[go: up one dir, main page]

AU2001240078A1 - Highly efficient gene transfer into human repopulating stem cells by rd114 pseudotyped retroviral vector particles - Google Patents

Highly efficient gene transfer into human repopulating stem cells by rd114 pseudotyped retroviral vector particles

Info

Publication number
AU2001240078A1
AU2001240078A1 AU2001240078A AU4007801A AU2001240078A1 AU 2001240078 A1 AU2001240078 A1 AU 2001240078A1 AU 2001240078 A AU2001240078 A AU 2001240078A AU 4007801 A AU4007801 A AU 4007801A AU 2001240078 A1 AU2001240078 A1 AU 2001240078A1
Authority
AU
Australia
Prior art keywords
stem cells
gene transfer
highly efficient
retroviral vector
vector particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001240078A
Inventor
Patrick F. Kelly
Elio F. Vanin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
St Jude Childrens Research Hospital
Original Assignee
St Jude Childrens Research Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by St Jude Childrens Research Hospital filed Critical St Jude Childrens Research Hospital
Publication of AU2001240078A1 publication Critical patent/AU2001240078A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/13045—Special targeting system for viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
    • C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
    • C12N2810/6045—RNA rev transcr viruses
    • C12N2810/6054—Retroviridae
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2001240078A 2000-03-07 2001-03-07 Highly efficient gene transfer into human repopulating stem cells by rd114 pseudotyped retroviral vector particles Abandoned AU2001240078A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18753400P 2000-03-07 2000-03-07
US60187534 2000-03-07
PCT/US2001/007212 WO2001066150A2 (en) 2000-03-07 2001-03-07 Highly efficient gene transfer into human repopulating stem cel ls by rd114 pseudotyped retroviral vector particles

Publications (1)

Publication Number Publication Date
AU2001240078A1 true AU2001240078A1 (en) 2001-09-17

Family

ID=22689373

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001240078A Abandoned AU2001240078A1 (en) 2000-03-07 2001-03-07 Highly efficient gene transfer into human repopulating stem cells by rd114 pseudotyped retroviral vector particles

Country Status (2)

Country Link
AU (1) AU2001240078A1 (en)
WO (1) WO2001066150A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0400443D0 (en) 2004-01-09 2004-02-11 Oxford Biomedica Ltd Cascade
WO2003025191A2 (en) * 2001-09-21 2003-03-27 Oxford Biomedica (Uk) Limited Pseudotyped retroviral vector system
EP2019144A1 (en) * 2007-07-23 2009-01-28 Institut National De La Sante Et De La Recherche Medicale (Inserm) Vector particles for targeting CD34+ cells
JP6691048B2 (en) * 2013-10-24 2020-04-28 オスペダーレ サン ラファエレ エス．アール．エル Method

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10507905A (en) * 1994-08-17 1998-08-04 ジェネティック セラピー インコーポレイテッド Retroviral vectors produced in cell lines resistant to lysis by human serum
GB2345063B (en) * 1997-09-23 2002-07-24 Oxford Biomedica Ltd Method
EP1042493A1 (en) * 1997-12-22 2000-10-11 Oxford Biomedica (UK) Limited Equine infectious anaemia virus (eiav) based retroviral vectors

Also Published As

Publication number Publication date
WO2001066150A2 (en) 2001-09-13
WO2001066150A3 (en) 2002-05-02
WO2001066150A9 (en) 2002-02-28

Similar Documents

Publication Publication Date Title
AU2002225997A1 (en) Two chamber cell culture vessel
AU4563300A (en) Regulation of viral gene expression
AU2001245924A1 (en) Aav5 vector for transducing brain cells and lung cells
AU769385C (en) Virus envelope vector for gene transfer
AU2001266337A1 (en) Virus vector for transferring gene into renal cells
AU6512299A (en) Gemini virus vectors for gene expression in plants
WO2000073478A3 (en) Recombinant adenoviral vectors expressing chimeric fiber proteins for cell specific infection and genome integration
AU3625997A (en) Chimeric gene containing several herbicide tolerance genes, plant cell and plant which are tolerant to several herbicides
AU1410399A (en) Nucleic acid transfer vector for the introduction of nucleic acid into the dna of a cell
AU2001233132A1 (en) Hybrid adeno-retroviral vector for the transfection of cells
AU2001290273A1 (en) Paramyxovirus vector for transferring foreign gene into skeletal muscle
WO2001088141A3 (en) Synthetic gagpol genes and their uses
WO2000055343A3 (en) Retrovirus producting cells utilizing a high multiplicity of transduction
AU2001240078A1 (en) Highly efficient gene transfer into human repopulating stem cells by rd114 pseudotyped retroviral vector particles
AU2002305453A1 (en) Trans-viral vector mediated gene transfer to the retina
EP0909811A3 (en) Bioreactor for culturing animal and/or human cells, particularly hepatocytes
AU2002327755A1 (en) Paramyxoviruses as gene transfer vectors to lung cells
AU2001256232A1 (en) Genes isolated from dendritic cells, gene products and methods employing the same
AU6859500A (en) Plant gene
CA2385872A1 (en) Gene transfer in human lymphocytes using retroviral scfv cell targeting
WO2001094588A3 (en) Gene (cur) related to a curly phenotype in plants
AU4203400A (en) Plant viral movement protein genes
AU3103599A (en) Plant cell cyclin genes
WO2000049138A3 (en) Pluripotential cells derived from embryonal teratocarcinoma cells and the nucleus of stomatic cells
AU1632002A (en) Hematopoietic stem cell gene therapy