AT208003B

AT208003B - Process for the preparation of iron-polyisomaltosate complexes

Info

Publication number: AT208003B
Application number: AT667758A
Authority: AT
Inventors: Arthur Dr Mueller; Theodor Dr Bersin
Original assignee: Hausmann Ag Labor
Priority date: 1958-09-23
Filing date: 1958-09-23
Publication date: 1960-03-10
Also published as: BE581929A; ES251613A1

Description

  

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  Verfahren zur Herstellung von   Eisen-Polyisomaltosat-Komplexen   
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    (III)-Polyisomaltosat-Komplexwasserstoffsäure,   neutralisiert werden. Nach der Oxydation kann die Eisenkomplex-Lösung dem Stand der Technik entsprechend von Nebenprodukten befreit werden. Gut wasserlösliche pulverförmige Präparate werden nach bekannten Verfahren durch schonendes Eindampfen der Lösungen oder durch Fällen mit einem geeigneten, wassermischbaren Lösungsmittel gewonnen. 



   Das erfindungsgemäss hergestellte Präparat liegt als gut wasserlösliches, hellbraunes, nicht hygroskopisches Pulver vor. Wird die Lösung tropfenweise mit   1- n HCI   unter Rühren versetzt, so tritt bei Raum- 
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 während 60 Minuten auf   650C   erwärmt und während des Abkühlens ein kräftiger Luftstrom durchgeleitet,   wobei die graugrüne Lösung eine rotbraun Farbe annahm. Das Reaktionsgemisch wurde durch Zentrifugieren von ungelösten Anteilen befreit, in die alkalische Lösung eine Mischung von 98 cm feuchtem, stark saurem Kationenaustauscher und 112 cm stark basischem Anionenaustauscher eingetragen, kurz   geschüttelt, die neutralisierte Lösung abfiltriert und mittels Vakuumdestillation soweit eingeengt, bis sie   5%   Eisen enthielt. 



   Beispiel 2 : Zu einer Lösung aus 50 cm Wasser und 25 g partiell depolymerisiertem Dextran ent- 
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    NaOHPATENTANSPRÜCHE   : 
1. Verfahren zur Herstellung eines therapeutisch verwendbaren   Eisen-Polyisomaltosat-Komplexes,   dadurch gekennzeichnet, dass man die Lösung eines wasserlöslichen Dextrans zusammen mit einer Lösung 
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 Komplex übergeführt wird.



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  Process for the preparation of iron-polyisomaltosate complexes
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    (III) polyisomaltosate complex hydrochloric acid. After the oxidation, the iron complex solution can be freed from by-products in accordance with the prior art. Preparations in powder form which are readily soluble in water are obtained by known processes by gently evaporating the solutions or by precipitating them with a suitable, water-miscible solvent.



   The preparation produced according to the invention is in the form of a readily water-soluble, light brown, non-hygroscopic powder. If the solution is mixed drop by drop with 1- n HCl with stirring, then at room temperature
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 heated to 650 ° C. for 60 minutes and a vigorous stream of air was passed through it while cooling, the gray-green solution taking on a red-brown color. The reaction mixture was freed of undissolved components by centrifugation, a mixture of 98 cm of moist, strongly acidic cation exchanger and 112 cm of strongly basic anion exchanger was added to the alkaline solution, shaken briefly, the neutralized solution was filtered off and concentrated by vacuum distillation until it contained 5% iron contained.



   Example 2: To a solution of 50 cm of water and 25 g of partially depolymerized dextran,
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    NaOH PATENT CLAIMS:
1. A process for the preparation of a therapeutically useful iron-polyisomaltosate complex, characterized in that the solution of a water-soluble dextran is combined with a solution
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 Complex is transferred.

Claims

2. The method according to claim 1, characterized in that the water-soluble dextran at 250C has a basic viscosity of 0.025 to 0.1.

3. The method according to claim l, characterized in that the dextran is first heated with metallic iron and acid or an acidic solution of a divalent iron salt until it has a basic viscosity of 0.025 to 0.1 at 250C, with, without the depolymerization product isolate, treated directly according to claim 1 with alkali and further processed.

4. Process according to Claims 1 and 3, characterized in that acid with the same anion as in the iron (II) salt is added to suppress the hydrolysis of the acidic iron (II) salt.

5. The method according to claims 1 to 4, characterized in that the solution of the iron-polyisomaltosate complex is made blood isotonic by dialysis against water or with the aid of ion exchangers.

6. Process according to claims 1 to 11 for the production of solid iron-polyisomaltosate complex, characterized in that the solution of the iron-polyisomaltosate is evaporated in vacuo or the complex is precipitated by adding a suitable water-miscible solvent, isolated and dried .