AU2001270171A1 - Methods for detecting activity of clotting factors - Google Patents
Methods for detecting activity of clotting factorsInfo
- Publication number
- AU2001270171A1 AU2001270171A1 AU2001270171A AU7017101A AU2001270171A1 AU 2001270171 A1 AU2001270171 A1 AU 2001270171A1 AU 2001270171 A AU2001270171 A AU 2001270171A AU 7017101 A AU7017101 A AU 7017101A AU 2001270171 A1 AU2001270171 A1 AU 2001270171A1
- Authority
- AU
- Australia
- Prior art keywords
- methods
- clotting factors
- detecting activity
- activity
- detecting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 102000015081 Blood Coagulation Factors Human genes 0.000 title 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 title 1
- 239000003114 blood coagulation factor Substances 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/607,716 US6423826B1 (en) | 2000-06-30 | 2000-06-30 | High molecular weight derivatives of vitamin K-dependent polypeptides |
| US09/607,716 | 2000-06-30 | ||
| PCT/US2001/020307 WO2002003075A2 (en) | 2000-06-30 | 2001-06-26 | Methods for detecting activity of clotting factors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2001270171A1 true AU2001270171A1 (en) | 2002-01-14 |
Family
ID=24433404
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001271508A Abandoned AU2001271508A1 (en) | 2000-06-30 | 2001-06-26 | High molecular weight derivatives of vitamin k-dependent polypeptides |
| AU2001270171A Abandoned AU2001270171A1 (en) | 2000-06-30 | 2001-06-26 | Methods for detecting activity of clotting factors |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001271508A Abandoned AU2001271508A1 (en) | 2000-06-30 | 2001-06-26 | High molecular weight derivatives of vitamin k-dependent polypeptides |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US6423826B1 (en) |
| AU (2) | AU2001271508A1 (en) |
| WO (2) | WO2002003075A2 (en) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6747003B1 (en) | 1997-10-23 | 2004-06-08 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| US7247708B2 (en) * | 1997-10-23 | 2007-07-24 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| CN100488562C (en) * | 2000-02-11 | 2009-05-20 | 拜耳医药保健有限公司 | Coagulation factor VII or VIIa-like molecules |
| US7220837B1 (en) | 2000-04-28 | 2007-05-22 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| US7812132B2 (en) * | 2000-04-28 | 2010-10-12 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| US7160540B2 (en) | 2000-06-30 | 2007-01-09 | Regents Of The University Of Minnesota | Methods for detecting activity of clottings factors |
| US20030211094A1 (en) | 2001-06-26 | 2003-11-13 | Nelsestuen Gary L. | High molecular weight derivatives of vitamin k-dependent polypeptides |
| WO2002039951A2 (en) * | 2000-11-15 | 2002-05-23 | Globe Immune, Inc. | Yeast-dentritic cell vaccines and uses thereof |
| US8008252B2 (en) | 2001-10-10 | 2011-08-30 | Novo Nordisk A/S | Factor VII: remodeling and glycoconjugation of Factor VII |
| US7795210B2 (en) | 2001-10-10 | 2010-09-14 | Novo Nordisk A/S | Protein remodeling methods and proteins/peptides produced by the methods |
| US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
| US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| US7696163B2 (en) | 2001-10-10 | 2010-04-13 | Novo Nordisk A/S | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| US7157277B2 (en) | 2001-11-28 | 2007-01-02 | Neose Technologies, Inc. | Factor VIII remodeling and glycoconjugation of Factor VIII |
| EP1485476A2 (en) * | 2002-03-12 | 2004-12-15 | Novo Nordisk A/S | Dimeric tf antagonist |
| RU2004134726A (en) * | 2002-04-30 | 2005-06-10 | Максиджен Холдингз Лтд. (Ky) | OPTIONS OF POLYPEPTIDE FACTOR VII OR VIIA |
| PL211175B1 (en) * | 2002-06-21 | 2012-04-30 | Novo Nordisk Healthcare Ag | Pegylated factor vii glycoforms |
| ATE505487T1 (en) * | 2002-09-30 | 2011-04-15 | Bayer Healthcare Llc | FVII OR FVIIA VARIANTS WITH INCREASED COAGULATION EFFECT |
| US20040198660A1 (en) * | 2002-11-06 | 2004-10-07 | Petersen Lars Christian | Tissue factor antagonist and protein C polypeptide compositions |
| AU2003290663A1 (en) * | 2002-11-13 | 2004-06-03 | Haematologic Technologies, Inc. | Assay for tissue factor and factor viia |
| CA2519092C (en) | 2003-03-14 | 2014-08-05 | Neose Technologies, Inc. | Branched water-soluble polymers and their conjugates |
| DK1608745T3 (en) * | 2003-03-20 | 2009-06-15 | Bayer Healthcare Llc | FVII or FVIIa variants |
| US8791070B2 (en) | 2003-04-09 | 2014-07-29 | Novo Nordisk A/S | Glycopegylated factor IX |
| EP1615945B1 (en) | 2003-04-09 | 2011-09-28 | BioGeneriX AG | Glycopegylation methods and proteins/peptides produced by the methods |
| EP1613261A4 (en) | 2003-04-09 | 2011-01-26 | Novo Nordisk As | INTRACELLULAR FORMATION OF PEPTIDE CONJUGATES |
| ATE540055T1 (en) | 2003-05-09 | 2012-01-15 | Biogenerix Ag | COMPOSITIONS AND METHODS FOR PRODUCING HUMAN GROWTH HORMONE GLYCOSYLATION MUTANTS |
| ATE458057T1 (en) * | 2003-06-19 | 2010-03-15 | Bayer Healthcare Llc | VARIANTS OF THE FACTOR VII OR VIIA GLA DOMAIN |
| WO2005012484A2 (en) | 2003-07-25 | 2005-02-10 | Neose Technologies, Inc. | Antibody-toxin conjugates |
| US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
| US8633157B2 (en) | 2003-11-24 | 2014-01-21 | Novo Nordisk A/S | Glycopegylated erythropoietin |
| CA2545474A1 (en) | 2003-12-01 | 2005-06-16 | Novo Nordisk Health Care Ag | Nanofiltration of factor vii solutions to remove virus |
| US7956032B2 (en) | 2003-12-03 | 2011-06-07 | Novo Nordisk A/S | Glycopegylated granulocyte colony stimulating factor |
| US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
| DK2298287T3 (en) | 2003-12-19 | 2018-07-23 | Novo Nordisk Healthcare Ag | Stabilized compositions of factor VII polypeptides |
| US8361961B2 (en) | 2004-01-08 | 2013-01-29 | Biogenerix Ag | O-linked glycosylation of peptides |
| KR101100059B1 (en) * | 2004-06-30 | 2011-12-29 | 넥타르 테라퓨틱스 | Conjugate of Polymer 'Factor I' Part |
| EP1771066A2 (en) | 2004-07-13 | 2007-04-11 | Neose Technologies, Inc. | Branched peg remodeling and glycosylation of glucagon-like peptide-1 glp-1 |
| US8268967B2 (en) | 2004-09-10 | 2012-09-18 | Novo Nordisk A/S | Glycopegylated interferon α |
| SI2586456T1 (en) | 2004-10-29 | 2016-05-31 | Ratiopharm Gmbh | Remodeling and glycopegylation of fibroblast growth factor (FGF) |
| RU2460735C2 (en) | 2004-12-23 | 2012-09-10 | Ново Нордиск Хелс Кеа Аг | Reducing content of protein contaminants in compositions containing vitamin k-dependent protein of interest |
| NZ556436A (en) | 2005-01-10 | 2010-11-26 | Biogenerix Ag | Glycopegylated granulocyte colony stimulating factor |
| US9187546B2 (en) | 2005-04-08 | 2015-11-17 | Novo Nordisk A/S | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
| EP1888098A2 (en) | 2005-05-25 | 2008-02-20 | Neose Technologies, Inc. | Glycopegylated erythropoietin formulations |
| US20080255026A1 (en) | 2005-05-25 | 2008-10-16 | Glycopegylated Factor 1X | Glycopegylated Factor Ix |
| EP2360170A3 (en) | 2005-06-17 | 2012-03-28 | Novo Nordisk Health Care AG | Selective reduction and derivatization of engineered proteins comprinsing at least one non-native cysteine |
| ES2397851T3 (en) | 2005-07-13 | 2013-03-11 | Novo Nordisk Health Care Ag | Host cell protein inactivation cells for the production of therapeutic proteins |
| US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
| JP5894722B2 (en) | 2005-09-01 | 2016-03-30 | ノボ ノルディスク ヘルス ケア アーゲー | Hydrophobic interaction chromatographic purification of factor VII polypeptides |
| US20090055942A1 (en) | 2005-09-14 | 2009-02-26 | Novo Nordisk Healthcare A/G | Human Coagulation Factor VII Polypeptides |
| US20090048440A1 (en) | 2005-11-03 | 2009-02-19 | Neose Technologies, Inc. | Nucleotide Sugar Purification Using Membranes |
| US20080242607A1 (en) | 2006-07-21 | 2008-10-02 | Neose Technologies, Inc. | Glycosylation of peptides via o-linked glycosylation sequences |
| US20100075375A1 (en) | 2006-10-03 | 2010-03-25 | Novo Nordisk A/S | Methods for the purification of polypeptide conjugates |
| ES2655639T3 (en) | 2006-12-15 | 2018-02-21 | Baxalta GmbH | Conjugate of factor VIIa - (poly) sialic acid that has a prolonged half-life in vivo |
| EP2114379A2 (en) * | 2006-12-20 | 2009-11-11 | Bayer HealthCare LLC | Factor vii and viia compositions |
| KR20100016160A (en) | 2007-04-03 | 2010-02-12 | 바이오제너릭스 에이지 | Methods of treatment using glycopegylated g-csf |
| JP2010525034A (en) | 2007-05-02 | 2010-07-22 | ノボ ノルディスク ヘルス ケア アーゲー | Highly concentrated factor VII polypeptide formulation comprising an aromatic preservative and an antioxidant |
| JP5876649B2 (en) | 2007-06-12 | 2016-03-02 | ラツィオファルム ゲーエムベーハーratiopharm GmbH | Improved process for producing nucleotide sugars |
| US8207112B2 (en) | 2007-08-29 | 2012-06-26 | Biogenerix Ag | Liquid formulation of G-CSF conjugate |
| CN101965200B (en) | 2008-02-27 | 2013-06-19 | 诺沃-诺迪斯克有限公司 | Conjugated factor VIII molecules |
| CN102083459A (en) * | 2008-05-23 | 2011-06-01 | 诺沃-诺迪斯克保健股份有限公司 | Low viscosity compositions comprising a PEGylated GLA-domain containing protein |
| PL2459224T3 (en) | 2009-07-27 | 2017-08-31 | Baxalta GmbH | Blood coagulation protein conjugates |
| US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| EP2459226B1 (en) | 2009-07-27 | 2016-06-29 | Lipoxen Technologies Limited | Glycopolysialylation of proteins other than blood coagulation proteins |
| US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| SG178141A1 (en) | 2009-07-27 | 2012-03-29 | Baxter Int | Blood coagulation protein conjugates |
| WO2011018515A1 (en) | 2009-08-14 | 2011-02-17 | Novo Nordisk Health Care Ag | Method of purifying pegylated proteins |
| TWI557135B (en) | 2010-11-03 | 2016-11-11 | 介控生化科技公司 | Modified ninth factor multi-peptide and use thereof |
| WO2012075138A1 (en) * | 2010-11-30 | 2012-06-07 | Progenetics Llc | Method of producing biologically active vitamin k dependent proteins in transgenic animals |
| EA032056B1 (en) | 2010-12-22 | 2019-04-30 | Баксалта Инкорпорейтид | Conjugate of a therapeutic protein and a fatty acid derivative, methods of preparing a conjugate of a therapeutic protein and a fatty acid derivative (embodiments) |
