 2007-07-12 | 2015-04-14 | Acumen Pharmaceuticals, Inc. | Methods of modifying amyloid β oligomers using non-peptidic compounds |
| CA2707309A1 (en) | 2007-12-18 | 2009-06-25 | Acumen Pharmaceuticals, Inc. | Novel addl receptor polypeptides, polynucleotides and host cells for recombinant production |
| US20090176711A1 (en) * | 2008-01-08 | 2009-07-09 | Chi-Bom Chae | Inhibitors of amyloid precursor protein processing |
| EA020740B1 (en) | 2008-06-13 | 2015-01-30 | Шионоги & Ко., Лтд. | SULFUR-CONTAINING HETEROCYCLIC DERIVATIVE HAVING β-SECRETASE-INHIBITING ACTIVITY |
| CN102186841A (en) * | 2008-10-22 | 2011-09-14 | 盐野义制药株式会社 | 2-aminopyridin-4-one and 2-aminopyridine derivative both having bace1-inhibiting activity |
| SG171932A1 (en) * | 2008-12-02 | 2011-07-28 | Hoffmann La Roche | Screening assays for the identification of bace2 inhibitors |
| EP2370579B1 (en) | 2008-12-04 | 2017-03-29 | CuRNA, Inc. | Treatment of erythropoietin (epo) related diseases by inhibition of natural antisense transcript to epo |
| WO2011029920A1 (en) | 2009-09-11 | 2011-03-17 | Probiodrug Ag | Heterocylcic derivatives as inhibitors of glutaminyl cyclase |
| TWI488852B (en) | 2009-12-11 | 2015-06-21 | Shionogi & Co | Purine derivative |
| EP2542549B1 (en) | 2010-03-03 | 2016-05-11 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
| AU2011226074B2 (en) | 2010-03-10 | 2015-01-22 | Vivoryon Therapeutics N.V. | Heterocyclic inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5) |
| US8541596B2 (en) | 2010-04-21 | 2013-09-24 | Probiodrug Ag | Inhibitors |
| AU2011321427A1 (en) | 2010-10-29 | 2013-05-02 | Shionogi & Co., Ltd. | Naphthyridine derivative |
| EP2634188A4 (en) | 2010-10-29 | 2014-05-07 | Shionogi & Co | Fused aminodihydropyrimidine derivative |
| US8530670B2 (en) | 2011-03-16 | 2013-09-10 | Probiodrug Ag | Inhibitors |
| CN103608345A (en) | 2011-04-26 | 2014-02-26 | 盐野义制药株式会社 | Oxazine derivative and BACE 1 inhibitor containing same |
| JP2013158281A (en) * | 2012-02-03 | 2013-08-19 | Shionogi & Co Ltd | Novel method for measuring bace1 activity |
| JP2015511494A (en) | 2012-03-15 | 2015-04-20 | キュアナ,インク. | Treatment of BDNF-related diseases by inhibition of natural antisense transcripts against brain-derived neurotrophic factor (BDNF) |
| WO2014065434A1 (en) | 2012-10-24 | 2014-05-01 | Shionogi & Co., Ltd. | Dihydrooxazine or oxazepine derivatives having bace1 inhibitory activity |
| DK3461819T3 (en) | 2017-09-29 | 2020-08-10 | Probiodrug Ag | GLUTAMINYL CYCLASE INHIBITORS |
| US12297244B2 (en) | 2019-06-05 | 2025-05-13 | Rensselaer Polytechnic Institute | Systems and methods for inhibiting γ-secretase production of amyloid-β peptides |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06507782A (en) | 1990-06-15 | 1994-09-08 | サイオス ノバ インコーポレイテッド | Non-human recombinant mammals exhibiting amyloid formation symptoms of Alzheimer's disease |
| US5912410A (en) | 1990-06-15 | 1999-06-15 | Scios Inc. | Transgenic non-human mice displaying the amyloid-forming pathology of alzheimer's disease |
