AT87632B - Process for the preparation of durable, solid hypochlorite preparations. - Google Patents
Process for the preparation of durable, solid hypochlorite preparations.Info
- Publication number
- AT87632B AT87632B AT87632DA AT87632B AT 87632 B AT87632 B AT 87632B AT 87632D A AT87632D A AT 87632DA AT 87632 B AT87632 B AT 87632B
- Authority
- AT
- Austria
- Prior art keywords
- preparation
- durable
- preparations
- acidic
- hypochlorite
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims description 12
- WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Chemical compound Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 title claims description 10
- 239000007787 solid Substances 0.000 title claims description 5
- 238000000034 method Methods 0.000 title claims description 4
- 230000002378 acidificating effect Effects 0.000 claims description 9
- 206010052428 Wound Diseases 0.000 claims description 7
- 208000027418 Wounds and injury Diseases 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 description 6
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 5
- 235000011941 Tilia x europaea Nutrition 0.000 description 5
- 239000004571 lime Substances 0.000 description 5
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 3
- 239000005708 Sodium hypochlorite Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 3
- 229910052938 sodium sulfate Inorganic materials 0.000 description 3
- 235000011152 sodium sulphate Nutrition 0.000 description 3
- ZKQDCIXGCQPQNV-UHFFFAOYSA-N Calcium hypochlorite Chemical compound [Ca+2].Cl[O-].Cl[O-] ZKQDCIXGCQPQNV-UHFFFAOYSA-N 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 150000008043 acidic salts Chemical class 0.000 description 2
- 150000001447 alkali salts Chemical class 0.000 description 2
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 2
- 235000019799 monosodium phosphate Nutrition 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 2
- ZNCPFRVNHGOPAG-UHFFFAOYSA-L sodium oxalate Chemical compound [Na+].[Na+].[O-]C(=O)C([O-])=O ZNCPFRVNHGOPAG-UHFFFAOYSA-L 0.000 description 2
- 229940039790 sodium oxalate Drugs 0.000 description 2
- 239000001488 sodium phosphate Substances 0.000 description 2
- 101100243951 Caenorhabditis elegans pie-1 gene Proteins 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 206010043376 Tetanus Diseases 0.000 description 1
- 239000003929 acidic solution Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 229940061607 dibasic sodium phosphate Drugs 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 159000000011 group IA salts Chemical class 0.000 description 1
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 229940045641 monobasic sodium phosphate Drugs 0.000 description 1
- 229940039748 oxalate Drugs 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
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Verfahren zur Darstellung von haltbaren, festen Hypochloritpräparaten.
Die vielgebrauchte Lösung des Natriumhypochlorits wird durch Umsetzung von Chlorkalk mit Natriumcarbonat oder auf elektrolytischem Wege gewonnen. Diese Lösungen sind stark alkalisch und daher für die Wundbehandlung in keiner Weise geeignet.
Dakin ("Chemisches Centralblatt", 19I5, S. I020) hat daher vorgeschlagen, zur Berieselung von zerrissenen Wunden, um die Infektion mit Tetanus usw. zu vermeiden, solche Lösungen des Natriumhypochlorits zu verwenden, die mit Hilfe von Borsäure schwach angesäuert worden sind, so dass in der Lösung eine geringe Menge freier unterchloriger Säure vorhanden ist. Derartige Lösungen haben den Nachteil, dass sie sehr unbeständig sind. In fester Form ist das Natriumhypochlorit nicht bekannt, da es sich beim Eindampfen der Lösung zersetzt (E. Schmidt, "Pharmazeutische Chemie" 1907, Band I, S. 584 ; v. Richter, "Anorganische Chemie", agio, S. 42I).
Man kann nun, wie gefunden wurde, für die Wundbehandlung sehr geeignete Hypo- chloritpräparate dadurch erhalten, dass man Chlorkalk bzw. das bekannte hochprozentige Calciumhypochlorit mit sauren Salzen, wie saurem Natriumsulfat, saurem Natriumoxalat bzw. saurem Natriumphosphat, mischt. Diese festen Präparate, vor ihrem Gebrauch mit Wasser behandelt, liefern in einfachster und bequemster Weise die zur Wundbehandlung geeigneten, schwach sauren Lösungen. Besonders die Verwendung des letzteren Salzes ist von grossem Wert, da es das Calcium fällt, während gleichzeitig die überschüssigen Phosphate eine wertvolle Wirkung ausüben, da sie je nach dem Bedürfnis des Körpers bald saure und bald schwach oder stark alkalische Salze zu bilden vermögen. Diese Vorteile bietet die Verwendung von neutralem Natriumsulfat bzw. Magnesiumsulfat (siehe D. R. P.
Nr. 145745 und "Therapeutische Monatshefte" 19I5, S. 456, Abs. i und S. 532, Sp.. 2, Mitte) nicht. Das Wesen der Darstellung der neuen, für die Wundbehandlung wichtigen Präparate ist die Bindung des freien Alkali durch die Verwendung von sauren Salzen.
Die Umsetzung des Calciumhypochlorits mit den erwähnten Alkalisalzen, die augenblicklich erfolgt, hat in therapeutischer Beziehung grossen Vorteil, da die Alkalisalze in der Wunde bedeutend weniger reizen als die Calciumsalze.
Je nach dem man ein Präparat herstellen will, das mehr oder weniger stark sauer sein soll, kann man die Umsetzung mit einer Mischung, z. B. von zweibasischem und einbasischem Natriumphosphat oder einer Mischung von saurem und neutralen Oxalat usw. ausführen.
Bei s pie 1 I : 75 Gewichtsteile 70%iger Chlorkalk werden mit 5 Gewichsteilen Mononatriumphosphat gemischt.
Beispiel II : 25 Gewichtsteile 6obiger Chlorkalk werden mit 7 Gewichsteilen wasserfreiem, saurem Natriumsulfat gemischt.
Beispiel III : 25 Gewichtsteile 3obiger Chlorkalk werden mit 6 Gewichtsteilen saurem Natriumoxalat gemischt.
Diese Mischungen können dann auf Tabletten verarbeitet werden.
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Process for the preparation of durable, solid hypochlorite preparations.
The widely used solution of sodium hypochlorite is obtained by reacting chlorinated lime with sodium carbonate or by electrolytic means. These solutions are strongly alkaline and therefore in no way suitable for treating wounds.
Dakin ("Chemisches Centralblatt", 19I5, p. 1020) has therefore proposed to use such solutions of sodium hypochlorite which have been weakly acidified with the help of boric acid to irrigate torn wounds in order to avoid infection with tetanus etc. so that there is a small amount of free hypochlorous acid in the solution. Such solutions have the disadvantage that they are very unstable. Sodium hypochlorite is not known in solid form because it decomposes when the solution is evaporated (E. Schmidt, "Pharmazeutische Chemie" 1907, Volume I, p. 584; v. Richter, "Anorganische Chemie", agio, p. 42I)) .
As has been found, hypochlorite preparations which are very suitable for treating wounds can be obtained by mixing chlorinated lime or the well-known high-percentage calcium hypochlorite with acidic salts such as acidic sodium sulfate, acidic sodium oxalate or acidic sodium phosphate. These solid preparations, treated with water before use, deliver the weakly acidic solutions suitable for wound treatment in the simplest and most convenient way. The use of the latter salt in particular is of great value, since it precipitates the calcium, while at the same time the excess phosphates have a valuable effect, since they can form acidic and weakly or strongly alkaline salts depending on the needs of the body. The use of neutral sodium sulfate or magnesium sulfate (see D. R. P.
No. 145745 and "Therapeutische Monatshefte" 19I5, p. 456, paragraph i and p. 532, col. 2, middle). The essence of the presentation of the new preparations, which are important for wound treatment, is the binding of the free alkali through the use of acidic salts.
The reaction of calcium hypochlorite with the alkali salts mentioned, which takes place immediately, has great therapeutic advantages, since the alkali salts in the wound are significantly less irritating than the calcium salts.
Depending on which one wants to produce a preparation that should be more or less strongly acidic, one can implement the reaction with a mixture, e.g. B. of dibasic and monobasic sodium phosphate or a mixture of acidic and neutral oxalate, etc. run.
At pie 1 I: 75 parts by weight of 70% chlorinated lime are mixed with 5 parts by weight of monosodium phosphate.
Example II: 25 parts by weight of the above chlorinated lime are mixed with 7 parts by weight of anhydrous, acidic sodium sulfate.
Example III: 25 parts by weight of the above chlorinated lime are mixed with 6 parts by weight of acidic sodium oxalate.
These mixtures can then be processed into tablets.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE87632X | 1917-03-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AT87632B true AT87632B (en) | 1922-03-10 |
Family
ID=5641830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT87632D AT87632B (en) | 1917-03-14 | 1918-03-04 | Process for the preparation of durable, solid hypochlorite preparations. |
Country Status (1)
| Country | Link |
|---|---|
| AT (1) | AT87632B (en) |
-
1918
- 1918-03-04 AT AT87632D patent/AT87632B/en active
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