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AU2001254794A1 - Diagnosis of diseases associated with dna adducts - Google Patents

Diagnosis of diseases associated with dna adducts

Info

Publication number
AU2001254794A1
AU2001254794A1 AU2001254794A AU5479401A AU2001254794A1 AU 2001254794 A1 AU2001254794 A1 AU 2001254794A1 AU 2001254794 A AU2001254794 A AU 2001254794A AU 5479401 A AU5479401 A AU 5479401A AU 2001254794 A1 AU2001254794 A1 AU 2001254794A1
Authority
AU
Australia
Prior art keywords
diagnosis
diseases associated
genes associated
dna transcription
dna adducts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001254794A
Inventor
Kurt Berlin
Alexander Olek
Christian Piepenbrock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Epigenomics AG
Original Assignee
Epigenomics AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10019058A external-priority patent/DE10019058A1/en
Priority claimed from DE10032529A external-priority patent/DE10032529A1/en
Application filed by Epigenomics AG filed Critical Epigenomics AG
Publication of AU2001254794A1 publication Critical patent/AU2001254794A1/en
Abandoned legal-status Critical Current

Links

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)

Abstract

The present invention relates to the chemically modified genomic sequences of genes associated with DNA transcription, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genes associated with DNA transcription which are directed against the sequence, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes associated with DNA transcription.
AU2001254794A 2000-04-06 2001-04-06 Diagnosis of diseases associated with dna adducts Abandoned AU2001254794A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
DE10019058A DE10019058A1 (en) 2000-04-06 2000-04-06 Designing primers and probes for analyzing diseases associated with cytosine methylation state e.g. arthritis, cancer, aging, arteriosclerosis comprising fragments of chemically modified genes associated with cell cycle
DE10019058.8 2000-04-06
DE10019173.8 2000-04-07
DE10019173 2000-04-07
DE10032529.7 2000-06-30
DE10032529A DE10032529A1 (en) 2000-06-30 2000-06-30 Diagnosis of major genetic parameters within the Major Histocompatibility Complex (MHC)
DE10043826.1 2000-09-01
DE10043826 2000-09-01
PCT/EP2001/004015 WO2001077378A2 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with dna adducts

Publications (1)

Publication Number Publication Date
AU2001254794A1 true AU2001254794A1 (en) 2001-10-23

Family

ID=27437807

Family Applications (9)

Application Number Title Priority Date Filing Date
AU2001254794A Abandoned AU2001254794A1 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with dna adducts
AU2001276330A Ceased AU2001276330B2 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with apoptosis
AU2001275663A Abandoned AU2001275663A1 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with DNA replication by assessing DNA methylation
AU2001276331A Abandoned AU2001276331A1 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with metastasis
AU2001254788A Abandoned AU2001254788A1 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with gene regulation
AU7633001A Pending AU7633001A (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with apoptosis
AU2001278420A Abandoned AU2001278420A1 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with dna repair
AU2001277487A Abandoned AU2001277487A1 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with metabolism
AU2001289600A Abandoned AU2001289600A1 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated dna transcription by means of assessing the methylation status of genes associated with dna transcription

Family Applications After (8)

Application Number Title Priority Date Filing Date
AU2001276330A Ceased AU2001276330B2 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with apoptosis
AU2001275663A Abandoned AU2001275663A1 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with DNA replication by assessing DNA methylation
AU2001276331A Abandoned AU2001276331A1 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with metastasis
AU2001254788A Abandoned AU2001254788A1 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with gene regulation
AU7633001A Pending AU7633001A (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with apoptosis
AU2001278420A Abandoned AU2001278420A1 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with dna repair
AU2001277487A Abandoned AU2001277487A1 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with metabolism
AU2001289600A Abandoned AU2001289600A1 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated dna transcription by means of assessing the methylation status of genes associated with dna transcription

Country Status (7)

Country Link
US (7) US20030162194A1 (en)
EP (9) EP1274866A2 (en)
JP (3) JP2004508807A (en)
AT (1) ATE353975T1 (en)
AU (9) AU2001254794A1 (en)
DE (1) DE60126593T2 (en)
WO (8) WO2001092565A2 (en)

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