| TW327194B (en) * | 1992-05-01 | 1998-02-21 | American Cyanamid Co | Novel amyloid precursor proteins and methods of using same |
| EP0848062A3 (en) | 1996-12-14 | 2000-07-05 | Smithkline Beecham Corporation | Aspartic protease ASP1 |
| AU1726199A (en) | 1997-12-31 | 1999-07-19 | Chiron Corporation | Metastatic cancer regulated gene |
| US20030224517A1 (en) * | 2002-06-04 | 2003-12-04 | Isis Pharmaceuticals Inc. | Antisense modulation of beta-site APP-cleaving enzyme 2 expression |
| US6844148B1 (en) * | 1998-09-24 | 2005-01-18 | Pharmacia & Upjohn Company | Alzheimer's disease secretase, APP substrates therefor, and uses therefor |
| US6699671B1 (en) * | 1998-09-24 | 2004-03-02 | Pharmacia & Upjohn Company | Alzheimer's disease secretase, APP substrates therefor, and uses therefor |
| US20060101532A1 (en) * | 1999-04-30 | 2006-05-11 | Nixon Ralph A | Methods for the identification of compounds for the treatment of Alzheimer's disease |
| US7087399B1 (en) * | 1999-05-13 | 2006-08-08 | Scios, Inc. | β-secretase and modulation of β-secretase activity |
| PE20010693A1 (en) | 1999-09-23 | 2001-06-24 | Upjohn Co | METHOD FOR THE DETERMINATION OF ALFA-SECRETASE ACTIVITY ON THE APP |
| US6713276B2 (en) * | 2000-06-28 | 2004-03-30 | Scios, Inc. | Modulation of Aβ levels by β-secretase BACE2 |
| CA2313828A1 (en) * | 2000-08-01 | 2002-02-01 | Institut De Recherches Cliniques De Montreal/Ircm | Post-translational processing of .beta.-secretase (bace): the pro-and transmembrane/cytosolic domains affect its cellular activity and amyloid a.beta. production |
| AU2002243391A1 (en) * | 2000-10-27 | 2002-06-24 | The Johns Hopkins University School Of Medicine | Beta-secretase transgenic organisms, anti-beta-secretase antibodies, and methods of use thereof |
| US20040203042A1 (en) * | 2003-03-04 | 2004-10-14 | Johnson Jason M | Alternatively spliced isoforms of aspartyl protease 1 (BACE2) |
-
2001
- 2001-06-20 US US09/886,143 patent/US6713276B2/en not_active Expired - Fee Related
- 2001-06-27 CA CA002413209A patent/CA2413209A1/en not_active Abandoned
- 2001-06-27 JP JP2002506227A patent/JP2004501652A/en not_active Withdrawn
- 2001-06-27 WO PCT/US2001/020465 patent/WO2002000913A2/en not_active Ceased
- 2001-06-27 AU AU2001270204A patent/AU2001270204A1/en not_active Abandoned
- 2001-06-27 EP EP01948768A patent/EP1315516A2/en not_active Withdrawn
- 2001-06-27 EP EP10184820A patent/EP2359847A1/en not_active Withdrawn
-
2003
- 2003-12-31 US US10/749,714 patent/US7183070B2/en not_active Expired - Fee Related
-
2007
- 2007-02-27 US US11/712,211 patent/US20070224656A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US7183070B2 (en) | 2007-02-27 |
| EP2359847A1 (en) | 2011-08-24 |
| JP2004501652A (en) | 2004-01-22 |
| US20070224656A1 (en) | 2007-09-27 |
| US20040248231A1 (en) | 2004-12-09 |
| CA2413209A1 (en) | 2002-01-03 |
| US6713276B2 (en) | 2004-03-30 |
| WO2002000913A9 (en) | 2002-10-24 |
| WO2002000913A3 (en) | 2003-03-13 |
| US20020159991A1 (en) | 2002-10-31 |
| WO2002000913A2 (en) | 2002-01-03 |
| EP1315516A2 (en) | 2003-06-04 |
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