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ATE371724T1 - Behandlung neurodegenerativer krankheiten - Google Patents

Behandlung neurodegenerativer krankheiten

Info

Publication number
ATE371724T1
ATE371724T1 AT04764730T AT04764730T ATE371724T1 AT E371724 T1 ATE371724 T1 AT E371724T1 AT 04764730 T AT04764730 T AT 04764730T AT 04764730 T AT04764730 T AT 04764730T AT E371724 T1 ATE371724 T1 AT E371724T1
Authority
AT
Austria
Prior art keywords
treatment
neurodegenerative diseases
fads2
medicament
inhibitors
Prior art date
Application number
AT04764730T
Other languages
English (en)
Inventor
Carsten Hopf
Original Assignee
Cellzome Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2003/013980 external-priority patent/WO2005023858A1/en
Application filed by Cellzome Ag filed Critical Cellzome Ag
Application granted granted Critical
Publication of ATE371724T1 publication Critical patent/ATE371724T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0083—Miscellaneous (1.14.99)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Neurology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT04764730T 2003-09-05 2004-09-02 Behandlung neurodegenerativer krankheiten ATE371724T1 (de)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
EP03019642 2003-09-05
PCT/EP2003/013980 WO2005023858A1 (en) 2003-09-05 2003-12-10 Protein complexes associated with app-processing
EP04001895 2004-01-29
EP04001894 2004-01-29
EP04007447 2004-03-26
EP2004004891 2004-05-07
EP2004004889 2004-05-07
EP04018874 2004-08-09
EP04764730A EP1670903B1 (de) 2003-09-05 2004-09-02 Behandlung neurodegenerativer krankheiten

Publications (1)

Publication Number Publication Date
ATE371724T1 true ATE371724T1 (de) 2007-09-15

Family

ID=37035440

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04764730T ATE371724T1 (de) 2003-09-05 2004-09-02 Behandlung neurodegenerativer krankheiten

Country Status (8)

Country Link
US (1) US20060216292A1 (de)
EP (1) EP1670903B1 (de)
AT (1) ATE371724T1 (de)
CA (1) CA2537844A1 (de)
DE (1) DE602004008658T2 (de)
DK (1) DK1670903T3 (de)
ES (1) ES2291917T3 (de)
WO (1) WO2005023833A2 (de)

Families Citing this family (20)

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EP1603585A2 (de) 2003-03-14 2005-12-14 Bristol-Myers Squibb Company Polynucleotid kodierend für eine neue humane g-proteingekoppelte rezeptor-variante von hm74, hgprbmy74
WO2006138355A2 (en) * 2005-06-14 2006-12-28 Albert Einstein College Of Medicine Of Yeshiva University Effect of bri proteins on abeta production
US20100077491A1 (en) * 2006-07-13 2010-03-25 Burnham Institute For Medical Research Modulators of RNF5 and Uses Thereof
EP2082237A2 (de) * 2006-12-06 2009-07-29 Universität Zürich Mittel und verfahren zur isolierung und bestimmung neuer zielmoleküle zur behandlung neurodegenerativer, neurologischer oder neuropsychiatrischer erkrankungen sowie diese enthaltende zusammensetzungen
EP3225251B1 (de) 2006-12-21 2020-02-12 H. Lundbeck A/S Modulation der proneurotrophinaktivität
JP2010516428A (ja) * 2007-01-31 2010-05-20 ヘラー， アダム 疼痛の電気化学的管理
JP5801206B2 (ja) 2009-01-30 2015-10-28 アルファベータ・エービーＡｌｐｈａＢｅｔａ ＡＢ アルツハイマー病の治療のための化合物および方法
WO2012138284A1 (en) * 2011-04-05 2012-10-11 Alphabeta Ab Amyloidosis target useful in methods of treatment and for screening of compounds
WO2012140148A2 (en) * 2011-04-12 2012-10-18 Universität Zürich Prorektorat Mnw Junction plakoglobin for diagnosis of cardiovascular diseases
KR101511737B1 (ko) * 2012-12-31 2015-04-20 대한민국 Sumo1 및 bace1의 결합 억제제를 유효성분으로 함유하는 퇴행성 뇌질환 예방 및 치료용 약학적 조성물
JP2019533022A (ja) 2016-10-24 2019-11-14 ユマニティ セラピューティクス，インコーポレーテッド 化合物及びその使用
KR101873249B1 (ko) 2016-11-08 2018-07-05 대한민국 혈액기반 유전자 발현패턴을 이용한 치매 진단 방법
EP3566055B1 (de) 2017-01-06 2025-03-12 Janssen Pharmaceutica NV Scd-hemmer zur behandlung von neurologischen erkrankungen
CA3083000A1 (en) 2017-10-24 2019-05-02 Yumanity Therapeutics, Inc. Compounds and uses thereof
CN118084800A (zh) 2018-03-23 2024-05-28 詹森药业有限公司 化合物和其用途
US12098146B2 (en) 2019-01-24 2024-09-24 Janssen Pharmaceutica Nv Compounds and uses thereof
CN110144360B (zh) * 2019-06-06 2021-03-16 华中农业大学 一种二化螟SDR基因及其编码的蛋白质和应用、dsRNA及其扩增的引物对和应用
EA202192047A1 (ru) 2019-11-13 2021-12-08 Юманити Терапьютикс, Инк. Соединения и их применение
CN112641948A (zh) * 2020-12-25 2021-04-13 西北农林科技大学 靶基因SLC4A8在制备调控乳腺上皮细胞分泌β酪蛋白的药物的应用
CN116139277B (zh) * 2021-11-23 2025-06-24 中国科学院大连化学物理研究所 肝癌药物的辅助治疗药物及应用和治疗肝癌药物混合物

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US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
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US5096815A (en) * 1989-01-06 1992-03-17 Protein Engineering Corporation Generation and selection of novel dna-binding proteins and polypeptides
US5198346A (en) * 1989-01-06 1993-03-30 Protein Engineering Corp. Generation and selection of novel DNA-binding proteins and polypeptides
US5498538A (en) * 1990-02-15 1996-03-12 The University Of North Carolina At Chapel Hill Totally synthetic affinity reagents
US5545806A (en) * 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5633425A (en) * 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5661016A (en) * 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5625126A (en) * 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
ATE300615T1 (de) * 1990-08-29 2005-08-15 Genpharm Int Transgene mäuse fähig zur produktion heterologer antikörper
US5582981A (en) * 1991-08-14 1996-12-10 Gilead Sciences, Inc. Method for identifying an oligonucleotide aptamer specific for a target
EP1035207A1 (de) * 1999-03-09 2000-09-13 MultiGene Biotech GmbH cDNA Moleküle der Mitglieder der Genfamilie, die für menschliche Fettsäuredesaturasen kodieren, und deren Verwendung in Diagnostik und Therapie
JP2004507202A (ja) * 1999-03-31 2004-03-11 キュラジェン　コーポレイション ポリペプチドをコードするオープンリーディングフレームを含む核酸；「ｏｒｆｘ」
DE10000161A1 (de) * 2000-01-06 2001-07-19 Boehringer Ingelheim Pharma Verfahren zur Identifikation eines Proteaseinhibitors
AU2001237412A1 (en) * 2000-02-25 2001-09-03 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Presenilin deficient multipotent cell lines and screening methods for intramembrane regulated proteolytic activities using these lines
CA2301158A1 (en) * 2000-03-24 2001-09-24 Stephen J. Allen Screening methods for compounds useful for modulating lipid metabolism in disease

Also Published As

Publication number Publication date
CA2537844A1 (en) 2005-03-17
US20060216292A1 (en) 2006-09-28
DE602004008658T2 (de) 2008-06-12
WO2005023833A2 (en) 2005-03-17
EP1670903A2 (de) 2006-06-21
ES2291917T3 (es) 2008-03-01
WO2005023833A3 (en) 2005-06-23
DK1670903T3 (da) 2008-01-02
DE602004008658D1 (de) 2007-10-11
EP1670903B1 (de) 2007-08-29

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