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ATE258176T1 - NEW AZABICYCLO DERIVATIVES AND THEIR USE - Google Patents

NEW AZABICYCLO DERIVATIVES AND THEIR USE

Info

Publication number
ATE258176T1
ATE258176T1 AT00901487T AT00901487T ATE258176T1 AT E258176 T1 ATE258176 T1 AT E258176T1 AT 00901487 T AT00901487 T AT 00901487T AT 00901487 T AT00901487 T AT 00901487T AT E258176 T1 ATE258176 T1 AT E258176T1
Authority
AT
Austria
Prior art keywords
derivatives
azabicyclo derivatives
new
new azabicyclo
labelled
Prior art date
Application number
AT00901487T
Other languages
German (de)
Inventor
Dan Peters
Joergen Scheel-Krueger
Elsebet Oestergaard Nielsen
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Application granted granted Critical
Publication of ATE258176T1 publication Critical patent/ATE258176T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The present invention relates to 8-azabicyclo[3.2.1]oct-2-ene derivatives in their labelled form. Furthermore, the present invention relates to the use of said derivatives in their labelled or unlabelled form in diagnostic methods, in particular for in vivo receptor imaging (neuroimaging).
AT00901487T 1999-01-28 2000-01-28 NEW AZABICYCLO DERIVATIVES AND THEIR USE ATE258176T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA199900106 1999-01-28
DKPA199900950 1999-07-01
PCT/DK2000/000038 WO2000044746A1 (en) 1999-01-28 2000-01-28 Novel azabicyclo derivatives and their use

Publications (1)

Publication Number Publication Date
ATE258176T1 true ATE258176T1 (en) 2004-02-15

Family

ID=26063317

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00901487T ATE258176T1 (en) 1999-01-28 2000-01-28 NEW AZABICYCLO DERIVATIVES AND THEIR USE

Country Status (6)

Country Link
US (1) US6617459B2 (en)
EP (1) EP1149095B1 (en)
AT (1) ATE258176T1 (en)
AU (1) AU2278700A (en)
DE (1) DE60007841T2 (en)
WO (1) WO2000044746A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2269467T3 (en) * 2000-10-13 2007-04-01 Neurosearch A/S TREATMENT OF AFFECTIVE DISORDERS BY THE COMBINED ACTION OF A NICOTINIC RECEIVER AGONIST AND A MONOAMINERGENIC SUBSTANCE.
US20030080191A1 (en) 2001-10-26 2003-05-01 Allen Lubow Method and apparatus for applying bar code information to products during production
US7156308B2 (en) 2001-12-17 2007-01-02 International Barcode Corporation Double-sided bar code doubling as a single bar code
US20070218002A1 (en) * 2004-05-07 2007-09-20 Barrio Jorge R Method for Detecting Alzheimer's Disease and other Forms of Dementia, and Measuring Their Progression
DE602005020314D1 (en) 2004-08-25 2010-05-12 Actelion Pharmaceuticals Ltd Bicyclophone derivatives as renin inhibitors
CN101061117A (en) * 2004-12-22 2007-10-24 神经研究公司 Novel naphthyl substituted azabicyclo derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
KR20070116867A (en) * 2005-04-08 2007-12-11 뉴로서치 에이/에스 (+)-And (-)-8-alkyl-3- (trifluoroalkylsulfonyloxy) -8-azabicycle (3.2.1) oct-2-ene
WO2006117218A2 (en) * 2005-05-04 2006-11-09 Charite Universitätsmedizin - Berlin Serotonin-transport-protein binding radiopharmaceutical for the production of a diagnostic medicament for the diagnosis of headache
EP1728520A1 (en) * 2005-05-04 2006-12-06 Charité - Universitätsmedizin Berlin Use of radiopharmaceutical compounds which are specific binders to serotonine transporters for the preparation of a diagnotic agent for the examination of headache related disorders
US8114382B2 (en) * 2006-12-11 2012-02-14 General Electric Company Myelin detection using benzofuran derivatives
AU2010286595A1 (en) * 2009-08-28 2012-02-23 NEBA Health, LLC. Systems and methods to identify a subgroup of ADHD at higher risk for complicating conditions

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3509161A (en) * 1967-07-10 1970-04-28 Boehringer & Soehne Gmbh 3-phenyl-granatene-(2)-derivatives
GB9507203D0 (en) * 1995-04-07 1995-05-31 Smithkline Beecham Plc Novel compounds
BR9610960A (en) * 1995-10-13 1999-03-02 Neurosearch As Derivatives of 8-azabicycles [3.2.1] oct -2- and their preparation and use
GB9706222D0 (en) * 1997-03-26 1997-05-14 Zeneca Ltd Bicyclic amine derivatives
CN1157392C (en) * 1997-05-30 2004-07-14 神经研究公司 8-Azabicyclo (3,2,1) oct-2-ene and octane derivatives as cholinergic ligands at nicotinic ACH receptors
AU736798B2 (en) * 1997-05-30 2001-08-02 Neurosearch A/S 9-Azabicyclo(3.3.1)non-2-ene and nonane derivatives as cholinergic ligands at nicotinic ACh receptors
AU2609999A (en) * 1998-01-28 1999-08-16 Neurosearch A/S 8-azabicyclo(3.2.1)oct-2-ene derivatives in labelled and use of 8-azabicyclo(3.2.1)oct-2-ene derivatives in labelled and unlabelled form

Also Published As

Publication number Publication date
US20010047028A1 (en) 2001-11-29
US6617459B2 (en) 2003-09-09
WO2000044746A1 (en) 2000-08-03
DE60007841D1 (en) 2004-02-26
EP1149095B1 (en) 2004-01-21
EP1149095A1 (en) 2001-10-31
AU2278700A (en) 2000-08-18
DE60007841T2 (en) 2004-07-08

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Legal Events

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