ATE288915T1 - SUBSTITUTED 2-ARYL-3-(HETEROARYL)-IMIDAZO(1,2-ALPHA)PYRIMIDINES AND THEIR RELATED DRUGS AND METHODS - Google Patents

SUBSTITUTED 2-ARYL-3-(HETEROARYL)-IMIDAZO(1,2-ALPHA)PYRIMIDINES AND THEIR RELATED DRUGS AND METHODS

Info

Publication number: ATE288915T1
Authority: AT; Austria
Prior art keywords: pyrimidines; imidazo; heteroaryl; aryl; alpha
Prior art date: 1999-11-10

Application number

AT00976710T

Other languages

German (de)

Inventor

John H Dodd

James R Henry

Kenneth C Rupert

Original Assignee

Ortho Mcneil Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-11-10

Filing date

2000-10-27

Publication date

2005-02-15

2000-10-27 Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc

2005-02-15 Application granted granted Critical

2005-02-15 Publication of ATE288915T1 publication Critical patent/ATE288915T1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Oncology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Communicable Diseases (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Orthopedic Medicine & Surgery (AREA)
Virology (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Dermatology (AREA)
Psychiatry (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Transplantation (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Obesity (AREA)

AT00976710T 1999-11-10 2000-10-27 SUBSTITUTED 2-ARYL-3-(HETEROARYL)-IMIDAZO(1,2-ALPHA)PYRIMIDINES AND THEIR RELATED DRUGS AND METHODS ATE288915T1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US16470099P	1999-11-10	1999-11-10
PCT/US2000/029875 WO2001034605A1 (en)	1999-11-10	2000-10-27	SUBSTITUTED 2-ARYL-3-(HETEROARYL)-IMIDAZO[1,2-a]PYRIMIDINES, AND RELATED PHARMACEUTICAL COMPOSITIONS AND METHODS

Publications (1)

Publication Number	Publication Date
ATE288915T1 true ATE288915T1 (en)	2005-02-15

Family

ID=22595694

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00976710T ATE288915T1 (en)	1999-11-10	2000-10-27	SUBSTITUTED 2-ARYL-3-(HETEROARYL)-IMIDAZO(1,2-ALPHA)PYRIMIDINES AND THEIR RELATED DRUGS AND METHODS

Country Status (27)

Country	Link
US (1)	US6610697B1 (en)
EP (1)	EP1140939B1 (en)
JP (1)	JP2003513977A (en)
KR (1)	KR20010089805A (en)
CN (1)	CN1255406C (en)
AR (1)	AR026410A1 (en)
AT (1)	ATE288915T1 (en)
AU (1)	AU784484B2 (en)
BG (1)	BG65106B1 (en)
BR (1)	BR0007447A (en)
CA (1)	CA2361139A1 (en)
CZ (1)	CZ20012494A3 (en)
DE (1)	DE60018037T2 (en)
ES (1)	ES2237470T3 (en)
HK (1)	HK1043591B (en)
HU (1)	HUP0200207A3 (en)
ID (1)	ID29514A (en)
IL (1)	IL144238A (en)
MX (1)	MXPA01007019A (en)
NO (1)	NO320422B1 (en)
NZ (1)	NZ512957A (en)
PL (1)	PL348924A1 (en)
PT (1)	PT1140939E (en)
RU (1)	RU2264403C2 (en)
SK (1)	SK9892001A3 (en)
UA (1)	UA70350C2 (en)
WO (1)	WO2001034605A1 (en)

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GB0124938D0 (en)	2001-10-17	2001-12-05	Glaxo Group Ltd	Chemical compounds
GB0124939D0 (en)	2001-10-17	2001-12-05	Glaxo Group Ltd	Chemical compounds
GB0124936D0 (en)	2001-10-17	2001-12-05	Glaxo Group Ltd	Chemical compounds
GB0124934D0 (en)	2001-10-17	2001-12-05	Glaxo Group Ltd	Chemical compounds
GB0124933D0 (en)	2001-10-17	2001-12-05	Glaxo Group Ltd	Chemical compounds
US6921762B2 (en) *	2001-11-16	2005-07-26	Amgen Inc.	Substituted indolizine-like compounds and methods of use
ATE323706T1 (en)	2001-12-17	2006-05-15	Smithkline Beecham Corp	PYRAZOLOPYRIDAZINE DERIVATIVES
SI1474395T1 (en)	2002-02-12	2008-02-29	Smithkline Beecham Corp	Nicotinamide derivates useful as p38 inhibitors
US7388009B2 (en)	2002-04-23	2008-06-17	Bristol-Myers Squibb Company	Heteroaryl-substituted pyrrolo-triazine compounds useful as kinase inhibitors
ATE418546T1 (en)	2002-04-23	2009-01-15	Bristol Myers Squibb Co	ARYLKETONE PYRROLOTRIAZINE COMPOUNDS SUITABLE AS KINASE INHIBITORS
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AU2003245989A1 (en)	2002-07-09	2004-01-23	Boehringer Ingelheim Pharma Gmbh And Co. Kg	Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases
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BRPI0411825B8 (en)	2003-06-26	2021-05-25	Novartis Ag	5-element heterocycle-based p38 kinase inhibitors, their preparation processes and their uses, as well as pharmaceutical composition
ATE482205T1 (en)	2003-07-25	2010-10-15	Novartis Ag	P-38 KINASE INHIBITORS
GB0318814D0 (en)	2003-08-11	2003-09-10	Smithkline Beecham Corp	Novel compounds
US7419978B2 (en)	2003-10-22	2008-09-02	Bristol-Myers Squibb Company	Phenyl-aniline substituted bicyclic compounds useful as kinase inhibitors
DK1718649T3 (en) *	2004-01-31	2009-08-24	Actimis Pharmaceuticals Inc	Imidazo [1,2-c] pyrimidinyleddikesyrederivater
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US7504521B2 (en)	2004-08-05	2009-03-17	Bristol-Myers Squibb Co.	Methods for the preparation of pyrrolotriazine compounds
US20060035893A1 (en)	2004-08-07	2006-02-16	Boehringer Ingelheim International Gmbh	Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
PE20060421A1 (en)	2004-08-12	2006-06-01	Bristol Myers Squibb Co	PROCEDURE FOR PREPARING A COMPOUND OF PYRROLOTRIAZINE ANILINE AS KINASE INHIBITORS
WO2006025567A1 (en) *	2004-08-31	2006-03-09	Banyu Pharmaceutical Co., Ltd.	Novel substituted imidazole derivatives
PE20060777A1 (en)	2004-12-24	2006-10-06	Boehringer Ingelheim Int	INDOLINONE DERIVATIVES FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES
EP1832588A4 (en) *	2004-12-28	2009-09-02	Takeda Pharmaceutical	IMIDAZOLE CONDENSE DERIVATIVE AND APPLICATIONS THEREOF
US20060178388A1 (en)	2005-02-04	2006-08-10	Wrobleski Stephen T	Phenyl-substituted pyrimidine compounds useful as kinase inhibitors
US7473784B2 (en)	2005-08-01	2009-01-06	Bristol-Myers Squibb Company	Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors
TW200800213A (en)	2005-09-02	2008-01-01	Abbott Lab	Novel imidazo based heterocycles
JP2009535295A (en)	2006-03-07	2009-10-01	ブリストル−マイヤーズスクイブカンパニー	Pyrrolotriazine aniline prodrug compounds useful as kinase inhibitors
US7683060B2 (en)	2006-08-07	2010-03-23	Incyte Corporation	Triazolotriazines as kinase inhibitors
EP2468717B1 (en)	2006-10-27	2013-11-20	Bristol-Myers Squibb Company	Heterocyclic Amide Compounds Useful as Kinase Inhibitors
SI3034075T1 (en)	2006-11-22	2018-12-31	Incyte Holdings Corporation	Imidazotriazines and imidazopyrimidines as kinase inhibitors
US7943617B2 (en)	2006-11-27	2011-05-17	Bristol-Myers Squibb Company	Heterobicyclic compounds useful as kinase inhibitors
US7977336B2 (en) *	2006-12-28	2011-07-12	Banyu Pharmaceutical Co. Ltd	Aminopyrimidine derivatives as PLK1 inhibitors
WO2008133192A1 (en) *	2007-04-19	2008-11-06	Takeda Pharmaceutical Company Limited	Fused imidazole compound and use thereof
EP1992344A1 (en)	2007-05-18	2008-11-19	Institut Curie	P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation
KR101002490B1 (en) *	2007-06-09	2010-12-17	동아제약주식회사	Pharmaceutical composition for treating chronic heart failure containing eudenafil as an active ingredient
CL2009001250A1 (en)	2008-05-21	2010-02-05		2-Fluoro-n-methyl-4- [7- (quinolin-6-ylmethyl) imidazol [1,2-b] [1,2,4] 1,2,4] triazin- dihydrochloric and dibenzenesulfonic acid salt 2-yl] benzamide; intermediate compounds; preparation processes; pharmaceutical composition; and use to treat cancer, atherosclerosis, pulmonary fibrosis, kidney disease, among others.
JP2011525183A (en)	2008-06-20	2011-09-15	ブリストル−マイヤーズスクイブカンパニー	Imidazopyridine and imidazopyrazine compounds useful as kinase inhibitors
EP2307411B1 (en)	2008-06-20	2014-01-01	Bristol-Myers Squibb Company	Triazolopyridine compounds useful as kinase inhibitors
ES2530884T3 (en) *	2009-09-24	2015-03-06	Hoffmann La Roche	Imidazopyridine or imidazopyrimidine derivatives as phosphodiesterase 10A inhibitors
BR112012019302B1 (en)	2010-02-03	2022-06-21	Incyte Holdings Corporation	Imidazo[1,2-b][1,2,4]triazines as c-met inhibitors, composition comprising them and in vitro methods of inhibiting c-met kinase activity, of inhibiting the hgf/ c-meth kinase in a cell and to inhibit the proliferative activity of a cell
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WO2012031057A1 (en)	2010-09-01	2012-03-08	Bristol-Myers Squibb Company	Bms- 582949 for the treatment of resistant rheumatic disease
BR112015025140A2 (en) *	2013-05-23	2017-07-18	Hoffmann La Roche	2-phenylimidazo [1,2-a] pyrimidines as imaging agents
GB201321736D0 (en) *	2013-12-09	2014-01-22	Ucb Pharma Sa	Therapeutic agents
JP6789941B2 (en) *	2014-11-21	2020-11-25	ライジェルファーマシューティカルズ，インコーポレイテッド	Condensed imidazole derivative as a TGF-beta inhibitor
US20190060286A1 (en)	2016-02-29	2019-02-28	University Of Florida Research Foundation, Incorpo	Chemotherapeutic Methods
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2000
- 2000-10-27 AT AT00976710T patent/ATE288915T1/en not_active IP Right Cessation
- 2000-10-27 EP EP00976710A patent/EP1140939B1/en not_active Expired - Lifetime
- 2000-10-27 RU RU2001122339/04A patent/RU2264403C2/en not_active IP Right Cessation
- 2000-10-27 PL PL00348924A patent/PL348924A1/en not_active IP Right Cessation
- 2000-10-27 AU AU14445/01A patent/AU784484B2/en not_active Ceased
- 2000-10-27 DE DE60018037T patent/DE60018037T2/en not_active Expired - Fee Related
- 2000-10-27 US US09/698,448 patent/US6610697B1/en not_active Expired - Lifetime
- 2000-10-27 HU HU0200207A patent/HUP0200207A3/en unknown
- 2000-10-27 ID IDW00200101720A patent/ID29514A/en unknown
- 2000-10-27 CZ CZ20012494A patent/CZ20012494A3/en unknown
- 2000-10-27 WO PCT/US2000/029875 patent/WO2001034605A1/en not_active Ceased
- 2000-10-27 SK SK989-2001A patent/SK9892001A3/en unknown
- 2000-10-27 NZ NZ512957A patent/NZ512957A/en unknown
- 2000-10-27 CN CNB008045682A patent/CN1255406C/en not_active Expired - Fee Related
- 2000-10-27 ES ES00976710T patent/ES2237470T3/en not_active Expired - Lifetime
- 2000-10-27 KR KR1020017008715A patent/KR20010089805A/en not_active Ceased
- 2000-10-27 PT PT00976710T patent/PT1140939E/en unknown
- 2000-10-27 MX MXPA01007019A patent/MXPA01007019A/en active IP Right Grant
- 2000-10-27 CA CA002361139A patent/CA2361139A1/en not_active Abandoned
- 2000-10-27 BR BR0007447-0A patent/BR0007447A/en not_active IP Right Cessation
- 2000-10-27 UA UA2001075135A patent/UA70350C2/en unknown
- 2000-10-27 HK HK02105224.5A patent/HK1043591B/en not_active IP Right Cessation
- 2000-10-27 JP JP2001536552A patent/JP2003513977A/en active Pending
- 2000-11-09 AR ARP000105910A patent/AR026410A1/en not_active Application Discontinuation
2001
- 2001-07-10 IL IL144238A patent/IL144238A/en not_active IP Right Cessation
- 2001-07-10 NO NO20013419A patent/NO320422B1/en not_active Application Discontinuation
- 2001-07-17 BG BG105712A patent/BG65106B1/en unknown

Also Published As

Publication number	Publication date
DE60018037D1 (en)	2005-03-17
UA70350C2 (en)	2004-10-15
NO20013419D0 (en)	2001-07-10
NZ512957A (en)	2005-01-28
BG65106B1 (en)	2007-02-28
AU1444501A (en)	2001-06-06
PL348924A1 (en)	2002-06-17
KR20010089805A (en)	2001-10-08
SK9892001A3 (en)	2002-04-04
HK1043591B (en)	2006-12-29
ES2237470T3 (en)	2005-08-01
HUP0200207A2 (en)	2002-05-29
WO2001034605A1 (en)	2001-05-17
JP2003513977A (en)	2003-04-15
BR0007447A (en)	2002-04-09
RU2264403C2 (en)	2005-11-20
AR026410A1 (en)	2003-02-12
EP1140939A1 (en)	2001-10-10
CZ20012494A3 (en)	2001-10-17
HK1043591A1 (en)	2002-09-20
EP1140939B1 (en)	2005-02-09
NO320422B1 (en)	2005-12-05
AU784484B2 (en)	2006-04-13
ID29514A (en)	2001-09-06
US6610697B1 (en)	2003-08-26
CN1342162A (en)	2002-03-27
CA2361139A1 (en)	2001-05-17
CN1255406C (en)	2006-05-10
IL144238A (en)	2007-03-08
NO20013419L (en)	2001-08-27
DE60018037T2 (en)	2006-01-12
HUP0200207A3 (en)	2004-07-28
MXPA01007019A (en)	2002-09-18
PT1140939E (en)	2005-05-31
BG105712A (en)	2002-06-28

Publication	Publication Date	Title
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DE502004007000D1 (en)	2008-06-12	NITROGEN SUBSTITUTED HEXAHYDRO-PYRAZINO 1,2-A PYRIMIDINE-4,7-DION DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, AND THEIR USE AS MEDICAMENTS
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