ATE263766T1 - Verfahren zur synthese von carbapenem- zwischenprodukten - Google Patents
Verfahren zur synthese von carbapenem- zwischenproduktenInfo
- Publication number
- ATE263766T1 ATE263766T1 AT99928594T AT99928594T ATE263766T1 AT E263766 T1 ATE263766 T1 AT E263766T1 AT 99928594 T AT99928594 T AT 99928594T AT 99928594 T AT99928594 T AT 99928594T AT E263766 T1 ATE263766 T1 AT E263766T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- formula
- carbapenem
- compound
- synthesis
- Prior art date
Links
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical compound C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical group CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- -1 carbapenem compound Chemical class 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/02—Preparation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8958598P | 1998-06-17 | 1998-06-17 | |
| PCT/US1999/013263 WO1999065921A1 (en) | 1998-06-17 | 1999-06-11 | Process for the synthesis of carbapenem intermediates, and compounds produced |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE263766T1 true ATE263766T1 (de) | 2004-04-15 |
Family
ID=22218455
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99928594T ATE263766T1 (de) | 1998-06-17 | 1999-06-11 | Verfahren zur synthese von carbapenem- zwischenprodukten |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6489471B1 (de) |
| EP (1) | EP1104424B1 (de) |
| JP (1) | JP2002518402A (de) |
| AT (1) | ATE263766T1 (de) |
| AU (1) | AU744644B2 (de) |
| CA (1) | CA2334820C (de) |
| DE (1) | DE69916287T2 (de) |
| ES (1) | ES2217768T3 (de) |
| WO (1) | WO1999065921A1 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3527554A3 (de) * | 2012-11-12 | 2019-09-25 | Victoria Link Limited | Salz und polymorphe formen von (3r, 4s)-l-((4-amino-5h-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4(methylthiomethyl)pyrrolidin-3-ol(mtdia) |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4309438A (en) | 1977-05-05 | 1982-01-05 | Merck & Co., Inc. | N-Alkyl-N-iminomethyl derivatives of thienamycin |
| US4994568A (en) | 1980-12-18 | 1991-02-19 | Merck & Co., Inc. | 6- and 4-substituted-1-azabicyclo(3.2.0)heptan-3, 7-dione-2-carboxylates |
| US4479947A (en) | 1981-07-13 | 1984-10-30 | Merck & Co., Inc. | Oral absorption enhancement of carboxylic acid pharmaceuticals using (5-alkyl-2-oxo-1,3-dioxolen-4-yl)methyl ester group |
| KR900006449B1 (ko) | 1982-08-24 | 1990-08-31 | 상꾜 가부시끼가이샤 | 아제티디논 화합물의 제조방법 |
| GB8520631D0 (en) | 1985-08-16 | 1985-09-25 | Hoechst Uk Ltd | Derivatives |
| JP2687347B2 (ja) * | 1987-04-22 | 1997-12-08 | 東ソー株式会社 | 芳香族ホスフィンおよびそれを用いる分析法 |
| GB8804058D0 (en) | 1988-02-22 | 1988-03-23 | Fujisawa Pharmaceutical Co | 3-alkenyl-1-azabicyclo(3 2 0)hept-2-ene-2-carboxylic acid compounds |
| JPH03120280A (ja) | 1989-10-03 | 1991-05-22 | Shionogi & Co Ltd | ハロメチルカルバペネム化合物の製法 |
| US5034384A (en) | 1990-08-01 | 1991-07-23 | Merck & Co., Inc. | 2-(9-fluorenonyl)-carbapenem antibacterial agents |
| IL99513A0 (en) | 1990-09-20 | 1992-08-18 | Hoechst Ag | Process for the preparation of carbapenem compounds |
| GB9202298D0 (en) | 1992-02-04 | 1992-03-18 | Ici Plc | Antibiotic compounds |
| EP0695753A1 (de) | 1994-08-05 | 1996-02-07 | Zeneca Limited | Carbapenem-Derivate mit einem bicyclischen Substituenten, Verfahren zu ihrer Herstellung und ihre Verwendung |
| WO1996028455A1 (en) | 1995-03-10 | 1996-09-19 | Meiji Seika Kabushiki Kaisha | Novel carbapenem derivatives |
| WO1997040048A1 (en) * | 1996-04-24 | 1997-10-30 | Merck & Co., Inc. | Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment |
| US5756725A (en) | 1996-04-24 | 1998-05-26 | Merck & Co., Inc. | Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment |
| EP1071685A4 (de) | 1998-04-16 | 2001-07-18 | Merck & Co Inc | Titan-katalysierte herstellung von carbapenem-zwischenprodukten |
-
1999
- 1999-06-11 AT AT99928594T patent/ATE263766T1/de not_active IP Right Cessation
- 1999-06-11 DE DE69916287T patent/DE69916287T2/de not_active Expired - Fee Related
- 1999-06-11 AU AU45628/99A patent/AU744644B2/en not_active Ceased
- 1999-06-11 US US09/719,503 patent/US6489471B1/en not_active Expired - Fee Related
- 1999-06-11 CA CA002334820A patent/CA2334820C/en not_active Expired - Fee Related
- 1999-06-11 JP JP2000554746A patent/JP2002518402A/ja active Pending
- 1999-06-11 EP EP99928594A patent/EP1104424B1/de not_active Expired - Lifetime
- 1999-06-11 ES ES99928594T patent/ES2217768T3/es not_active Expired - Lifetime
- 1999-06-11 WO PCT/US1999/013263 patent/WO1999065921A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999065921A1 (en) | 1999-12-23 |
| AU4562899A (en) | 2000-01-05 |
| ES2217768T3 (es) | 2004-11-01 |
| DE69916287D1 (de) | 2004-05-13 |
| CA2334820A1 (en) | 1999-12-23 |
| EP1104424A4 (de) | 2002-01-23 |
| JP2002518402A (ja) | 2002-06-25 |
| US6489471B1 (en) | 2002-12-03 |
| EP1104424A1 (de) | 2001-06-06 |
| AU744644B2 (en) | 2002-02-28 |
| DE69916287T2 (de) | 2005-03-24 |
| CA2334820C (en) | 2007-01-23 |
| EP1104424B1 (de) | 2004-04-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |