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ATE171474T1 - Hochstabile rekombinante hefen für die herstellung von rekombinanten proteinen - Google Patents

Hochstabile rekombinante hefen für die herstellung von rekombinanten proteinen

Info

Publication number
ATE171474T1
ATE171474T1 AT92918054T AT92918054T ATE171474T1 AT E171474 T1 ATE171474 T1 AT E171474T1 AT 92918054 T AT92918054 T AT 92918054T AT 92918054 T AT92918054 T AT 92918054T AT E171474 T1 ATE171474 T1 AT E171474T1
Authority
AT
Austria
Prior art keywords
recombinant
yeasts
highly stable
production
proteins
Prior art date
Application number
AT92918054T
Other languages
English (en)
Inventor
Reinhard Fleer
Alain Fournier
Patrice Yeh
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Application granted granted Critical
Publication of ATE171474T1 publication Critical patent/ATE171474T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
AT92918054T 1991-08-02 1992-08-03 Hochstabile rekombinante hefen für die herstellung von rekombinanten proteinen ATE171474T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9109854A FR2679920A1 (fr) 1991-08-02 1991-08-02 Levures recombinantes hautement stables pour la production de proteines recombinantes, leur preparation et leur utilisation.

Publications (1)

Publication Number Publication Date
ATE171474T1 true ATE171474T1 (de) 1998-10-15

Family

ID=9415866

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92918054T ATE171474T1 (de) 1991-08-02 1992-08-03 Hochstabile rekombinante hefen für die herstellung von rekombinanten proteinen

Country Status (13)

