ATE163012T1 - N-substituierte 4-pyrimidinamine und - pyrimidindiamine, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel - Google Patents

N-substituierte 4-pyrimidinamine und - pyrimidindiamine, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel

Info

Publication number: ATE163012T1
Authority: AT; Austria
Prior art keywords: loweralkyl; hydrogen; pyrimidinamines; aryl; pyrimidindiamines
Prior art date: 1989-09-05

Application number

AT90116826T

Other languages

English (en)

Inventor

Richard Charles Effland

Joseph Thomas Klein

Larry Davis

Gordon Edward Olsen

Original Assignee

Hoechst Marion Roussel Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-09-05

Filing date

1990-09-01

Publication date

1998-02-15

1990-09-01 Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc

1998-02-15 Application granted granted Critical

1998-02-15 Publication of ATE163012T1 publication Critical patent/ATE163012T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT90116826T 1989-09-05 1990-09-01 N-substituierte 4-pyrimidinamine und - pyrimidindiamine, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel ATE163012T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/402,415 US4983608A (en)	1989-09-05	1989-09-05	N-substituted-4-pyrimidinamines and pyrimidinediamines

Publications (1)

Publication Number	Publication Date
ATE163012T1 true ATE163012T1 (de)	1998-02-15

Family

ID=23591798

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90116826T ATE163012T1 (de)	1989-09-05	1990-09-01	N-substituierte 4-pyrimidinamine und - pyrimidindiamine, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel

Country Status (18)

Country	Link
US (1)	US4983608A (de)
EP (1)	EP0417584B1 (de)
JP (1)	JPH07116181B2 (de)
KR (1)	KR0162641B1 (de)
AT (1)	ATE163012T1 (de)
AU (1)	AU626450B2 (de)
CA (1)	CA2024572C (de)
DE (1)	DE69032020T2 (de)
DK (1)	DK0417584T3 (de)
ES (1)	ES2112830T3 (de)
FI (1)	FI904327A7 (de)
GR (1)	GR3026318T3 (de)
IE (1)	IE903213A1 (de)
IL (1)	IL95568A (de)
NO (1)	NO903851L (de)
NZ (1)	NZ235145A (de)
PT (1)	PT95202B (de)
ZA (1)	ZA907033B (de)

Families Citing this family (56)

