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ATA750879A - Verfahren zur herstellung von neuen 1,2,4,5-tetra--alkyl-4-aryl-piperidinen und ihren salzen - Google Patents

Verfahren zur herstellung von neuen 1,2,4,5-tetra--alkyl-4-aryl-piperidinen und ihren salzen

Info

Publication number
ATA750879A
ATA750879A AT0750879A AT750879A ATA750879A AT A750879 A ATA750879 A AT A750879A AT 0750879 A AT0750879 A AT 0750879A AT 750879 A AT750879 A AT 750879A AT A750879 A ATA750879 A AT A750879A
Authority
AT
Austria
Prior art keywords
piperidines
tetra
aryl
salts
alkyl
Prior art date
Application number
AT0750879A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ATA750879A publication Critical patent/ATA750879A/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
AT0750879A 1978-11-29 1979-11-27 Verfahren zur herstellung von neuen 1,2,4,5-tetra--alkyl-4-aryl-piperidinen und ihren salzen ATA750879A (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/965,137 US4284635A (en) 1978-11-29 1978-11-29 Analgesic 1,2,4,5-tetra-alkyl-4-arylpiperidines

Publications (1)

Publication Number Publication Date
ATA750879A true ATA750879A (de) 1983-03-15

Family

ID=25509504

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0750879A ATA750879A (de) 1978-11-29 1979-11-27 Verfahren zur herstellung von neuen 1,2,4,5-tetra--alkyl-4-aryl-piperidinen und ihren salzen

Country Status (26)

Country Link
US (1) US4284635A (de)
EP (1) EP0013078A3 (de)
JP (1) JPS5573657A (de)
KR (1) KR830001214A (de)
AR (1) AR224138A1 (de)
AT (1) ATA750879A (de)
AU (1) AU529136B2 (de)
BE (1) BE880220A (de)
CA (1) CA1121357A (de)
DD (1) DD147537A5 (de)
DK (1) DK504979A (de)
EG (1) EG14137A (de)
ES (2) ES8101551A1 (de)
FI (1) FI793663A7 (de)
FR (2) FR2442836A1 (de)
GB (1) GB2038812B (de)
GR (1) GR72292B (de)
HU (1) HU178532B (de)
IL (1) IL58793A0 (de)
IT (1) IT1126406B (de)
LU (1) LU81923A1 (de)
PH (1) PH15420A (de)
PL (1) PL123672B1 (de)
PT (1) PT70486A (de)
SU (1) SU967275A3 (de)
ZA (1) ZA796336B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5212183A (en) * 1981-11-14 1993-05-18 Basf Aktiengesellschaft 4-(p-tert.-butylphenyl)-3-methylpiperidines substituted at the nitrogen, their quaternary salts and their use as fungicides
US4485109A (en) * 1982-05-07 1984-11-27 E. I. Du Pont De Nemours And Company 4-Aryl-4-piperidinecarbinols
US4581456A (en) * 1983-09-21 1986-04-08 Eli Lilly And Company Processes for preparing picenadol precursors and novel intermediates thereof
ZW10287A1 (en) * 1986-07-15 1988-01-13 Hoffmann La Roche Tetrahydronaphthaline and indane derivatives
EP0299549A3 (de) * 1987-07-09 1989-02-08 Duphar International Research B.V Tertiäre 2,5-Dialkyl-3-phenyl-piperidin-Derivate mit Opiatantagonistischer Wirkung
CA1337418C (en) * 1988-03-28 1995-10-24 Engelbert Ciganek 4-aryl-4-piperiding (or pyrrolidine or hexahydroazepine) carbinols and heterocyclic analogs thereof
US5136040A (en) * 1991-02-26 1992-08-04 Eli Lilly And Company Preparation of substituted tetrahydropyridines
US5159081A (en) * 1991-03-29 1992-10-27 Eli Lilly And Company Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists
US5270328A (en) * 1991-03-29 1993-12-14 Eli Lilly And Company Peripherally selective piperidine opioid antagonists
US5250542A (en) * 1991-03-29 1993-10-05 Eli Lilly And Company Peripherally selective piperidine carboxylate opioid antagonists
GB9912413D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912411D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912417D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912410D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912415D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912416D0 (en) * 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2892842A (en) * 1959-06-30 Their preparation
US2956058A (en) * 1957-08-19 1960-10-11 Lilly Co Eli Novel substituted piperidines and pyrrolidines
US3043845A (en) * 1958-12-29 1962-07-10 Abbott Lab Phenylmethylpiperidine derivatives
US3080372A (en) * 1960-03-25 1963-03-05 Res Lab Dr C Janssen 1-aroylalkyl-4-arylpiperidine derivatives
NL123743C (de) * 1963-09-18
US3574219A (en) * 1967-09-27 1971-04-06 Tanabe Seiyaku Co 1-(beta-hydroxyphenethyl)-2,3-dimethyl-3-(3-hydroxyphenyl)-piperidine
US3936468A (en) * 1969-10-27 1976-02-03 Sumitomo Chemical Company, Ltd. Phenylbutanol derivatives
GB1403942A (en) * 1973-04-05 1975-08-28 Ciba Geigy Ag Piperidine derivatives
AR206937A1 (es) * 1974-09-06 1976-08-31 Lilly Co Eli Procedimiento para preparar compuestos de 1-sustituido-4-alquil-4-fenil-piperidina
US4115400A (en) * 1976-05-27 1978-09-19 Eli Lilly And Company 1-Azoniabicyclo[3.1.0]hexanes
ZA777356B (en) * 1976-12-17 1979-01-31 Rohm & Haas Arthropod repellents

Also Published As

Publication number Publication date
HU178532B (en) 1982-05-28
SU967275A3 (ru) 1982-10-15
IT7927614A0 (it) 1979-11-27
AU529136B2 (en) 1983-05-26
ZA796336B (en) 1981-06-24
BE880220A (fr) 1980-05-23
IT1126406B (it) 1986-05-21
FR2442836B1 (de) 1983-07-29
PL219885A1 (de) 1980-12-01
AR224138A1 (es) 1981-10-30
EG14137A (en) 1983-09-30
US4284635A (en) 1981-08-18
PL123672B1 (en) 1982-11-30
FR2453154A1 (fr) 1980-10-31
ES8200664A1 (es) 1981-11-16
GB2038812B (en) 1983-01-06
ES486425A0 (es) 1980-12-16
FR2442836A1 (fr) 1980-06-27
IL58793A0 (en) 1980-02-29
KR830001214A (ko) 1983-04-29
EP0013078A3 (de) 1980-10-01
GR72292B (de) 1983-10-17
FR2453154B1 (de) 1983-05-27
ES8101551A1 (es) 1980-12-16
GB2038812A (en) 1980-07-30
JPS5573657A (en) 1980-06-03
PT70486A (en) 1979-12-01
DK504979A (da) 1980-05-30
DD147537A5 (de) 1981-04-08
CA1121357A (en) 1982-04-06
ES493915A0 (es) 1981-11-16
PH15420A (en) 1983-01-07
FI793663A7 (fi) 1980-05-30
LU81923A1 (fr) 1980-04-22
AU5310079A (en) 1980-05-29
EP0013078A2 (de) 1980-07-09

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