ATE341542T1 - 1-(4-piperidyl)-benzimidazole mit neurotropher aktivität - Google Patents
1-(4-piperidyl)-benzimidazole mit neurotropher aktivitätInfo
- Publication number
- ATE341542T1 ATE341542T1 AT97919397T AT97919397T ATE341542T1 AT E341542 T1 ATE341542 T1 AT E341542T1 AT 97919397 T AT97919397 T AT 97919397T AT 97919397 T AT97919397 T AT 97919397T AT E341542 T1 ATE341542 T1 AT E341542T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- disease
- acyl
- amino
- hydrogen
- Prior art date
Links
- QYCKVZZMAXDBHQ-UHFFFAOYSA-N 1-piperidin-4-ylbenzimidazole Chemical compound C1CNCCC1N1C2=CC=CC=C2N=C1 QYCKVZZMAXDBHQ-UHFFFAOYSA-N 0.000 title 1
- 230000000508 neurotrophic effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 208000033808 peripheral neuropathy Diseases 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 206010012289 Dementia Diseases 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 125000005354 acylalkyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004983 dialkoxyalkyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001841 imino group Chemical group [H]N=* 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 230000003902 lesion Effects 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000003961 neuronal insult Effects 0.000 abstract 1
- 201000001119 neuropathy Diseases 0.000 abstract 1
- 230000007823 neuropathy Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 210000000578 peripheral nerve Anatomy 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000000278 spinal cord Anatomy 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 230000000472 traumatic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK45996 | 1996-04-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE341542T1 true ATE341542T1 (de) | 2006-10-15 |
Family
ID=8093796
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97919397T ATE341542T1 (de) | 1996-04-19 | 1997-04-21 | 1-(4-piperidyl)-benzimidazole mit neurotropher aktivität |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6180649B1 (de) |
| EP (1) | EP0898568B1 (de) |
| AT (1) | ATE341542T1 (de) |
| AU (1) | AU2388697A (de) |
| DE (1) | DE69736776T2 (de) |
| WO (1) | WO1997040035A1 (de) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20010020172A (ko) | 1997-05-30 | 2001-03-15 | 나가사까 겐지로 | 2-옥소이미다졸 유도체 |
| ES2175925T3 (es) | 1998-01-19 | 2002-11-16 | Pfizer | Compuestos 4-(2-ceto-1-benzilimidazolinil)piperidina como agonistas del receptor orl1. |
| MA26659A1 (fr) * | 1998-08-06 | 2004-12-20 | Pfizer | Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation. |
| US6340681B1 (en) | 1999-07-16 | 2002-01-22 | Pfizer Inc | 2-benzimidazolylamine compounds as ORL-1-receptor agonists |
| SE9903544D0 (sv) | 1999-10-01 | 1999-10-01 | Astra Pharma Prod | Novel compounds |
| ATE302770T1 (de) * | 1999-12-06 | 2005-09-15 | Euro Celtique Sa | Benzimidazolverbindungen die nociceptinrezeptoraffinität haben |
| JP3989247B2 (ja) | 1999-12-06 | 2007-10-10 | ユーロ−セルティーク エス．エイ． | ノシセプチン受容体親和性を有するトリアゾスピロ化合物 |
| EP1244437A4 (de) | 1999-12-06 | 2005-02-09 | Euro Celtique Sa | Tertiäre aminoverbindungen mit opioid-rezeptor affinität |
| ES2249237T3 (es) | 2000-01-05 | 2006-04-01 | Pfizer Inc. | Compuestos de bencimidazol como antagonistas del receptor orl1. |
| GB2359078A (en) | 2000-02-11 | 2001-08-15 | Astrazeneca Uk Ltd | Pharmaceutically active pyrimidine derivatives |
| GB2359081A (en) | 2000-02-11 | 2001-08-15 | Astrazeneca Uk Ltd | Pharmaceutically active thiazolopyrimidines |
| GB2359551A (en) | 2000-02-23 | 2001-08-29 | Astrazeneca Uk Ltd | Pharmaceutically active pyrimidine derivatives |
| GB0005642D0 (en) | 2000-03-10 | 2000-05-03 | Astrazeneca Uk Ltd | Chemical compounds |
| DE10040016A1 (de) * | 2000-08-16 | 2002-02-28 | Boehringer Ingelheim Pharma | Neue beta-Amyloid Inhibitoren, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| SE0003828D0 (sv) | 2000-10-20 | 2000-10-20 | Astrazeneca Ab | Novel compounds |
| US6653478B2 (en) | 2000-10-27 | 2003-11-25 | Ortho-Mcneil Pharmaceutical, Inc. | Substituted benzimidazol-2-ones as vasopressin receptor antagonists and neuropeptide Y modulators |
| MXPA03009185A (es) * | 2001-04-09 | 2004-02-17 | Neurosearch As | Antagonistas de receptor a2a de adenosina combinados con compuestos de actividad neurotrofica en el tratamiento de la enfermedad de parkinson. |
| SE0101322D0 (sv) | 2001-04-12 | 2001-04-12 | Astrazeneca Ab | Novel compounds |
| JP4380992B2 (ja) | 2001-04-18 | 2009-12-09 | ユーロ−セルティーク エス．エイ． | ノシセプチン類似体 |
| DE60228072D1 (de) | 2001-04-18 | 2008-09-18 | Euro Celtique Sa | Benzimidazolon-verbindungen |
| ATE424385T1 (de) | 2001-04-18 | 2009-03-15 | Euro Celtique Sa | 1-(4-piperidinyl)-1,3-dihydro-2h-benzoxazole-2- one derivate und verwandte verbindungen als nociceptin analoge und orl1 liganden zur behandlung von schmerz |
| RU2299883C2 (ru) | 2001-04-18 | 2007-05-27 | Эро-Селтик, С.А. | Соединения спиропиразола, содержащая их фармацевтическая композиция, способ модуляции опиоидного рецептора и способ лечения с применением таких соединений |
| EP2033644A1 (de) | 2001-04-18 | 2009-03-11 | Euro-Celtique S.A. | Spiroinden- und Spiroindan-Verbindungen |
| US7164024B2 (en) | 2001-04-20 | 2007-01-16 | Banyu Pharmaceutical Co., Ltd. | Benzimidazolone derivatives |
| JP3896309B2 (ja) | 2001-07-09 | 2007-03-22 | ファイザー株式会社 | プロテインキナーゼｃ阻害物質としてのピラゾロキノリノン誘導体 |
| US7244744B2 (en) * | 2001-11-01 | 2007-07-17 | Icagen, Inc. | Piperidines |
| KR100453916B1 (ko) * | 2002-03-11 | 2004-10-20 | 주식회사 코오롱 | 1,2,5,6-테트라히드로피리디닐벤즈이미다졸 유도체 및 그제조방법 |
| GB0221828D0 (en) | 2002-09-20 | 2002-10-30 | Astrazeneca Ab | Novel compound |
| GB0328243D0 (en) | 2003-12-05 | 2004-01-07 | Astrazeneca Ab | Methods |
| AR054816A1 (es) * | 2005-07-13 | 2007-07-18 | Banyu Pharma Co Ltd | Derivados de n-dihidroxialquil 2-oxo- imidazol sustituidos |
| US7300947B2 (en) * | 2005-07-13 | 2007-11-27 | Banyu Pharmaceutical Co., Ltd. | N-dihydroxyalkyl-substituted 2-oxo-imidazole derivatives |
| EP1987009A1 (de) | 2006-01-30 | 2008-11-05 | Euro-Celtique S.A. | Cycloharnstoffverbindung als calciumkanalblocker |
| US20080287479A1 (en) * | 2006-12-20 | 2008-11-20 | Pfizer Inc | Inhibitors of serine palmitoyltransferase |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE633495A (de) | 1962-06-13 | |||
| US3318900A (en) * | 1964-05-06 | 1967-05-09 | Janssen Pharmaceutica Nv | Derivatives of benzimidazolinyl piperidine |
| US3989707A (en) | 1974-06-21 | 1976-11-02 | Janssen Pharmaceutica N.V. | Benzimidazolinone derivatives |
| US4048058A (en) * | 1975-08-13 | 1977-09-13 | Standard Oil Company (Indiana) | Methods to be used in reforming processes employing multi-metallic catalysts |
| US3963727A (en) * | 1975-06-06 | 1976-06-15 | Daiichi Seiyaku Co., Ltd. | 1,2 Disubstituted benzimidazole derivatives |
| US4264613A (en) | 1979-08-01 | 1981-04-28 | Science Union Et Cie, Societe Francaise De Recherche Medicale | Piperidylbenzimidazolinone compounds |
| FR2485151A1 (fr) | 1980-04-22 | 1981-12-24 | Glaxo Group Ltd | Distribution de liquides dans des recipients sous pression |
| JPS58180481A (ja) | 1982-04-15 | 1983-10-21 | Kyowa Hakko Kogyo Co Ltd | 新規なピペリジン誘導体 |
| FR2708608B1 (fr) * | 1993-07-30 | 1995-10-27 | Sanofi Sa | Dérivés de N-sulfonylbenzimidazolone, leur préparation, les compositions pharmaceutiques en contenant. |
| WO1995022327A1 (en) * | 1994-02-22 | 1995-08-24 | Knoll Ag | Use of 1-(arylalkylaminoalkyl) imidazoles for treating neurological damage |
-
1997
- 1997-04-21 AT AT97919397T patent/ATE341542T1/de not_active IP Right Cessation
- 1997-04-21 AU AU23886/97A patent/AU2388697A/en not_active Abandoned
- 1997-04-21 EP EP97919397A patent/EP0898568B1/de not_active Expired - Lifetime
- 1997-04-21 WO PCT/EP1997/002011 patent/WO1997040035A1/en not_active Ceased
- 1997-04-21 US US09/171,530 patent/US6180649B1/en not_active Expired - Fee Related
- 1997-04-21 DE DE69736776T patent/DE69736776T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69736776D1 (de) | 2006-11-16 |
| EP0898568A1 (de) | 1999-03-03 |
| AU2388697A (en) | 1997-11-12 |
| EP0898568B1 (de) | 2006-10-04 |
| WO1997040035A1 (en) | 1997-10-30 |
| US6180649B1 (en) | 2001-01-30 |
| DE69736776T2 (de) | 2007-01-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |