ATE382699T1 - Verfahren zum entwurf von rekombitopen peptiden - Google Patents

Verfahren zum entwurf von rekombitopen peptiden

Info

Publication number: ATE382699T1
Authority: AT; Austria
Prior art keywords: peptides; protein; recombitope peptides; cell; designing
Prior art date: 1991-10-16

Application number

AT92922494T

Other languages

English (en)

Inventor

Bruce Rogers

Jay Morgenstern

Julian Bond

Richard Garman

Mei-Chang Kuo

Malcolm Morville

Julia Greenstein

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-10-16

Filing date

1992-10-16

Publication date

2008-01-15

1991-12-13 Priority claimed from US07/807,529 external-priority patent/US5547669A/en

1992-10-16 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2008-01-15 Application granted granted Critical

2008-01-15 Publication of ATE382699T1 publication Critical patent/ATE382699T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
- C07K14/43531—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from mites
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Immunology (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biomedical Technology (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
Urology & Nephrology (AREA)
Physics & Mathematics (AREA)
Insects & Arthropods (AREA)
Hematology (AREA)
Wood Science & Technology (AREA)
Microbiology (AREA)
General Engineering & Computer Science (AREA)
Tropical Medicine & Parasitology (AREA)
Physiology (AREA)
Food Science & Technology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Plant Pathology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Cell Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pulmonology (AREA)
Analytical Chemistry (AREA)

AT92922494T 1991-10-16 1992-10-16 Verfahren zum entwurf von rekombitopen peptiden ATE382699T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US77785991A	1991-10-16	1991-10-16
US07/807,529 US5547669A (en)	1989-11-03	1991-12-13	Recombinant peptides comprising T cell epitopes of the cat allergen, Fel d I

Publications (1)

Publication Number	Publication Date
ATE382699T1 true ATE382699T1 (de)	2008-01-15

Family

ID=27119373

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92922494T ATE382699T1 (de)	1991-10-16	1992-10-16	Verfahren zum entwurf von rekombitopen peptiden

Country Status (15)

Country	Link
EP (1)	EP0610335B1 (de)
JP (1)	JP4246794B2 (de)
KR (1)	KR100271417B1 (de)
AT (1)	ATE382699T1 (de)
AU (1)	AU682658B2 (de)
CA (1)	CA2121498C (de)
DK (1)	DK0610335T3 (de)
ES (1)	ES2300100T3 (de)
FI (1)	FI109809B (de)
HU (1)	HU227959B1 (de)
IL (1)	IL103456A (de)
NO (1)	NO316073B1 (de)
NZ (2)	NZ244782A (de)
PT (1)	PT100978B (de)
WO (1)	WO1993008280A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6120769A (en) *	1989-11-03	2000-09-19	Immulogic Pharmaceutical Corporation	Human T cell reactive feline protein (TRFP) isolated from house dust and uses therefor
US6019972A (en)	1989-11-03	2000-02-01	Immulogic Pharmaceutical Corporation	Peptides of human T cell reactive feline protein (TRFP)
IL105153A (en) *	1992-03-25	1999-12-22	Immulogic Pharma Corp	Therapeutic compositions comprising peptides derived from human t cell reactive feline protein
US6759234B1 (en) *	1994-09-02	2004-07-06	Immulogic Pharmaceutical Corporation	Compositions and methods for administering to humans, peptides capable of down regulating an antigen specific immune response
EP0923940B1 (de) *	1996-03-10	2008-09-03	Meiji Dairies Corporation	Auf peptiden basierendes immunotherapeutisches mittel gegen allergien
US6737406B1 (en)	1996-03-21	2004-05-18	Circassia, Ltd.	Cryptic peptides and method for their identification
US6514731B1 (en)	1996-05-24	2003-02-04	Chiron Corporation	Methods for the preparation of hepatitis C virus multiple copy epitope fusion antigens
DE69734776T2 (de) *	1996-05-24	2006-08-17	Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville	Fusionsprotein mit multiplen Epitopen
DE69737659T2 (de)	1996-06-14	2007-12-27	Meiji Dairies Corp.	Peptide aus t-zellepitopen
JP4176750B2 (ja) *	1996-06-14	2008-11-05	明治乳業株式会社	Ｔ細胞エピトープペプチド
IL132611A0 (en)	1999-10-27	2001-03-19	Yeda Res & Dev	Synthetic genes and polypeptides and pharmaceutical compositions comprising them
AUPQ776100A0 (en)	2000-05-26	2000-06-15	Australian National University, The	Synthetic molecules and uses therefor
EP1221317A1 (de)	2000-12-28	2002-07-10	SHAN-Beteiligungsgesellschaft m.b.H.	Impfstoffe, die hybride Polypeptide mit mindestens zwei verschiedenen Allergenen enthalten
RU2188032C1 (ru) *	2001-02-07	2002-08-27	Цепелев Виктор Львович	Средство, стимулирующее дифференцировку т-лимфоцитов
ATE307141T1 (de) *	2003-01-21	2005-11-15	Biomay Prod & Handel	Verfahren zur vorbereitung von hypoallergenen mosaikproteine
AT503690A1 (de) *	2006-06-09	2007-12-15	Biomay Ag	Hypoallergene moleküle
GB2455108A (en) *	2007-11-28	2009-06-03	Circassia Ltd	T-Cell dependent method for detecting non-allergic or intrinsic disorders
KR20160096206A (ko)	2013-12-23	2016-08-12	알크-아벨로 에이/에스	먼지 진드기 알레르기를 치료하기 위한 펩타이드 조합 및 그의 용도
CN117069865B (zh) *	2023-10-12	2024-03-01	中国农业科学院饲料研究所	一种基于T细胞抗原表位猫过敏原蛋白嵌合肽cFel d 1的原核表达及其卵黄抗体的制备

