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ATA151591A - Gereinigte polypeptide mit einem molekulargewicht von mindestens 35.000 und verfahren zu ihrer herstellung - Google Patents

Gereinigte polypeptide mit einem molekulargewicht von mindestens 35.000 und verfahren zu ihrer herstellung

Info

Publication number
ATA151591A
ATA151591A AT0151591A AT151591A ATA151591A AT A151591 A ATA151591 A AT A151591A AT 0151591 A AT0151591 A AT 0151591A AT 151591 A AT151591 A AT 151591A AT A151591 A ATA151591 A AT A151591A
Authority
AT
Austria
Prior art keywords
production
molecular weight
purified polypeptides
polypeptides
purified
Prior art date
Application number
AT0151591A
Other languages
English (en)
Other versions
AT402503B (de
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909016882A external-priority patent/GB9016882D0/en
Priority claimed from GB909016840A external-priority patent/GB9016840D0/en
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of ATA151591A publication Critical patent/ATA151591A/de
Application granted granted Critical
Publication of AT402503B publication Critical patent/AT402503B/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/88—Post-polymerisation treatment
    • C08G63/90—Purification; Drying

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT0151591A 1990-08-01 1991-07-30 Gereinigte polypeptide mit einem molekulargewicht von mindestens 35.000 und verfahren zu ihrer herstellung AT402503B (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909016882A GB9016882D0 (en) 1990-08-01 1990-08-01 Improvements in or relating to organic compounds
GB909016840A GB9016840D0 (en) 1990-08-01 1990-08-01 Improvements in or relating to organic compounds

Publications (2)

Publication Number Publication Date
ATA151591A true ATA151591A (de) 1996-10-15
AT402503B AT402503B (de) 1997-06-25

Family

ID=26297417

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0151591A AT402503B (de) 1990-08-01 1991-07-30 Gereinigte polypeptide mit einem molekulargewicht von mindestens 35.000 und verfahren zu ihrer herstellung

Country Status (27)

Country Link
EP (2) EP0469520B1 (de)
JP (1) JP3137368B2 (de)
KR (1) KR100255904B1 (de)
AT (1) AT402503B (de)
AU (1) AU650277B2 (de)
CA (1) CA2048200C (de)
CH (1) CH683772A5 (de)
CY (1) CY1986A (de)
DE (1) DE4124468B4 (de)
DK (2) DK0469520T3 (de)
ES (2) ES2243966T3 (de)
FI (2) FI108040B (de)
FR (1) FR2665453B1 (de)
GB (1) GB2246573B (de)
GR (1) GR3026322T3 (de)
HK (1) HK11797A (de)
HU (1) HUT59837A (de)
IE (1) IE66185B1 (de)
IL (1) IL99007A (de)
IT (1) IT1252944B (de)
LU (1) LU87985A1 (de)
MY (1) MY108621A (de)
NO (1) NO912960D0 (de)
NZ (1) NZ239184A (de)
PH (1) PH31047A (de)
PT (1) PT98491B (de)
TW (2) TW218025B (de)

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US5527524A (en) * 1986-08-18 1996-06-18 The Dow Chemical Company Dense star polymer conjugates
US5560929A (en) * 1986-08-18 1996-10-01 The Dow Chemical Company Structured copolymers and their use as absorbents, gels and carriers of metal ions
US5225521A (en) * 1991-12-31 1993-07-06 E. I. Du Pont De Nemours And Company Star-shaped hydroxyacid polymers
US5525357A (en) * 1992-08-24 1996-06-11 The United States Of America As Represented By The Department Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US5405919A (en) * 1992-08-24 1995-04-11 The United States Of America As Represented By The Secretary Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders
US6200558B1 (en) 1993-09-14 2001-03-13 The United States Of America As Represented By The Department Of Health And Human Services Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
JPH06116381A (ja) * 1992-10-09 1994-04-26 Mitsui Toatsu Chem Inc ポリヒドロキシカルボン酸の精製方法
DE4412317A1 (de) * 1993-04-21 1994-10-27 Basf Ag Polylactid mit verbreiterter Molmassenverteilung
US5359026A (en) * 1993-07-30 1994-10-25 Cargill, Incorporated Poly(lactide) copolymer and process for manufacture thereof
US5496923A (en) * 1993-09-20 1996-03-05 Mitsui Toatsu Chemicals, Inc. Purification process of aliphatic polyester
RU2178695C2 (ru) * 1993-11-19 2002-01-27 Жансен Фармасетика Н.В. Микрокапсулы, содержащие рисперидон, фармацевтическая композиция и способы их получения
DE69533569T2 (de) * 1994-03-07 2006-01-05 Dendritic Nanotechnologies, Inc., Mt. Pleasant Bioaktive und/oder gezielte dendrimere-konjugate enthaltend genetisches material
PT1112095E (pt) 1998-09-11 2003-04-30 Axel Stemberger Implantes biologicamente activos
US6362308B1 (en) 2000-08-10 2002-03-26 Alkermes Controlled Therapeutics Inc. Ii Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content
WO2003006525A1 (en) * 2001-07-10 2003-01-23 Kureha Chemical Industry Company, Limited Polyhydroxycarboxylic acid and its production process
FR2830448B1 (fr) * 2001-10-10 2004-03-19 Pf Medicament Microspheres biodegradables a liberation prolongee et leur procede de preparation
MXPA04003433A (es) * 2001-10-10 2004-08-11 Pf Medicament Microesferas biodegradables de liberacion prolongada y metodo para preparar las mismas.
AU2013204972B2 (en) * 2002-11-19 2016-04-21 Novartis Ag Pharmaceutical composition comprising octreotide microparticles
US20040097419A1 (en) * 2002-11-19 2004-05-20 Holger Petersen Organic compounds
GB0226993D0 (en) * 2002-11-19 2002-12-24 Novartis Ag Organic compounds
ATE549011T1 (de) 2005-11-10 2012-03-15 Chemi Spa Formulierungen mit verzögerter freisetzung, die somatostatin-analoge wachstumshormoninhibitoren enthalten
CN101193531B (zh) 2006-11-29 2010-12-01 富准精密工业(深圳)有限公司 散热装置
CN101910246B (zh) * 2007-12-31 2013-01-02 株式会社三养生物制药 包含源自α-羟酸的疏水嵌段的高纯两亲共聚物及其制备方法
EP2411440B1 (de) * 2009-03-23 2018-01-17 Micell Technologies, Inc. Verbesserte biologisch abbaubare polymere
JP5594996B2 (ja) 2009-09-14 2014-09-24 三菱重工業株式会社 航空機の操縦システム
WO2011162534A2 (ko) 2010-06-21 2011-12-29 주식회사 엘지화학 내열성이 우수한 폴리락타이드 수지 및 이의 제조방법
EP2455414A1 (de) * 2010-11-17 2012-05-23 Evonik Röhm GmbH Verfahren zur Herstellung von hochmolekularen, resorbierbaren Polyestern, die mit dem Verfahren herstellbaren hochmolekularen resorbierbaren Polyester und deren Verwendung
EP2455415A1 (de) * 2010-11-17 2012-05-23 Evonik Röhm GmbH Verfahren zur Herstellung von niedermolekularen, resorbierbaren Polyestern, die mit dem Verfahren herstellbaren niedermolekularen resorbierbaren Polyester und deren Verwendung
CN105820332B (zh) * 2015-01-09 2018-06-29 北京化工大学 一种星形聚氨基酸和星形聚氨基酸载药纳米胶束及制备方法
WO2017132350A1 (en) * 2016-01-29 2017-08-03 Tolmar Inc. Purification and decolorization of polymers
WO2019046748A1 (en) * 2017-08-31 2019-03-07 Evonik Corporation ENHANCED RESORBABLE POLYMER PURIFICATION METHOD
GR1009392B (el) * 2017-09-19 2018-10-25 Φαρματεν Αβεε Φαρμακευτικο σκευασμα που περιλαμβανει ενα πεπτιδικο φαρμακο και μεθοδος για την παρασκευη αυτου
GB2568526A (en) * 2017-11-20 2019-05-22 Rebio Tech Oy Composition
CN112940234B (zh) * 2021-01-28 2022-05-03 广东粤港澳大湾区黄埔材料研究院 一种高纯度聚乙丙交酯的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1467970A (en) * 1975-05-02 1977-03-23 Ici Ltd Purification of polyethers
US4273920A (en) * 1979-09-12 1981-06-16 Eli Lilly And Company Polymerization process and product
CH656884A5 (de) * 1983-08-26 1986-07-31 Sandoz Ag Polyolester, deren herstellung und verwendung.
CA1236641A (en) * 1984-07-06 1988-05-10 Motoaki Tanaka Copolymer of lactic acid and glycolic acid and method for producing same
CA1268481A (en) * 1984-11-13 1990-05-01 Atsushi Aoshima Process for purification of polyether
JP2551756B2 (ja) * 1985-05-07 1996-11-06 武田薬品工業株式会社 ポリオキシカルボン酸エステルおよびその製造法
JPH0610252B2 (ja) * 1985-08-21 1994-02-09 和光純薬工業株式会社 重合体の製造法
DE3641692A1 (de) * 1986-12-06 1988-06-09 Boehringer Ingelheim Kg Katalysatorfreie resorbierbare homopolymere und copolymere
DE3708916A1 (de) * 1987-03-19 1988-09-29 Boehringer Ingelheim Kg Verfahren zur reinigung resorbierbarer polyester
JP2714454B2 (ja) * 1988-11-07 1998-02-16 三井東圧化学株式会社 生体吸収性ポリエステルの製造方法
CA2040141C (en) * 1990-04-13 2002-05-14 Minoru Yamada Biodegradable high-molecular polymers, production and use therof

Also Published As

Publication number Publication date
FI111268B (fi) 2003-06-30
EP0469520A2 (de) 1992-02-05
HU912452D0 (en) 1991-12-30
EP0816413A3 (de) 1998-11-11
ES2243966T3 (es) 2005-12-01
GB9116396D0 (en) 1991-09-11
IE66185B1 (en) 1995-12-13
GR3026322T3 (en) 1998-06-30
FI108040B (fi) 2001-11-15
CY1986A (en) 1997-09-05
CH683772A5 (de) 1994-05-13
IT1252944B (it) 1995-07-05
JPH0641279A (ja) 1994-02-15
FI913641L (fi) 1992-02-02
EP0469520B1 (de) 1998-02-25
TW218025B (de) 1993-12-21
HK11797A (en) 1997-02-14
GB2246573A (en) 1992-02-05
PH31047A (en) 1998-02-03
IL99007A0 (en) 1992-07-15
LU87985A1 (fr) 1993-02-15
CA2048200A1 (en) 1992-02-02
IL99007A (en) 1994-12-29
ITRM910553A1 (it) 1993-01-23
KR100255904B1 (ko) 2000-05-01
PT98491A (pt) 1992-06-30
EP0816413B1 (de) 2005-06-08
DE4124468B4 (de) 2010-10-28
EP0469520A3 (en) 1992-10-07
NO912960D0 (no) 1991-07-30
DK0816413T3 (da) 2005-08-29
KR920003990A (ko) 1992-03-27
NZ239184A (en) 1994-09-27
EP0816413A2 (de) 1998-01-07
JP3137368B2 (ja) 2001-02-19
IE912697A1 (en) 1992-02-12
GB2246573B (en) 1994-05-11
MY108621A (en) 1996-10-31
FR2665453B1 (fr) 1995-01-27
PT98491B (pt) 1997-12-31
FI913641A0 (fi) 1991-07-30
AU650277B2 (en) 1994-06-16
AU8143091A (en) 1992-02-27
FI20011189L (fi) 2001-06-05
FR2665453A1 (fr) 1992-02-07
TW282477B (de) 1996-08-01
HUT59837A (en) 1992-07-28
ES2112259T3 (es) 1998-04-01
DE4124468A1 (de) 1992-02-06
ITRM910553A0 (it) 1991-07-23
DK0469520T3 (da) 1998-09-23
CA2048200C (en) 1999-06-29
AT402503B (de) 1997-06-25

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