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AU2001249920A1 - Two-dimensional spectral imaging system - Google Patents

Two-dimensional spectral imaging system

Info

Publication number
AU2001249920A1
AU2001249920A1 AU2001249920A AU4992001A AU2001249920A1 AU 2001249920 A1 AU2001249920 A1 AU 2001249920A1 AU 2001249920 A AU2001249920 A AU 2001249920A AU 4992001 A AU4992001 A AU 4992001A AU 2001249920 A1 AU2001249920 A1 AU 2001249920A1
Authority
AU
Australia
Prior art keywords
spectra
detection region
identifiable
probes
labels
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001249920A
Inventor
Stephen A. Empedocles
Andrew R. Watson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Life Technologies Corp
Original Assignee
Quantum Dot Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quantum Dot Corp filed Critical Quantum Dot Corp
Publication of AU2001249920A1 publication Critical patent/AU2001249920A1/en
Abandoned legal-status Critical Current

Links

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    • G01N21/272—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration for following a reaction, e.g. for determining photometrically a reaction rate (photometric cinetic analysis)
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Abstract

Improved devices, systems (14), and methods for sensing and/or identifying signals from within a signal detection region are well-suited for identification of spectral codes. Large numbers of independently identifiable spectral codes can be generated by quite small bodies (12a, 12b), and a plurality of such bodies or probes (12a, 12b) may be present within a detection region. Simultaneously imaging of identifiable spectra (60) from throughout the detection region allows the probes (12a, 12b) to be identified. As the identifiable spectra can be treated as being generated from a point source within a much larger detection field, a prism, diffractive grading, holographic transmissive grading, or the like (56) can spectrally disperse the images of the labels across a sensor surface. A CCD (18) can identify the relative wavelengths of signals making up the spectra. Absolute signal wavelengths may be determined by determining positions of the labels, by an interval wavelength reference within the spectra (60), or the like.
AU2001249920A 2000-04-06 2001-04-06 Two-dimensional spectral imaging system Abandoned AU2001249920A1 (en)

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US19552000P 2000-04-06 2000-04-06
US60195520 2000-04-06
PCT/US2001/011320 WO2001077678A1 (en) 2000-04-06 2001-04-06 Two-dimensional spectral imaging system

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AU2001255240A Abandoned AU2001255240A1 (en) 2000-04-06 2001-04-06 Differentiable spectral bar code methods and systems
AU2001249920A Abandoned AU2001249920A1 (en) 2000-04-06 2001-04-06 Two-dimensional spectral imaging system
AU2001253244A Abandoned AU2001253244A1 (en) 2000-04-06 2001-04-06 Spatial positioning of spectrally labeled beads

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Families Citing this family (230)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6908737B2 (en) 1999-04-15 2005-06-21 Vitra Bioscience, Inc. Systems and methods of conducting multiplexed experiments
US7253435B2 (en) 1999-04-15 2007-08-07 Millipore Corporation Particles with light-polarizing codes
US7192778B2 (en) * 1999-10-06 2007-03-20 Natan Michael J Surface enhanced spectroscopy-active composite nanoparticles
US8497131B2 (en) * 1999-10-06 2013-07-30 Becton, Dickinson And Company Surface enhanced spectroscopy-active composite nanoparticles comprising Raman-active reporter molecules
WO2002079764A1 (en) 2001-01-26 2002-10-10 Nanoplex Technologies, Inc. Surface-enhanced spectroscopy-active sandwich nanoparticles
US6734420B2 (en) * 2000-04-06 2004-05-11 Quantum Dot Corporation Differentiable spectral bar code methods and systems
US20020090650A1 (en) * 2000-04-06 2002-07-11 Quantum Dot Corporation Two-dimensional spectral imaging system
US6898367B2 (en) * 2000-06-17 2005-05-24 Leica Microsystems Heidelberg Gmbh Method and instrument for microscopy
US6586190B2 (en) * 2000-08-18 2003-07-01 Syngenta Participations Ag Parallel high throughput method and kit
ATE425457T1 (en) 2000-10-06 2009-03-15 Life Technologies Corp CELLS WITH A SPECTRAL SIGNATURE AND METHOD FOR THEIR PRODUCTION AND USE
EP1395601A4 (en) * 2000-10-18 2006-04-12 Vitra Bioscience Inc Multiplexed cell analysis system
JP2004537712A (en) 2000-10-18 2004-12-16 バーチャル・アレイズ・インコーポレーテッド Multiple cell analysis system
EP1353848A2 (en) * 2000-12-29 2003-10-22 Siemens Dematic Postal Automation L.P. Low visual impact labeling method and system
US6586745B2 (en) * 2001-06-19 2003-07-01 Southwest Research Institute Ultraviolet target designator and methodology
WO2003003015A2 (en) * 2001-06-28 2003-01-09 Advanced Research And Technology Institute, Inc. Methods of preparing multicolor quantum dot tagged beads and conjugates thereof
US7473767B2 (en) 2001-07-03 2009-01-06 The Institute For Systems Biology Methods for detection and quantification of analytes in complex mixtures
US20030066998A1 (en) * 2001-08-02 2003-04-10 Lee Howard Wing Hoon Quantum dots of Group IV semiconductor materials
US7005669B1 (en) 2001-08-02 2006-02-28 Ultradots, Inc. Quantum dots, nanocomposite materials with quantum dots, devices with quantum dots, and related fabrication methods
US6794265B2 (en) * 2001-08-02 2004-09-21 Ultradots, Inc. Methods of forming quantum dots of Group IV semiconductor materials
US6819845B2 (en) * 2001-08-02 2004-11-16 Ultradots, Inc. Optical devices with engineered nonlinear nanocomposite materials
US6710366B1 (en) 2001-08-02 2004-03-23 Ultradots, Inc. Nanocomposite materials with engineered properties
US7309568B2 (en) * 2001-09-26 2007-12-18 Hitachi, Ltd. Method in inspecting DNA and apparatus therefor
DE10153829A1 (en) * 2001-11-05 2003-05-28 Bayer Ag Assay based on doped nanoparticles
US8271202B1 (en) 2002-02-11 2012-09-18 Fernandez Dennis S Modified host bio-data management
US20040026684A1 (en) * 2002-04-02 2004-02-12 Nanosys, Inc. Nanowire heterostructures for encoding information
US6996292B1 (en) * 2002-04-18 2006-02-07 Sandia Corporation Staring 2-D hadamard transform spectral imager
GB2387903A (en) * 2002-04-24 2003-10-29 Smartbead Technologies Ltd Multiparameter analysis using tagged molecules
US6788416B2 (en) * 2002-05-22 2004-09-07 Texas Instruments Incorporated Method and apparatus for dynamic DMD testing
GB0216197D0 (en) * 2002-07-12 2002-08-21 Univ Strathclyde Serrs active particles
KR20050058373A (en) * 2002-08-19 2005-06-16 프라게놈 가부시키가이샤 Cipher information-containing material, its identifying method, and its identifying system
US20050227252A1 (en) * 2002-08-20 2005-10-13 Moon John A Diffraction grating-based encoded articles for multiplexed experiments
US7164533B2 (en) * 2003-01-22 2007-01-16 Cyvera Corporation Hybrid random bead/chip based microarray
CA2496287A1 (en) 2002-08-20 2004-03-04 Cyvera Corporation Diffraction grating-based optical identification element
US7923260B2 (en) 2002-08-20 2011-04-12 Illumina, Inc. Method of reading encoded particles
US7508608B2 (en) * 2004-11-17 2009-03-24 Illumina, Inc. Lithographically fabricated holographic optical identification element
US7619819B2 (en) * 2002-08-20 2009-11-17 Illumina, Inc. Method and apparatus for drug product tracking using encoded optical identification elements
US7901630B2 (en) * 2002-08-20 2011-03-08 Illumina, Inc. Diffraction grating-based encoded microparticle assay stick
US7441703B2 (en) * 2002-08-20 2008-10-28 Illumina, Inc. Optical reader for diffraction grating-based encoded optical identification elements
US7872804B2 (en) 2002-08-20 2011-01-18 Illumina, Inc. Encoded particle having a grating with variations in the refractive index
US7900836B2 (en) * 2002-08-20 2011-03-08 Illumina, Inc. Optical reader system for substrates having an optically readable code
WO2004025563A1 (en) 2002-09-12 2004-03-25 Cyvera Corporation Diffraction grating-based encoded micro-particles for multiplexed experiments
US20100255603A9 (en) 2002-09-12 2010-10-07 Putnam Martin A Method and apparatus for aligning microbeads in order to interrogate the same
EP1552475A1 (en) 2002-09-12 2005-07-13 Cyvera Corporation Chemical synthesis using diffraction grating-based encoded optical elements
AU2003267192A1 (en) 2002-09-12 2004-04-30 Cyvera Corporation Method and apparatus for aligning elongated microbeads in order to interrogate the same
WO2004025562A1 (en) 2002-09-12 2004-03-25 Cyvera Corp. Method and apparatus for labelling using diffraction grating-based encoded optical identification elements
US7092160B2 (en) * 2002-09-12 2006-08-15 Illumina, Inc. Method of manufacturing of diffraction grating-based optical identification element
US7985590B2 (en) * 2002-09-26 2011-07-26 Science Application International Corporation Method and system for detection using nanodot taggants
WO2004028682A2 (en) * 2002-09-27 2004-04-08 Carlsberg A/S Spatially encoded polymer matrix
US7035308B1 (en) 2002-10-28 2006-04-25 Science Applications International Corporation Method and system for countering laser technology
FR2846445B1 (en) * 2002-10-29 2005-04-08 Claude Lambert METHOD OF AUTHENTICATING BY MARKING OR CHEMICAL TRACING AN OBJECT OR SUBSTANCE.
DE10252628A1 (en) * 2002-11-11 2004-05-19 Forschungszentrum Jülich GmbH Procedure to encode information using fluorescent colors to print encoded data
DE20306138U1 (en) 2003-04-16 2003-09-04 Monajembashi, Shamci, Dr., 69126 Heidelberg Preparation of biological target cells, with auxiliary erythrocytes, has a glass carrier for use with a multi-beam laser as optical tweezers for manipulation to examine the cell elasticity
US7917298B1 (en) 2003-04-17 2011-03-29 Nanosys, Inc. Nanocrystal taggants
US20040259270A1 (en) * 2003-06-19 2004-12-23 Wolf David E. System, device and method for exciting a sensor and detecting analyte
US8796030B2 (en) * 2003-07-12 2014-08-05 Parallel Synthesis Technologies, Inc. Methods for optically encoding an object with upconverting materials and compositions used therein
US7538869B2 (en) * 2004-06-30 2009-05-26 Chemimage Corporation Multipoint method for identifying hazardous agents
US20060057729A1 (en) * 2003-09-12 2006-03-16 Illumina, Inc. Diffraction grating-based encoded element having a substance disposed thereon
US7488451B2 (en) 2003-09-15 2009-02-10 Millipore Corporation Systems for particle manipulation
AU2003285133A1 (en) * 2003-11-05 2005-06-24 The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services Biofunctionalized quantum dots for biological imaging
US20070275007A1 (en) * 2003-11-05 2007-11-29 The Government Of The United States Of America, Represented By The Secretary Of Health And Human S Carbohydrate Antigen-Nanoparticle Conjugates and Uses Thereof as Antimetastatic Agents in Treating Cancer
US20050136412A1 (en) * 2003-12-22 2005-06-23 Affymetrix, Inc. Light-based detection and manipulation of single molecules
US7869011B2 (en) 2003-12-22 2011-01-11 Novo Norkisk A/S Apparatus and methods for analysis and sorting of particles such as polymer beads
US7433123B2 (en) 2004-02-19 2008-10-07 Illumina, Inc. Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein
US7202943B2 (en) * 2004-03-08 2007-04-10 National Research Council Of Canada Object identification using quantum dots fluorescence allocated on Fraunhofer solar spectral lines
US7999455B2 (en) * 2006-11-13 2011-08-16 Research Triangle Institute Luminescent device including nanofibers and light stimulable particles disposed on a surface of or at least partially within the nanofibers
US7815854B2 (en) * 2004-04-30 2010-10-19 Kimberly-Clark Worldwide, Inc. Electroluminescent illumination source for optical detection systems
US20060019265A1 (en) * 2004-04-30 2006-01-26 Kimberly-Clark Worldwide, Inc. Transmission-based luminescent detection systems
US7796266B2 (en) 2004-04-30 2010-09-14 Kimberly-Clark Worldwide, Inc. Optical detection system using electromagnetic radiation to detect presence or quantity of analyte
US7837675B2 (en) 2004-07-22 2010-11-23 Shaser, Inc. Method and device for skin treatment with replaceable photosensitive window
WO2006044982A1 (en) * 2004-10-20 2006-04-27 Massachusetts Institute Of Technology Infrared detection material and method of production
US8927892B2 (en) 2004-10-22 2015-01-06 Parallel Synthesis Technologies Rare earth downconverting phosphor compositions for optically encoding objects and methods and apparatus relating to same
US7682782B2 (en) 2004-10-29 2010-03-23 Affymetrix, Inc. System, method, and product for multiple wavelength detection using single source excitation
EP1817571B1 (en) 2004-11-04 2011-09-07 Renishaw Diagnostics Limited Metal nano-void photonic crystal for enhanced raman spectroscopy
AU2005307746B2 (en) 2004-11-16 2011-05-12 Illumina, Inc. And methods and apparatus for reading coded microbeads
US7602952B2 (en) 2004-11-16 2009-10-13 Illumina, Inc. Scanner having spatial light modulator
US7604173B2 (en) * 2004-11-16 2009-10-20 Illumina, Inc. Holographically encoded elements for microarray and other tagging labeling applications, and method and apparatus for making and reading the same
US20060134324A1 (en) * 2004-11-17 2006-06-22 Illumina, Inc. Filament with easily removed protective coating and methods for stripping the same
SE0402996D0 (en) * 2004-12-09 2004-12-09 Alexander M Grishin Microwave Readable Ferroelectric Barcode
JP2008524600A (en) * 2004-12-16 2008-07-10 インヴィトロジェン コーポレーション Quantum dot-encoded bead set for multiplex assay calibration and quantification and method of use thereof
US7586684B2 (en) * 2005-01-21 2009-09-08 New York University Solute characterization by optoelectronkinetic potentiometry in an inclined array of optical traps
CN101297190B (en) * 2005-02-18 2012-01-18 美洲染料资源公司 Method for encoding material with luminescent label and instrument for reading it out
US7277169B2 (en) * 2005-02-18 2007-10-02 The Regents Of The University Of Michigan Whole spectrum fluorescence detection with ultrafast white light excitation
US20060229819A1 (en) * 2005-04-12 2006-10-12 Eastman Kodak Company Method for imaging an array of microspheres
US8351026B2 (en) 2005-04-22 2013-01-08 Affymetrix, Inc. Methods and devices for reading microarrays
US20060243809A1 (en) * 2005-04-27 2006-11-02 Hodgson Rodney T Combination logo and identification code
US7238957B2 (en) * 2005-05-02 2007-07-03 Raytheon Company Methods and apparatus for presenting images
BRPI0609385A2 (en) * 2005-05-10 2011-10-18 Commw Scientifc And Ind Res Organisation E The Boeing Company methods for marking and tracking an industrial process material, system, and portable luminescence reader
US9297092B2 (en) 2005-06-05 2016-03-29 Qd Vision, Inc. Compositions, optical component, system including an optical component, devices, and other products
WO2007103310A2 (en) * 2006-03-07 2007-09-13 Qd Vision, Inc. An article including semiconductor nanocrystals
US20060290000A1 (en) * 2005-06-28 2006-12-28 Wojciech Worwag Composite metal layer formed using metal nanocrystalline particles in an electroplating bath
US7663750B2 (en) 2005-06-30 2010-02-16 Applied Biosystems, Llc Two-dimensional spectral imaging system
US7227128B2 (en) * 2005-06-30 2007-06-05 Applera Corporation System and methods for improving signal/noise ratio for signal detectors
US7817273B2 (en) * 2005-06-30 2010-10-19 Life Technologies Corporation Two-dimensional spectral imaging system
AU2006272626B2 (en) * 2005-07-26 2010-12-09 Oregon Health & Science University Nanoparticle probes for capture, sorting and placement of targets
US8232092B2 (en) * 2005-08-09 2012-07-31 Maxwell Sensors, Inc. Apparatus and method for digital magnetic beads analysis
US7858307B2 (en) * 2005-08-09 2010-12-28 Maxwell Sensors, Inc. Light transmitted assay beads
US7871770B2 (en) 2005-08-09 2011-01-18 Maxwell Sensors, Inc. Light transmitted assay beads
WO2007035597A2 (en) * 2005-09-16 2007-03-29 Hypermed, Inc. Disposable calibration-fiducial mark for hyperspectral imaging
US7745788B2 (en) * 2005-09-23 2010-06-29 Massachusetts Institute Of Technology Optical trapping with a semiconductor
US8673107B2 (en) * 2005-10-28 2014-03-18 Parallel Synthesis Technologies Methods for fabricating optically encoded particles and methods for optically encoding objects with such particles
EP1948829A4 (en) * 2005-11-15 2009-08-26 Becton Dickinson Co SERS-BASED PROCESSES FOR THE DETECTION OF BIOAGENTS
US7623624B2 (en) 2005-11-22 2009-11-24 Illumina, Inc. Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction
US8409863B2 (en) 2005-12-14 2013-04-02 Becton, Dickinson And Company Nanoparticulate chemical sensors using SERS
US20100015607A1 (en) 2005-12-23 2010-01-21 Nanostring Technologies, Inc. Nanoreporters and methods of manufacturing and use thereof
US7723100B2 (en) 2006-01-13 2010-05-25 Becton, Dickinson And Company Polymer coated SERS nanotag
US8835185B2 (en) * 2006-01-18 2014-09-16 Canon Kabushiki Kaisha Target substance-detecting element
US7226752B1 (en) 2006-01-19 2007-06-05 Avago Technologies General Ip (Singapore) Pte. Ltd. Methods for detecting an analyte in a sample
WO2007090058A2 (en) * 2006-01-27 2007-08-09 Oxonica, Inc. Lateral flow immunoassay with encapsulated detection modality
US7995202B2 (en) 2006-02-13 2011-08-09 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7692783B2 (en) * 2006-02-13 2010-04-06 Pacific Biosciences Of California Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7715001B2 (en) * 2006-02-13 2010-05-11 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
CA2571904A1 (en) * 2006-02-15 2007-08-15 Fio Corporation System and method of detecting pathogens
