ATE362768T1 - Prb2/p130 peptidinhibitoren der cdk2 kinaseaktivität - Google Patents
Prb2/p130 peptidinhibitoren der cdk2 kinaseaktivitätInfo
- Publication number
- ATE362768T1 ATE362768T1 AT98939257T AT98939257T ATE362768T1 AT E362768 T1 ATE362768 T1 AT E362768T1 AT 98939257 T AT98939257 T AT 98939257T AT 98939257 T AT98939257 T AT 98939257T AT E362768 T1 ATE362768 T1 AT E362768T1
- Authority
- AT
- Austria
- Prior art keywords
- kinase activity
- prb2
- cdk2 kinase
- peptide inhibitors
- cdk2
- Prior art date
Links
- 230000000694 effects Effects 0.000 title abstract 3
- 102100033943 Basic salivary proline-rich protein 2 Human genes 0.000 title 1
- 102000015792 Cyclin-Dependent Kinase 2 Human genes 0.000 title 1
- 108010024986 Cyclin-Dependent Kinase 2 Proteins 0.000 title 1
- 101001068639 Homo sapiens Basic salivary proline-rich protein 2 Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 2
- 102100022828 Retinoblastoma-like protein 2 Human genes 0.000 abstract 2
- 108050002651 Retinoblastoma-like protein 2 Proteins 0.000 abstract 2
- 101150073031 cdk2 gene Proteins 0.000 abstract 2
- 102000020233 phosphotransferase Human genes 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5620797P | 1997-08-21 | 1997-08-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE362768T1 true ATE362768T1 (de) | 2007-06-15 |
Family
ID=22002895
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98939257T ATE362768T1 (de) | 1997-08-21 | 1998-08-06 | Prb2/p130 peptidinhibitoren der cdk2 kinaseaktivität |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6297357B1 (de) |
| EP (1) | EP1015015B1 (de) |
| JP (1) | JP4323716B2 (de) |
| AT (1) | ATE362768T1 (de) |
| CA (1) | CA2301333C (de) |
| DE (1) | DE69837808T2 (de) |
| WO (1) | WO1999008700A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1629090B1 (de) * | 2002-11-06 | 2014-03-05 | iBio, Inc. | Expression von fremdsequenzen in pflanzen unter verwendung eines trans-aktivierungssystems |
| US7692063B2 (en) * | 2002-11-12 | 2010-04-06 | Ibio, Inc. | Production of foreign nucleic acids and polypeptides in sprout systems |
| US7683238B2 (en) * | 2002-11-12 | 2010-03-23 | iBio, Inc. and Fraunhofer USA, Inc. | Production of pharmaceutically active proteins in sprouted seedlings |
| EP1594956A4 (de) | 2003-02-03 | 2007-08-01 | Fraunhofer Usa Inc | System zur expression von genen in pflanzen |
| CN1922306B (zh) * | 2004-02-20 | 2010-10-06 | 美国弗劳恩霍夫股份有限公司 | 用于植物中克隆表达的系统和方法 |
| US20090054333A1 (en) * | 2006-10-17 | 2009-02-26 | Antonio Giordano | Peptide inhibitors of cyclin-dependent kinase activity and uses thereof |
| US7470670B2 (en) * | 2006-10-17 | 2008-12-30 | Sbarro Health Research Organization, Inc. | Peptide inhibitors of cyclin-dependent kinase activity and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5596079A (en) | 1991-12-16 | 1997-01-21 | Smith; James R. | Mimetics of senescent cell derived inhibitors of DNA synthesis |
| US5496731A (en) | 1993-03-25 | 1996-03-05 | Xu; Hong-Ji | Broad-spectrum tumor suppressor genes, gene products and methods for tumor suppressor gene therapy |
| US5457049A (en) * | 1993-08-12 | 1995-10-10 | Temple University - Of The Commonwealth System Of Higher Education | Tumor suppressor protein pRb2, related gene products, and DNA encoding therefor |
| US5688665A (en) * | 1994-01-07 | 1997-11-18 | Fred Hutchinson Cancer Research Center | Isolated nucleic acid molecules encoding the p27 KIP-1 protein |
| US5625031A (en) * | 1994-02-08 | 1997-04-29 | Bristol-Myers Squibb Company | Peptide inhibitors of the p33cdk2 and p34cdc2 cell cycle regulatory kinases and human papillomavirus E7 oncoprotein |
| US5672508A (en) * | 1996-01-23 | 1997-09-30 | Mitotix, Inc. | Inhibitors of cell-cycle progression, and uses related thereto |
-
1998
- 1998-08-06 WO PCT/US1998/016381 patent/WO1999008700A1/en not_active Ceased
- 1998-08-06 EP EP98939257A patent/EP1015015B1/de not_active Expired - Lifetime
- 1998-08-06 CA CA2301333A patent/CA2301333C/en not_active Expired - Lifetime
- 1998-08-06 AT AT98939257T patent/ATE362768T1/de not_active IP Right Cessation
- 1998-08-06 US US09/130,425 patent/US6297357B1/en not_active Expired - Lifetime
- 1998-08-06 JP JP2000509437A patent/JP4323716B2/ja not_active Expired - Fee Related
- 1998-08-06 DE DE69837808T patent/DE69837808T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2301333A1 (en) | 1999-02-25 |
| JP2002500160A (ja) | 2002-01-08 |
| CA2301333C (en) | 2011-12-06 |
| DE69837808D1 (de) | 2007-07-05 |
| US6297357B1 (en) | 2001-10-02 |
| EP1015015A1 (de) | 2000-07-05 |
| JP4323716B2 (ja) | 2009-09-02 |
| WO1999008700A1 (en) | 1999-02-25 |
| EP1015015B1 (de) | 2007-05-23 |
| DE69837808T2 (de) | 2008-02-07 |
| EP1015015A4 (de) | 2004-12-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |