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AU1158000A - Method for producing 4- ((2',5'- diamino-6'- halopyrimidine- 4'-YL)amino)- cyclopent- 2-enylmethanols - Google Patents

Method for producing 4- ((2',5'- diamino-6'- halopyrimidine- 4'-YL)amino)- cyclopent- 2-enylmethanols

Info

Publication number
AU1158000A
AU1158000A AU11580/00A AU1158000A AU1158000A AU 1158000 A AU1158000 A AU 1158000A AU 11580/00 A AU11580/00 A AU 11580/00A AU 1158000 A AU1158000 A AU 1158000A AU 1158000 A AU1158000 A AU 1158000A
Authority
AU
Australia
Prior art keywords
halopyrimidine
diamino
enylmethanols
cyclopent
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU11580/00A
Inventor
Walter Brieden
Elie Saikali
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza AG
Original Assignee
Lonza AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza AG filed Critical Lonza AG
Publication of AU1158000A publication Critical patent/AU1158000A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention relates to a novel method for producing 4- [(2',5'-diamino- 6'-halopyrimidine- 4'-yl)amino]- cyclopent- 2-enylmethanols of general formula (I), wherein X represents a halogen atom. According to the inventive method, a 2,5-diamino-4,6-halopyrimidine of general formula (II), wherein X has the aforementioned meaning, is reacted with a 4- aminocyclopent-2- enylmethanol of formula (III) or with a salt thereof in the presence of a base in a polar protic solvent.
AU11580/00A 1998-10-30 1999-10-29 Method for producing 4- ((2',5'- diamino-6'- halopyrimidine- 4'-YL)amino)- cyclopent- 2-enylmethanols Abandoned AU1158000A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP98120529 1998-10-30
EP98120529 1998-10-30
US14610599P 1999-07-29 1999-07-29
US60146105 1999-07-29
PCT/EP1999/008270 WO2000026193A1 (en) 1998-10-30 1999-10-29 Method for producing 4- [(2',5'- diamino-6'- halopyrimidine- 4'-yl)amino]- cyclopent- 2-enylmethanols

Publications (1)

Publication Number Publication Date
AU1158000A true AU1158000A (en) 2000-05-22

Family

ID=56289961

Family Applications (1)

Application Number Title Priority Date Filing Date
AU11580/00A Abandoned AU1158000A (en) 1998-10-30 1999-10-29 Method for producing 4- ((2',5'- diamino-6'- halopyrimidine- 4'-YL)amino)- cyclopent- 2-enylmethanols

Country Status (14)

Country Link
EP (1) EP1124805B1 (en)
JP (1) JP4457496B2 (en)
CN (1) CN1115338C (en)
AT (1) ATE240945T1 (en)
AU (1) AU1158000A (en)
CA (1) CA2348374C (en)
CZ (1) CZ300155B6 (en)
DK (1) DK1124805T3 (en)
ES (1) ES2200594T3 (en)
HU (1) HU227559B1 (en)
IL (1) IL142760A (en)
PL (1) PL198180B1 (en)
SK (1) SK285271B6 (en)
WO (1) WO2000026193A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100606625B1 (en) 1998-10-30 2006-07-28 론자 아게 Method for preparing 4-[(2 ', 5'-diamino-6'-halopyrimidin-4'-yl) amino] -cyclopent-2-enylmethanol
EP2805945B1 (en) 2007-01-10 2019-04-03 MSD Italia S.r.l. Amide substituted indazoles as poly(ADP-ribose)polymerase (PARP) inhibitors
JP5989965B2 (en) 2008-01-08 2016-09-07 メルク シャープ エンド ドーム リミテッド Pharmaceutically acceptable salt of 2- {4-[(3S) -piperidin-3-yl] phenyl} -2H-indazole-7-carboxamide
CN103626745B (en) * 2013-12-04 2016-02-24 青岛黄海制药有限责任公司 A kind of preparation method of ticagrelor midbody
US20210347758A1 (en) 2018-10-03 2021-11-11 Tesaro, Inc. Crystalline Forms of Niraparib Freebase

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE62275B1 (en) * 1988-01-20 1995-01-25 Univ Minnesota Dideoxydidehydrocarbocyclic nucleosides
GB8916698D0 (en) * 1989-07-21 1989-09-06 Beecham Group Plc Novel process
MY104575A (en) * 1989-12-22 1994-04-30 The Wellcome Foundation Ltd Therapeutic nucleosides.
CA2145928C (en) * 1994-04-27 2007-10-09 Gerhard Stucky N-(2-amino-4,6-dichloropyrimidin-5-yl)formamide, and a process for its preparation
US6368850B1 (en) * 1996-05-30 2002-04-09 Lonza Ag Process for the preparation of amino alcohols and derivatives thereof

Also Published As

Publication number Publication date
JP4457496B2 (en) 2010-04-28
ATE240945T1 (en) 2003-06-15
CA2348374C (en) 2009-04-07
CZ20011486A3 (en) 2001-10-17
JP2003500333A (en) 2003-01-07
PL198180B1 (en) 2008-06-30
CZ300155B6 (en) 2009-02-25
HU227559B1 (en) 2011-08-29
ES2200594T3 (en) 2004-03-01
CA2348374A1 (en) 2000-05-11
EP1124805A1 (en) 2001-08-22
PL347503A1 (en) 2002-04-08
CN1325386A (en) 2001-12-05
HUP0104045A3 (en) 2002-07-29
IL142760A0 (en) 2002-03-10
HUP0104045A2 (en) 2002-05-29
DK1124805T3 (en) 2003-09-15
IL142760A (en) 2005-12-18
SK5692001A3 (en) 2001-12-03
SK285271B6 (en) 2006-10-05
EP1124805B1 (en) 2003-05-21
WO2000026193A1 (en) 2000-05-11
CN1115338C (en) 2003-07-23

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase