ATE3110T1 - Verfahren zur herstellung eines benzhydrolderivats und dabei verwendetes zwischenprodukt. - Google Patents
Verfahren zur herstellung eines benzhydrolderivats und dabei verwendetes zwischenprodukt.Info
- Publication number
- ATE3110T1 ATE3110T1 AT81300101T AT81300101T ATE3110T1 AT E3110 T1 ATE3110 T1 AT E3110T1 AT 81300101 T AT81300101 T AT 81300101T AT 81300101 T AT81300101 T AT 81300101T AT E3110 T1 ATE3110 T1 AT E3110T1
- Authority
- AT
- Austria
- Prior art keywords
- preparation
- methyl
- intermediate used
- hydroxyethyl
- amino
- Prior art date
Links
- QILSFLSDHQAZET-UHFFFAOYSA-N diphenylmethanol Chemical class C=1C=CC=CC=1C(O)C1=CC=CC=C1 QILSFLSDHQAZET-UHFFFAOYSA-N 0.000 title 1
- OPKOKAMJFNKNAS-UHFFFAOYSA-N N-methylethanolamine Chemical compound CNCCO OPKOKAMJFNKNAS-UHFFFAOYSA-N 0.000 abstract 1
- RGPDEAGGEXEMMM-UHFFFAOYSA-N Nefopam Chemical compound C12=CC=CC=C2CN(C)CCOC1C1=CC=CC=C1 RGPDEAGGEXEMMM-UHFFFAOYSA-N 0.000 abstract 1
- ZSOXNXDUYPYGJO-UHFFFAOYSA-N [2-(chloromethyl)phenyl]-phenylmethanone Chemical compound ClCC1=CC=CC=C1C(=O)C1=CC=CC=C1 ZSOXNXDUYPYGJO-UHFFFAOYSA-N 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- CNNVSINJDJNHQK-UHFFFAOYSA-N hydron;5-methyl-1-phenyl-1,3,4,6-tetrahydro-2,5-benzoxazocine;chloride Chemical compound [Cl-].C12=CC=CC=C2C[NH+](C)CCOC1C1=CC=CC=C1 CNNVSINJDJNHQK-UHFFFAOYSA-N 0.000 abstract 1
- 239000003158 myorelaxant agent Substances 0.000 abstract 1
- 229960000751 nefopam Drugs 0.000 abstract 1
- 229910000033 sodium borohydride Inorganic materials 0.000 abstract 1
- 239000012279 sodium borohydride Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
- C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
- C07C215/32—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton containing hydroxy groups and carbon atoms of two six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI800076A FI800076A7 (fi) | 1980-01-11 | 1980-01-11 | Menetelmä bentshydroliderivaatin valmistamiseksi. |
| EP81300101A EP0033585B1 (de) | 1980-01-11 | 1981-01-09 | Verfahren zur Herstellung eines Benzhydrol-Derivats und dabei verwendetes Zwischenprodukt |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE3110T1 true ATE3110T1 (de) | 1983-05-15 |
Family
ID=8513177
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT81300101T ATE3110T1 (de) | 1980-01-11 | 1981-01-09 | Verfahren zur herstellung eines benzhydrolderivats und dabei verwendetes zwischenprodukt. |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0033585B1 (de) |
| JP (1) | JPS56103142A (de) |
| AT (1) | ATE3110T1 (de) |
| DE (1) | DE3160187D1 (de) |
| DK (1) | DK7981A (de) |
| FI (1) | FI800076A7 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102363610A (zh) * | 2011-11-01 | 2012-02-29 | 安徽万和制药有限公司 | 一种合成盐酸奈福泮的新方法 |
| CN102924320B (zh) * | 2012-11-15 | 2015-01-14 | 南京海陵中药制药工艺技术研究有限公司 | 一种制备奈福泮中间体ⅰ的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3487153A (en) * | 1968-01-19 | 1969-12-30 | Rexall Drug Chemical | Method of treating mental depression |
| AT306705B (de) * | 1970-10-22 | 1973-04-25 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung von α-substituierten 2-Aminomethyl-benzylalkoholen sowie deren Säureadditionssalzen |
| GB1586578A (en) * | 1977-08-05 | 1981-03-18 | Riker Laboratories Inc | Process for the preparation of 2-(n-(2-hydroxyyethyl)-n-lower alkylaminomethyl) benzhydrols |
| US4208349A (en) * | 1978-07-27 | 1980-06-17 | Riker Laboratories, Inc. | Process for the preparation of 2-[N-(2-hydroxyethyl)-N-lower alkylaminomethyl]benzhydrols |
-
1980
- 1980-01-11 FI FI800076A patent/FI800076A7/fi not_active Application Discontinuation
-
1981
- 1981-01-09 AT AT81300101T patent/ATE3110T1/de not_active IP Right Cessation
- 1981-01-09 EP EP81300101A patent/EP0033585B1/de not_active Expired
- 1981-01-09 DK DK7981A patent/DK7981A/da not_active Application Discontinuation
- 1981-01-09 DE DE8181300101T patent/DE3160187D1/de not_active Expired
- 1981-01-09 JP JP255281A patent/JPS56103142A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JPS56103142A (en) | 1981-08-18 |
| DK7981A (da) | 1981-07-12 |
| DE3160187D1 (en) | 1983-05-26 |
| EP0033585A1 (de) | 1981-08-12 |
| EP0033585B1 (de) | 1983-04-20 |
| FI800076A7 (fi) | 1981-01-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |