[go: up one dir, main page]

AU1927601A - Catalytic RNAs with aminoacylation activity - Google Patents

Catalytic RNAs with aminoacylation activity

Info

Publication number
AU1927601A
AU1927601A AU19276/01A AU1927601A AU1927601A AU 1927601 A AU1927601 A AU 1927601A AU 19276/01 A AU19276/01 A AU 19276/01A AU 1927601 A AU1927601 A AU 1927601A AU 1927601 A AU1927601 A AU 1927601A
Authority
AU
Australia
Prior art keywords
molecules
aminoacylation activity
aminoacylation
catalytic
catalytic rnas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU19276/01A
Inventor
Neil Bonzagni
Kourouklis Dimitrios
Suga Hiroaki
Saito Hirohide
Nick Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Foundation of the State University of New York
Original Assignee
Research Foundation of the State University of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Foundation of the State University of New York filed Critical Research Foundation of the State University of New York
Publication of AU1927601A publication Critical patent/AU1927601A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes

Landscapes

  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)

Abstract

The present invention provides catalytic RNA molecules having cis or trans aminoacylation activity. The catalytic RNA molecules having cis aminoacylation activity comprise a catalytic domain and an aminoacylation domain. The catalytic RNA molecules having trans aminoacylation activity only have the catalytic domain. A method is provided for constructing and screening of these molecules. These molecules are suitable for aminoacylating tRNA-like molecules with specific amino acids.
AU19276/01A 1999-11-24 2000-11-22 Catalytic RNAs with aminoacylation activity Abandoned AU1927601A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US16733199P 1999-11-24 1999-11-24
US60167331 1999-11-24
US21438200P 2000-06-28 2000-06-28
US60214382 2000-06-28
PCT/US2000/032184 WO2001038582A1 (en) 1999-11-24 2000-11-22 CATALYTIC RNAs WITH AMINOACYLATION ACTIVITY

Publications (1)

Publication Number Publication Date
AU1927601A true AU1927601A (en) 2001-06-04

Family

ID=26863053

Family Applications (1)

Application Number Title Priority Date Filing Date
AU19276/01A Abandoned AU1927601A (en) 1999-11-24 2000-11-22 Catalytic RNAs with aminoacylation activity

Country Status (8)

Country Link
US (1) US7001723B1 (en)
EP (1) EP1232285B1 (en)
JP (1) JP4745577B2 (en)
AT (1) ATE397672T1 (en)
AU (1) AU1927601A (en)
CA (1) CA2391433C (en)
DE (1) DE60039120D1 (en)
WO (1) WO2001038582A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003070740A1 (en) 2002-02-15 2003-08-28 The Research Foundation Of State University Of New York RIBOZYMES WITH BROAD tRNA AMINOACYLATION ACTIVITY
US8188260B2 (en) * 2005-12-06 2012-05-29 The University Of Tokyo Versatile acylation catalytic RNAs and uses thereof
JP5200241B2 (en) 2006-11-17 2013-06-05 国立大学法人 東京大学 Translational synthesis of polypeptides with non-natural backbone at the N-terminus and their applications
WO2008117833A1 (en) 2007-03-26 2008-10-02 The University Of Tokyo Process for synthesizing cyclic peptide compound
WO2012074029A1 (en) 2010-12-01 2012-06-07 田辺三菱製薬株式会社 Polynucleotide construct capable of presenting fab in acellular translation system, and method for manufacturing and screening fab using same
JP5948673B2 (en) 2011-03-10 2016-07-06 ジーンフロンティア株式会社 COMPOSITION FOR PROTEIN SYNTHESIS WITH REDUCED LIPO POLUCHIsaccharide CONTENT AND METHOD FOR PRODUCING PROTEIN USING THE COMPOSITION

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639595A (en) * 1990-05-01 1997-06-17 Isis Phamaceuticals, Inc. Identification of novel drugs and reagents
US5270163A (en) 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
DK0533838T3 (en) 1990-06-11 1998-02-23 Nexstar Pharmaceuticals Inc Nucleic acid
US5998142A (en) 1993-09-08 1999-12-07 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chemi-SELEX
US6063566A (en) 1994-05-13 2000-05-16 The Scripps Research Institute Catalytic RNA molecules
ES2127106B1 (en) 1996-03-21 1999-11-16 Menarini Lab BENZOPYRANIC DERIVATIVES WITH ANTAGONISTIC ACTION OF THE LEUCOTRENEES, PROCEDURE FOR THEIR PREPARATION AND USE OF THE SAME.
US5792613A (en) * 1996-06-12 1998-08-11 The Curators Of The University Of Missouri Method for obtaining RNA aptamers based on shape selection
US5871924A (en) * 1997-01-27 1999-02-16 Nexstar Pharmaceuticals, Inc. Method for the production of ligands capable of facilitating aminoacyl-RNA synthesis
DE19801153A1 (en) * 1998-01-14 1999-07-15 Jenne Andreas Selection of a ribozymes useful for, e.g. inhibiting gene expression and improving nuclease resistance

Also Published As

Publication number Publication date
JP4745577B2 (en) 2011-08-10
EP1232285A4 (en) 2005-01-12
JP2003514572A (en) 2003-04-22
CA2391433A1 (en) 2001-05-31
CA2391433C (en) 2011-02-08
ATE397672T1 (en) 2008-06-15
WO2001038582A1 (en) 2001-05-31
EP1232285A1 (en) 2002-08-21
DE60039120D1 (en) 2008-07-17
US7001723B1 (en) 2006-02-21
EP1232285B1 (en) 2008-06-04

Similar Documents

Publication Publication Date Title
AU2003213136A1 (en) RIBOZYMES WITH BROAD tRNA AMINOACYLATION ACTIVITY
WO2005062832A3 (en) Enzyme expression methods
EP1224266A4 (en) Lysosomal targeting pathway enzymes
HUP0105331A3 (en) Novel carbonyl reductase, gene thereof and method of using the same
AU7171098A (en) Directed evolution of enzymes and antibodies
AU9381598A (en) Method of amplifying dna and rna mismatch cleavage products
AU9220498A (en) Oligonucleotide probes bearing quenchable fluorescent labels, and methods of usethereof
AU6571700A (en) Enzymatic synthesis of deoxyribonucleosides
ZA985026B (en) Method for enhancing the activity of an enzyme.
ATE226254T1 (en) REAGENT FOR THE TREATMENT OF ARTHRITIC CONDITIONS
AU1927601A (en) Catalytic RNAs with aminoacylation activity
AU3425700A (en) Non-ribosomal peptide synthetases, method for producing same and the use thereof
AU3354499A (en) Human mekk proteins, corresponding nucleic acid molecules, and uses therefor
AU2003235506A1 (en) Targeted enzymes and methods of making and using targeted enzymes.
AU7729498A (en) Methods and uses for transposon-based gene targeting
AU4397797A (en) Method of gene introduction
WO2002083932A3 (en) Enzymatic degradation chains
AU1719497A (en) An enzyme with pectin esterase activity
WO1994029452A3 (en) Enzymatic rna molecules and their application in the treatment of fibrosis and fibrous tissue disease
AU3037797A (en) Generation of replicative molecules in vivo
EA200000135A1 (en) METHOD OF OBTAINING AMIDES
WO1999055847A3 (en) Enzymatic nucleic acids molecules which modulate the expressions and/or replication of hepatitis c virus
AU1143601A (en) Method and composition for enhancing the activity of an enzyme
AU2002365903A1 (en) Method for the generation of proteins with new enzymatic function
AU7938900A (en) Method for creating divergent populations of nucleic acid molecules and proteins

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase