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AU2001245734A1 - Coating that promotes endothelial cell adherence - Google Patents

Coating that promotes endothelial cell adherence

Info

Publication number
AU2001245734A1
AU2001245734A1 AU2001245734A AU4573401A AU2001245734A1 AU 2001245734 A1 AU2001245734 A1 AU 2001245734A1 AU 2001245734 A AU2001245734 A AU 2001245734A AU 4573401 A AU4573401 A AU 4573401A AU 2001245734 A1 AU2001245734 A1 AU 2001245734A1
Authority
AU
Australia
Prior art keywords
stent
coating
luminal
exterior surface
vivo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001245734A
Inventor
Robert John Cottone Jr.
Michael John Bradley Kutryk
Stephen Maxwell Rowland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orbus Medical Technologies Inc
Original Assignee
Orbus Medical Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26885401&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2001245734(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Orbus Medical Technologies Inc filed Critical Orbus Medical Technologies Inc
Publication of AU2001245734A1 publication Critical patent/AU2001245734A1/en
Abandoned legal-status Critical Current

Links

Classifications

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Abstract

The invention relates to a method for healing blood vessels by stimulating the formation of a confluent endothelial autologous cell layer in vivo on an implantable metallic stent having a lumen and a luminal surface, and an exterior surface. More specifically, the method includes implanting the stent with a coating in a patient in need of thereof; wherein the coating includes one or more layers of a matrix covalently adherent on said luminal and exterior surface of said stent containing one or more pharmaceutical substances on said exterior surface and a therapeutically effective amount of a single type of antibody, antibody fragments or combinations thereof being compatible to binding selectively to a specific cell surface antigen of circulating autologous endothelial progenitor cells in peripheral blood. In addition, genetically engineered endothelial progenitor cells can be captured on said luminal surface of stent in vivo, to proliferate to form rapidly a confluent endothelium in situ.
AU2001245734A 2000-03-15 2001-03-15 Coating that promotes endothelial cell adherence Abandoned AU2001245734A1 (en)

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US18967400P 2000-03-15 2000-03-15
US60189674 2000-03-15
US20178900P 2000-05-04 2000-05-04
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