ATE238983T1 - Herstellung einer substituierten 2,5-diamino-3- hydroxyhexan - Google Patents
Herstellung einer substituierten 2,5-diamino-3- hydroxyhexanInfo
- Publication number
- ATE238983T1 ATE238983T1 AT99101692T AT99101692T ATE238983T1 AT E238983 T1 ATE238983 T1 AT E238983T1 AT 99101692 T AT99101692 T AT 99101692T AT 99101692 T AT99101692 T AT 99101692T AT E238983 T1 ATE238983 T1 AT E238983T1
- Authority
- AT
- Austria
- Prior art keywords
- loweralkyl
- independently selected
- alkoxy
- hydrogen
- trifluoromethyl
- Prior art date
Links
- GQYLTNRRTTVXGQ-UHFFFAOYSA-N 2,5-diaminohexan-3-ol Chemical class CC(N)CC(O)C(C)N GQYLTNRRTTVXGQ-UHFFFAOYSA-N 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- -1 loweralkyl Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
- C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
- C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C251/36—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C251/40—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14179593A | 1993-10-22 | 1993-10-22 | |
| US08/281,502 US5491253A (en) | 1993-10-22 | 1994-07-27 | Process for the preparation of a substituted 2,5-diamino-3-hydroxyhexane |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE238983T1 true ATE238983T1 (de) | 2003-05-15 |
Family
ID=26839452
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94929340T ATE183993T1 (de) | 1993-10-22 | 1994-09-26 | Zwischenprodukte für die herstellung einer substituierten 2,5-diamino-3-hydroxyhexan. |
| AT99101692T ATE238983T1 (de) | 1993-10-22 | 1994-09-26 | Herstellung einer substituierten 2,5-diamino-3- hydroxyhexan |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94929340T ATE183993T1 (de) | 1993-10-22 | 1994-09-26 | Zwischenprodukte für die herstellung einer substituierten 2,5-diamino-3-hydroxyhexan. |
Country Status (11)
| Country | Link |
|---|---|
| US (11) | US5491253A (de) |
| EP (2) | EP0916646B1 (de) |
| JP (2) | JP3822233B2 (de) |
| AT (2) | ATE183993T1 (de) |
| CA (1) | CA2174000C (de) |
| DE (2) | DE69420421T2 (de) |
| DK (2) | DK0724563T3 (de) |
| ES (2) | ES2138667T3 (de) |
| GR (1) | GR3031939T3 (de) |
| PT (1) | PT916646E (de) |
| WO (1) | WO1995011224A1 (de) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995023793A1 (en) * | 1994-03-02 | 1995-09-08 | Daicel Chemical Industries, Ltd. | 2-isoxazoline derivative and process for producing the same, and process for producing related derivatives from the same |
| JP3338227B2 (ja) * | 1995-02-28 | 2002-10-28 | 高砂香料工業株式会社 | ケトニトリル誘導体及びヘキセノン誘導体の製造方法 |
| US6037157A (en) | 1995-06-29 | 2000-03-14 | Abbott Laboratories | Method for improving pharmacokinetics |
| US5932766A (en) * | 1997-05-30 | 1999-08-03 | Abbott Laboratories | Process for the preparation of substituted keto-enamines |
| MY145265A (en) | 1998-07-20 | 2012-01-13 | Abbott Lab | Amorphous ritonavir |
| US6307090B1 (en) | 1999-01-22 | 2001-10-23 | The United States Of America As Represented By The Department Of Health And Human Services | Acylated oligopeptide derivatives having cell signal inhibiting activity |
| EP1163262B1 (de) * | 1999-03-23 | 2011-05-11 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Phenylalanin- derivate |
| US7226991B1 (en) * | 1999-03-23 | 2007-06-05 | United States Of America, Represented By The Secretary, Department Of Health And Human Services | Phenylalanine derivatives |
| US6765019B1 (en) * | 1999-05-06 | 2004-07-20 | University Of Kentucky Research Foundation | Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids |
| US6573409B1 (en) * | 1999-07-02 | 2003-06-03 | The Nutrasweet Company | Process for the preparation of 3,3-dimethylbutanal |
| AU767558B2 (en) * | 1999-09-16 | 2003-11-13 | Mitsubishi Tanabe Pharma Corporation | Aromatic nitrogenous six-membered ring compounds |
| IT1313624B1 (it) | 1999-09-21 | 2002-09-09 | Archimica Spa Ora Clariant Lif | Procedimento per la sintesi del ritonavir |
| ATE362767T1 (de) | 1999-10-22 | 2007-06-15 | Us Gov Health & Human Serv | Hemmung der zellmotilität und angiogenese mit grb2 sh2-domäne inhibitoren |
| US7871981B2 (en) * | 1999-10-22 | 2011-01-18 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibition of cell motility, angiogenesis, and metastasis |
| IL150265A0 (en) | 2000-01-19 | 2002-12-01 | Abbott Lab | Improved pharmaceutical formulations comprising one or more solubilized hiv protease inhibiting compounds |
| US7425537B2 (en) * | 2000-08-22 | 2008-09-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | SH2 domain binding inhibitors |
| CA2419870A1 (en) * | 2000-08-22 | 2002-02-28 | Yang Gao | Sh2 domain binding inhibitors |
| US7060165B2 (en) * | 2002-02-14 | 2006-06-13 | Pcbu Services, Inc. | Processes for purification and production of fluorocarbons |
| EP1411045B1 (de) * | 2002-10-18 | 2008-01-16 | Tohru Yokozawa | Verfahren zur Herstellung optisch aktiver Aminoalkohole |
| US20040138104A1 (en) * | 2003-01-14 | 2004-07-15 | The Government Of The United States Of America Represented By The Secretary, | Peptides |
| US6933504B2 (en) * | 2003-03-12 | 2005-08-23 | General Electric Company | CT detector having a segmented optical coupler and method of manufacturing same |
| US20050119163A1 (en) | 2003-09-18 | 2005-06-02 | The Government Of The United States Of America, As Represented By The Secretary, | SH2 domain binding inhibitors |
| WO2006090264A1 (en) * | 2005-02-28 | 2006-08-31 | Ranbaxy Laboratories Limited | A process for the synthesis of 2-amino-5-protected amino-3-hydroxy-1, 6-diphenylhexane or a salt thereof - an intermediate for antiviral drugs |
| EP1937233B1 (de) | 2005-09-02 | 2013-01-09 | Amgen Inc. | Modulierung des darmflüssigkeitsgleichgewichtes mittels calcimimetika |
| US20080160204A1 (en) * | 2006-12-28 | 2008-07-03 | Lavoie Adrien R | Spontaneous copper seed deposition process for metal interconnects |
| WO2008149228A1 (en) * | 2007-06-08 | 2008-12-11 | Aurobindo Pharma Limited | An improved process for the preparation of substantially pure (2s,3s,5s)-5-amino-2-n,n-dibenzylamino-3-hydroxy-1,6-diphenylhexane |
| JP5204438B2 (ja) * | 2007-07-31 | 2013-06-05 | 東ソ−・エフテック株式会社 | 含フッ素アミン化合物の製造方法 |
| CN101967130B (zh) * | 2010-07-02 | 2012-12-26 | 厦门市亨瑞生化有限公司 | 利托那韦中间体的合成方法 |
| CN107602454B (zh) * | 2017-09-19 | 2020-12-01 | 佛山科学技术学院 | 磺酰胺类化合物及其制备方法和用途 |
| US10529439B2 (en) | 2017-10-24 | 2020-01-07 | Spin Memory, Inc. | On-the-fly bit failure detection and bit redundancy remapping techniques to correct for fixed bit defects |
| US10438995B2 (en) | 2018-01-08 | 2019-10-08 | Spin Memory, Inc. | Devices including magnetic tunnel junctions integrated with selectors |
| CN113636957A (zh) * | 2021-08-24 | 2021-11-12 | 广东东阳光药业有限公司 | 利托那韦中间体的晶体及其制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2784228A (en) * | 1953-08-26 | 1957-03-05 | North Carolina Pharmacentical | Alkaline hydrogenation of oximinoketones |
| GB1383186A (en) * | 1972-07-26 | 1975-02-05 | Luso Farmaco Inst | Beta-aminoketone derivatives |
| US5142056A (en) * | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| US5177259A (en) * | 1986-04-11 | 1993-01-05 | Warner-Lambert Company | Diarylalkanoids having activity as lipoxygenase inhibitors |
| AU7968687A (en) * | 1986-09-30 | 1988-04-21 | Upjohn Company, The | Renin inhibitory peptides having novel c-terminal moieties |
| NO169837C (no) * | 1987-12-21 | 1992-08-12 | Astra Ab | Analogifremgangsmaate for fremstilling av nye terapeutisk aktive forbindelser |
| DE3829594A1 (de) * | 1988-09-01 | 1990-03-15 | Bayer Ag | Neue renininhibitoren, verfahren zur herstellung und ihre verwendung in arzneimitteln |
| US5354866A (en) * | 1989-05-23 | 1994-10-11 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| IE913840A1 (en) * | 1990-11-20 | 1992-05-20 | Abbott Lab | Retroviral protease inhibiting compounds |
| JPH06184069A (ja) * | 1991-11-19 | 1994-07-05 | Lonza Ag | α−ヒドロキシ−β−アミノカルボン酸の製造方法 |
| EP0674513B1 (de) * | 1992-12-29 | 1996-09-25 | Abbott Laboratories | Inhibitoren der retroviralen protease |
| IL110752A (en) * | 1993-09-13 | 2000-07-26 | Abbott Lab | Liquid semi-solid or solid pharmaceutical composition for an HIV protease inhibitor |
-
1994
- 1994-07-27 US US08/281,502 patent/US5491253A/en not_active Expired - Lifetime
- 1994-09-26 ES ES94929340T patent/ES2138667T3/es not_active Expired - Lifetime
- 1994-09-26 CA CA002174000A patent/CA2174000C/en not_active Expired - Lifetime
- 1994-09-26 DK DK94929340T patent/DK0724563T3/da active
- 1994-09-26 EP EP99101692A patent/EP0916646B1/de not_active Expired - Lifetime
- 1994-09-26 DE DE69420421T patent/DE69420421T2/de not_active Expired - Fee Related
- 1994-09-26 WO PCT/US1994/010852 patent/WO1995011224A1/en not_active Ceased
- 1994-09-26 DE DE69432611T patent/DE69432611T2/de not_active Expired - Fee Related
- 1994-09-26 DK DK99101692T patent/DK0916646T3/da active
- 1994-09-26 EP EP94929340A patent/EP0724563B1/de not_active Expired - Lifetime
- 1994-09-26 JP JP51182995A patent/JP3822233B2/ja not_active Expired - Lifetime
- 1994-09-26 AT AT94929340T patent/ATE183993T1/de not_active IP Right Cessation
- 1994-09-26 PT PT99101692T patent/PT916646E/pt unknown
- 1994-09-26 AT AT99101692T patent/ATE238983T1/de not_active IP Right Cessation
- 1994-09-26 ES ES99101692T patent/ES2198094T3/es not_active Expired - Lifetime
-
1995
- 1995-03-31 US US08/414,876 patent/US5508409A/en not_active Expired - Lifetime
- 1995-03-31 US US08/414,974 patent/US5565604A/en not_active Expired - Lifetime
- 1995-04-03 US US08/415,385 patent/US5541328A/en not_active Expired - Lifetime
- 1995-04-03 US US08/415,403 patent/US5543549A/en not_active Expired - Lifetime
- 1995-04-07 US US08/418,705 patent/US5616776A/en not_active Expired - Lifetime
- 1995-04-07 US US08/418,727 patent/US5569777A/en not_active Expired - Lifetime
- 1995-04-10 US US08/419,301 patent/US5543551A/en not_active Expired - Lifetime
- 1995-04-10 US US08/419,168 patent/US5625092A/en not_active Expired - Lifetime
- 1995-04-10 US US08/419,327 patent/US5543552A/en not_active Expired - Lifetime
-
1996
- 1996-03-29 US US08/625,783 patent/US5654466A/en not_active Expired - Lifetime
-
1999
- 1999-11-25 GR GR990403031T patent/GR3031939T3/el unknown
-
2006
- 2006-02-28 JP JP2006052376A patent/JP4172717B2/ja not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
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| UEP | Publication of translation of european patent specification |
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| REN | Ceased due to non-payment of the annual fee |