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AU2001255449A1 - Mixtures of triblock polyesterpolyethylene glycol copolymers - Google Patents

Mixtures of triblock polyesterpolyethylene glycol copolymers

Info

Publication number
AU2001255449A1
AU2001255449A1 AU2001255449A AU5544901A AU2001255449A1 AU 2001255449 A1 AU2001255449 A1 AU 2001255449A1 AU 2001255449 A AU2001255449 A AU 2001255449A AU 5544901 A AU5544901 A AU 5544901A AU 2001255449 A1 AU2001255449 A1 AU 2001255449A1
Authority
AU
Australia
Prior art keywords
polyesterpolyethylene
triblock
mixtures
glycol copolymers
copolymers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001255449A
Inventor
Shih Chung
Ai-Zhi Piao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MacroMed Inc
Original Assignee
MacroMed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MacroMed Inc filed Critical MacroMed Inc
Publication of AU2001255449A1 publication Critical patent/AU2001255449A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Materials For Medical Uses (AREA)
AU2001255449A 2000-04-27 2001-04-18 Mixtures of triblock polyesterpolyethylene glycol copolymers Abandoned AU2001255449A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09559799 2000-04-27
US09/559,799 US7018645B1 (en) 2000-04-27 2000-04-27 Mixtures of various triblock polyester polyethylene glycol copolymers having improved gel properties
PCT/US2001/012576 WO2001082970A1 (en) 2000-04-27 2001-04-18 Mixtures of triblock polyesterpolyethylene glycol copolymers

Publications (1)

Publication Number Publication Date
AU2001255449A1 true AU2001255449A1 (en) 2001-11-12

Family

ID=24235070

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001255449A Abandoned AU2001255449A1 (en) 2000-04-27 2001-04-18 Mixtures of triblock polyesterpolyethylene glycol copolymers

Country Status (15)

