AU1277799A - Polycyclic alpha-amino-$m(e)-caprolactams and related compounds - Google Patents

Polycyclic alpha-amino-$m(e)-caprolactams and related compounds

Info

Publication number: AU1277799A
Authority: AU; Australia
Prior art keywords: caprolactams; polycyclic; alpha; amino; related compounds
Prior art date: 1997-12-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU12777/99A

Inventor

James E Audia

Thomas E Mabry

Stacey L. Mcdaniel

Jeffrey S Nissen

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Elan Pharmaceuticals LLC

Eli Lilly and Co

Original Assignee

Elan Pharmaceuticals LLC

Eli Lilly and Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-22

Filing date

1998-10-29

Publication date

1999-07-12

1997-12-22 Priority claimed from US08/996,422 external-priority patent/US6635632B1/en

1998-10-29 Application filed by Elan Pharmaceuticals LLC, Eli Lilly and Co filed Critical Elan Pharmaceuticals LLC

1999-07-12 Publication of AU1277799A publication Critical patent/AU1277799A/en

Status Abandoned legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Peptides Or Proteins (AREA)
Pyrrole Compounds (AREA)

AU12777/99A 1997-12-22 1998-10-29 Polycyclic alpha-amino-$m(e)-caprolactams and related compounds Abandoned AU1277799A (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US08996422		1997-12-22
US08/996,422 US6635632B1 (en)	1996-12-23	1997-12-22	Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US10272698A	1998-06-22	1998-06-22
US09102726		1998-06-22
PCT/US1998/022637 WO1999032453A1 (en)	1997-12-22	1998-10-29	POLYCYCLIC α-AMINO-⊂-CAPROLACTAMS AND RELATED COMPOUNDS

Publications (1)

Publication Number	Publication Date
AU1277799A true AU1277799A (en)	1999-07-12

Family

ID=26799672

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU12777/99A Abandoned AU1277799A (en)	1997-12-22	1998-10-29	Polycyclic alpha-amino-$m(e)-caprolactams and related compounds

Country Status (9)

Country	Link
EP (1)	EP1042298A1 (en)
JP (1)	JP2003521438A (en)
KR (1)	KR20010033408A (en)
AU (1)	AU1277799A (en)
BR (1)	BR9812773A (en)
CA (1)	CA2307221A1 (en)
HU (1)	HUP0100294A3 (en)
IL (1)	IL135564A0 (en)
WO (1)	WO1999032453A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HRP990246A2 (en)	1998-08-07	2000-06-30	Du Pont Pharm Co	Succinoylamino benzodiazepines as inhibitors of a beta protein production
NZ509241A (en)	1998-08-07	2003-08-29	Du Pont Pharm Co	Succinoylamino lactams as inhibitors of alpha-beta protein production
IL142816A0 (en)	1998-12-24	2002-03-10	Du Pont Pharm Co	SUCCINOYLAMINO BENZODIAZEPINES AS INHIBITORS OF Aβ PROTEIN PRODUCTION
AU6071400A (en)	1999-07-06	2001-01-22	Vertex Pharmaceuticals Incorporated	Cyclized amide derivatives
US6960576B2 (en)	1999-09-13	2005-11-01	Bristol-Myers Squibb Pharma Company	Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production
BR0014269A (en) *	1999-09-13	2002-07-02	Bristol Myers Squibb Pharma Co	Lactam compounds, their pharmaceutically acceptable salts and prodrugs, pharmaceutical composition, method of treating neurological disorders associated with the production of "beta" -amyloid, method of inhibiting "alpha" -secretase activity and uses of the compounds
US6503902B2 (en)	1999-09-13	2003-01-07	Bristol-Myers Squibb Pharma Company	Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production
WO2001027108A1 (en) *	1999-10-08	2001-04-19	Bristol-Myers Squibb Pharma Company	AMINO LACTAM SULFONAMIDES AS INHIBITORS OF Aβ PROTEIN PRODUCTION
US6525044B2 (en)	2000-02-17	2003-02-25	Bristol-Myers Squibb Company	Succinoylamino carbocycles and heterocycles as inhibitors of a-β protein production
BR0110051A (en)	2000-04-03	2004-12-07	Bristol Myers Squibb Pharma Co	Compound, Compound Use, Pharmaceutical Composition and Method of Treatment of Alzheimer's Disease
EP1268433A1 (en)	2000-04-03	2003-01-02	Bristol-Myers Squibb Pharma Company	Cyclic lactams as inhibitors of a-beta-protein production
US6632812B2 (en)	2000-04-11	2003-10-14	Dupont Pharmaceuticals Company	Substituted lactams as inhibitors of Aβ protein production
WO2001092235A1 (en)	2000-06-01	2001-12-06	Bristol-Myers Squibb Pharma Company	LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Aβ PROTEIN PRODUCTION
US6432944B1 (en)	2000-07-06	2002-08-13	Bristol-Myers Squibb Company	Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4666829A (en) *	1985-05-15	1987-05-19	University Of California	Polypeptide marker for Alzheimer's disease and its use for diagnosis
JP3553592B2 (en) *	1992-10-26	2004-08-11	ビー．シェンク，デイル	Methods and compositions for the detection of soluble β-amyloid peptide
IL110525A0 (en) *	1993-08-09	1994-11-11	Lilly Co Eli	Identification and use of protease inhibitors
US5580979A (en) *	1994-03-15	1996-12-03	Trustees Of Tufts University	Phosphotyrosine peptidomimetics for inhibiting SH2 domain interactions
US6251928B1 (en) *	1994-03-16	2001-06-26	Eli Lilly And Company	Treatment of alzheimer's disease employing inhibitors of cathepsin D
DE69739236D1 (en) *	1996-12-23	2009-03-12	Lilly Co Eli	CYCLOALKYL, LACTAM, LACTON AND RELATED COMPOUNDS AS AN INHIBITORS OF THE BETA AMYLOID PEPTIDE EXTRACTION
AR011164A1 (en) *	1997-02-28	2000-08-02	Lilly Co Eli	HETEROCICLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND THEM, AND METHODS TO INHIBIT THE RELEASE OF THE BETA-AMYLOID PEPTIDE AND / OR ITS SYNTHESIS THROUGH THE USE OF SUCH COMPOUNDS

1998
- 1998-10-29 CA CA002307221A patent/CA2307221A1/en not_active Abandoned
- 1998-10-29 EP EP98956198A patent/EP1042298A1/en not_active Withdrawn
- 1998-10-29 KR KR1020007006883A patent/KR20010033408A/en not_active Withdrawn
- 1998-10-29 JP JP2000525390A patent/JP2003521438A/en not_active Withdrawn
- 1998-10-29 AU AU12777/99A patent/AU1277799A/en not_active Abandoned
- 1998-10-29 WO PCT/US1998/022637 patent/WO1999032453A1/en not_active Ceased
- 1998-10-29 IL IL13556498A patent/IL135564A0/en unknown
- 1998-10-29 BR BR9812773-0A patent/BR9812773A/en not_active IP Right Cessation
- 1998-10-29 HU HU0100294A patent/HUP0100294A3/en unknown

Also Published As

Publication number	Publication date
IL135564A0 (en)	2001-05-20
WO1999032453A1 (en)	1999-07-01
JP2003521438A (en)	2003-07-15
HUP0100294A3 (en)	2003-04-28
KR20010033408A (en)	2001-04-25
EP1042298A1 (en)	2000-10-11
BR9812773A (en)	2000-10-10
HUP0100294A2 (en)	2001-09-28
CA2307221A1 (en)	1999-07-01

Publication	Publication Date	Title
AU9790198A (en)	1999-04-27	Compounds and methods
AU1709299A (en)	1999-06-16	Mixer-injectors
AU8921698A (en)	1999-03-16	Follistatin-3
AU9414098A (en)	1998-11-27	Ascorbyl-phosphoryl-cholesterol
AU6598798A (en)	1998-11-19	Resorcinyl-triazines
AU1027499A (en)	1999-04-23	32P-polyphosphazene
AU9513298A (en)	1999-04-23	Fluoranthenopyrans
AU1277799A (en)	1999-07-12	Polycyclic alpha-amino-$m(e)-caprolactams and related compounds
AU9066598A (en)	1999-03-01	Substituted 4-benzoyl-pyrazoles
AU5272198A (en)	1998-07-30	EMP-charge-eliminator
AU6998698A (en)	1998-12-10	Dioxacycloalkan-8-one
AU4117497A (en)	1999-03-01	Micropolarimeter
AU8695298A (en)	1999-03-01	Compounds and uses thereof
AU6185898A (en)	1998-09-18	Clavaspirins
AU8214598A (en)	1999-01-04	3-benzylpiperidine
AU8072498A (en)	1999-01-04	Heregulin-like factor
AU7761998A (en)	1998-12-11	Korrosionsschutzanstrichstoff
AU6090898A (en)	1998-07-31	Substituted 4-benzoyl-pyrazoles
AU8693198A (en)	1999-03-01	Compounds and uses thereof
AU7530198A (en)	1998-11-27	Substituted 4-benzoyl-pyrazoles
AU5391798A (en)	1998-08-20	Thiamacrolides
AU9183798A (en)	1999-03-22	Catamaran - bicycle - kayak
AU8991998A (en)	1999-03-22	Renovative pipeliner
AU4469997A (en)	1999-04-05	Heregulin-gamma
AU6560598A (en)	1998-09-29	Functionally-graded materials

Legal Events

Date	Code	Title	Description
2000-09-07	MK6	Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase