ATE353318T1 - Neue indolderivate mit affinität zum 5-ht6- rezeptor - Google Patents

Neue indolderivate mit affinität zum 5-ht6- rezeptor

Info

Publication number: ATE353318T1
Authority: AT; Austria
Prior art keywords: affinity; receptor; indole derivatives; new indole; new
Prior art date: 2001-06-07

Application number

AT02735394T

Other languages

English (en)

Inventor

Colin Charles Beard

Robin Douglas Clark

Lawrence Emerson Fisher

Ralph New Harris Iii

David Bruce Repke

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-07

Filing date

2002-05-29

Publication date

2007-02-15

2002-05-29 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2007-02-15 Application granted granted Critical

2007-02-15 Publication of ATE353318T1 publication Critical patent/ATE353318T1/de

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Psychology (AREA)
Anesthesiology (AREA)
Physical Education & Sports Medicine (AREA)
Hospice & Palliative Care (AREA)
Orthopedic Medicine & Surgery (AREA)
Child & Adolescent Psychology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT02735394T 2001-06-07 2002-05-29 Neue indolderivate mit affinität zum 5-ht6- rezeptor ATE353318T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US29670501P	2001-06-07	2001-06-07
US34021201P	2001-12-13	2001-12-13

Publications (1)

Publication Number	Publication Date
ATE353318T1 true ATE353318T1 (de)	2007-02-15

Family

ID=26969776

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02735394T ATE353318T1 (de)	2001-06-07	2002-05-29	Neue indolderivate mit affinität zum 5-ht6- rezeptor

Country Status (32)

Country	Link
US (3)	US6787535B2 (de)
EP (1)	EP1401813B1 (de)
JP (1)	JP4187642B2 (de)
KR (1)	KR100600240B1 (de)
CN (1)	CN1257892C (de)
AR (1)	AR036233A1 (de)
AT (1)	ATE353318T1 (de)
AU (1)	AU2002310747B2 (de)
BG (1)	BG108420A (de)
BR (1)	BR0210929A (de)
CA (1)	CA2449874C (de)
CO (1)	CO5630036A2 (de)
CZ (1)	CZ20033529A3 (de)
DE (1)	DE60218037T2 (de)
ES (1)	ES2280546T3 (de)
HR (1)	HRP20030984A2 (de)
HU (1)	HUP0401307A2 (de)
IL (1)	IL158997A0 (de)
MA (1)	MA27032A1 (de)
MX (1)	MXPA03011244A (de)
NO (1)	NO20035359D0 (de)
NZ (1)	NZ529631A (de)
PA (1)	PA8546601A1 (de)
PE (1)	PE20030039A1 (de)
PL (1)	PL367305A1 (de)
RU (1)	RU2294932C2 (de)
SK (1)	SK16052003A3 (de)
TW (1)	TW591015B (de)
UY (1)	UY27322A1 (de)
WO (1)	WO2002098857A1 (de)
YU (1)	YU96103A (de)
ZA (1)	ZA200309005B (de)

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MXPA03005432A (es) *	2000-12-22	2003-09-10	Wyeth Corp	Compuestos de heterociclilindazol y -azaindazol como ligandos de 5-hidroxitriptamina-6.
PL363238A1 (en) *	2000-12-22	2004-11-15	Wyeth	Heterocyclylalkylindole or -azaindole compounds as 5-hydroxytryptamine-6 ligands
TW593278B (en) *	2001-01-23	2004-06-21	Wyeth Corp	1-aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands
CA2444095A1 (en) *	2001-04-20	2002-10-31	Wyeth	Heterocyclyloxy-, -thioxy- and -aminobenzazole derivatives as 5-hydroxytryptamine-6 ligands
EP1414442A1 (de) *	2001-08-07	2004-05-06	Smithkline Beecham Plc	3-arylsulfonyl-7-piperazinyl-indole, -benzofurane und -benzothiophene mit 5-ht6-rezeptor-affinität für die behandlung von erkrankungen des zentralen nervensystems
BR0315317A (pt) *	2002-10-18	2005-09-06	Hoffmann La Roche	4-piperazinil benzenossulfonil indóis com afinidade para o receptor de 5-ht6

2002
- 2002-05-29 EP EP02735394A patent/EP1401813B1/de not_active Expired - Lifetime
- 2002-05-29 CZ CZ20033529A patent/CZ20033529A3/cs unknown
- 2002-05-29 ES ES02735394T patent/ES2280546T3/es not_active Expired - Lifetime
- 2002-05-29 SK SK16052003A patent/SK16052003A3/sk unknown
- 2002-05-29 MX MXPA03011244A patent/MXPA03011244A/es active IP Right Grant
- 2002-05-29 BR BR0210929-8A patent/BR0210929A/pt not_active Application Discontinuation
- 2002-05-29 HR HR20030984A patent/HRP20030984A2/hr not_active Application Discontinuation
- 2002-05-29 HU HU0401307A patent/HUP0401307A2/hu unknown
- 2002-05-29 DE DE60218037T patent/DE60218037T2/de not_active Expired - Lifetime
- 2002-05-29 AU AU2002310747A patent/AU2002310747B2/en not_active Ceased
- 2002-05-29 AT AT02735394T patent/ATE353318T1/de not_active IP Right Cessation
- 2002-05-29 WO PCT/EP2002/005890 patent/WO2002098857A1/en not_active Ceased
- 2002-05-29 PL PL02367305A patent/PL367305A1/xx not_active Application Discontinuation
- 2002-05-29 NZ NZ529631A patent/NZ529631A/en unknown
- 2002-05-29 RU RU2003136731/04A patent/RU2294932C2/ru not_active IP Right Cessation
- 2002-05-29 KR KR1020037016022A patent/KR100600240B1/ko not_active Expired - Fee Related
- 2002-05-29 JP JP2003501846A patent/JP4187642B2/ja not_active Expired - Fee Related
- 2002-05-29 YU YU96103A patent/YU96103A/sh unknown
- 2002-05-29 CA CA002449874A patent/CA2449874C/en not_active Expired - Fee Related
- 2002-05-29 CN CNB028115244A patent/CN1257892C/zh not_active Expired - Fee Related
- 2002-05-29 IL IL15899702A patent/IL158997A0/xx unknown
- 2002-06-03 TW TW091111843A patent/TW591015B/zh not_active IP Right Cessation
- 2002-06-04 AR ARP020102066A patent/AR036233A1/es not_active Application Discontinuation
- 2002-06-04 PA PA20028546601A patent/PA8546601A1/es unknown
- 2002-06-06 US US10/164,660 patent/US6787535B2/en not_active Expired - Fee Related
- 2002-06-06 UY UY27322A patent/UY27322A1/es not_active Application Discontinuation
- 2002-06-07 PE PE2002000481A patent/PE20030039A1/es not_active Application Discontinuation
2003
- 2003-11-19 ZA ZA200309005A patent/ZA200309005B/en unknown
- 2003-12-02 CO CO03106073A patent/CO5630036A2/es not_active Application Discontinuation
- 2003-12-02 NO NO20035359A patent/NO20035359D0/no not_active Application Discontinuation
- 2003-12-03 MA MA27422A patent/MA27032A1/fr unknown
- 2003-12-05 BG BG108420A patent/BG108420A/xx unknown
2004
- 2004-06-25 US US10/876,863 patent/US20040248902A1/en not_active Abandoned
2005
- 2005-03-03 US US11/071,726 patent/US20050171118A1/en not_active Abandoned

Also Published As

Publication number	Publication date
ES2280546T3 (es)	2007-09-16
ZA200309005B (en)	2005-02-21
KR100600240B1 (ko)	2006-07-13
WO2002098857A8 (en)	2004-04-22
CN1527816A (zh)	2004-09-08
RU2294932C2 (ru)	2007-03-10
HK1068610A1 (en)	2005-04-29
JP4187642B2 (ja)	2008-11-26
CA2449874C (en)	2009-06-23
US20050171118A1 (en)	2005-08-04
PE20030039A1 (es)	2003-02-13
EP1401813B1 (de)	2007-02-07
AR036233A1 (es)	2004-08-25
AU2002310747B2 (en)	2007-10-11
WO2002098857A1 (en)	2002-12-12
HUP0401307A2 (hu)	2004-12-28
JP2004533460A (ja)	2004-11-04
KR20040004702A (ko)	2004-01-13
EP1401813A1 (de)	2004-03-31
PA8546601A1 (es)	2003-01-24
CO5630036A2 (es)	2006-04-28
CN1257892C (zh)	2006-05-31
RU2003136731A (ru)	2005-05-20
TW591015B (en)	2004-06-11
DE60218037D1 (de)	2007-03-22
US20030073700A1 (en)	2003-04-17
BR0210929A (pt)	2004-06-08
HRP20030984A2 (en)	2005-10-31
NO20035359D0 (no)	2003-12-02
US20040248902A1 (en)	2004-12-09
NZ529631A (en)	2006-08-31
MXPA03011244A (es)	2004-02-27
DE60218037T2 (de)	2007-08-23
SK16052003A3 (en)	2004-10-05
IL158997A0 (en)	2004-05-12
CA2449874A1 (en)	2002-12-12
UY27322A1 (es)	2003-02-28
YU96103A (sh)	2006-08-17
US6787535B2 (en)	2004-09-07
CZ20033529A3 (cs)	2004-04-14
PL367305A1 (en)	2005-02-21
BG108420A (en)	2005-02-28
MA27032A1 (fr)	2004-12-20

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ATE487694T1 (de)	2010-11-15	Neue phthalamidderivate
IS6434A (is)	2002-06-19	Nýjar indól afleiður

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