US8460879B2 (en) 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US7583378B2 (en) * 2006-02-23 2009-09-01 Itt Manufacturing Enterprises, Inc. Spectrograph calibration using known light source and Raman scattering
US8849087B2 (en) 2006-03-07 2014-09-30 Qd Vision, Inc. Compositions, optical component, system including an optical component, devices, and other products
WO2007112088A2 (en) 2006-03-24 2007-10-04 Qd Vision, Inc. Hyperspectral imaging device
WO2007117698A2 (en) 2006-04-07 2007-10-18 Qd Vision, Inc. Composition including material, methods of depositing material, articles including same and systems for depositing material
US7830575B2 (en) * 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time
JP5277165B2 (en) * 2006-07-24 2013-08-28 ベクトン・ディキンソン・アンド・カンパニー Analytical particle agglomeration and imaging apparatus and method
US7764361B2 (en) * 2006-07-27 2010-07-27 Northwestern University Systems and methods to analyze multiplexed bead-based assays using backscattered light
WO2008034102A2 (en) * 2006-09-15 2008-03-20 Haemonetics Corporation Surface mapping by optical manipulation of particles in relation to a functionalized surface
US8709789B2 (en) * 2006-11-20 2014-04-29 Hypromatrix, Inc. Methods and devices for rapid and specific detection of multiple proteins
WO2008063652A1 (en) * 2006-11-21 2008-05-29 Qd Vision, Inc. Blue emitting semiconductor nanocrystals and compositions and devices including same
CA2580589C (en) * 2006-12-19 2016-08-09 Fio Corporation Microfluidic detection system
EP2109900A1 (en) * 2007-01-08 2009-10-21 Plextronics, Inc. Quantum dot photovoltaic device
US8836212B2 (en) 2007-01-11 2014-09-16 Qd Vision, Inc. Light emissive printed article printed with quantum dot ink
WO2008095081A2 (en) * 2007-02-01 2008-08-07 Evident Technologies Markers comprising light-emitting semiconductor nanocrystals and their use
GB0702092D0 (en) * 2007-02-02 2007-03-14 Fracture Code Corp Aps Graphic Code Application Apparatus and Method
US20080191027A1 (en) * 2007-02-12 2008-08-14 San Ming Yang Semiconductor nanocrystals as marking devices
US20090024003A1 (en) * 2007-03-28 2009-01-22 N.V. Organon Accurate method to assess disease severity in clinical trials concerning psychopathology
US8360321B2 (en) 2007-04-02 2013-01-29 Fio Corporation System and method of deconvolving multiplexed fluorescence spectral signals generated by quantum dot optical coding technology
EP2137523A1 (en) * 2007-04-04 2009-12-30 Network Biosystems, Inc. Plastic microfluidic separation and detection platforms
US8003314B2 (en) 2007-04-16 2011-08-23 Diagnostic Hybrids, Inc. Methods for direct fluorescent antibody virus detection in liquids
US8597729B2 (en) 2007-06-22 2013-12-03 Fio Corporation Systems and methods for manufacturing quantum dot-doped polymer microbeads
US8551786B2 (en) 2007-07-09 2013-10-08 Fio Corporation Systems and methods for enhancing fluorescent detection of target molecules in a test sample
KR101720040B1 (en) * 2007-07-23 2017-03-27 피오 코포레이션 A method and system for collating, storing, analyzing and enabling access to collected and analyzed data associated with biological and environmental test subjects
JPWO2009017142A1 (en) * 2007-07-31 2010-10-21 日本電信電話株式会社 Spectrometer
WO2009025616A1 (en) * 2007-08-22 2009-02-26 Phadia Ab Read-out method and apparatus
CA2734029C (en) 2007-08-30 2016-03-29 The Trustees Of Tufts College Methods for determining the concentration of an analyte in solution
EP2193468B1 (en) * 2007-09-26 2019-03-27 Massachusetts Institute of Technology High-resolution 3d imaging of single semiconductor nanocrystals
WO2009048833A1 (en) * 2007-10-09 2009-04-16 Siemens Healthcare Diagnostics Inc. Two dimensional imaging of reacted areas on a reagent
CA2702367C (en) 2007-10-12 2012-08-21 Fio Corporation Flow focusing method and system for forming concentrated volumes of microbeads, and microbeads formed further thereto
JP5186176B2 (en) * 2007-10-19 2013-04-17 株式会社ジェーシービー Authentication system and portable media for authentication
US9395534B2 (en) * 2007-11-27 2016-07-19 Wisconsin Alumni Research Foundation Optical system for correction of tissue induced aberration
US8540702B2 (en) * 2008-03-11 2013-09-24 Shaser, Inc. Enhancing the brightness of optical radiation used in light-based dermatologic treatment systems
WO2009128938A1 (en) * 2008-04-17 2009-10-22 Maxwell Sensors, Inc. Hydrodynamic focusing for analyzing rectangular microbeads
WO2009137053A1 (en) 2008-05-06 2009-11-12 Qd Vision, Inc. Optical components, systems including an optical component, and devices
EP2297762B1 (en) 2008-05-06 2017-03-15 Samsung Electronics Co., Ltd. Solid state lighting devices including quantum confined semiconductor nanoparticles
US9207385B2 (en) 2008-05-06 2015-12-08 Qd Vision, Inc. Lighting systems and devices including same
WO2010002540A2 (en) 2008-06-05 2010-01-07 Life Technologies Corporation Activation and monitoring of cellular transmembrane potentials
WO2009147874A1 (en) * 2008-06-06 2009-12-10 Idec株式会社 Identification information containing article, information identification device and information identification method
CA2729023C (en) 2008-06-25 2013-02-26 Fio Corporation Bio-threat alert system
EP2303771B1 (en) * 2008-06-30 2018-05-30 Life Technologies Corporation Methods for isolating and purifying nanoparticles from a complex medium
WO2010011875A2 (en) 2008-07-24 2010-01-28 The Regents Of The University Of California Apparatus and method for dispersive fourier-transform imaging
CA2733609C (en) 2008-08-14 2018-03-06 Nanostring Technologies, Inc. Stable nanoreporters
US8446463B2 (en) 2008-08-22 2013-05-21 Genprime, Inc. Apparatus, method and article to perform assays using assay strips
US20100050793A1 (en) * 2008-08-28 2010-03-04 Dong June Ahn Flexible chemical sensors
MX2011002235A (en) 2008-08-29 2011-04-05 Fio Corp A single-use handheld diagnostic test device, and an associated system and method for testing biological and environmental test samples.
CN102348986B (en) 2009-01-13 2015-05-06 Fio公司 Handheld diagnostic test device and method for use in combination with electronic devices and test cartridges in rapid diagnostic tests
US20110130297A1 (en) * 2009-01-23 2011-06-02 Bae Systems Information And Electronic Systems Integration Inc. Quantum dot-sensory array for biological recognition
US8886206B2 (en) 2009-05-01 2014-11-11 Digimarc Corporation Methods and systems for content processing
JP2012529908A (en) 2009-06-15 2012-11-29 ネットバイオ・インコーポレーテッド Improved method for quantification of forensic DNA
US9749607B2 (en) 2009-07-16 2017-08-29 Digimarc Corporation Coordinated illumination and image signal capture for enhanced signal detection
JP2013502047A (en) 2009-08-14 2013-01-17 キユーデイー・ビジヨン・インコーポレーテツド LIGHTING DEVICE, OPTICAL COMPONENT AND METHOD FOR LIGHTING DEVICE
CA2773798A1 (en) * 2009-09-09 2011-03-17 Absolute Software Corporation Alert for real-time risk of theft or loss
AU2010306862B2 (en) 2009-10-13 2015-08-27 Bruker Spatial Biology, Inc. Protein detection via nanoreporters
EP2494353B1 (en) 2009-10-30 2017-09-27 Illumina Inc. An apparatus comprising a plurality of encoded microvessels and a plurality of compartments and a method of reading a plurality of encoded micro vessels
US8889416B2 (en) * 2010-01-21 2014-11-18 California Institute Of Technology Methods and devices for micro-isolation, extraction, and/or analysis of microscale components
EP2516681B1 (en) 2010-02-11 2017-10-18 Nanostring Technologies, Inc Compositions and methods for the detection of preferably small rnas by bridge hybridisation and ligation
JP4965706B2 (en) * 2010-02-26 2012-07-04 Ｉｄｅｃ株式会社 Fluorescence spectrum identification method
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
JP5363663B2 (en) 2010-03-01 2013-12-11 クワンテリクス コーポレーション Method or system for extending the dynamic range in an assay to detect molecules or particles
US9678068B2 (en) 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
JP5855646B2 (en) * 2010-06-14 2016-02-09 トルタグ・テクノロジーズ・インコーポレーテッドＴｒｕｔａｇ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃｏｒｐｏｒａｔｅｄ System for creating a packaging product with an identifier, product packaging, and product
US8695618B2 (en) 2010-12-22 2014-04-15 Carnegie Mellon University 3D chemical pattern control in 2D fluidics devices
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
US9758834B2 (en) 2011-03-28 2017-09-12 Nanostring Technologies, Inc. Compositions and methods for diagnosing cancer
US9228898B2 (en) 2011-03-31 2016-01-05 Gnubio, Inc. Scalable spectroscopic detection and measurement
US20140302532A1 (en) 2011-04-12 2014-10-09 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury
NZ735051A (en) 2011-05-12 2022-11-25 Netbio Inc Methods and compositions for rapid multiplex amplification of str loci
US8610970B1 (en) * 2011-08-20 2013-12-17 Darwin Hu Liquid crystal display (LCD) scanners
WO2013039883A1 (en) 2011-09-12 2013-03-21 Abbvie Biotherapeutics Inc. Artificial nk cells and uses thereof
WO2013076531A1 (en) * 2011-11-23 2013-05-30 Nokia Corporation An apparatus and method comprising a beam splitter
WO2013116780A1 (en) 2012-02-03 2013-08-08 California Institute Of Technology Signal encoding and decoding in multiplexed biochemical assays
US9593982B2 (en) 2012-05-21 2017-03-14 Digimarc Corporation Sensor-synchronized spectrally-structured-light imaging
CA2880678A1 (en) * 2012-07-31 2014-02-06 Juan Carlos Jaime A procedure for obtaining and detecting a genetic marker of objects to be identified, the marker, method for authentication and method for verification
EP2880184B1 (en) 2012-08-03 2021-03-31 California Institute of Technology Multiplexing and quantification in pcr with reduced hardware and requirements
CA2881841A1 (en) 2012-08-23 2014-02-27 The Regents Of The University Of California Spectrally encoded microbeads and methods and devices for making and using same
JP5864040B2 (en) 2012-10-23 2016-02-17 コチ・ウニヴェルシテシＫｏｃ Ｕｎｉｖｅｒｓｉｔｅｓｉ Method and apparatus for the detection of tagging substances in a fluid
US9932626B2 (en) 2013-01-15 2018-04-03 Quanterix Corporation Detection of DNA or RNA using single molecule arrays and other techniques
JP6434919B2 (en) * 2013-01-29 2018-12-05 フィリップス ライティング ホールディング ビー ヴィ Light source, luminaire and surgical lighting unit
DE102013006545B4 (en) * 2013-04-16 2020-02-27 Dräger Safety AG & Co. KGaA Measuring device and measuring method for a reaction carrier
US9621760B2 (en) 2013-06-07 2017-04-11 Digimarc Corporation Information coding and decoding in spectral differences
JP6206871B2 (en) * 2013-07-17 2017-10-04 国立研究開発法人理化学研究所 Optical microscope system
WO2015124942A2 (en) * 2014-02-20 2015-08-27 Malvern Instruments Limited Heterogeneous fluid sample characterization
DE112015002758T5 (en) * 2014-06-11 2017-04-20 Micromass Uk Limited Marking of ADC coalescence
ES2942637T3 (en) 2014-07-17 2023-06-05 Kuantag Nanoteknolojiler Gelistirme Ve Uretim Anonim Sirketi Fluorescent Substance Detection System
US10113910B2 (en) 2014-08-26 2018-10-30 Digimarc Corporation Sensor-synchronized spectrally-structured-light imaging
US9920315B2 (en) 2014-10-10 2018-03-20 California Institute Of Technology Methods and devices for micro-isolation, extraction, and/or analysis of microscale components in an array
US9677935B2 (en) * 2014-11-03 2017-06-13 Trutag Technologies, Inc. Fabry-perot spectral image measurement
US9727941B1 (en) 2014-11-19 2017-08-08 Digimarc Corporation Optimizing optical scanners for digital watermark detection
US9867250B1 (en) 2015-04-20 2018-01-09 The Arizona Board Of Regents On Behalf Of The University Of Arizona System having a configurable pico-second pulsed LED driver circuit and photomultiplier tube biasing and gating circuits for real-time, time-resolved transient recording of fluorescence
US20160371704A1 (en) 2015-06-18 2016-12-22 Kuantag Nanoteknolojiler Gelistirme Ve Uretim A.S. Integrated fuel tracking system
US10482361B2 (en) 2015-07-05 2019-11-19 Thewhollysee Ltd. Optical identification and characterization system and tags
ES2975361T3 (en) 2015-07-17 2024-07-04 Nanostring Technologies Inc Simultaneous quantification of a plurality of proteins in a user-defined region of a cross-sectioned tissue
WO2017015099A1 (en) 2015-07-17 2017-01-26 Nanostring Technologies, Inc. Simultaneous quantification of gene expression in a user-defined region of a cross-sectioned tissue
US10870111B2 (en) * 2015-07-22 2020-12-22 The University Of North Carolina At Chapel Hill Fluidic devices with bead well geometries with spatially separated bead retention and signal detection segments and related methods
US10203246B2 (en) * 2015-11-20 2019-02-12 Verifood, Ltd. Systems and methods for calibration of a handheld spectrometer
WO2017218777A1 (en) 2016-06-17 2017-12-21 California Institute Of Technology Nucleic acid reactions and related methods and compositions
US10347364B2 (en) 2016-09-14 2019-07-09 International Business Machines Corporation Encoding data from genetic traits relevant to illness diagnosis and heritage
US10576475B2 (en) 2016-09-15 2020-03-03 Genprime, Inc. Diagnostic assay strip cassette
JP6659062B2 (en) * 2016-10-13 2020-03-04 国立研究開発法人産業技術総合研究所 Nanoparticle evaluation method and nanoparticle observation device
JP6730525B2 (en) 2016-11-21 2020-07-29 ナノストリング テクノロジーズ，インコーポレイティド Chemical composition and method of using the same
US10324041B2 (en) * 2016-12-21 2019-06-18 Abbott Japan Co., Ltd. Optical imaging system using lateral illumination for digital assays
US11047854B2 (en) 2017-02-06 2021-06-29 Abbott Japan Llc Methods for reducing noise in signal-generating digital assays
JP7089719B2 (en) * 2017-02-07 2022-06-23 ナノフォトン株式会社 Spectroscopic microscope and spectroscopic observation method
FR3075926B1 (en) * 2017-12-21 2021-04-02 Valeo Vision AUTOMOTIVE VEHICLE LIGHTING DEVICE
EP3752635A1 (en) 2018-02-12 2020-12-23 Nanostring Technologies, Inc. Biomolecular probes and methods of detecting gene and protein expression
US12454720B2 (en) 2018-04-17 2025-10-28 ChromaCode, Inc. Methods and systems for multiplex analysis
JP7525402B2 (en) 2018-05-14 2024-07-30 ナノストリング テクノロジーズ，インコーポレイティド Chemical compositions and methods of using same
US12203129B2 (en) 2018-07-03 2025-01-21 ChromaCode, Inc. Formulations and signal encoding and decoding methods for massively multiplexed biochemical assays
JP7022670B2 (en) * 2018-09-10 2022-02-18 株式会社日立ハイテク Spectrum calibration device and spectrum calibration method
JP7447897B2 (en) * 2019-05-30 2024-03-12 ソニーグループ株式会社 Optical measurement device and optical measurement system
DE102019216003B4 (en) * 2019-10-17 2022-04-07 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Optical security feature suitable for Track & Trace and/or serialization systems
CN111474154B (en) * 2020-04-27 2023-01-17 广东博创佳禾科技有限公司 Light source excitation method and system for detection of R. solanacearum
WO2022067164A1 (en) * 2020-09-25 2022-03-31 The Regents Of The University Of California Devices and related methods for physiological examination
CN113514446B (en) * 2021-05-26 2022-11-22 哈尔滨工业大学 Method for rapidly matching and identifying SERS spectrogram
JP2025059660A (en) * 2023-09-29 2025-04-10 株式会社日立ハイテクサイエンス Particle measuring device, particle measuring method, and reflectance standard sample

Family Cites Families (123)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6603007A (en) * 1965-03-08 1966-09-09
US3663813A (en) * 1970-01-19 1972-05-16 American Cyanamid Co Optical reader for luminescent codes luminescing in different wavelengths
US3628016A (en) * 1970-11-27 1971-12-14 Pitney Bowes Alpex Photoelectric reader for fluorescent ink imprinted coded document
US4215275A (en) 1977-12-07 1980-07-29 Luxtron Corporation Optical temperature measurement technique utilizing phosphors
US4485308A (en) * 1982-04-26 1984-11-27 General Electric Company Photo detection system
JPS59214725A (en) * 1983-05-20 1984-12-04 Agency Of Ind Science & Technol Vapor pressure thermometer
DK641487A (en) * 1987-12-07 1989-06-08 Gluetech Aps PROCEDURE FOR MODIFYING POLYMER SURFACES
JPH03279860A (en) * 1990-03-29 1991-12-11 Mitsui Petrochem Ind Ltd Inspecting method and inspecting reagent
US5723218A (en) * 1990-04-16 1998-03-03 Molecular Probes, Inc. Dipyrrometheneboron difluoride labeled flourescent microparticles
US5079169A (en) 1990-05-22 1992-01-07 The Regents Of The Stanford Leland Junior University Method for optically manipulating polymer filaments
US5460831A (en) 1990-06-22 1995-10-24 The Regents Of The University Of California Targeted transfection nanoparticles
US5495334A (en) * 1990-07-26 1996-02-27 Research Development Corporation Of Japan Fourier transform spectroscope with quadrangular common path interferometer
US5665582A (en) 1990-10-29 1997-09-09 Dekalb Genetics Corp. Isolation of biological materials
US5817462A (en) * 1995-02-21 1998-10-06 Applied Spectral Imaging Method for simultaneous detection of multiple fluorophores for in situ hybridization and multicolor chromosome painting and banding
JPH07502479A (en) * 1991-11-22 1995-03-16 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Semiconductor microcrystals covalently bonded to solid inorganic surfaces using self-assembled monolayers
US5377003A (en) * 1992-03-06 1994-12-27 The United States Of America As Represented By The Department Of Health And Human Services Spectroscopic imaging device employing imaging quality spectral filters
JPH0622798A (en) * 1992-07-07 1994-02-01 Hitachi Ltd Method for determining base sequence
GB9220564D0 (en) * 1992-09-29 1992-11-11 Univ London The method of rheological investigation
CA2155186A1 (en) * 1993-02-01 1994-08-18 Kevin M. Ulmer Methods and apparatus for dna sequencing
US5543158A (en) 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
JP3371113B2 (en) * 1993-09-08 2003-01-27 三信工業株式会社 Fuel supply system for vertical multi-cylinder engine
US5462880A (en) 1993-09-13 1995-10-31 Optical Sensors Incorporated Ratiometric fluorescence method to measure oxygen
JP2576027B2 (en) 1993-10-20 1997-01-29 カシオ計算機株式会社 Document format setting method and apparatus
US5958782A (en) 1993-10-21 1999-09-28 Minnesota Mining And Manufacturing Company Cation-sensing composite structure and compounds for use therein
US5695928A (en) * 1993-12-10 1997-12-09 Novartis Corporation Rapid immunoassay for detection of antibodies or antigens incorporating simultaneous sample extraction and immunogenic reaction
JPH07227299A (en) * 1994-02-14 1995-08-29 Kyoto Daiichi Kagaku:Kk Method for detecting specific base sequence of dna and device therefor
US5512745A (en) 1994-03-09 1996-04-30 Board Of Trustees Of The Leland Stanford Jr. University Optical trap system and method
EP0700980B1 (en) * 1994-03-17 1999-11-17 Hitachi Maxell, Ltd. PHOSPHOR, PHOSPHOR COMPOSITION and FLUORESCENT MARK CARRIER
US5537000A (en) * 1994-04-29 1996-07-16 The Regents, University Of California Electroluminescent devices formed using semiconductor nanocrystals as an electron transport media and method of making such electroluminescent devices
US5483338A (en) 1994-05-26 1996-01-09 Martin Marietta Energy Systems, Inc. Method and apparatus for evaluating structural weakness in polymer matrix composites
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5525798A (en) * 1994-12-01 1996-06-11 Pitney Bowes Inc. Bar code scanner for reading a lower layer luminescent invisible ink that is printed below a upper layer luminescent invisible ink
US6352854B1 (en) * 1995-04-25 2002-03-05 Discovery Partners International, Inc. Remotely programmable matrices with memories
EP0822861B1 (en) * 1995-04-25 2003-11-26 Discovery Partners International, Inc. Remotely programmable matrices with memories and uses thereof
US5631141A (en) * 1995-05-05 1997-05-20 The Regents Of The University Of California High resolution biosensor for in-situ microthermometry
US6017434A (en) * 1995-05-09 2000-01-25 Curagen Corporation Apparatus and method for the generation, separation, detection, and recognition of biopolymer fragments
US5776674A (en) * 1995-06-05 1998-07-07 Seq, Ltd Chemical biochemical and biological processing in thin films
US5620857A (en) 1995-06-07 1997-04-15 United States Of America, As Represented By The Secretary Of Commerce Optical trap for detection and quantitation of subzeptomolar quantities of analytes
US6057103A (en) * 1995-07-18 2000-05-02 Diversa Corporation Screening for novel bioactivities
US5981180A (en) * 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
US5756007A (en) * 1995-11-16 1998-05-26 Lucent Technologies Inc. Composition for protection of devices
JP3886153B2 (en) 1996-03-19 2007-02-28 ユニバーシティー オブ ユタ リサーチ ファンデーション Lens and connectable flow cell
US5945526A (en) * 1996-05-03 1999-08-31 Perkin-Elmer Corporation Energy transfer dyes with enhanced fluorescence
US6582921B2 (en) 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
CA2263850C (en) * 1996-08-22 2003-04-29 Eastman Chemical Company On-line quantitative analysis of chemical compositions by raman spectrometry
US5786219A (en) * 1996-10-28 1998-07-28 Molecular Probes, Inc. Microspheres with fluorescent spherical zones
US6024925A (en) 1997-01-23 2000-02-15 Sequenom, Inc. Systems and methods for preparing low volume analyte array elements
US6054325A (en) 1996-12-02 2000-04-25 Glaxo Wellcom Inc. Method and apparatus for transferring and combining distinct chemical compositions with reagents
US5990476A (en) * 1996-12-17 1999-11-23 Physical Electronics Inc Control of surface potential of insulating specimens in surface analysis
US5939021A (en) 1997-01-23 1999-08-17 Hansen; W. Peter Homogeneous binding assay
ATE349697T1 (en) 1997-02-20 2007-01-15 Univ California PLASMON VIBRATION PARTICLES, METHOD AND APPARATUS
JPH1151935A (en) * 1997-08-06 1999-02-26 Aisin Seiki Co Ltd Simultaneous detection of multiple types of target molecules
US6297018B1 (en) * 1998-04-17 2001-10-02 Ljl Biosystems, Inc. Methods and apparatus for detecting nucleic acid polymorphisms
US7348181B2 (en) * 1997-10-06 2008-03-25 Trustees Of Tufts College Self-encoding sensor with microspheres
US7115884B1 (en) 1997-10-06 2006-10-03 Trustees Of Tufts College Self-encoding fiber optic sensor
US6322901B1 (en) * 1997-11-13 2001-11-27 Massachusetts Institute Of Technology Highly luminescent color-selective nano-crystalline materials
US5990479A (en) 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6207392B1 (en) 1997-11-25 2001-03-27 The Regents Of The University Of California Semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6055106A (en) * 1998-02-03 2000-04-25 Arch Development Corporation Apparatus for applying optical gradient forces
JP3944996B2 (en) * 1998-03-05 2007-07-18 株式会社日立製作所 DNA probe array
US6388788B1 (en) 1998-03-16 2002-05-14 Praelux, Inc. Method and apparatus for screening chemical compounds
US6501091B1 (en) * 1998-04-01 2002-12-31 Massachusetts Institute Of Technology Quantum dot white and colored light emitting diodes
AU3555599A (en) * 1998-04-13 1999-11-01 Luminex Corporation Liquid labeling with fluorescent microparticles
US6384409B1 (en) * 1998-04-22 2002-05-07 Mqs, Inc. Optical tracking system
US6139831A (en) * 1998-05-28 2000-10-31 The Rockfeller University Apparatus and method for immobilizing molecules onto a substrate
US7060431B2 (en) * 1998-06-24 2006-06-13 Illumina, Inc. Method of making and decoding of array sensors with microspheres
WO1999067639A1 (en) * 1998-06-25 1999-12-29 Caliper Technologies Corporation High throughput methods, systems and apparatus for performing cell based screening assays
US6159749A (en) * 1998-07-21 2000-12-12 Beckman Coulter, Inc. Highly sensitive bead-based multi-analyte assay system using optical tweezers
EP1101083A1 (en) * 1998-07-27 2001-05-23 Cedars-Sinai Medical Center Spectral topography of mammalian matter
CN1155074C (en) * 1998-09-02 2004-06-23 Memc电子材料有限公司 Silicon on insulator structure from low-defect density single crystal silicon
IL141759A0 (en) * 1998-09-03 2002-03-10 Trellis Bioinformatics Inc Multihued labels
US6642062B2 (en) * 1998-09-03 2003-11-04 Trellis Bioinformatics, Inc. Multihued labels
US6821402B1 (en) * 1998-09-16 2004-11-23 Applera Corporation Spectral calibration of fluorescent polynucleotide separation apparatus
US6326144B1 (en) * 1998-09-18 2001-12-04 Massachusetts Institute Of Technology Biological applications of quantum dots
US6617583B1 (en) * 1998-09-18 2003-09-09 Massachusetts Institute Of Technology Inventory control
EP1113986A2 (en) * 1998-09-18 2001-07-11 Massachusetts Institute Of Technology Inventory control
