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AU2001256272A1 - Process for preparing substituted benzimidazole compounds - Google Patents

Process for preparing substituted benzimidazole compounds

Info

Publication number
AU2001256272A1
AU2001256272A1 AU2001256272A AU5627201A AU2001256272A1 AU 2001256272 A1 AU2001256272 A1 AU 2001256272A1 AU 2001256272 A AU2001256272 A AU 2001256272A AU 5627201 A AU5627201 A AU 5627201A AU 2001256272 A1 AU2001256272 A1 AU 2001256272A1
Authority
AU
Australia
Prior art keywords
substituted benzimidazole
preparing substituted
benzimidazole compounds
compounds
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001256272A
Inventor
Stephen Freeman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of AU2001256272A1 publication Critical patent/AU2001256272A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The invention relates to new methods of preparing substituted benzimidazole compounds, such as 2-bromo-5,6-dichlorobenzimidazole, which are useful in the preparation of compounds having antiviral activity.
AU2001256272A 2000-04-11 2001-04-10 Process for preparing substituted benzimidazole compounds Abandoned AU2001256272A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0008939 2000-04-11
GBGB0008939.1A GB0008939D0 (en) 2000-04-11 2000-04-11 Process for preparing substituted benzimidazole compounds
PCT/EP2001/004080 WO2001077083A1 (en) 2000-04-11 2001-04-10 Process for preparing substituted benzimidazole compounds

Publications (1)

Publication Number Publication Date
AU2001256272A1 true AU2001256272A1 (en) 2001-10-23

Family

ID=9889715

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001256272A Abandoned AU2001256272A1 (en) 2000-04-11 2001-04-10 Process for preparing substituted benzimidazole compounds

Country Status (9)

Country Link
US (4) US7101994B2 (en)
EP (2) EP1584620A1 (en)
JP (2) JP4841793B2 (en)
AT (1) ATE298746T1 (en)
AU (1) AU2001256272A1 (en)
DE (1) DE60111732T2 (en)
ES (1) ES2243488T3 (en)
GB (1) GB0008939D0 (en)
WO (1) WO2001077083A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1177831C (en) 1998-12-04 2004-12-01 神经研究公司 Novel benzimidazolone-, benzoxazolone- or benzothiazolinone derivatives as ion channel modulators
NZ537301A (en) * 2002-06-07 2006-06-30 Cortical Pty Ltd Therapeutic molecules and methods-1
WO2007064932A2 (en) * 2005-12-02 2007-06-07 Bayer Healthcare Llc. Pyrrolotriazine derivatives useful for treating cancer through inhibition of aurora kinase
US7655004B2 (en) 2007-02-15 2010-02-02 Ethicon Endo-Surgery, Inc. Electroporation ablation apparatus, system, and method
US8888792B2 (en) 2008-07-14 2014-11-18 Ethicon Endo-Surgery, Inc. Tissue apposition clip application devices and methods
US8157834B2 (en) 2008-11-25 2012-04-17 Ethicon Endo-Surgery, Inc. Rotational coupling device for surgical instrument with flexible actuators
US20110098704A1 (en) 2009-10-28 2011-04-28 Ethicon Endo-Surgery, Inc. Electrical ablation devices
US8546344B2 (en) 2010-10-28 2013-10-01 Viropharma Incorporated Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl)-1H-benzimidazole
US9233241B2 (en) 2011-02-28 2016-01-12 Ethicon Endo-Surgery, Inc. Electrical ablation devices and methods
US9254169B2 (en) 2011-02-28 2016-02-09 Ethicon Endo-Surgery, Inc. Electrical ablation devices and methods
CN102952104A (en) * 2011-08-17 2013-03-06 黑龙江省松花江药业有限公司 Furan compound
US9427255B2 (en) 2012-05-14 2016-08-30 Ethicon Endo-Surgery, Inc. Apparatus for introducing a steerable camera assembly into a patient
US9545290B2 (en) 2012-07-30 2017-01-17 Ethicon Endo-Surgery, Inc. Needle probe guide
US10314649B2 (en) 2012-08-02 2019-06-11 Ethicon Endo-Surgery, Inc. Flexible expandable electrode and method of intraluminal delivery of pulsed power
US9277957B2 (en) 2012-08-15 2016-03-08 Ethicon Endo-Surgery, Inc. Electrosurgical devices and methods
US10098527B2 (en) 2013-02-27 2018-10-16 Ethidcon Endo-Surgery, Inc. System for performing a minimally invasive surgical procedure
HUE072879T2 (en) 2022-10-12 2025-12-28 Takeda Pharmaceuticals Co Method of preparing maribavir

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3839743A1 (en) * 1988-11-25 1990-05-31 Hoechst Ag METHOD FOR PRODUCING BENZIMIDAZOLONES
JP2955358B2 (en) * 1989-06-09 1999-10-04 ファルマシア・アンド・アップジョン・カンパニー Heterocyclic amines with central nervous system activity
US5248672A (en) 1990-11-01 1993-09-28 The Regents Of The University Of Michigan Polysubstituted benzimidazole nucleosides as antiviral agents
GB9205071D0 (en) 1992-03-09 1992-04-22 Wellcome Found Therapeutic nucleosides
GB9413724D0 (en) * 1994-07-07 1994-08-24 Wellcome Found Therapeutic nucleosides
JPH10505092A (en) 1994-09-09 1998-05-19 ザ・ウエルカム・ファンデーション・リミテッド Antiviral nucleoside analogs containing substituted benzimidazole bases linked to a cyclic carbon
JPH11511170A (en) 1995-08-18 1999-09-28 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 5'-Substituted ribofuranosylbenzimidazoles as antiviral agents
GB9600143D0 (en) 1996-01-05 1996-03-06 Wellcome Found Therapeutic compounds
GB9600142D0 (en) 1996-01-05 1996-03-06 Wellcome Found Chemical compounds
CA2244378A1 (en) 1996-01-23 1997-07-31 The Regents Of The University Of Michigan Modified benzimidazole nucleosides as antiviral agents
EP0970100B1 (en) 1997-02-13 2003-11-12 Glaxo Group Limited Benzimidazole derivatives
WO1998056761A2 (en) * 1997-06-10 1998-12-17 Glaxo Group Limited Benzimidazole derivatives
CA2297076A1 (en) 1997-07-30 1999-02-11 The Regents Of The University Of Michigan Lyxofuranosyl benzimidazoles as antiviral agents
GB9807355D0 (en) * 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
GB9807354D0 (en) * 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
GB9815696D0 (en) * 1998-07-20 1998-09-16 Pfizer Ltd Heterocyclics

Also Published As

Publication number Publication date
US20090187015A1 (en) 2009-07-23
JP4841793B2 (en) 2011-12-21
US7101994B2 (en) 2006-09-05
DE60111732T2 (en) 2006-05-04
JP2011173906A (en) 2011-09-08
DE60111732D1 (en) 2005-08-04
EP1272473B1 (en) 2005-06-29
US7375235B2 (en) 2008-05-20
JP2003530385A (en) 2003-10-14
EP1272473A1 (en) 2003-01-08
JP5192061B2 (en) 2013-05-08
WO2001077083A1 (en) 2001-10-18
EP1584620A1 (en) 2005-10-12
US20050261211A1 (en) 2005-11-24
US20080188668A1 (en) 2008-08-07
US20030191127A1 (en) 2003-10-09
ES2243488T3 (en) 2005-12-01
US7858773B2 (en) 2010-12-28
US7514568B2 (en) 2009-04-07
GB0008939D0 (en) 2000-05-31
ATE298746T1 (en) 2005-07-15

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