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AU2001264043A1 - 4-(2-phenylthiazol-5-yl)-1,4-diazabicyclo-(3.2.2)nonane derivatives, preparationand therapeutic use thereof - Google Patents

4-(2-phenylthiazol-5-yl)-1,4-diazabicyclo-(3.2.2)nonane derivatives, preparationand therapeutic use thereof

Info

Publication number
AU2001264043A1
AU2001264043A1 AU2001264043A AU6404301A AU2001264043A1 AU 2001264043 A1 AU2001264043 A1 AU 2001264043A1 AU 2001264043 A AU2001264043 A AU 2001264043A AU 6404301 A AU6404301 A AU 6404301A AU 2001264043 A1 AU2001264043 A1 AU 2001264043A1
Authority
AU
Australia
Prior art keywords
preparationand
phenylthiazol
diazabicyclo
therapeutic use
nonane derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001264043A
Inventor
Thierry Gallet
Frederic Galli
Odile Leclerc
Alistair Lochead
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA
Publication of AU2001264043A1 publication Critical patent/AU2001264043A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2001264043A 2000-05-31 2001-05-29 4-(2-phenylthiazol-5-yl)-1,4-diazabicyclo-(3.2.2)nonane derivatives, preparationand therapeutic use thereof Abandoned AU2001264043A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0006978A FR2809732B1 (en) 2000-05-31 2000-05-31 DERIVATIVES OF 4 (-2-PHENYLTHIAZOL-5-yl) -1,4-DIAZABICYCLO- [3.2.2] NONANE, THEIR PREPARATION AND THEIR THERAPY APPLICATION
FR0006978 2000-05-31
PCT/FR2001/001650 WO2001092260A1 (en) 2000-05-31 2001-05-29 4-(2-phenylthiazol-5-yl)-1,4-diazabicyclo-[3.2.2]nonane derivatives, preparation and therapeutic use thereof

Publications (1)

Publication Number Publication Date
AU2001264043A1 true AU2001264043A1 (en) 2001-12-11

Family

ID=8850829

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001264043A Abandoned AU2001264043A1 (en) 2000-05-31 2001-05-29 4-(2-phenylthiazol-5-yl)-1,4-diazabicyclo-(3.2.2)nonane derivatives, preparationand therapeutic use thereof

Country Status (11)

Country Link
US (1) US7001902B2 (en)
EP (1) EP1289987B1 (en)
JP (1) JP4939720B2 (en)
AR (1) AR028649A1 (en)
AT (1) ATE267201T1 (en)
AU (1) AU2001264043A1 (en)
DE (1) DE60103394T2 (en)
FR (1) FR2809732B1 (en)
HU (1) HU229600B1 (en)
TW (1) TW591028B (en)
WO (1) WO2001092260A1 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0000540D0 (en) 2000-02-18 2000-02-18 Astrazeneca Ab New compounds
FR2832713B1 (en) * 2001-11-23 2004-02-13 Sanofi Synthelabo DERIVATIVES OF 4- (1,3,4-THIADIAZOL-2-YL) -1,4-DIAZABICYCLO [3.2.2] NONANE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
SE0202465D0 (en) * 2002-08-14 2002-08-14 Astrazeneca Ab New compounds
SE0202430D0 (en) * 2002-08-14 2002-08-14 Astrazeneca Ab New Compounds
BR0314485A (en) 2002-09-25 2005-07-26 Memory Pharm Corp Indazoles, benzothiazoles and benzoisothiazoles, compound, pharmaceutical composition, deactivation / selective stimulation method of a-7 nicotinic receptors in a mammal and method of treatment and / or prevention of a disease with them
BR0314183A (en) * 2002-09-30 2005-08-09 Neurosearch As 1,4-Diazabicycloalkane derivatives, any of their enantiomers or any mixture of their enantiomers, or a pharmaceutically acceptable addition salt or n-oxide thereof, pharmaceutical composition, use of said compound, any of its enantiomers or any mixture of their enantiomers, or a pharmaceutically acceptable addition salt thereof, and, method of treating, preventing or alleviating a disease or disorder or condition of a living animal body
DE60326894D1 (en) * 2002-09-30 2009-05-07 Neurosearch As 1,4-Diazabicycloalkane derivatives, their preparation and use
AU2003280309A1 (en) * 2002-11-11 2004-06-03 Neurosearch A/S 1,4-diazabicyclo (3,2,2)nonane derivatives, preparation and therapeutical use thereof
US7223753B2 (en) 2002-11-11 2007-05-29 Neurosearch A/S Diazabicyclic biaryl derivatives
PT1697378E (en) 2003-12-22 2008-02-28 Memory Pharm Corp Indoles, 1h-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof
JP2007520527A (en) * 2004-02-04 2007-07-26 ノイロサーチ アクティーゼルスカブ Diaza bicyclic aryl derivatives as nicotinic acetylcholine receptor ligands
DE602005018020D1 (en) 2004-02-04 2010-01-14 Neurosearch As DIAZABICYCLIC ARYL DERIVATIVES AS CHOLINERGE RECEPTOR MODULATORS
BRPI0508771A (en) 2004-03-25 2007-08-14 Memory Pharm Corp indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and their preparation and uses
WO2006001894A1 (en) 2004-04-22 2006-01-05 Memory Pharmaceutical Corporation Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof
US7632831B2 (en) 2004-05-07 2009-12-15 Memory Pharmaceuticals Corporation 1H-indazoles, benzothiazoles, 1,2-benzoisoxazoles, 1,2-benzoisothiazoles, and chromones and preparation and uses thereof
US20080113983A1 (en) * 2004-12-15 2008-05-15 Astrazeneca Ab Nicotinic Acetylcholine Receptor Ligands
EP1828179B1 (en) 2004-12-22 2010-01-20 Memory Pharmaceuticals Corporation Nicotinic alpha-7 receptor ligands against cns-related diseases
US7662812B2 (en) 2005-02-16 2010-02-16 Neurosearch A/S Diazabicyclic aryl derivatives and their use as chinolinergic ligands at nicotinic acetylcholine receptors
US8106066B2 (en) 2005-09-23 2012-01-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
US8173658B2 (en) 2005-12-06 2012-05-08 Neurosearch A/S Diazabicycylic aryl derivatives and their medical use
EP2029607A1 (en) 2006-05-23 2009-03-04 NeuroSearch A/S Novel 8,10-diaza-bicycloý4.3.1¨decane derivatives and their medical use
ZA200807756B (en) * 2006-05-30 2009-11-25 Neurosearch As Novel 1,4-diaza-bicyclo[3.2.2] nonyl oxadiazolyl derivatives and their medical use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN166416B (en) * 1985-09-18 1990-05-05 Pfizer
NZ226000A (en) * 1987-09-10 1991-06-25 Merck Sharp & Dohme Oxadiazolyl-azabicycloheptanes and pharmaceutical compositions
US5478939A (en) * 1994-07-20 1995-12-26 American Cyanamid Company (R,R) and (S,S) 2,5-diazabicyclo [2,2,1]heptane derivatives
FR2786770B1 (en) 1998-12-04 2001-01-19 Synthelabo NONANE 1,4-DIAZABICYCLO [3.2.2.] DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Also Published As

Publication number Publication date
DE60103394D1 (en) 2004-06-24
FR2809732A1 (en) 2001-12-07
EP1289987A1 (en) 2003-03-12
ATE267201T1 (en) 2004-06-15
HU229600B1 (en) 2014-02-28
HUP0302157A2 (en) 2003-10-28
HUP0302157A3 (en) 2011-03-28
DE60103394T2 (en) 2005-06-02
WO2001092260A1 (en) 2001-12-06
US7001902B2 (en) 2006-02-21
EP1289987B1 (en) 2004-05-19
JP4939720B2 (en) 2012-05-30
FR2809732B1 (en) 2002-07-19
TW591028B (en) 2004-06-11
AR028649A1 (en) 2003-05-21
US20040029884A1 (en) 2004-02-12
JP2003535090A (en) 2003-11-25

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