ATE363481T1 - Pyrazolderivate als gnrh-inhibitoren - Google Patents
Pyrazolderivate als gnrh-inhibitorenInfo
- Publication number
- ATE363481T1 ATE363481T1 AT03792484T AT03792484T ATE363481T1 AT E363481 T1 ATE363481 T1 AT E363481T1 AT 03792484 T AT03792484 T AT 03792484T AT 03792484 T AT03792484 T AT 03792484T AT E363481 T1 ATE363481 T1 AT E363481T1
- Authority
- AT
- Austria
- Prior art keywords
- sup
- compounds
- pyrazole derivatives
- gnrh inhibitors
- gnrh
- Prior art date
Links
- 101000904173 Homo sapiens Progonadoliberin-1 Proteins 0.000 title 1
- 102100024028 Progonadoliberin-1 Human genes 0.000 title 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical class C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 229940121381 gonadotrophin releasing hormone (gnrh) antagonists Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Detergent Compositions (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02292075 | 2002-08-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE363481T1 true ATE363481T1 (de) | 2007-06-15 |
Family
ID=31896980
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03792484T ATE363481T1 (de) | 2002-08-21 | 2003-08-19 | Pyrazolderivate als gnrh-inhibitoren |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7253290B2 (de) |
| EP (1) | EP1539743B1 (de) |
| JP (1) | JP2006501231A (de) |
| AT (1) | ATE363481T1 (de) |
| AU (1) | AU2003255811A1 (de) |
| DE (1) | DE60314158T2 (de) |
| ES (1) | ES2286493T3 (de) |
| WO (1) | WO2004018459A1 (de) |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2240108A1 (en) | 1995-12-14 | 1997-06-19 | Peter Lin | Antagonists of gonadotropin releasing hormone |
| US6197975B1 (en) | 1995-12-14 | 2001-03-06 | Merck & Co. , Inc. | Antagonists of gonadotropin releasing hormone |
| US6200957B1 (en) * | 1995-12-14 | 2001-03-13 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| SK77598A3 (en) | 1995-12-14 | 1999-01-11 | Merck & Co Inc | Nonpeptide derivatives, pharmaceutical composition containing them and their use |
| WO1997021435A1 (en) | 1995-12-14 | 1997-06-19 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| WO1997044339A1 (en) | 1996-05-20 | 1997-11-27 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| JP2002502428A (ja) | 1997-06-05 | 2002-01-22 | メルク エンド カンパニー インコーポレーテッド | ゴナドトロピン放出ホルモンの拮抗薬 |
| JP2002502427A (ja) | 1997-06-05 | 2002-01-22 | メルク エンド カンパニー インコーポレーテッド | ゴナドトロピン放出ホルモンの拮抗薬 |
| WO1998055119A1 (en) | 1997-06-05 | 1998-12-10 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| EP0986550A1 (de) | 1997-06-05 | 2000-03-22 | Merck & Co., Inc. | Antagonisten des gonadotropin freisetzenden hormons |
| US6156772A (en) | 1997-06-05 | 2000-12-05 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| AU729663B2 (en) | 1997-06-05 | 2001-02-08 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| JP2001520997A (ja) | 1997-10-28 | 2001-11-06 | メルク エンド カムパニー インコーポレーテッド | 性腺刺激ホルモン放出ホルモン拮抗薬 |
| EP1027046A4 (de) | 1997-10-28 | 2002-04-03 | Merck & Co Inc | Antagonisten des gonadotropin freisetzenden hormons |
| AU2597899A (en) | 1998-02-11 | 1999-08-30 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| WO1999041251A1 (en) | 1998-02-11 | 1999-08-19 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| JP2002510630A (ja) | 1998-04-02 | 2002-04-09 | メルク エンド カムパニー インコーポレーテッド | 性腺刺激ホルモン放出ホルモン拮抗薬 |
| AU3367999A (en) | 1998-04-02 | 1999-10-25 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| JP2002510628A (ja) | 1998-04-02 | 2002-04-09 | メルク エンド カムパニー インコーポレーテッド | 性腺刺激ホルモン放出ホルモン拮抗薬 |
| JP2002510684A (ja) | 1998-04-02 | 2002-04-09 | メルク エンド カムパニー インコーポレーテッド | 性腺刺激ホルモン放出ホルモン拮抗薬 |
| AU3368299A (en) | 1998-04-02 | 1999-10-25 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| WO1999051232A1 (en) | 1998-04-02 | 1999-10-14 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| JP2002538206A (ja) | 1999-03-10 | 2002-11-12 | メルク エンド カムパニー インコーポレーテッド | 性腺刺激ホルモン放出ホルモン拮抗薬としての６−アザインドール化合物 |
| AU3868900A (en) | 1999-03-10 | 2000-09-28 | Merck & Co., Inc. | 6-azaindole compounds as antagonists of gonadotropin releasing hormone |
| JP2002538205A (ja) | 1999-03-10 | 2002-11-12 | メルク エンド カムパニー インコーポレーテッド | 性腺刺激ホルモン放出ホルモン拮抗薬としての６−アザインドール化合物 |
| WO2000053185A1 (en) | 1999-03-10 | 2000-09-14 | Merck & Co., Inc. | 6-azaindole compounds as antagonists of gonadotropin releasing hormone |
| JP2002539124A (ja) | 1999-03-10 | 2002-11-19 | メルク エンド カムパニー インコーポレーテッド | 性腺刺激ホルモン放出ホルモン拮抗薬としての６−アザインドール化合物 |
| WO2000053178A1 (en) | 1999-03-10 | 2000-09-14 | Merck & Co., Inc. | 6-azaindole compounds as antagonists of gonadotropin releasing hormone |
| SE0100566D0 (sv) | 2001-02-20 | 2001-02-20 | Astrazeneca Ab | Compounds |
| SE0101692D0 (sv) | 2001-05-14 | 2001-05-14 | Astrazeneca Ab | Compounds |
-
2003
- 2003-08-19 EP EP03792484A patent/EP1539743B1/de not_active Expired - Lifetime
- 2003-08-19 AT AT03792484T patent/ATE363481T1/de not_active IP Right Cessation
- 2003-08-19 ES ES03792484T patent/ES2286493T3/es not_active Expired - Lifetime
- 2003-08-19 AU AU2003255811A patent/AU2003255811A1/en not_active Abandoned
- 2003-08-19 WO PCT/GB2003/003623 patent/WO2004018459A1/en not_active Ceased
- 2003-08-19 US US10/525,111 patent/US7253290B2/en not_active Expired - Fee Related
- 2003-08-19 DE DE60314158T patent/DE60314158T2/de not_active Expired - Fee Related
- 2003-08-19 JP JP2004530359A patent/JP2006501231A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1539743A1 (de) | 2005-06-15 |
| ES2286493T3 (es) | 2007-12-01 |
| EP1539743B1 (de) | 2007-05-30 |
| WO2004018459A1 (en) | 2004-03-04 |
| DE60314158T2 (de) | 2008-01-31 |
| AU2003255811A1 (en) | 2004-03-11 |
| US7253290B2 (en) | 2007-08-07 |
| JP2006501231A (ja) | 2006-01-12 |
| US20050239858A1 (en) | 2005-10-27 |
| DE60314158D1 (de) | 2007-07-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |