AU2001263775A1 - Glucose dependent release of insulin from glucose sensing insulin derivatives - Google Patents

Glucose dependent release of insulin from glucose sensing insulin derivatives

Info

Publication number: AU2001263775A1
Authority: AU; Australia
Prior art keywords: insulin; glucose; dependent release; derivatives; sensing
Prior art date: 2000-06-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU2001263775A

Inventor

Per Balschmidt

Svend Havelund

Thomas Hoeg Jensen

Ib Jonassen

Jan Markussen

Soren Ostergaard

Signe Ridderberg

Lauge Schaffer

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novo Nordisk AS

Original Assignee

Novo Nordisk AS

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-02

Filing date

2001-06-01

Publication date

2001-12-11

2001-06-01 Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS

2001-12-11 Publication of AU2001263775A1 publication Critical patent/AU2001263775A1/en

Status Abandoned legal-status Critical Current

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 3
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title 2
239000008103 glucose Substances 0.000 title 2
102000004877 Insulin Human genes 0.000 title 1
108090001061 Insulin Proteins 0.000 title 1
230000001419 dependent effect Effects 0.000 title 1
229940125396 insulin Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Diabetes (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Endocrinology (AREA)
Zoology (AREA)
Emergency Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Botany (AREA)
Toxicology (AREA)
Hematology (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)

AU2001263775A 2000-06-02 2001-06-01 Glucose dependent release of insulin from glucose sensing insulin derivatives Abandoned AU2001263775A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DKPA200000858		2000-06-02
DKPA200000858		2000-06-02
PCT/DK2001/000382 WO2001092334A1 (en)	2000-06-02	2001-06-01	Glucose dependent release of insulin from glucose sensing insulin derivatives

Publications (1)

Publication Number	Publication Date
AU2001263775A1 true AU2001263775A1 (en)	2001-12-11

Family

ID=8159532

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU2001263775A Abandoned AU2001263775A1 (en)	2000-06-02	2001-06-01	Glucose dependent release of insulin from glucose sensing insulin derivatives

Country Status (4)

Country	Link
EP (1)	EP1290024A1 (en)
JP (1)	JP2003535106A (en)
AU (1)	AU2001263775A1 (en)
WO (1)	WO2001092334A1 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2003037337A1 (en)	2001-10-30	2003-05-08	Novartis Ag	Depot formulations of iloperidone and a star polymer
JP2005526009A (en) *	2001-12-02	2005-09-02	ノボ　ノルディスク　アクティーゼルスカブ	Novel glucose-dependent insulin
US7317000B2 (en)	2001-12-02	2008-01-08	Novo Nordisk A/S	Glucose-dependent insulins
WO2003105860A1 (en) *	2002-06-14	2003-12-24	Novo Nordisk A/S	Pharmaceutical use of boronic acids and esters thereof
GB0216416D0 (en)	2002-07-15	2002-08-21	Novartis Ag	Organic compounds
US8173437B2 (en) *	2005-06-10	2012-05-08	Mannatech, Incorporated	Rapid serum sugar biomarker assay of rheumatoid arthritis
KR101755434B1 (en)	2008-03-18	2017-07-10	노보 노르디스크 에이/에스	Protease stabilized, acylated insulin analogues
CA2750223A1 (en)	2009-01-28	2010-08-05	Smartcells, Inc.	Exogenously triggered controlled release materials and uses thereof
US8940690B2 (en)	2009-01-28	2015-01-27	National Institutes Of Health (Nih)	Synthetic conjugates and uses thereof
CN102341409A (en)	2009-01-28	2012-02-01	斯马特塞尔斯公司	Crystalline insulin-conjugates
ES2791683T3 (en) *	2009-01-28	2020-11-05	Smartcells Inc	Conjugated systems for controlled drug delivery
WO2010107519A1 (en)	2009-03-20	2010-09-23	Smartcells, Inc.	Terminally-functionalized conjugates and uses thereof
US8569231B2 (en)	2009-03-20	2013-10-29	Smartcells, Inc.	Soluble non-depot insulin conjugates and uses thereof
ES2611040T3 (en) *	2009-06-30	2017-05-04	Novo Nordisk A/S	Insulin derivatives
US8933207B2 (en)	2010-07-28	2015-01-13	Smartcells, Inc.	Drug-ligand conjugates, synthesis thereof, and intermediates thereto
AU2011282988A1 (en)	2010-07-28	2013-01-31	Smartcells, Inc.	Recombinantly expressed insulin polypeptides and uses thereof
EP2598522A4 (en)	2010-07-28	2014-11-12	Smartcells Inc	RECOMBINANT LECTINES, LECTINES WITH MODIFIED BINDING SITE AND USES THEREOF
WO2014093696A2 (en) *	2012-12-12	2014-06-19	Massachusetts Institute Of Technology	Insulin derivatives for diabetes treatment
EP2981310B1 (en)	2013-04-05	2017-07-12	Novo Nordisk A/S	Dose logging device for a drug delivery device
MX366852B (en)	2013-10-04	2019-07-25	Merck Sharp & Dohme	Glucose-responsive insulin conjugates.
WO2016149222A2 (en)	2015-03-13	2016-09-22	Case Western Reserve University	Insulin analogues containing a glucose-regulated conformational switch
CN105954526B (en) *	2016-04-26	2017-10-10	南华大学	A kind of enzyme immunoassay (EIA) method of insulin
BR112018074716A2 (en)	2016-06-02	2019-03-12	Sanofi	conjugates of a pharmaceutical agent and moiety capable of binding to a glucose sensitive protein
DK3554534T3 (en)	2016-12-16	2021-08-23	Novo Nordisk As	PHARMACEUTICAL COMPOSITION INCLUDING INSULIN
CN107320733A (en) *	2017-07-01	2017-11-07	台州学院	The preparation method of sugar response insulin carrier under a kind of physiological condition
JP7254792B2 (en) *	2017-11-09	2023-04-10	ノヴォノルディスクアー／エス	glucose-sensitive albumin-binding derivative
JP2021504402A (en)	2017-12-01	2021-02-15	サノフイＳａｎｏｆｉ	A novel conjugate of the drug and the part that can bind to the glucose-sensing protein
WO2021022116A1 (en) *	2019-07-31	2021-02-04	Thermalin Inc.	Insulin analogues with glucose regulated conformational switch
WO2025002419A1 (en) *	2023-06-30	2025-01-02	浙江大学	Glucose-responsive molecular connector, and preparation method therefor and use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU628674B2 (en) *	1989-10-19	1992-09-17	Nippon Oil And Fats Company, Limited	Polymer complexes of a sugar response type