Country Link
US (2) USRE37767E1 (de)
EP (2) EP0597035B1 (de)
JP (1) JPH06509234A (de)
AT (1) ATE171474T1 (de)
AU (1) AU2474892A (de)
CA (1) CA2113551A1 (de)
DE (1) DE69227116T2 (de)
DK (1) DK0597035T3 (de)
ES (1) ES2123006T3 (de)
FR (1) FR2679920A1 (de)
NZ (1) NZ243782A (de)
WO (1) WO1993003159A1 (de)
ZA (1) ZA925735B (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6265186B1 (en) 1997-04-11 2001-07-24 Dsm N.V. Yeast cells comprising at least two copies of a desired gene integrated into the chromosomal genome at more than one non-ribosomal RNA encoding domain, particularly with Kluyveromyces
US6849605B1 (en) * 1999-03-05 2005-02-01 The Trustees Of University Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of viral infections
US7704958B1 (en) 1999-03-05 2010-04-27 Bio Holding, Inc. Methods and compositions for inhibiting apoptosis using serine protease inhibitors
AU3511500A (en) 1999-03-05 2000-09-21 Trustees Of University Technology Corporation, The Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide-induced clinical conditions
DE10101962B4 (de) * 2001-01-17 2006-07-27 Tad Pharma Gmbh DNA-Sequenz mit regulatorischen Bereichen zur Expression von Proteinen
ATE472556T1 (de) * 2002-12-02 2010-07-15 Amgen Fremont Inc Gegen den tumor nekrose faktor gerichtete antikörper und deren verwendungen
US20040220242A1 (en) * 2003-05-02 2004-11-04 Leland Shapiro Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions
DE102008057451A1 (de) * 2008-11-14 2010-05-20 Martin-Luther-Universität Halle-Wittenberg Verfahren zur oralen Vakzinierung mittels rekombinanter Hefen
CA2746818A1 (en) 2008-12-24 2010-07-01 C5 Yeast Company B.V. Xylose isomerase genes and their use in fermentation of pentose sugars
UA108853C2 (uk) 2009-07-10 2015-06-25 Спосіб ферментації галактози
BR112012027024A2 (pt) 2010-04-21 2016-12-06 Dsm Ip Assets Bv processo para a produção de células que são capazes de converter arabinose.
WO2011149353A1 (en) 2010-05-27 2011-12-01 C5 Yeast Company B.V. Yeast strains engineered to produce ethanol from acetic acid and glycerol
EP2576804B1 (de) 2010-05-28 2016-12-14 Codexis, Inc. Pentosefermentierung durch einen rekombinanten mikroorganismus
AU2011315569C1 (en) 2010-10-13 2016-02-04 Dsm Ip Assets B.V. Pentose and glucose fermenting yeast cell
WO2012067510A1 (en) 2010-11-18 2012-05-24 C5 Yeast Company B.V. Yeast strains engineered to produce ethanol from glycerol
WO2012125027A1 (en) 2011-03-14 2012-09-20 Dsm Ip Assets B.V. Yeast strains that ferment uronic acids
WO2012135110A1 (en) 2011-03-30 2012-10-04 Codexis, Inc. Pentose fermentation by a recombinant microorganism
BR112013027197A2 (pt) 2011-04-22 2016-11-29 Dsm Ip Assets Bv célula de levedura capaz de converter açúcares incluindo arabinose e xilose
BR112013033614A2 (pt) 2011-06-30 2018-05-29 Codexis Inc fermentação de pentose por microorganismo recombinante
EP2546336A1 (de) 2011-07-11 2013-01-16 DSM IP Assets B.V. Hefestränge, die Uronsäure verbrauchen und Fermentierungsprodukte wie Ethanol herstellen
AR087423A1 (es) 2011-08-04 2014-03-19 Dsm Ip Assets Bv Celula capaz de fermentar azucares pentosas
EP2554668A1 (de) 2011-08-04 2013-02-06 DSM IP Assets B.V. Zelle zur Fermentierung von Pentosezucker
PL2785849T3 (pl) 2011-11-30 2018-02-28 Dsm Ip Assets B.V. Szczepy drożdży zaprojektowane do produkcji etanolu z kwasu octowego i glicerolu
DK3327112T3 (en) 2012-07-19 2020-05-04 Dsm Ip Assets Bv Agse-deficient stamme
WO2014033019A1 (en) 2012-08-28 2014-03-06 Dsm Ip Assets B.V. Yeast strains engineered to produce ethanol from acetate
WO2014033018A1 (en) 2012-08-28 2014-03-06 Dsm Ip Assets B.V. Yeast strains engineered to produce ethanol from acetate
US10273507B2 (en) 2012-10-16 2019-04-30 Dsm Ip Assets B.V. Cells with improved pentose conversion
CA2891482A1 (en) 2012-11-20 2014-05-30 Codexis, Inc. Pentose fermentation by a recombinant microorganism
ES2802807T3 (es) 2013-02-04 2021-01-21 Dsm Ip Assets Bv Polipéptido degradador de carbohidratos y sus usos
WO2014202622A2 (en) 2013-06-19 2014-12-24 Dsm Ip Assets B.V. Rasamsonia gene and use thereof
WO2014202620A2 (en) 2013-06-19 2014-12-24 Dsm Ip Assets B.V. Rasamsonia gene and use thereof
WO2014202624A2 (en) 2013-06-19 2014-12-24 Dsm Ip Assets B.V. Rasamsonia gene and use thereof
WO2014202621A1 (en) 2013-06-20 2014-12-24 Dsm Ip Assets B.V. Carbohydrate degrading polypeptide and uses thereof
WO2014207113A1 (en) 2013-06-26 2014-12-31 Abengoa Bioenergia Nuevas Tecnologias S.A. Yeasts engineered for the production of valuable chemicals from sugars
WO2015160257A1 (en) 2014-04-18 2015-10-22 Moralco B.V. Use of acetaldehyde in the fermentative production of ethanol
DE102014210308A1 (de) 2014-05-30 2015-12-03 Wacker Chemie Ag Hefestamm zur Produktion von Carotinoiden
WO2017050652A1 (en) 2015-09-25 2017-03-30 Dsm Ip Assets B.V. Asparaginase
CA3009871A1 (en) 2015-12-30 2017-07-06 Dsm Ip Assets B.V. Partial enzymatic hydrolysis of triacylglycerols
CA3010288A1 (en) 2015-12-30 2017-07-06 Dsm Ip Assets B.V. Partial enzymatic hydrolysis of triacylglycerols
WO2017211930A1 (en) 2016-06-10 2017-12-14 Dsm Ip Assets B.V. Mutant lipase and use thereof
US11692187B2 (en) 2016-12-21 2023-07-04 Vib Vzw Xylose isomerases that confer efficient xylose fermentation capability to yeast
US11739166B2 (en) 2020-07-02 2023-08-29 Davol Inc. Reactive polysaccharide-based hemostatic agent
US12161777B2 (en) 2020-07-02 2024-12-10 Davol Inc. Flowable hemostatic suspension
JP2024500994A (ja) 2020-12-28 2024-01-10 デボル，インコーポレイテッド タンパク質及び多官能化変性ポリエチレングリコール系架橋剤を含む反応性乾燥粉末状止血用材料
EP4415737A2 (de) * 2021-10-15 2024-08-21 The Trustees Of Columbia University In The City Of New York Zusammensetzungen und verfahren zur behandlung von hauterkrankungen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857467A (en) * 1986-07-23 1989-08-15 Phillips Petroleum Company Carbon and energy source markers for transformation of strains of the genes Pichia
FR2635115B1 (fr) * 1988-08-05 1992-04-03 Rhone Poulenc Sante Procede de preparation de la serum albumine humaine a partir d'une levure
FR2649991B2 (fr) * 1988-08-05 1994-03-04 Rhone Poulenc Sante Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces

Also Published As

Publication number Publication date
AU2474892A (en) 1993-03-02
USRE37767E1 (en) 2002-06-25
EP0597035A1 (de) 1994-05-18
JPH06509234A (ja) 1994-10-20
DE69227116D1 (de) 1998-10-29
FR2679920B1 (de) 1994-08-19
CA2113551A1 (fr) 1993-02-18
ZA925735B (en) 1993-04-28
ES2123006T3 (es) 1999-01-01
WO1993003159A1 (fr) 1993-02-18
DE69227116T2 (de) 1999-03-25
EP0531181A1 (de) 1993-03-10
US5593858A (en) 1997-01-14
FR2679920A1 (fr) 1993-02-05
NZ243782A (en) 1994-07-26
EP0597035B1 (de) 1998-09-23
DK0597035T3 (da) 1999-02-15

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