| PL2717898T3 (en) | 2011-06-10 | 2019-06-28 | Bioverativ Therapeutics Inc. | Pro-coagulant compounds and methods of use thereof |
| WO2016120341A2 (en) * | 2015-01-27 | 2016-08-04 | Vitak B.V. | Epidermal skin health |
| US11491212B1 (en) | 2017-09-27 | 2022-11-08 | Catalyst Biosciences, Inc. | Subcutaneous administration of modified factor IX polypeptides and treatment of hemophilia B |
| WO2021154414A2 (en) | 2020-01-29 | 2021-08-05 | Catalyst Biosciences, Inc. | Gene therapy for hemophilia b with a chimeric aav capsid vector encoding modified factor ix polypeptides |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5217705A (en) | 1987-09-25 | 1993-06-08 | Neorx Corporation | Method of diagnosing blood clots using fibrin-binding proteins |
| US5318910A (en) * | 1988-11-10 | 1994-06-07 | International Technidyne Corp. | Standard whole blood composition for determining the potency of blood clotting inhibitory substances |
| US5580560A (en) | 1989-11-13 | 1996-12-03 | Novo Nordisk A/S | Modified factor VII/VIIa |
| GB8927722D0 (en) | 1989-12-07 | 1990-02-07 | British Bio Technology | Proteins and nucleic acids |
| DE69131292T2 (en) | 1990-01-29 | 1999-09-30 | Zymogenetics, Inc. | ANTICOAGULATING PROTEINS |
| US5583107A (en) * | 1990-09-04 | 1996-12-10 | Cor Therapeutics, Inc. | Agents affecting thrombosis and hemostasis |
| US5788965A (en) | 1991-02-28 | 1998-08-04 | Novo Nordisk A/S | Modified factor VII |
| US5861374A (en) | 1991-02-28 | 1999-01-19 | Novo Nordisk A/S | Modified Factor VII |
| US5817788A (en) | 1991-02-28 | 1998-10-06 | Zymogenetics, Inc. | Modified factor VII |
| US5833982A (en) | 1991-02-28 | 1998-11-10 | Zymogenetics, Inc. | Modified factor VII |
| US6037452A (en) | 1992-04-10 | 2000-03-14 | Alpha Therapeutic Corporation | Poly(alkylene oxide)-Factor VIII or Factor IX conjugate |
| US5621039A (en) | 1993-06-08 | 1997-04-15 | Hallahan; Terrence W. | Factor IX- polymeric conjugates |
| AU1096595A (en) * | 1993-11-12 | 1995-05-29 | Gilead Sciences, Inc. | Thrombin mutants |
| JPH0892294A (en) | 1994-09-29 | 1996-04-09 | Teijin Ltd | Human activated protein c derivative |
| SE9503380D0 (en) | 1995-09-29 | 1995-09-29 | Pharmacia Ab | Protein derivatives |
| ATE200030T1 (en) | 1997-01-29 | 2001-04-15 | Polymasc Pharmaceuticals Plc | PEGYLATION PROCEDURE |
| US6017882A (en) | 1997-10-23 | 2000-01-25 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
| JP2003504315A (en) | 1999-07-01 | 2003-02-04 | エール ユニバーシティ | Angiogenesis target immune complex |
| CN100488562C (en) | 2000-02-11 | 2009-05-20 | 拜耳医药保健有限公司 | Coagulation factor VII or VIIa-like molecules |
-
2000
- 2000-06-30 US US09/607,716 patent/US6423826B1/en not_active Expired - Lifetime
-
2001
- 2001-06-26 WO PCT/US2001/020307 patent/WO2002003075A2/en not_active Ceased
- 2001-06-26 AU AU2001271508A patent/AU2001271508A1/en not_active Abandoned
- 2001-06-26 WO PCT/US2001/020395 patent/WO2002002764A2/en not_active Ceased
- 2001-06-26 AU AU2001270171A patent/AU2001270171A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002003075A3 (en) | 2002-12-27 |
| WO2002003075A2 (en) | 2002-01-10 |
| WO2002002764A3 (en) | 2002-08-01 |
| AU2001271508A1 (en) | 2002-01-14 |
| US6423826B1 (en) | 2002-07-23 |
| WO2002002764A2 (en) | 2002-01-10 |
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