ATE109766T1 - Acylaminophenolderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen. - Google Patents
Acylaminophenolderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.Info
- Publication number
- ATE109766T1 ATE109766T1 AT92400576T AT92400576T ATE109766T1 AT E109766 T1 ATE109766 T1 AT E109766T1 AT 92400576 T AT92400576 T AT 92400576T AT 92400576 T AT92400576 T AT 92400576T AT E109766 T1 ATE109766 T1 AT E109766T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- represent
- different
- pharmaceutical compositions
- preparation
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 102000007330 LDL Lipoproteins Human genes 0.000 abstract 3
- 108010007622 LDL Lipoproteins Proteins 0.000 abstract 3
- 102000001494 Sterol O-Acyltransferase Human genes 0.000 abstract 2
- 108010054082 Sterol O-acyltransferase Proteins 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 1
- 208000032928 Dyslipidaemia Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052802 copper Inorganic materials 0.000 abstract 1
- 239000010949 copper Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/26—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a saturated carbon skeleton containing rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/27—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9102800A FR2673625B1 (fr) | 1991-03-08 | 1991-03-08 | Nouveaux derives d'acylaminophenol, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE109766T1 true ATE109766T1 (de) | 1994-08-15 |
Family
ID=9410501
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92400576T ATE109766T1 (de) | 1991-03-08 | 1992-03-06 | Acylaminophenolderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5254590A (de) |
| EP (1) | EP0508842B1 (de) |
| JP (1) | JPH07587B2 (de) |
| AT (1) | ATE109766T1 (de) |
| AU (1) | AU643368B2 (de) |
| CA (1) | CA2062437A1 (de) |
| DE (1) | DE69200311T2 (de) |
| DK (1) | DK0508842T3 (de) |
| ES (1) | ES2062870T3 (de) |
| FR (1) | FR2673625B1 (de) |
| IE (1) | IE65579B1 (de) |
| NZ (1) | NZ241864A (de) |
| ZA (1) | ZA921703B (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3720395B2 (ja) | 1994-09-20 | 2005-11-24 | 京都薬品工業株式会社 | 新規ヘテロ環誘導体、その製造方法およびその医薬用途 |
| EP0726247B1 (de) * | 1995-02-08 | 1998-07-08 | Nippon Shoji Kaisha, Limited | Anilinderivate, die einen mehrfach ungesättigten Fettsäurerest tragen und ihre Anwendung |
| KR100388345B1 (ko) * | 1995-10-05 | 2004-03-30 | 교토 야쿠힝 고교 가부시키가이샤 | 신규헤테로시클릭유도체및이것의의약용도 |
| FR2741619B1 (fr) * | 1995-11-28 | 1998-02-13 | Pf Medicament | Nouveaux derives de 2,3,5-trimethyl-4-hydroxy-anilides, leur preparation et leur application en therapeutique |
| AU3458697A (en) * | 1996-07-12 | 1998-02-09 | Yamanouchi Pharmaceutical Co., Ltd. | Propionanilide derivatives or salts thereof |
| IT1309421B1 (it) | 1998-09-16 | 2002-01-23 | Med Dia S R L | Impiego della batocuproina (acido disolfonico) per la valutazione delpotere antiossidante (pao) nei liquidi e soluzioni. |
| PL374919A1 (en) | 2002-07-17 | 2005-11-14 | Kyoto Pharmaceutical Industries, Ltd. | Novel indoline compound and medicinal use thereof |
| US7566808B2 (en) * | 2004-02-17 | 2009-07-28 | President And Fellows Of Harvard College | Management of ophthalmologic disorders, including macular degeneration |
| US20050288379A1 (en) * | 2004-06-21 | 2005-12-29 | Xiaoqiang Yan | Benzoquinone compounds as anti-cancer agents |
| EP1784172A4 (de) * | 2004-06-21 | 2007-12-19 | Hutchison Medipharma Entpr Ltd | Krebs-chemotherapie |
| US20070286906A1 (en) * | 2006-04-28 | 2007-12-13 | Hutchison Medipharma Enterprises Limited | Dihydrobenzoquinone compounds |
| FR2973374B1 (fr) * | 2011-04-04 | 2013-08-23 | Pf Medicament | Nouveaux alkylthioethers, leur preparation et leur application en therapeutique |
| WO2014080306A2 (en) * | 2012-11-20 | 2014-05-30 | Mahesh Kandula | Compositions and methods for the treatment of cardiovascular diseases |
| EP3186046B1 (de) | 2014-08-26 | 2021-01-06 | Kando Innovation Limited | Produktivitätsverbesserung für bandsäge |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2852540A (en) * | 1954-08-09 | 1958-09-16 | Exxon Research Engineering Co | Oil soluble alkali and alkaline earth metal salts of p-acylamino phenols |
| US3621043A (en) * | 1963-02-06 | 1971-11-16 | Sumitomo Chemical Co | N-substituted octadecadienoic acid amides as cholesterol lowering agents |
| GB1051286A (de) * | 1964-04-28 | |||
| US3479377A (en) * | 1965-12-20 | 1969-11-18 | Ashland Oil Inc | Hydroxy phenyl fatty amides and polymers thereof,their preparation and use |
| NL150334B (nl) * | 1966-10-04 | 1976-08-16 | Sumito Chemical | Werkwijze voor het bereiden van een geneesmiddel met cholesterolspiegel-verlagende werking, alsmede gevormd geneesmiddel. |
| US3784577A (en) * | 1971-10-26 | 1974-01-08 | Sumitomo Chemical Co | Fatty acid amide derivatives |
| US4751026A (en) * | 1986-03-24 | 1988-06-14 | Warner-Lambert Company | Substituted anilides of oleic, linoleic, or linolenic acid as inhibitors of acyl-coa:cholesterol acyltransferase |
| US4716175A (en) * | 1987-02-24 | 1987-12-29 | Warner-Lambert Company | Saturated fatty acid amides as inhibitors of acyl-CoA:cholesterol acyltransferase |
| WO1991015464A1 (en) * | 1990-04-11 | 1991-10-17 | Warner-Lambert Company | Amide ester acat inhibitors |
| JPH0454119A (ja) * | 1990-06-20 | 1992-02-21 | Tanabe Seiyaku Co Ltd | ５―リポキシゲナーゼ阻害剤 |
-
1991
- 1991-03-08 FR FR9102800A patent/FR2673625B1/fr not_active Expired - Fee Related
-
1992
- 1992-03-05 US US07/847,599 patent/US5254590A/en not_active Expired - Fee Related
- 1992-03-06 IE IE920719A patent/IE65579B1/en not_active IP Right Cessation
- 1992-03-06 JP JP4049817A patent/JPH07587B2/ja not_active Expired - Lifetime
- 1992-03-06 DK DK92400576.2T patent/DK0508842T3/da active
- 1992-03-06 AU AU11469/92A patent/AU643368B2/en not_active Ceased
- 1992-03-06 AT AT92400576T patent/ATE109766T1/de not_active IP Right Cessation
- 1992-03-06 ZA ZA921703A patent/ZA921703B/xx unknown
- 1992-03-06 DE DE69200311T patent/DE69200311T2/de not_active Expired - Fee Related
- 1992-03-06 NZ NZ241864A patent/NZ241864A/en unknown
- 1992-03-06 CA CA002062437A patent/CA2062437A1/fr not_active Abandoned
- 1992-03-06 ES ES92400576T patent/ES2062870T3/es not_active Expired - Lifetime
- 1992-03-06 EP EP92400576A patent/EP0508842B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH07587B2 (ja) | 1995-01-11 |
| IE920719A1 (en) | 1992-09-09 |
| DE69200311T2 (de) | 1995-03-30 |
| DE69200311D1 (de) | 1994-09-15 |
| NZ241864A (en) | 1993-10-26 |
| EP0508842B1 (de) | 1994-08-10 |
| ZA921703B (en) | 1992-11-25 |
| AU643368B2 (en) | 1993-11-11 |
| ES2062870T3 (es) | 1994-12-16 |
| JPH04327564A (ja) | 1992-11-17 |
| CA2062437A1 (fr) | 1992-09-09 |
| IE65579B1 (en) | 1995-11-01 |
| US5254590A (en) | 1993-10-19 |
| DK0508842T3 (da) | 1995-01-02 |
| FR2673625A1 (fr) | 1992-09-11 |
| EP0508842A1 (de) | 1992-10-14 |