Country Link
US (2) US7018645B1 (en)
EP (1) EP1276505B1 (en)
JP (1) JP4895457B2 (en)
KR (1) KR100754550B1 (en)
AR (1) AR028382A1 (en)
AT (1) ATE342066T1 (en)
AU (1) AU2001255449A1 (en)
CA (1) CA2407298C (en)
CY (1) CY1107540T1 (en)
DE (1) DE60123772T2 (en)
DK (1) DK1276505T3 (en)
ES (1) ES2273834T3 (en)
PT (1) PT1276505E (en)
TW (1) TW539718B (en)
WO (1) WO2001082970A1 (en)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040185101A1 (en) * 2001-03-27 2004-09-23 Macromed, Incorporated. Biodegradable triblock copolymers as solubilizing agents for drugs and method of use thereof
US6863859B2 (en) * 2001-08-16 2005-03-08 Objet Geometries Ltd. Reverse thermal gels and the use thereof for rapid prototyping
WO2003017972A2 (en) * 2001-08-27 2003-03-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Multi-component polymeric systems with reverse thermal gelation behaviour (e.g. peo-ppo copolymers)
US7649023B2 (en) 2002-06-11 2010-01-19 Novartis Ag Biodegradable block copolymeric compositions for drug delivery
EP1556086A2 (en) * 2002-10-31 2005-07-27 Pfizer Products Inc. Solid and semi-solid polymeric ionic conjugates
WO2004039410A2 (en) 2002-10-31 2004-05-13 Pfizer Products Inc. Liquid conjugates of solid pharmaceuticals
DE602004016161D1 (en) * 2003-07-07 2008-10-09 Nof Corp TRIBLOCK COPOLYMER, MANUFACTURING METHOD AND BIOCOMPATIBLE MATERIAL
US20060224095A1 (en) * 2005-04-05 2006-10-05 University Of New Hampshire Biocompatible polymeric vesicles self assembled from triblock copolymers
DE102005033101A1 (en) * 2005-07-15 2007-01-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Resorbable polyether esters and their use for the manufacture of medical implants
CA2618404A1 (en) * 2005-08-04 2007-02-15 Angiotech International Ag Block copolymer compositions and uses thereof
US8608760B2 (en) * 2006-06-21 2013-12-17 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for joining non-conjoined lumens
US8197499B2 (en) * 2006-06-21 2012-06-12 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for joining non-conjoined lumens
US8216259B2 (en) * 2006-06-21 2012-07-10 The Board Of Trustees Of The Leland Stanford Jr. University Compositions and methods for joining non-conjoined lumens
US20080140106A1 (en) * 2006-12-12 2008-06-12 Kimberly-Clark Worldwide, Inc. Enhanced cuff sealing for endotracheal tubes
JP5539856B2 (en) * 2007-04-09 2014-07-02 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア Flexible and tough elastomer composition from semi-crystalline amorphous polyolefin block copolymer
US7897168B2 (en) 2007-04-13 2011-03-01 Medtronic Vascular, Inc. Degradable polymers incorporating gamma-butyrolactone
US20100204432A1 (en) * 2007-05-28 2010-08-12 Husam Younes Biodegradable elastomers prepared by the condensation of an organic di-, tri- or tetra-carboxylic acid and an organic diol
JP2011507635A (en) * 2007-12-20 2011-03-10 トートナ グループ， リミテッド パートナーシップ Compositions and methods for joining uncoupled lumens
US20090183503A1 (en) * 2008-01-18 2009-07-23 Alberto Verdesi Exhaust apparatus
US11969501B2 (en) 2008-04-21 2024-04-30 Dompé Farmaceutici S.P.A. Auris formulations for treating otic diseases and conditions
BRPI0910850B1 (en) 2008-04-21 2022-06-14 Otonomy, Inc. INTRATYMPANIC COMPOSITION INCLUDING BRAIN-DERIVED NEUROTROPHIC GROWTH FACTOR (BDNF) FOR THE TREATMENT OR PREVENTION OF HEARING LOSS
CN102105133B (en) 2008-07-21 2015-06-17 奥德纳米有限公司 Controlled release otic structure modulating and innate immune system modulating compositions and methods of treating otic disorders
US8318817B2 (en) 2008-07-21 2012-11-27 Otonomy, Inc. Controlled release antimicrobial compositions and methods for the treatment of otic disorders
US8784870B2 (en) 2008-07-21 2014-07-22 Otonomy, Inc. Controlled release compositions for modulating free-radical induced damage and methods of use thereof
US8563037B2 (en) * 2009-02-06 2013-10-22 Tautona Group, L.P. Compositions and methods for joining non-conjoined lumens
KR101838303B1 (en) * 2009-09-18 2018-03-13 비티지 인터내셔널 리미티드 Reconstitutable reverse thermal gelling polymers
US8753621B2 (en) * 2009-09-18 2014-06-17 Protherics Salt Lake City, Inc. BAB triblock polymers having improved release characteristics
KR101838304B1 (en) 2009-09-18 2018-03-13 비티지 인터내셔널 리미티드 BAB triblock polymers having improved release characteristics
US9155722B2 (en) * 2009-09-18 2015-10-13 Protherics Salt Lake City, Inc. Reconstitutable reverse thermal gelling polymers
US8551531B2 (en) 2010-04-12 2013-10-08 The Curators Of The University Of Missouri Pentablock polymers
US8614190B2 (en) 2010-06-30 2013-12-24 Industrial Technology Research Institute Thermal responsive composition for treating bone diseases
CA2831469C (en) 2011-03-31 2020-02-18 Ingell Technologies Holding B.V. Biodegradable compositions suitable for controlled release
CA2831471C (en) 2011-03-31 2020-02-25 Ingell Technologies Holding B.V. Biodegradable compositions suitable for controlled release
WO2013055331A1 (en) * 2011-10-12 2013-04-18 The Curators Of The University Of Missouri Pentablock polymers
ES2885523T3 (en) 2011-11-23 2021-12-14 Therapeuticsmd Inc Natural combination hormone replacement formulations and therapies
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
WO2014186669A1 (en) 2013-05-16 2014-11-20 The Curators Of The University Of Missouri Drug loading pentablock polymers
US10682415B2 (en) 2013-07-22 2020-06-16 Wisconsin Alumni Research Foundation Thermogel formulation for combination drug delivery
JP2016534121A (en) 2013-08-27 2016-11-04 オトノミ—，インク． Treatment of childhood ear disease
AR100562A1 (en) 2014-05-22 2016-10-12 Therapeuticsmd Inc PHARMACEUTICAL COMPOSITION OF ESTRADIOL AND PROGESTERONE FOR HORMONAL REPLACEMENT THERAPY
EP3164115A4 (en) 2014-07-03 2017-05-17 Otonomy, Inc. Sterilization of ciprofloxacin composition
AU2015316873A1 (en) 2014-09-15 2017-04-06 Novioponics B.V. Composition comprising a hydrogel and pesticides
US9925233B2 (en) 2015-01-30 2018-03-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9375478B1 (en) 2015-01-30 2016-06-28 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9744209B2 (en) 2015-01-30 2017-08-29 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9687526B2 (en) 2015-01-30 2017-06-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9937223B2 (en) 2015-01-30 2018-04-10 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9750785B2 (en) 2015-01-30 2017-09-05 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
DK3370789T3 (en) * 2015-11-04 2019-09-30 Ingell Tech Holding B V COMPOSITIONS CONTAINING TRIBLE COPOLYMERS
ES2964696T3 (en) 2015-11-16 2024-04-09 Medincell S A A method of morselyzing and/or directing pharmaceutically active ingredients to synovial tissue
WO2017100576A1 (en) 2015-12-11 2017-06-15 Otonomy, Inc. Ciprofloxacin otic composition and kits and method for using same
WO2017173044A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd Inc. Steroid hormone compositions in medium chain oils
CA3020153A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
US11040004B2 (en) 2016-09-16 2021-06-22 Otonomy, Inc. Otic gel formulations for treating otitis externa
US11911532B2 (en) 2017-03-29 2024-02-27 The Regents Of The University Of Colorado, A Body Corporate Reverse thermal gels and their use as vascular embolic repair agents
WO2018183984A1 (en) * 2017-03-31 2018-10-04 Rowan University Optically clear, in-situ forming biodegradable nano-carriers for ocular therapy, and methods using same
US11612563B2 (en) * 2017-07-17 2023-03-28 Medincell Pharmaceutical composition
EP3880754A1 (en) * 2018-11-15 2021-09-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Lactide containing polyester-polyethylene glycol triblock thermoresponsive copolymers
WO2020254249A1 (en) 2019-06-21 2020-12-24 Proqr Therapeutics Ii B.V. Delivery of nucleic acids for the treatment of auditory disorders
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations
CN113462330B (en) * 2021-06-30 2022-10-11 佛山南宝高盛高新材料有限公司 Hot melt adhesive for plaster and preparation method thereof

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE37983T1 (en) 1982-04-22 1988-11-15 Ici Plc DELAYED RELEASE AGENT.
US4438253A (en) 1982-11-12 1984-03-20 American Cyanamid Company Poly(glycolic acid)/poly(alkylene glycol) block copolymers and method of manufacturing the same
JPS60100516A (en) 1983-11-04 1985-06-04 Takeda Chem Ind Ltd Preparation of sustained release microcapsule
GB8416234D0 (en) 1984-06-26 1984-08-01 Ici Plc Biodegradable amphipathic copolymers
US4716183A (en) 1985-11-22 1987-12-29 Raychem Corp. Styrene-diene block copolymer compositions
US4892903A (en) * 1986-07-07 1990-01-09 Shell Oil Company Elastomeric fibers, structures fashioned therefrom and elastomeric films
EP0258780B1 (en) 1986-09-05 1993-06-23 American Cyanamid Company Polyesters containing alkylene oxide blocks as drug delivery systems
JP2670680B2 (en) 1988-02-24 1997-10-29 株式会社ビーエムジー Polylactic acid microspheres containing physiologically active substance and method for producing the same
JPH064540B2 (en) * 1988-09-14 1994-01-19 多木化学株式会社 Medical composition
US4938763B1 (en) 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5324519A (en) 1989-07-24 1994-06-28 Atrix Laboratories, Inc. Biodegradable polymer composition
US5674192A (en) * 1990-12-28 1997-10-07 Boston Scientific Corporation Drug delivery
HU222501B1 (en) 1991-06-28 2003-07-28 Endorecherche Inc. For the preparation of a sustained release pharmaceutical composition and method comprising MPA or MGA
US5165713A (en) 1991-07-03 1992-11-24 5Th Boot Industries Inc. Fifth wheel cover
US5330768A (en) 1991-07-05 1994-07-19 Massachusetts Institute Of Technology Controlled drug delivery using polymer/pluronic blends
GB9211268D0 (en) 1992-05-28 1992-07-15 Ici Plc Salts of basic peptides with carboxyterminated polyesters
US5643605A (en) 1993-10-25 1997-07-01 Genentech, Inc. Methods and compositions for microencapsulation of adjuvants
FR2721665B1 (en) 1994-06-22 1996-07-19 Snecma Lock nuts or screws and assemblies thus formed.
JPH08176016A (en) * 1994-12-19 1996-07-09 Univ Miami Biodegradable and injectable drug delivery polymer
US5939485A (en) * 1995-06-19 1999-08-17 Medlogic Global Corporation Responsive polymer networks and methods of their use
US5702717A (en) * 1995-10-25 1997-12-30 Macromed, Inc. Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers
US6117949A (en) * 1998-10-01 2000-09-12 Macromed, Inc. Biodegradable low molecular weight triblock poly (lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US6004573A (en) * 1997-10-03 1999-12-21 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
DE69829204T2 (en) * 1997-10-03 2005-12-15 Macromed Inc., Salt Lake City BIODEGRADABLE TRIBLOCK-POLY (LACTIDE-CO-GLYCOLIDE) POLYETHYLENE GLYCOL COPOLYMERS WITH REVERSED THERMAL GELING
GB9814609D0 (en) * 1998-07-07 1998-09-02 Smith & Nephew Polymers
US6451346B1 (en) * 1998-12-23 2002-09-17 Amgen Inc Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents
US6287588B1 (en) * 1999-04-29 2001-09-11 Macromed, Inc. Agent delivering system comprised of microparticle and biodegradable gel with an improved releasing profile and methods of use thereof

Also Published As

Publication number Publication date
CY1107540T1 (en) 2013-03-13
CA2407298A1 (en) 2001-11-08
ATE342066T1 (en) 2006-11-15
DK1276505T3 (en) 2007-02-12
DE60123772D1 (en) 2006-11-23
JP2003531927A (en) 2003-10-28
TW539718B (en) 2003-07-01
US20040185104A1 (en) 2004-09-23
US7018645B1 (en) 2006-03-28
EP1276505B1 (en) 2006-10-11
WO2001082970A1 (en) 2001-11-08
ES2273834T3 (en) 2007-05-16
EP1276505A4 (en) 2005-06-29
US7135190B2 (en) 2006-11-14
EP1276505A1 (en) 2003-01-22
JP4895457B2 (en) 2012-03-14
KR20030001446A (en) 2003-01-06
PT1276505E (en) 2007-01-31
DE60123772T2 (en) 2007-10-04
CA2407298C (en) 2010-01-12
KR100754550B1 (en) 2007-09-05
AR028382A1 (en) 2003-05-07

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