2001
- 2001-06-01 AU AU2001263775A patent/AU2001263775A1/en not_active Abandoned
- 2001-06-01 WO PCT/DK2001/000382 patent/WO2001092334A1/en not_active Ceased
- 2001-06-01 EP EP01938005A patent/EP1290024A1/en not_active Withdrawn
- 2001-06-01 JP JP2002500945A patent/JP2003535106A/en not_active Withdrawn

Also Published As

Publication number	Publication date
WO2001092334A1 (en)	2001-12-06
JP2003535106A (en)	2003-11-25
EP1290024A1 (en)	2003-03-12

Publication	Publication Date	Title
AU2001263775A1 (en)	2001-12-11	Glucose dependent release of insulin from glucose sensing insulin derivatives
AU2002349295A1 (en)	2003-06-17	Glucose dependant release of insulin from glucose sensing insulin derivatives
AU7830400A (en)	2001-04-24	Synthesis of insulin derivatives
AU2002234176A1 (en)	2002-05-21	Glucose sensor system
AU4063200A (en)	2000-10-16	Pressure sensing cannula
AU2001235691A1 (en)	2001-08-27	Use of paullone derivatives for making medicines
AU2001260130A1 (en)	2001-09-24	Implantable analyte sensor
AU2002300341A1 (en)	2003-06-12	Sensor Release for a Blood Glucose Sensor Dispensing Instrument
AU2001259656A1 (en)	2001-11-26	Implantable sensor
AU2001251339A1 (en)	2001-11-12	Optically based transcutaneous blood gas sensor
AU2001255319A1 (en)	2001-10-30	Infrared atr glucose measurement system
AU2001278093A1 (en)	2002-02-13	Integrated sensor
AU7355900A (en)	2001-04-10	Oximeter sensor with functional liner
AU2001286677A1 (en)	2002-03-04	Controlled release of substances
AU2001241008A1 (en)	2001-09-17	Object tracking using a single sensor or a pair of sensors
AU5377200A (en)	2000-12-18	Sensors for detecting physical conditions
AU6931500A (en)	2001-03-26	Glucose biosensor
AU2002214006A1 (en)	2002-04-22	Drugs for diabetes
AU2001235621A1 (en)	2001-08-27	Gyroscopic sensor
AU2177001A (en)	2001-06-04	Use of indirubine derivatives for making medicines
AU2001278694A1 (en)	2002-02-18	Avermectin derivatives
AU2002232468A1 (en)	2002-07-01	Pharmaceutical heterocyclic compounds
AU2001232948A1 (en)	2001-08-07	Controlled release of drugs
AU4213299A (en)	2000-12-18	Controlled release of substances
AU2002234169A1 (en)	2002-05-06	Measurement of electrophysiologic response