| AU1146992A (en) | 1992-09-10 |
| FR2673625B1 (fr) | 1993-05-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE109766T1 (de) | Acylaminophenolderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen. | |
| DE59204094D1 (de) | Amidinophenylalaninderivate, Verfahren zu deren Herstellung, deren Verwendung und diese enthaltende Mittel als Antikoagulantien. | |
| ES2095432T3 (es) | Derivados de 2,4-tiazolidin-diona, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. | |
| ES2074846T3 (es) | Nuevas naftil-etil-ureas y naftil-etil-tioureas, su procedimiento de preparacion y las composiciones farmaceuticas que las contienen. | |
| DE59108530D1 (de) | Antimikrobielle Mittel sowie substituierte 2-Cyclohexan-1-yl-amin-Derivate und deren Herstellung | |
| ES2102475T3 (es) | Nuevas alquil-amidas heterociclicas, su procedimiento de preparacion y composiciones farmaceuticas que las contienen. | |
| ES2128519T3 (es) | Nuevas pirido-tiadiazinas, su procedimiento de preparacion y composiciones farmaceuticas que las contienen. | |
| ATE138647T1 (de) | 23-oxa-derivate in der vitamin-d-reihe, verfahren zu ihrer herstellung, diese derivate enthaltende pharmazeutische präparate sowie deren verwendung als arzneimittel | |
| ES2122637T3 (es) | Derivados de tiazolidina, su preparacion y los medicamentos que les contienen. | |
| ES2055637T3 (es) | Nuevos compuestos poli-yodados, procedimiento de preparacion, producto de contraste que los contiene. | |
| UA50711C2 (uk) | Антрациклінові похідні, їх застосування при лікуванні амілоїдозу та фармацевтична композиція | |
| ES2098023T3 (es) | Compuestos de estructura guanidinica y composiciones farmaceuticas que los contienen. | |
| ES2176321T3 (es) | Derivados tetrasustituidos del imidazol, su procedimiento de preparacion, su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen. | |
| ES2129112T3 (es) | Compuestos aromaticos policiclicos, composiciones farmaceuticas y cosmeticas que los contienen y utilizaciones. | |
| DE69321861D1 (de) | 3-Aminochroman-Spiroderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen | |
| ES2111871T3 (es) | Nuevos derivados de aminoacidos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen. | |
| DK0609336T3 (da) | Anvendelse af prostacyclin-derivater til forebyggelse eller behandling af lidelser i mikrocirkulationssystemet ved administ | |
| DE3870167D1 (de) | N-(vinblastinoyl-23)-derivate von 1-aminomethylposphonsaeure, verfahren zu ihrer herstellung und sie enthaltende arzneimittel. | |
| DE69201368D1 (de) | 1-(Alkoxybenzyl)piperazineamide, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen. | |
| MX9203577A (es) | Nuevos derivados de sinergistinas y composiciones farmaceuticas que los contienen. | |
| DE59008921D1 (de) | Dibenzo(1,5)dioxocin-5-one-Derivate, ihre Verwendung in Arzneimitteln und Verfahren zu ihrer Herstellung. | |
| ATE10841T1 (de) | Tricyclische thiazolyloxamidsaeuren und derivate, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel. | |
| AR016212A1 (es) | Uso de compuestos farmaceuticos que tienen una actividad antagonista de nmda para preparar un medicamento para el tratamiento del sindrome de intestino irritable (ibs), y composiciones farmaceuticas | |
| ATE89261T1 (de) | Aryloxypropanolaminotetraline, verfahren zu ihrer herstellung und diese verbindungen enthaltendes arzneimittel. | |
| ES2095431T3 (es) | N-(isoquinolein-5-il)-sulfonil-azacicloalcanos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |