ATE466026T1 - Derivate von glp-1 und exendin mit verlängertem wirkdauer-profil - Google Patents

Derivate von glp-1 und exendin mit verlängertem wirkdauer-profil

Info

Publication number: ATE466026T1
Authority: AT; Austria
Prior art keywords: glp; exendin; derivatives; extended duration; duration profile
Prior art date: 1998-02-27

Application number

AT99936077T

Other languages

English (en)

Inventor

Liselotte Knudsen

Per Huusfeldt

Per Nielsen

Kjeld Madsen

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-02-27

Filing date

1999-02-25

Publication date

2010-05-15

1999-02-25 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1999-02-25 Priority claimed from PCT/DK1999/000086 external-priority patent/WO1999043708A1/en

2010-05-15 Application granted granted Critical

2010-05-15 Publication of ATE466026T1 publication Critical patent/ATE466026T1/de

Links

DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical class C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 title abstract 2
125000001433 C-terminal amino-acid group Chemical group 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Endocrinology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Toxicology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Vascular Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT99936077T 1998-02-27 1999-02-25 Derivate von glp-1 und exendin mit verlängertem wirkdauer-profil ATE466026T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK27498		1998-02-27
PCT/DK1999/000086 WO1999043708A1 (en)	1998-02-27	1999-02-25	Glp-1 derivatives of glp-1 and exendin with protracted profile of action

Publications (1)

Publication Number	Publication Date
ATE466026T1 true ATE466026T1 (de)	2010-05-15

Family

ID=8091706

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99936077T ATE466026T1 (de)	1998-02-27	1999-02-25	Derivate von glp-1 und exendin mit verlängertem wirkdauer-profil

Country Status (4)

Country	Link
EP (1)	EP1840134B1 (de)
AT (1)	ATE466026T1 (de)
DE (1)	DE69942305D1 (de)
ZA (1)	ZA991571B (de)

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4683202A (en)	1985-03-28	1987-07-28	Cetus Corporation	Process for amplifying nucleic acid sequences
WO1987006941A1 (en)	1986-05-05	1987-11-19	The General Hospital Corporation	Insulinotropic hormone
US5614492A (en) *	1986-05-05	1997-03-25	The General Hospital Corporation	Insulinotropic hormone GLP-1 (7-36) and uses thereof
NZ222907A (en)	1986-12-16	1990-08-28	Novo Industri As	Preparation for intranasal administration containing a phospholipid absorption enhancing system
ATE193541T1 (de) *	1989-03-20	2000-06-15	Gen Hospital Corp	Insulinotropes hormon
US5545618A (en) *	1990-01-24	1996-08-13	Buckley; Douglas I.	GLP-1 analogs useful for diabetes treatment
DK36392D0 (da)	1992-03-19	1992-03-19	Novo Nordisk As	Anvendelse af kemisk forbindelse
DK36492D0 (da)	1992-03-19	1992-03-19	Novo Nordisk As	Praeparat
US5424286A (en)	1993-05-24	1995-06-13	Eng; John	Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same
US5869602A (en) *	1995-03-17	1999-02-09	Novo Nordisk A/S	Peptide derivatives
CN1183158C (zh)	1996-06-05	2005-01-05	罗赫诊断器材股份有限公司	Exendin类似物,其制备方法及含有它们的药物制剂
CA2468374C (en) *	1996-08-30	2010-12-21	Novo-Nordisk A/S	Glp-1 derivatives

1999
- 1999-02-25 AT AT99936077T patent/ATE466026T1/de not_active IP Right Cessation
- 1999-02-25 EP EP07109581.4A patent/EP1840134B1/de not_active Expired - Lifetime
- 1999-02-25 DE DE69942305T patent/DE69942305D1/de not_active Expired - Lifetime
- 1999-02-26 ZA ZA9901571A patent/ZA991571B/xx unknown

Also Published As

Publication number	Publication date
DE69942305D1 (de)	2010-06-10
EP1840134A2 (de)	2007-10-03
EP1840134B1 (de)	2016-04-13
EP1840134A3 (de)	2008-01-23
ZA991571B (en)	1999-09-02

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Legal Events

Date	Code	Title	Description
2010-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties