ATE365169T1 - Regioselektive synthese von cci-779 - Google Patents
Regioselektive synthese von cci-779Info
- Publication number
- ATE365169T1 ATE365169T1 AT04778398T AT04778398T ATE365169T1 AT E365169 T1 ATE365169 T1 AT E365169T1 AT 04778398 T AT04778398 T AT 04778398T AT 04778398 T AT04778398 T AT 04778398T AT E365169 T1 ATE365169 T1 AT E365169T1
- Authority
- AT
- Austria
- Prior art keywords
- cci
- regioselective synthesis
- regioselective
- synthesis
- Prior art date
Links
- CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 229960000235 temsirolimus Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49324903P | 2003-08-07 | 2003-08-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE365169T1 true ATE365169T1 (de) | 2007-07-15 |
Family
ID=34193170
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04778398T ATE365169T1 (de) | 2003-08-07 | 2004-07-15 | Regioselektive synthese von cci-779 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7153957B2 (de) |
| EP (1) | EP1658295B1 (de) |
| JP (1) | JP4227649B2 (de) |
| KR (1) | KR20060057605A (de) |
| CN (1) | CN1829722B (de) |
| AR (1) | AR045217A1 (de) |
| AT (1) | ATE365169T1 (de) |
| AU (1) | AU2004265267A1 (de) |
| BR (1) | BRPI0412667A (de) |
| CA (1) | CA2532988A1 (de) |
| CO (1) | CO5650251A2 (de) |
| CR (1) | CR8189A (de) |
| DE (1) | DE602004007145T2 (de) |
| DK (1) | DK1658295T3 (de) |
| EC (1) | ECSP066413A (de) |
| ES (1) | ES2287772T3 (de) |
| IL (1) | IL173134A0 (de) |
| MX (1) | MXPA06000951A (de) |
| NO (1) | NO20060494L (de) |
| PL (1) | PL1658295T3 (de) |
| PT (1) | PT1658295E (de) |
| RU (1) | RU2339639C2 (de) |
| TW (1) | TW200508241A (de) |
| UA (1) | UA83245C2 (de) |
| WO (1) | WO2005016935A2 (de) |
| ZA (1) | ZA200601055B (de) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002085908A1 (en) | 2001-04-24 | 2002-10-31 | Purdue Research Foundation | Folate mimetics and folate-receptor binding conjugates thereof |
| AU2003243226A1 (en) * | 2002-05-15 | 2003-12-02 | Endocyte, Inc. | Vitamin-mitomycin conjugates |
| JP2005537285A (ja) * | 2002-07-30 | 2005-12-08 | ワイス | ラパマイシンヒドロキシエステルを含有する非経口製剤 |
| CA2512867C (en) | 2003-01-27 | 2014-08-26 | Endocyte, Inc. | Vitamin receptor binding drug delivery conjugates |
| CN1874771A (zh) * | 2003-09-03 | 2006-12-06 | 惠氏公司 | 3－羟基－2－(羟甲基)－2－甲基丙酸的非晶态雷帕霉素42－酯及其包含相同化合物的药用组合物 |
| UA84903C2 (ru) * | 2004-01-08 | 2008-12-10 | Уайет | Фармацевтическая композиция для перорального использования ссі-779, полученная прямым прессованием |
| AU2005238432A1 (en) * | 2004-04-14 | 2005-11-10 | Wyeth | Process for preparing rapamycin 42-esters and FK-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies |
| SG152234A1 (en) | 2004-04-14 | 2009-05-29 | Wyeth Corp | Regiospecific synthesis of rapamycin 42-ester derivatives |
| MXPA06011883A (es) | 2004-04-14 | 2006-12-14 | Wyeth Corp | 42-ester de prolina-rapamicina con acido 2,2-bis(hidroximetil)propionico y sintesis enzimatica de dos etapas de 42-ester de prolina-rapamicina con acido 2,2-bis(hidroximetil)propionico y 42-ester de rapamicina con acido 2,2-bis(hidroximetil)propionic |
| BRPI0510277A (pt) * | 2004-04-27 | 2007-10-30 | Wyeth Corp | método para marcar especificamente uma rapamicina, rapamicina especificamente marcada, composição, e, kit |
| WO2006012527A1 (en) | 2004-07-23 | 2006-02-02 | Endocyte, Inc. | Bivalent linkers and conjugates thereof |
| SV2006002188A (es) | 2004-08-10 | 2006-03-15 | Wyeth Corp | Derivados de cci - 779 y metodos para su preparacion ref. am-101759salvo |
| MX2007005153A (es) | 2004-10-28 | 2007-06-26 | Wyeth Corp | Uso de un inhibidor del mtor en el tratamiento de leiomioma del utero. |
| US7442707B2 (en) * | 2005-02-09 | 2008-10-28 | Wyeth | CCI-779 polymorph and use thereof |
| CA2599580A1 (en) | 2005-03-02 | 2006-09-08 | Wyeth | Recovery of cci-779 from mother liquors |
| MX2007010716A (es) | 2005-03-02 | 2008-01-16 | Wyeth Corp | Purificacion de rapamicina. |
| EP1863816B1 (de) | 2005-03-16 | 2014-06-25 | Endocyte, Inc. | Synthese und aufreinigung von pteroinsäure und konjugaten davon |
| EP1948241B1 (de) | 2005-08-19 | 2014-03-05 | Endocyte, Inc. | Multi-arzneimittel-liganden-konjugate |
| US20080280937A1 (en) * | 2005-08-19 | 2008-11-13 | Christopher Paul Leamon | Ligand Conjugates of Vinca Alkaloids, Analogs, and Derivatives |
| WO2007056175A2 (en) * | 2005-11-04 | 2007-05-18 | Wyeth | 41-methoxy isotope labeled rapamycin 42-ester |
| KR101354828B1 (ko) | 2005-11-04 | 2014-02-18 | 와이어쓰 엘엘씨 | ｍＴＯＲ 저해자, 헤르셉틴, 및/또는 ＨＫＩ-272의항신생물성 조합 |
| AU2006322024A1 (en) | 2005-12-07 | 2007-06-14 | Wyeth | Scalable process for the preparation of a rapamycin 42-ester from a rapamycin 42-ester boronate |
| KR20080077618A (ko) * | 2005-12-07 | 2008-08-25 | 와이어쓰 | 정제된 결정체 ｃｃｉ-779 의 제조 방법 |
| EP1957964A2 (de) * | 2005-12-07 | 2008-08-20 | Wyeth Pharmaceuticals | Verfahren zur herstellung von kristallinem rapamycin und zur messung der kristallinität von rapamycin-verbindungen über differenzscanning-kalorimetrie |
| RU2008121713A (ru) * | 2005-12-20 | 2010-01-27 | Вайет (Us) | Контроль стабильности лекарственной формы cci-779 посредством контроля примесей лекарственныхого вещества |
| US20070203169A1 (en) * | 2006-02-28 | 2007-08-30 | Zhao Jonathon Z | Isomers and 42-epimers of rapamycin ester analogs, methods of making and using the same |
| TW200824713A (en) | 2006-10-18 | 2008-06-16 | Wyeth Corp | Processes for the synthesis of individual isomers of mono-PEG CCI-779 |
| US8414909B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US9737640B2 (en) | 2006-11-20 | 2017-08-22 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US8998846B2 (en) | 2006-11-20 | 2015-04-07 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
| US8425459B2 (en) | 2006-11-20 | 2013-04-23 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent |
| US8414910B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US9700704B2 (en) | 2006-11-20 | 2017-07-11 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
| US8430055B2 (en) | 2008-08-29 | 2013-04-30 | Lutonix, Inc. | Methods and apparatuses for coating balloon catheters |
| US8414526B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids |
| US8414525B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US20080276935A1 (en) | 2006-11-20 | 2008-11-13 | Lixiao Wang | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
| WO2008101231A2 (en) * | 2007-02-16 | 2008-08-21 | Endocyte, Inc. | Methods and compositions for treating and diagnosing kidney disease |
| EP2139523B1 (de) * | 2007-03-14 | 2014-10-22 | Endocyte, Inc. | Konjugate aus folat und tubulysinen zur zielgerichteten wirkstofffreisetzung |
| TW200845960A (en) * | 2007-04-05 | 2008-12-01 | Wyeth Corp | Wortmannin-rapalog conjugate and uses thereof |
| TW200901989A (en) * | 2007-04-10 | 2009-01-16 | Wyeth Corp | Anti-tumor activity of CCI-779 in papillary renal cell cancer |
| US9877965B2 (en) | 2007-06-25 | 2018-01-30 | Endocyte, Inc. | Vitamin receptor drug delivery conjugates for treating inflammation |
| WO2009002993A1 (en) * | 2007-06-25 | 2008-12-31 | Endocyte, Inc. | Conjugates containing hydrophilic spacer linkers |
| WO2009055562A1 (en) | 2007-10-25 | 2009-04-30 | Endocyte, Inc. | Tubulysins and processes for preparing |
| EP2480557A2 (de) | 2009-09-25 | 2012-08-01 | Cadila Healthcare Limited | Verfahren zur herstellung von rapamycinderivaten |
| AU2011210227A1 (en) * | 2010-01-28 | 2012-08-30 | Fresenius Kabi Oncology Ltd. | Process for the preparation of Temsirolimus and its intermediates |
| CN102020661B (zh) * | 2011-01-07 | 2013-02-13 | 天津市炜杰科技有限公司 | 一种驮瑞塞尔合成方法 |
| CN102020662B (zh) * | 2011-01-07 | 2013-02-13 | 天津市炜杰科技有限公司 | 一种驮瑞塞尔制备方法 |
| BR112013025085A2 (pt) * | 2011-04-01 | 2016-07-19 | Sandoz Ag | processo para a acilação de rapamicina e processo para sintetizar tensirolimo |
| WO2013126797A1 (en) | 2012-02-24 | 2013-08-29 | Purdue Research Foundation | Cholecystokinin b receptor targeting for imaging and therapy |
| US20140080175A1 (en) | 2012-03-29 | 2014-03-20 | Endocyte, Inc. | Processes for preparing tubulysin derivatives and conjugates thereof |
| EA201590622A1 (ru) | 2012-10-16 | 2015-10-30 | Эндосайт, Инк. | Конъюгаты для доставки лекарственного средства, содержащие не встречающиеся в природе аминокислоты, и способы применения |
| CN104086564B (zh) * | 2014-07-30 | 2019-02-05 | 江苏奥赛康药业股份有限公司 | 一种高纯度坦罗莫司的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5362718A (en) | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
| DE19857765A1 (de) * | 1998-12-15 | 2000-06-21 | Clariant Gmbh | Verfahren zur Herstellung von para-Oxadiazolyl-phenyl-boronsäuren |
| US6277983B1 (en) * | 2000-09-27 | 2001-08-21 | American Home Products Corporation | Regioselective synthesis of rapamycin derivatives |
-
2004
- 2004-07-15 CN CN2004800217944A patent/CN1829722B/zh not_active Expired - Fee Related
- 2004-07-15 KR KR1020067002610A patent/KR20060057605A/ko not_active Ceased
- 2004-07-15 ES ES04778398T patent/ES2287772T3/es not_active Expired - Lifetime
- 2004-07-15 WO PCT/US2004/022860 patent/WO2005016935A2/en not_active Ceased
- 2004-07-15 BR BRPI0412667-0A patent/BRPI0412667A/pt not_active IP Right Cessation
- 2004-07-15 UA UAA200602447A patent/UA83245C2/ru unknown
- 2004-07-15 CA CA002532988A patent/CA2532988A1/en not_active Abandoned
- 2004-07-15 PL PL04778398T patent/PL1658295T3/pl unknown
- 2004-07-15 JP JP2006522574A patent/JP4227649B2/ja not_active Expired - Fee Related
- 2004-07-15 PT PT04778398T patent/PT1658295E/pt unknown
- 2004-07-15 MX MXPA06000951A patent/MXPA06000951A/es active IP Right Grant
- 2004-07-15 AT AT04778398T patent/ATE365169T1/de not_active IP Right Cessation
- 2004-07-15 DK DK04778398T patent/DK1658295T3/da active
- 2004-07-15 EP EP04778398A patent/EP1658295B1/de not_active Expired - Lifetime
- 2004-07-15 DE DE602004007145T patent/DE602004007145T2/de not_active Expired - Fee Related
- 2004-07-15 RU RU2006106910/04A patent/RU2339639C2/ru not_active IP Right Cessation
- 2004-07-15 AU AU2004265267A patent/AU2004265267A1/en not_active Abandoned
- 2004-07-30 US US10/903,062 patent/US7153957B2/en not_active Expired - Fee Related
- 2004-08-04 AR ARP040102778A patent/AR045217A1/es unknown
- 2004-08-05 TW TW093123422A patent/TW200508241A/zh unknown
-
2006
- 2006-01-12 IL IL173134A patent/IL173134A0/en unknown
- 2006-01-13 CR CR8189A patent/CR8189A/es not_active Application Discontinuation
- 2006-01-31 NO NO20060494A patent/NO20060494L/no not_active Application Discontinuation
- 2006-02-06 ZA ZA200601055A patent/ZA200601055B/en unknown
- 2006-02-28 CO CO06019898A patent/CO5650251A2/es unknown
- 2006-03-07 EC EC2006006413A patent/ECSP066413A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| UA83245C2 (en) | 2008-06-25 |
| CA2532988A1 (en) | 2005-02-24 |
| IL173134A0 (en) | 2006-06-11 |
| TW200508241A (en) | 2005-03-01 |
| DE602004007145T2 (de) | 2008-02-28 |
| ES2287772T3 (es) | 2007-12-16 |
| JP4227649B2 (ja) | 2009-02-18 |
| CR8189A (es) | 2006-10-04 |
| AU2004265267A1 (en) | 2005-02-24 |
| BRPI0412667A (pt) | 2006-09-26 |
| DK1658295T3 (da) | 2007-09-24 |
| US7153957B2 (en) | 2006-12-26 |
| RU2006106910A (ru) | 2007-09-20 |
| EP1658295B1 (de) | 2007-06-20 |
| AR045217A1 (es) | 2005-10-19 |
| CO5650251A2 (es) | 2006-06-30 |
| CN1829722A (zh) | 2006-09-06 |
| WO2005016935A3 (en) | 2005-04-07 |
| HK1085482A1 (en) | 2006-08-25 |
| WO2005016935A2 (en) | 2005-02-24 |
| ECSP066413A (es) | 2006-09-18 |
| CN1829722B (zh) | 2010-10-27 |
| KR20060057605A (ko) | 2006-05-26 |
| EP1658295A2 (de) | 2006-05-24 |
| ZA200601055B (en) | 2008-07-30 |
| PT1658295E (pt) | 2007-09-25 |
| DE602004007145D1 (de) | 2007-08-02 |
| US20050033046A1 (en) | 2005-02-10 |
| PL1658295T3 (pl) | 2007-11-30 |
| RU2339639C2 (ru) | 2008-11-27 |
| JP2007501783A (ja) | 2007-02-01 |
| NO20060494L (no) | 2006-03-06 |
| MXPA06000951A (es) | 2006-03-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1658295 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |