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AU2001260314A1 - Method for selecting enzyme inhibitors - Google Patents

Method for selecting enzyme inhibitors

Info

Publication number
AU2001260314A1
AU2001260314A1 AU2001260314A AU6031401A AU2001260314A1 AU 2001260314 A1 AU2001260314 A1 AU 2001260314A1 AU 2001260314 A AU2001260314 A AU 2001260314A AU 6031401 A AU6031401 A AU 6031401A AU 2001260314 A1 AU2001260314 A1 AU 2001260314A1
Authority
AU
Australia
Prior art keywords
enzyme inhibitors
selecting enzyme
selecting
inhibitor
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001260314A
Inventor
Michael Hallek
Ruth Mathes
Markus Warmuth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt GmbH
Original Assignee
Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt GmbH filed Critical Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt GmbH
Publication of AU2001260314A1 publication Critical patent/AU2001260314A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention relates to a method of selecting inhibitors for enzymes and use of the selected inhibitor as a therapeutic and/or prophylactic agent, a mutant which can be used in the method and a method of testing an inhibitor for its specificity in a modelling system.
AU2001260314A 2000-05-17 2001-05-17 Method for selecting enzyme inhibitors Abandoned AU2001260314A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10024174.3 2000-05-17
DE10024174A DE10024174A1 (en) 2000-05-17 2000-05-17 Method for selecting inhibitors for enzymes
PCT/EP2001/005661 WO2001088530A2 (en) 2000-05-17 2001-05-17 Method for selecting enzyme inhibitors

Publications (1)

Publication Number Publication Date
AU2001260314A1 true AU2001260314A1 (en) 2001-11-26

Family

ID=7642398

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001260314A Abandoned AU2001260314A1 (en) 2000-05-17 2001-05-17 Method for selecting enzyme inhibitors

Country Status (8)

Country Link
US (1) US20030162222A1 (en)
EP (1) EP1282827B1 (en)
AT (1) ATE288081T1 (en)
AU (1) AU2001260314A1 (en)
CA (1) CA2409809A1 (en)
DE (2) DE10024174A1 (en)
IL (1) IL152906A0 (en)
WO (1) WO2001088530A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3009793A1 (en) 2001-06-14 2002-12-27 The Regents Of The University Of California Mutations in the bcr-abl tyrosine kinase associated with resistance to sti-571
JP2007522792A (en) * 2003-05-22 2007-08-16 エスジーエックス ファーマシューティカルズ，インコーポレイティド Crystal and structure of c-Ab1 tyrosine kinase domain
EP1541694A1 (en) * 2003-12-12 2005-06-15 Sirenade Pharmaceuticals AG Methods of identifying, selecting and/or characterizing compounds which modulate the activity of a Src family kinase
CA2567813C (en) 2004-05-23 2015-11-24 Gerard M. Housey Theramutein modulators
US8431110B2 (en) * 2005-05-23 2013-04-30 Hmi Medical Innovations, Llc. Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators
US20100029676A1 (en) * 2005-11-04 2010-02-04 Sawyers Charles L T315a and f317i mutations of bcr-abl kinase domain
CA2631182C (en) 2005-11-23 2019-08-06 Gerard M. Housey Compounds and methods of identifying, synthesizing, optimizing and profiling protein modulators

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6390821B1 (en) * 1997-02-07 2002-05-21 Princeton University Engineered protein kinases which can utilize modified nucleotide triphosphate substrates

Also Published As

Publication number Publication date
CA2409809A1 (en) 2002-11-15
WO2001088530A2 (en) 2001-11-22
EP1282827A2 (en) 2003-02-12
WO2001088530A3 (en) 2002-11-14
US20030162222A1 (en) 2003-08-28
DE10024174A1 (en) 2001-11-29
EP1282827B1 (en) 2005-01-26
DE50105206D1 (en) 2005-03-03
IL152906A0 (en) 2003-06-24
ATE288081T1 (en) 2005-02-15

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Legal Events

Date Code Title Description
MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application
TH Corrigenda

Free format text: IN VOL 21, NO 1, PAGE(S) 17 UNDER THE HEADING APPLICATIONS LAPSED, REFUSED OR WITHDRAWN, PATENTS CEASED OR EXPIRED - 2001 DELETE ALL REFERENCE TO 2001260314

MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted