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AU2081788A - Novel thrombolytic proteins - Google Patents

Novel thrombolytic proteins

Info

Publication number
AU2081788A
AU2081788A AU20817/88A AU2081788A AU2081788A AU 2081788 A AU2081788 A AU 2081788A AU 20817/88 A AU20817/88 A AU 20817/88A AU 2081788 A AU2081788 A AU 2081788A AU 2081788 A AU2081788 A AU 2081788A
Authority
AU
Australia
Prior art keywords
novel thrombolytic
thrombolytic proteins
proteins
novel
thrombolytic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU20817/88A
Inventor
Tim Ahern
Pennina Langer-Safer
Glenn R. Larsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetics Institute LLC
Original Assignee
Genetics Institute LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Institute LLC filed Critical Genetics Institute LLC
Publication of AU2081788A publication Critical patent/AU2081788A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
AU20817/88A 1987-07-06 1988-07-06 Novel thrombolytic proteins Abandoned AU2081788A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US7001287A 1987-07-06 1987-07-06
US18412188A 1988-04-20 1988-04-20
US184121 1988-04-20
US070012 1997-12-30

Publications (1)

Publication Number Publication Date
AU2081788A true AU2081788A (en) 1989-01-30

Family

ID=26750667

Family Applications (1)

Application Number Title Priority Date Filing Date
AU20817/88A Abandoned AU2081788A (en) 1987-07-06 1988-07-06 Novel thrombolytic proteins

Country Status (4)

Country Link
EP (1) EP0394261A4 (en)
JP (1) JPH03500002A (en)
AU (1) AU2081788A (en)
WO (1) WO1989000191A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU627475B2 (en) * 1988-06-24 1992-08-27 British Bio-Technology Limited Tissue plasminogen activator analogues having improved activity
AU645344B2 (en) * 1990-07-31 1994-01-13 Genentech Inc. Tissue plasminogen activator variants with decreased clearance

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5108901A (en) * 1988-09-02 1992-04-28 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5258180A (en) * 1988-09-02 1993-11-02 Genetech, Inc. Tissue plasminogen activator having fibrin specific properties and deletion of amino acids 466-970, compositions and methods of treatment
ES2107041T3 (en) * 1992-06-03 1997-11-16 Genentech Inc TISSUE PLASMINOGEN ACTIVATOR VARIANTS OBTAINED BY GLYCOSILATION, WHICH PRESENT THERAPEUTIC PROPERTIES.
US6706504B1 (en) 1996-11-12 2004-03-16 The Scripps Research Institute Tissue type plasminogen activator (t-PA) variants: compositions and methods of use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL68561A (en) * 1982-05-05 1991-01-31 Genentech Inc Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof
GB8334498D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Compounds
US4753879A (en) * 1984-08-27 1988-06-28 Biogen N.V. Modified tissue plasminogen activators
PT82326B (en) * 1985-04-04 1988-10-14 Beecham Group Plc METHOD FOR THE PREPARATION OF FIBRINOLITICALLY ACTIVE TISSULAR TYPE PLASMINOGEN ACTIVATOR
US4916071A (en) * 1985-08-14 1990-04-10 American Home Products Corporation Poly-kringle plasminogen activator
GB8528321D0 (en) * 1985-11-18 1985-12-24 Ciba Geigy Ag Modified fibrinolytic agents
DE3789664T3 (en) * 1986-01-31 2004-09-16 Genetics Institute, LLC, Cambridge NEW THROMBOLYTIC PROTEINS.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU627475B2 (en) * 1988-06-24 1992-08-27 British Bio-Technology Limited Tissue plasminogen activator analogues having improved activity
AU645344B2 (en) * 1990-07-31 1994-01-13 Genentech Inc. Tissue plasminogen activator variants with decreased clearance

Also Published As

Publication number Publication date
EP0394261A1 (en) 1990-10-31
EP0394261A4 (en) 1991-09-11
WO1989000191A1 (en) 1989-01-12
JPH03500002A (en) 1991-01-10

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