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2013359A6 (es) *	1988-11-04	1990-05-01	Corporacion Biolog Farmaceutic	Procedimiento para la fabricacion de alergenos inmunogenicos polimerizados.
JP3251012B2 (ja) *	1989-11-03	2002-01-28	イミユロジク・フアーマシユーチカル・コーポレーシヨン	室内塵から単離したヒトｔ細胞反応性猫蛋白質（ｔｒｆｐ）及びその利用
JP3592709B2 (ja) *	1990-09-11	2004-11-24	インスティテュート・フォー・チャイルド・ヘルス・リサーチ	ダーマトファゴイデス（家塵ダニ）のアレルゲンのクローニングおよびシークエンシング

1992
- 1992-10-16 NZ NZ244782A patent/NZ244782A/en not_active IP Right Cessation
- 1992-10-16 ES ES92922494T patent/ES2300100T3/es not_active Expired - Lifetime
- 1992-10-16 HU HU9401109A patent/HU227959B1/hu unknown
- 1992-10-16 WO PCT/US1992/008694 patent/WO1993008280A1/en not_active Ceased
- 1992-10-16 AT AT92922494T patent/ATE382699T1/de active
- 1992-10-16 KR KR1019940701294A patent/KR100271417B1/ko not_active Expired - Lifetime
- 1992-10-16 IL IL103456A patent/IL103456A/en not_active IP Right Cessation
- 1992-10-16 NZ NZ299122A patent/NZ299122A/en not_active IP Right Cessation
- 1992-10-16 AU AU27940/92A patent/AU682658B2/en not_active Expired
- 1992-10-16 DK DK92922494T patent/DK0610335T3/da active
- 1992-10-16 JP JP50774893A patent/JP4246794B2/ja not_active Expired - Lifetime
- 1992-10-16 PT PT100978A patent/PT100978B/pt not_active IP Right Cessation
- 1992-10-16 EP EP92922494A patent/EP0610335B1/de not_active Expired - Lifetime
- 1992-10-16 CA CA002121498A patent/CA2121498C/en not_active Expired - Lifetime
1994
- 1994-04-15 NO NO19941370A patent/NO316073B1/no not_active IP Right Cessation
- 1994-04-15 FI FI941758A patent/FI109809B/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
IL103456A (en)	2006-06-11
WO1993008280A1 (en)	1993-04-29
HU9401109D0 (en)	1994-07-28
KR100271417B1 (ko)	2000-12-01
JP4246794B2 (ja)	2009-04-02
DK0610335T3 (da)	2008-04-28
PT100978A (pt)	1994-01-31
IL103456A0 (en)	1993-03-15
NO941370L (no)	1994-06-08
NZ299122A (en)	2005-02-25
FI941758A0 (fi)	1994-04-15
EP0610335A1 (de)	1994-08-17
FI109809B (fi)	2002-10-15
CA2121498C (en)	2009-02-17
PT100978B (pt)	1999-10-29
JPH07503362A (ja)	1995-04-13
AU682658B2 (en)	1997-10-16
NO941370D0 (no)	1994-04-15
NO316073B1 (no)	2003-12-08
NZ244782A (en)	1996-12-20
FI941758L (fi)	1994-06-16
AU2794092A (en)	1993-05-21
CA2121498A1 (en)	1993-04-29
HU227959B1 (en)	2012-07-30
ES2300100T3 (es)	2008-06-01
EP0610335B1 (de)	2008-01-02
HUT70263A (en)	1995-09-28

Publication	Publication Date	Title
ATE382699T1 (de)	2008-01-15	Verfahren zum entwurf von rekombitopen peptiden
FI973120A7 (fi)	1997-07-25	Ihmisen gp39:n eri epitoopeille spesifisiä monoklonaalisia vasta-aineita ja menetelmiä niiden käyttämiseksi diagnosoinnissa ja terapiassa
DE69233772D1 (de)	2009-11-12	T-zell epitopen von den wichtigsten allergene von dermatophagoides (hausmilbe)
TR199801722T2 (xx)	1998-12-21	Peptit imm�nojenler.
EP0794797A4 (de)	2001-09-05	Methoden und zubehör zur immunisierung von wirtsorganismen durch verabreichung nackter polynucleotide , welche für antigene peptide codieren
ATE132197T1 (de)	1996-01-15	Monoklonale antikörper
ATE128627T1 (de)	1995-10-15	Immunomodulare mittel und deren verwendung.
FI900808A0 (fi)	1990-02-19	Humant mannos bindande protein.
GR3029774T3 (en)	1999-06-30	Method of preparing a radioactive rhenium complex solution.
BR9106303A (pt)	1993-04-13	Imonogeno humano composicao,celula de mamifero,peptido,vacina contra sintomas de esclerose multipla,metodo para tratar ou prevenir doenca com sintomas de esclerose multipla e conjunto para diagnosticar esclerose multipla
ATE244299T1 (de)	2003-07-15	Test und behandlung von demyelinierenden krankheiten wie multiple sklerosis
WO1993021321A3 (en)	1994-02-03	T CELL EPITOPES OF THE MAJOR ALLERGENS FROM $i(AMBROSIA ARTEMISIIFOLIA)
NZ328940A (en)	1999-05-28	Methods and use t cell epitopes of lol p v ryegrass pollen antigens
Ipsen et al.	1988	Immunotherapy with partially purified and standardized tree pollen extracts: III. Specific IgE response to the major allergens of alder, birch and hazel pollen during immunotherapy
SE9602677D0 (sv)	1996-07-05	Methods for determining brain antigens
ATE137674T1 (de)	1996-05-15	Von mca 16-88 erkanntes antigen
NO883603L (no)	1988-08-12	Humane monoklonale antistoffer og profylaktiske og terapeutiske midler mot infektioese sykdommer inneholdende disse som effektiv bestanddel.
Schröder et al.	1981	Direct Detection of Specific Serum IgE Antibodies to Electrophoretically Separated Honey Bee Venom Allergens
NO900745L (no)	1990-04-06	Humant mannose-bindende protein.

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