US6306610B1 (en) 1998-09-18 2001-10-23 Massachusetts Institute Of Technology Biological applications of quantum dots
EP0990903B1 (en) 1998-09-18 2003-03-12 Massachusetts Institute Of Technology Biological applications of semiconductor nanocrystals
US6251303B1 (en) * 1998-09-18 2001-06-26 Massachusetts Institute Of Technology Water-soluble fluorescent nanocrystals
AU3468500A (en) 1998-09-24 2000-06-05 Advanced Research And Technology Institute, Inc. Water-soluble luminescent quantum dots and biomolecular conjugates thereof and related compositions and methods of use
IN187160B (en) 1998-09-26 2002-02-16 Kijang Medical Co
US6333110B1 (en) * 1998-11-10 2001-12-25 Bio-Pixels Ltd. Functionalized nanocrystals as visual tissue-specific imaging agents, and methods for fluorescence imaging
AU1717600A (en) * 1998-11-10 2000-05-29 Biocrystal Limited Methods for identification and verification
US6309701B1 (en) * 1998-11-10 2001-10-30 Bio-Pixels Ltd. Fluorescent nanocrystal-labeled microspheres for fluorescence analyses
US6274873B1 (en) * 1998-11-18 2001-08-14 Dna Technologies Inc. Spectrum analyzer for reading authentication marks
US6255116B1 (en) * 1998-12-17 2001-07-03 Smithkline Beecham Corporation Apparatus and process for arraying beads
US6429027B1 (en) * 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
US6263104B1 (en) * 1998-12-31 2001-07-17 Mcgrew Stephen P. Method and apparatus for reading and verifying holograms
EP2177627B1 (en) * 1999-02-23 2012-05-02 Caliper Life Sciences, Inc. Manipulation of microparticles in microfluidic systems
US6294343B1 (en) * 1999-11-09 2001-09-25 Eos Biotechnology, Inc. Methods of diagnosing colorectal cancer, compositions, and methods of screening for colorectal cancer modulators
US6235540B1 (en) 1999-03-30 2001-05-22 Coulter International Corp. Semiconductor nanoparticles for analysis of blood cell populations and methods of making same
EP1175505A4 (en) * 1999-04-15 2005-04-20 Vitra Bioscience Inc Combinatorial chemical library supports having indicia at coding positions and methods of use
US6284465B1 (en) * 1999-04-15 2001-09-04 Agilent Technologies, Inc. Apparatus, systems and method for locating nucleic acids bound to surfaces
US6534266B1 (en) * 1999-04-22 2003-03-18 Albert Einstein College Of Medicine Of Yeshiva University Assay of transcription sites by multi-fluor fish
US20010055764A1 (en) * 1999-05-07 2001-12-27 Empedocles Stephen A. Microarray methods utilizing semiconductor nanocrystals
EP1179185B1 (en) 1999-05-07 2009-08-12 Life Technologies Corporation A method of detecting an analyte using semiconductor nanocrystals
US6544732B1 (en) * 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
WO2001013119A1 (en) 1999-08-17 2001-02-22 Luminex Corporation Encapsulation of fluorescent particles
US6358684B1 (en) * 1999-08-27 2002-03-19 Pe Corporation UV excitable fluorescent energy transfer dyes
US6274320B1 (en) 1999-09-16 2001-08-14 Curagen Corporation Method of sequencing a nucleic acid
US6252664B1 (en) * 1999-10-15 2001-06-26 Biocrystal Ltd. Fluorescence filter cube for fluorescence detection and imaging
US20050069956A1 (en) * 1999-11-22 2005-03-31 Michael Seul Color-encoding and in-situ interrogation of matrix-coupled chemical compounds
US6225198B1 (en) 2000-02-04 2001-05-01 The Regents Of The University Of California Process for forming shaped group II-VI semiconductor nanocrystals, and product formed using process
US7361488B2 (en) * 2000-02-07 2008-04-22 Illumina, Inc. Nucleic acid detection methods using universal priming
US20020004246A1 (en) * 2000-02-07 2002-01-10 Daniels Robert H. Immunochromatographic methods for detecting an analyte in a sample which employ semiconductor nanocrystals as detectable labels
US6770441B2 (en) * 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
AU2001238447A1 (en) * 2000-02-16 2001-08-27 Quantum Dot Corporation Single target counting assays using semiconductor nanocrystals
JP2003522962A (en) * 2000-02-16 2003-07-29 クァンタム・ドット・コーポレイション Microarray method using semiconductor nanocrystals
US20030099940A1 (en) * 2000-02-16 2003-05-29 Empedocles Stephen A. Single target counting assays using semiconductor nanocrystals
US20020028457A1 (en) * 2000-02-16 2002-03-07 Quantum Dot Corporation Single target counting assays using semiconductor nanocrystals
WO2001063284A2 (en) * 2000-02-25 2001-08-30 Luminex Corporation Internal standards and controls for multiplexed assay
JP2004500109A (en) * 2000-03-22 2004-01-08 クァンタム・ドット・コーポレイション Use of semiconductor nanocrystals in bead-based nucleic acid assays
US20020090650A1 (en) * 2000-04-06 2002-07-11 Quantum Dot Corporation Two-dimensional spectral imaging system
US6734420B2 (en) 2000-04-06 2004-05-11 Quantum Dot Corporation Differentiable spectral bar code methods and systems
US7892854B2 (en) 2000-06-21 2011-02-22 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US6649138B2 (en) * 2000-10-13 2003-11-18 Quantum Dot Corporation Surface-modified semiconductive and metallic nanoparticles having enhanced dispersibility in aqueous media
WO2003003015A2 (en) * 2001-06-28 2003-01-09 Advanced Research And Technology Institute, Inc. Methods of preparing multicolor quantum dot tagged beads and conjugates thereof
ATE556845T1 (en) * 2001-07-20 2012-05-15 Life Technologies Corp LUMINESCENT NANOPARTICLES AND THEIR PRODUCTION
US7041453B2 (en) * 2002-08-22 2006-05-09 Bioarray Solutions Ltd. Molecular constructs and methods of use for detection of biochemical reactions
CA2500761C (en) * 2002-10-15 2012-11-20 Bernhard O. Palsson Methods and systems to identify operational reaction pathways
JP2008524600A (en) * 2004-12-16 2008-07-10 インヴィトロジェン コーポレーション Quantum dot-encoded bead set for multiplex assay calibration and quantification and method of use thereof
US8360321B2 (en) 2007-04-02 2013-01-29 Fio Corporation System and method of deconvolving multiplexed fluorescence spectral signals generated by quantum dot optical coding technology
US7799558B1 (en) 2007-05-22 2010-09-21 Dultz Shane C Ligand binding assays on microarrays in closed multiwell plates

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