ATE7917T1 - Pyranoindolderivat und verfahren zu seiner herstellung. - Google Patents
Pyranoindolderivat und verfahren zu seiner herstellung.Info
- Publication number
- ATE7917T1 ATE7917T1 AT81401010T AT81401010T ATE7917T1 AT E7917 T1 ATE7917 T1 AT E7917T1 AT 81401010 T AT81401010 T AT 81401010T AT 81401010 T AT81401010 T AT 81401010T AT E7917 T1 ATE7917 T1 AT E7917T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- atom
- lower alkyl
- image
- hereinabove
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000004429 atom Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- ABPJREHLAYHTHW-UHFFFAOYSA-N pyrano[2,3-g]indole Chemical class O1C=CC=C2C3=NC=CC3=CC=C21 ABPJREHLAYHTHW-UHFFFAOYSA-N 0.000 abstract 2
- 101150048931 COY1 gene Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 125000006294 amino alkylene group Chemical group 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- WGJAJRYZSGZQNG-UHFFFAOYSA-N pyrano[3,2-f]indole Chemical class C1=COC2=CC3=NC=CC3=CC2=C1 WGJAJRYZSGZQNG-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000005424 tosyloxy group Chemical group S(=O)(=O)(C1=CC=C(C)C=C1)O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/64—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with oxygen atoms directly attached in position 8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8014246A FR2485539A1 (fr) | 1980-06-26 | 1980-06-26 | Nouveau derive de pyranno-indole, son procede de preparation et son application en therapeutique |
| EP81401010A EP0043752B1 (de) | 1980-06-26 | 1981-06-23 | Pyranoindolderivat und Verfahren zu seiner Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE7917T1 true ATE7917T1 (de) | 1984-06-15 |
Family
ID=9243559
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT81401010T ATE7917T1 (de) | 1980-06-26 | 1981-06-23 | Pyranoindolderivat und verfahren zu seiner herstellung. |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US4436915A (de) |
| EP (1) | EP0043752B1 (de) |
| JP (1) | JPS5738782A (de) |
| AT (1) | ATE7917T1 (de) |
| DE (1) | DE3164140D1 (de) |
| ES (1) | ES8204993A1 (de) |
| FR (1) | FR2485539A1 (de) |
| GR (1) | GR75709B (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2485539A1 (fr) * | 1980-06-26 | 1981-12-31 | Sori Soc Rech Ind | Nouveau derive de pyranno-indole, son procede de preparation et son application en therapeutique |
| US4769367A (en) * | 1984-04-24 | 1988-09-06 | Glaxo Group Limited | Heterocyclic amino compounds |
| IL75011A (en) * | 1984-04-24 | 1990-02-09 | Glaxo Group Ltd | Trans substituted-2,3,3a,9a,-tetrahydro-1h-(1,4)benzo-dioxino(2,3-c)pyrroles,their preparation and pharmaceutical compositions containing them |
| GB9326192D0 (en) * | 1993-12-22 | 1994-02-23 | Glaxo Group Ltd | Chemical compounds |
| JP4088444B2 (ja) * | 2000-03-17 | 2008-05-21 | アルコン，インコーポレイテッド | 緑内障を処置するためのピラノインドール |
| US7012090B1 (en) | 2000-03-17 | 2006-03-14 | Alcon, Inc. | Pyranoindoles for treating glaucoma |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU163443B (de) * | 1970-08-26 | 1973-08-28 | ||
| FR2267777A1 (en) * | 1974-04-18 | 1975-11-14 | Delalande Sa | 1-Phenyl-2-methyl-3-ethoxy carbonyl pyrrolo chromanes - useful as anti-ulcer agents, analgesics, anti-inflammatories, respiratory analeptics and anti-broncho constrictors |
| FR2485539A1 (fr) * | 1980-06-26 | 1981-12-31 | Sori Soc Rech Ind | Nouveau derive de pyranno-indole, son procede de preparation et son application en therapeutique |
-
1980
- 1980-06-26 FR FR8014246A patent/FR2485539A1/fr active Granted
-
1981
- 1981-06-23 US US06/276,643 patent/US4436915A/en not_active Expired - Fee Related
- 1981-06-23 AT AT81401010T patent/ATE7917T1/de not_active IP Right Cessation
- 1981-06-23 EP EP81401010A patent/EP0043752B1/de not_active Expired
- 1981-06-23 DE DE8181401010T patent/DE3164140D1/de not_active Expired
- 1981-06-24 GR GR65327A patent/GR75709B/el unknown
- 1981-06-26 ES ES503405A patent/ES8204993A1/es not_active Expired
- 1981-06-26 JP JP10037981A patent/JPS5738782A/ja active Pending
-
1984
- 1984-03-12 US US06/588,566 patent/US4680411A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US4436915A (en) | 1984-03-13 |
| FR2485539B1 (de) | 1983-07-29 |
| DE3164140D1 (en) | 1984-07-19 |
| JPS5738782A (en) | 1982-03-03 |
| FR2485539A1 (fr) | 1981-12-31 |
| US4680411A (en) | 1987-07-14 |
| EP0043752B1 (de) | 1984-06-13 |
| ES503405A0 (es) | 1982-05-16 |
| ES8204993A1 (es) | 1982-05-16 |
| GR75709B (de) | 1984-08-02 |
| EP0043752A1 (de) | 1982-01-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EEIH | Change in the person of patent owner | ||
| REN | Ceased due to non-payment of the annual fee |