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US5214038A (en) *	1991-04-15	1993-05-25	Hoechst-Roussel Pharmaceuticals Inc.	1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles and intermediates for the preparation thereof
US5319096A (en) *	1992-04-03	1994-06-07	Hoechst-Roussel Pharmaceuticals Inc.	(1H-indol-1-yl)-2-(amino) acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, pharmaceutical composition and use
US5459274A (en) *	1994-05-13	1995-10-17	Hoechst-Roussel Pharmaceuticals Inc.	Preparation of N-alkyl-N-pyridinyl-1H-indol-1-amines
US5935966A (en) *	1995-09-01	1999-08-10	Signal Pharmaceuticals, Inc.	Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions
JPH11512390A (ja) *	1995-09-01	1999-10-26	シグナルファーマシューティカルズ，インコーポレイテッド	ピリミジンカルボキシレートおよび関連化合物ならびに炎症状態を処置するための方法
US5852028A (en) *	1995-12-18	1998-12-22	Signal Pharmaceuticals, Inc.	Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions
ZA989365B (en) *	1997-10-15	1999-04-15	Boehringer Mannheim Pharm Corp	Preparation for treating alzheimer's disease
IL137922A0 (en)	1998-02-17	2001-10-31	Tularik Inc	Anti-viral pyrimidine derivatives
ES2274634T3 (es) *	1998-08-29	2007-05-16	Astrazeneca Ab	Compuestos de pirimidina.
ATE336484T1 (de)	1998-08-29	2006-09-15	Astrazeneca Ab	Pyrimidine verbindungen
GB9828511D0 (en)	1998-12-24	1999-02-17	Zeneca Ltd	Chemical compounds
GB9905075D0 (en)	1999-03-06	1999-04-28	Zeneca Ltd	Chemical compounds
GB9907658D0 (en)	1999-04-06	1999-05-26	Zeneca Ltd	Chemical compounds
GB9919778D0 (en)	1999-08-21	1999-10-27	Zeneca Ltd	Chemical compounds
AU770600B2 (en) *	1999-10-07	2004-02-26	Amgen, Inc.	Triazine kinase inhibitors
US6410726B1 (en)	2000-01-12	2002-06-25	Tularik Inc.	Arylsulfonic acid salts of pyrimidine-based antiviral
US20030004174A9 (en) *	2000-02-17	2003-01-02	Armistead David M.	Kinase inhibitors
GB0004887D0 (en)	2000-03-01	2000-04-19	Astrazeneca Uk Ltd	Chemical compounds
GB0004886D0 (en)	2000-03-01	2000-04-19	Astrazeneca Uk Ltd	Chemical compounds
GB0004888D0 (en) *	2000-03-01	2000-04-19	Astrazeneca Uk Ltd	Chemical compounds
GB0004890D0 (en)	2000-03-01	2000-04-19	Astrazeneca Uk Ltd	Chemical compounds
GB0007371D0 (en)	2000-03-28	2000-05-17	Astrazeneca Uk Ltd	Chemical compounds
GB0016877D0 (en)	2000-07-11	2000-08-30	Astrazeneca Ab	Chemical compounds
GB0021726D0 (en) *	2000-09-05	2000-10-18	Astrazeneca Ab	Chemical compounds
GB0103926D0 (en) *	2001-02-17	2001-04-04	Astrazeneca Ab	Chemical compounds
GB0113041D0 (en)	2001-05-30	2001-07-18	Astrazeneca Ab	Chemical compounds
US7115617B2 (en) *	2001-08-22	2006-10-03	Amgen Inc.	Amino-substituted pyrimidinyl derivatives and methods of use
US6939874B2 (en)	2001-08-22	2005-09-06	Amgen Inc.	Substituted pyrimidinyl derivatives and methods of use
TWI329105B (en) *	2002-02-01	2010-08-21	Rigel Pharmaceuticals Inc	2,4-pyrimidinediamine compounds and their uses
GB0205690D0 (en) *	2002-03-09	2002-04-24	Astrazeneca Ab	Chemical compounds
GB0205688D0 (en) *	2002-03-09	2002-04-24	Astrazeneca Ab	Chemical compounds
GB0205693D0 (en) *	2002-03-09	2002-04-24	Astrazeneca Ab	Chemical compounds
WO2003076434A1 (en) *	2002-03-09	2003-09-18	Astrazeneca Ab	4- imidazolyl substuited pyrimidine derivatives with cdk inhibitiory activity
NZ537752A (en)	2002-07-29	2006-12-22	Rigel Pharmaceuticals Inc	Use of 2,4-pyrimidinediamine compounds in the preparation of medicaments for treating autoimmune diseases
EP2130541A3 (de)	2002-07-29	2013-12-18	Rigel Pharmaceuticals, Inc.	Verfahren zur Behandlung oder Vorbeugung von Autoimmunerkrankungen mit 2,4-Pyrimidindiaminverbindungen
US7109337B2 (en) *	2002-12-20	2006-09-19	Pfizer Inc	Pyrimidine derivatives for the treatment of abnormal cell growth
UA80767C2 (en) *	2002-12-20	2007-10-25	Pfizer Prod Inc	Pyrimidine derivatives for the treatment of abnormal cell growth
AU2003285614B2 (en) *	2002-12-20	2009-05-14	Pfizer Products, Inc.	Pyrimidine derivatives for the treatment of abnormal cell growth
GB0311274D0 (en) *	2003-05-16	2003-06-18	Astrazeneca Ab	Chemical compounds
GB0311276D0 (en) *	2003-05-16	2003-06-18	Astrazeneca Ab	Chemical compounds
JP4886511B2 (ja) *	2003-07-30	2012-02-29	ライジェルファーマシューティカルズ，インコーポレイテッド	２，４−ピリミジンジアミン化合物による自己免疫疾患の治療または予防方法
TW200528101A (en) *	2004-02-03	2005-09-01	Astrazeneca Ab	Chemical compounds
JP2007537230A (ja) *	2004-05-14	2007-12-20	ファイザー・プロダクツ・インク	異常細胞増殖の処置用のピリミジン誘導体
US20060205945A1 (en) *	2004-05-14	2006-09-14	Pfizer Inc	Pyrimidine derivatives for the treatment of abnormal cell growth
JP2007537238A (ja) *	2004-05-14	2007-12-20	ファイザー・プロダクツ・インク	異常細胞増殖の治療のためのピリミジン誘導体
WO2005111024A1 (en) *	2004-05-14	2005-11-24	Pfizer Products Inc.	Pyrimidine derivatives for the treatment of abnormal cell growth
EP1786783A1 (de) *	2004-09-01	2007-05-23	Rigel Pharmaceuticals, Inc.	Synthese von 2,4-pyrimidindiaminverbindungen
DK1814878T3 (da)	2004-11-24	2012-05-07	Rigel Pharmaceuticals Inc	Spiro-2, 4-pyrimidindiamin-forbindelser og anvendelser deraf
WO2006064251A1 (en) *	2004-12-17	2006-06-22	Astrazeneca Ab	4- (4- (imidazol-4-yl) pyrimidin-2-ylamino) benzamides as cdk inhibitors
CA2604551A1 (en) *	2005-05-03	2007-03-08	Rigel Pharmaceuticals, Inc.	Jak kinase inhibitors and their uses
US20080280906A1 (en) *	2005-07-30	2008-11-13	David Andrews	Imidazolyl-Pyrimidine Compounds for Use in the Treatment of Proliferative Disorders
CA2623374A1 (en) *	2005-09-30	2007-04-05	Astrazeneca Ab	Imidazo [1,2-a] pyridine having anti-cell-proliferation activity
TW200811169A (en) *	2006-05-26	2008-03-01	Astrazeneca Ab	Chemical compounds
CN101657422A (zh)	2007-04-13	2010-02-24	塞诺菲-安万特股份有限公司	过渡金属催化的n-氨基吲哚的合成
GB2553716B (en) *	2015-04-17	2020-06-17	Univ Holy Ghost Duquesne	Pyrrolopyrimidines as antitumor agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4752610A (en) *	1985-12-04	1988-06-21	Hoechst-Roussel Pharmaceuticals Inc.	N-(pyrrol-1-yl)pyridinamines having memory enhancing properties
US4792562A (en)	1985-12-04	1988-12-20	Hoechst-Roussel Pharmaceuticals, Inc.	N-(pyrrol-1-yl)pyridinamines having memory enhancing activity
EP0287982B1 (de) *	1987-04-24	1994-12-07	Hoechst-Roussel Pharmaceuticals Incorporated	N-(Pyridinyl)-1H-indol-1-amine, Verfahren zu deren Herstellung und ihre Verwendung als Arzneimittel
US4806554A (en) *	1988-01-11	1989-02-21	Hoechst-Roussel Pharmaceuticals, Inc.	Pyrazol and indazolpyridinamines
US4868190A (en) *	1988-12-27	1989-09-19	Hoechst-Roussel Pharmaceuticals, Inc.	N-pyridinyl-9H-carbazol-9-amines

1989
- 1989-09-05 US US07/402,415 patent/US4983608A/en not_active Expired - Lifetime
1990
- 1990-09-01 AT AT90116826T patent/ATE163012T1/de not_active IP Right Cessation
- 1990-09-01 ES ES90116826T patent/ES2112830T3/es not_active Expired - Lifetime
- 1990-09-01 DE DE69032020T patent/DE69032020T2/de not_active Expired - Lifetime
- 1990-09-01 EP EP90116826A patent/EP0417584B1/de not_active Expired - Lifetime
- 1990-09-01 DK DK90116826T patent/DK0417584T3/da active
- 1990-09-03 NZ NZ235145A patent/NZ235145A/en unknown
- 1990-09-03 IL IL9556890A patent/IL95568A/en unknown
- 1990-09-03 FI FI904327A patent/FI904327A7/fi not_active IP Right Cessation
- 1990-09-04 KR KR1019900013896A patent/KR0162641B1/ko not_active Expired - Lifetime
- 1990-09-04 AU AU62089/90A patent/AU626450B2/en not_active Ceased
- 1990-09-04 ZA ZA907033A patent/ZA907033B/xx unknown
- 1990-09-04 PT PT95202A patent/PT95202B/pt not_active IP Right Cessation
- 1990-09-04 IE IE321390A patent/IE903213A1/en not_active IP Right Cessation
- 1990-09-04 JP JP2232639A patent/JPH07116181B2/ja not_active Expired - Lifetime
- 1990-09-04 NO NO90903851A patent/NO903851L/no unknown
- 1990-09-04 CA CA002024572A patent/CA2024572C/en not_active Expired - Lifetime
1998
- 1998-03-11 GR GR980400509T patent/GR3026318T3/el unknown

Also Published As

Publication number	Publication date
IE903213A1 (en)	1991-03-13
EP0417584A2 (de)	1991-03-20
IL95568A0 (en)	1991-06-30
JPH0393784A (ja)	1991-04-18
NO903851D0 (no)	1990-09-04
ES2112830T3 (es)	1998-04-16
KR910006277A (ko)	1991-04-29
DE69032020T2 (de)	1998-07-09
AU626450B2 (en)	1992-07-30
US4983608A (en)	1991-01-08
ZA907033B (en)	1991-06-26
DE69032020D1 (de)	1998-03-12
EP0417584A3 (en)	1992-02-26
IL95568A (en)	1995-01-24
CA2024572A1 (en)	1991-03-06
FI904327A0 (fi)	1990-09-03
GR3026318T3 (en)	1998-06-30
PT95202A (pt)	1991-05-22
JPH07116181B2 (ja)	1995-12-13
CA2024572C (en)	2000-09-26
PT95202B (pt)	1997-06-30
KR0162641B1 (ko)	1998-12-01
EP0417584B1 (de)	1998-02-04
NO903851L (no)	1991-03-06
DK0417584T3 (da)	1998-09-23
AU6208990A (en)	1991-03-14
FI904327A7 (fi)	1991-03-06
NZ235145A (en)	1992-12-23

Publication	Publication Date	Title
ATE163012T1 (de)	1998-02-15	N-substituierte 4-pyrimidinamine und - pyrimidindiamine, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel
ATE81123T1 (de)	1992-10-15	3-(4(1-substituierte-4-piperazinyl)butyl>-4thiazolidinone, verfahren zu deren herstellung und ihre anwendung als arzneimittel.
DE3772905D1 (de)	1991-10-17	Alpha-alkyl-4-amino-3-chinolin-methanole und 1-(4-aralkylamino-3-chinolyl)alkanone, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
ES2132284T3 (es)	1999-08-16	Derivados de carbamato de 2-(piperidin-4-il, piridin-4-il y tetrahidropiridin-4-il)-benzofurano-7, su preparacion y su uso como inhibidores de acetilcolinesterasa.
DE69016530D1 (de)	1995-03-16	1,3-Dihydro-1-(pyridinylamino)-2H-indol-2-one, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel.
DE69022294D1 (de)	1995-10-19	N-Heteroaryl-purin-6-amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel.
DE69028605D1 (de)	1996-10-24	Aminocarbonylcarbamate verwandt mit Physostigmin, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
ATE138377T1 (de)	1996-06-15	N-(aryloxyalkyl)heteroaryl-8- azabicyclo(3.2.1>octan, zwischenverbindungen und verfahren zu deren herstellung und deren verwendung als arzneimittel
DE69011013D1 (de)	1994-09-01	1-(Pyridinylamino)-2-pyrrolidinone, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel.
ATE66913T1 (de)	1991-09-15	Amidverbindungen, verfahren zu ihrer herstellung und zusammensetzung zur aktivierung gastromotorischer funktionen.
DE69016531D1 (de)	1995-03-16	2,3-Dihydro-1-(pyridinylamino)-indole, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel.
DE68902386D1 (de)	1992-09-10	N-pyridinyl-9h-carbazol-9-amine, verfahren zu ihrer herstellung und ihre verwendung als medikamente.
DE69110219D1 (de)	1995-07-13	3-(1H-Indazol-3-yl)-4-pyridiname, Verfahren und Zwischenprodukte zu ihrer Herstellung und ihre Verwendung als Arzneimittel.
DE68914600D1 (de)	1994-05-19	Kondensierte heterocyclische Derivate von 1,2,3,4-Tetrahydroacridin, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament.

Legal Events

Date	Code	Title
1998-09-15	UEP	Publication of translation of european patent specification
2005-03-15	EEFA	Change of the company name
2010-12-15	EELA	Cancelled due to lapse of time