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AU2001264679A1 - Synthesis of n-(n-(3,3-dimethylbutyl)-l-alpha-aspartyl)-l-phenylalanine 1-methylester using oxazolidinone derivatives - Google Patents

Synthesis of n-(n-(3,3-dimethylbutyl)-l-alpha-aspartyl)-l-phenylalanine 1-methylester using oxazolidinone derivatives

Info

Publication number
AU2001264679A1
AU2001264679A1 AU2001264679A AU6467901A AU2001264679A1 AU 2001264679 A1 AU2001264679 A1 AU 2001264679A1 AU 2001264679 A AU2001264679 A AU 2001264679A AU 6467901 A AU6467901 A AU 6467901A AU 2001264679 A1 AU2001264679 A1 AU 2001264679A1
Authority
AU
Australia
Prior art keywords
dimethylbutyl
phenylalanine
aspartyl
alpha
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001264679A
Inventor
Indra Prakash
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nutrasweet Co
Original Assignee
Nutrasweet Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nutrasweet Co filed Critical Nutrasweet Co
Publication of AU2001264679A1 publication Critical patent/AU2001264679A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Synthesis of N-[N-(3,3-dimethylbutyl)-L-alpha-aspartyl]-L-phenylalanine 1-methyl ester by treating N-(3,3-dimethylbutyl)-L-aspartic acid with ketones to give oxazolidinone derivatives, which are condensed with L-phenylalanine methyl ester.
AU2001264679A 2000-05-19 2001-05-18 Synthesis of n-(n-(3,3-dimethylbutyl)-l-alpha-aspartyl)-l-phenylalanine 1-methylester using oxazolidinone derivatives Abandoned AU2001264679A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20569400P 2000-05-19 2000-05-19
US60205694 2000-05-19
PCT/US2001/016144 WO2001090138A2 (en) 2000-05-19 2001-05-18 SYNTHESIS OF N-[N-(3,3-DIMETHYLBUTYL)-L-α-ASPARTYL]-L-PHENYLALANINE 1-METHYL ESTER USING OXAZOLIDINONE DERIVATIVES

Publications (1)

Publication Number Publication Date
AU2001264679A1 true AU2001264679A1 (en) 2001-12-03

Family

ID=22763255

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001264679A Abandoned AU2001264679A1 (en) 2000-05-19 2001-05-18 Synthesis of n-(n-(3,3-dimethylbutyl)-l-alpha-aspartyl)-l-phenylalanine 1-methylester using oxazolidinone derivatives

Country Status (7)

Country Link
US (2) US6852875B2 (en)
EP (1) EP1284991B1 (en)
AT (1) ATE288446T1 (en)
AU (1) AU2001264679A1 (en)
DE (1) DE60108745T2 (en)
ES (1) ES2233647T3 (en)
WO (1) WO2001090138A2 (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE288446T1 (en) * 2000-05-19 2005-02-15 Nutrasweet Co PRODUCTION OF N-(N-(3,3-DIMETHYLBUTYL)-L-ALPHA-ASPARTYL)-L-PHENYLALANINE METHYL ESTER USING OXAZOLIDINONE DERIVATIVES
US9514436B2 (en) 2006-09-05 2016-12-06 The Nielsen Company (Us), Llc Method and system for predicting audience viewing behavior
US20100004977A1 (en) * 2006-09-05 2010-01-07 Innerscope Research Llc Method and System For Measuring User Experience For Interactive Activities
CA2662632C (en) 2006-09-05 2016-08-02 Innerscope Research, Llc Method and system for determining audience response to a sensory stimulus
US8484081B2 (en) 2007-03-29 2013-07-09 The Nielsen Company (Us), Llc Analysis of marketing and entertainment effectiveness using central nervous system, autonomic nervous system, and effector data
US8392253B2 (en) 2007-05-16 2013-03-05 The Nielsen Company (Us), Llc Neuro-physiology and neuro-behavioral based stimulus targeting system
CN101815467B (en) 2007-07-30 2013-07-17 神经焦点公司 Neuro-response stimulus and stimulus attribute resonance estimator
US8386313B2 (en) 2007-08-28 2013-02-26 The Nielsen Company (Us), Llc Stimulus placement system using subject neuro-response measurements
US8392255B2 (en) 2007-08-29 2013-03-05 The Nielsen Company (Us), Llc Content based selection and meta tagging of advertisement breaks
US20090083129A1 (en) 2007-09-20 2009-03-26 Neurofocus, Inc. Personalized content delivery using neuro-response priming data
US8151292B2 (en) 2007-10-02 2012-04-03 Emsense Corporation System for remote access to media, and reaction and survey data from viewers of the media
US20090133047A1 (en) 2007-10-31 2009-05-21 Lee Hans C Systems and Methods Providing Distributed Collection and Centralized Processing of Physiological Responses from Viewers
CN102015686B (en) * 2008-03-21 2014-07-02 诺华股份有限公司 Novel heterocyclic compounds and uses therof
US20100250325A1 (en) 2009-03-24 2010-09-30 Neurofocus, Inc. Neurological profiles for market matching and stimulus presentation
US10987015B2 (en) 2009-08-24 2021-04-27 Nielsen Consumer Llc Dry electrodes for electroencephalography
US20110106750A1 (en) 2009-10-29 2011-05-05 Neurofocus, Inc. Generating ratings predictions using neuro-response data
US9560984B2 (en) 2009-10-29 2017-02-07 The Nielsen Company (Us), Llc Analysis of controlled and automatic attention for introduction of stimulus material
WO2011133548A2 (en) 2010-04-19 2011-10-27 Innerscope Research, Inc. Short imagery task (sit) research method
US9569986B2 (en) 2012-02-27 2017-02-14 The Nielsen Company (Us), Llc System and method for gathering and analyzing biometric user feedback for use in social media and advertising applications
US9292858B2 (en) 2012-02-27 2016-03-22 The Nielsen Company (Us), Llc Data collection system for aggregating biologically based measures in asynchronous geographically distributed public environments
US9451303B2 (en) 2012-02-27 2016-09-20 The Nielsen Company (Us), Llc Method and system for gathering and computing an audience's neurologically-based reactions in a distributed framework involving remote storage and computing
CN104030942B (en) * 2014-06-09 2016-08-24 浙江普洛医药科技有限公司 A kind of preparation method of L-alpha-amido butanamide hydrochloride
US9936250B2 (en) 2015-05-19 2018-04-03 The Nielsen Company (Us), Llc Methods and apparatus to adjust content presented to an individual

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2697844B1 (en) 1992-11-12 1995-01-27 Claude Nofre New compounds derived from dipeptides or dipeptide analogues useful as sweetening agents, process for their preparation.
KR960009572B1 (en) * 1992-12-22 1996-07-20 주식회사 미원 Method for preparing alpha (α) -L (L) -aspartyl-L (L) -phenylalanine methyl ester
FR2719590B1 (en) * 1994-05-09 1996-07-26 Claude Nofre Improved process for the preparation of a compound derived from aspartame useful as a sweetening agent.
CN1057773C (en) * 1996-08-28 2000-10-25 中国科学院成都有机化学研究所 N -protection aspartic sweet piptide preparation method
US5728862A (en) * 1997-01-29 1998-03-17 The Nutrasweet Company Method for preparing and purifying an N-alkylated aspartame derivative
NL1010063C2 (en) 1998-09-10 2000-03-13 Holland Sweetener Co Method for the preparation of neotame.
US6465677B1 (en) * 1998-11-19 2002-10-15 The Nutrasweet Company Method for the preparation of N-neohexyl-α-aspartyl-L-phenylalanine methyl ester from imidazolidin-4-one intermediates
US6423864B1 (en) * 1998-11-25 2002-07-23 The Nutrasweet Company Purification of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester via crystallization
US6077962A (en) 1998-12-24 2000-06-20 The Nutrasweet Company N-3, 3-dimethylbutyl-L-aspartic acid and esters thereof, the process of preparing the same, and the process for preparing N-(N-(3,3-dimethylbutyl) -α L-aspartyl)-L- phenylalanine 1-methyl ester therefrom
ATE288446T1 (en) * 2000-05-19 2005-02-15 Nutrasweet Co PRODUCTION OF N-(N-(3,3-DIMETHYLBUTYL)-L-ALPHA-ASPARTYL)-L-PHENYLALANINE METHYL ESTER USING OXAZOLIDINONE DERIVATIVES

Also Published As

Publication number Publication date
US6852875B2 (en) 2005-02-08
EP1284991A2 (en) 2003-02-26
WO2001090138A3 (en) 2002-03-21
DE60108745D1 (en) 2005-03-10
US7193103B2 (en) 2007-03-20
US20050014967A1 (en) 2005-01-20
ATE288446T1 (en) 2005-02-15
WO2001090138A2 (en) 2001-11-29
DE60108745T2 (en) 2005-07-07
US20020013490A1 (en) 2002-01-31
ES2233647T3 (en) 2005-06-16
EP1284991B1 (en) 2005-02-02

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