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AR241463A1 - Procedimiento para preparar aza derivados de piperiliden cicloheptenos, y procedimiento para preparar composiciones farmaceuticas utiles. - Google Patents

Procedimiento para preparar aza derivados de piperiliden cicloheptenos, y procedimiento para preparar composiciones farmaceuticas utiles.

Info

Publication number
AR241463A1
AR241463A1 AR86303933A AR30393386A AR241463A1 AR 241463 A1 AR241463 A1 AR 241463A1 AR 86303933 A AR86303933 A AR 86303933A AR 30393386 A AR30393386 A AR 30393386A AR 241463 A1 AR241463 A1 AR 241463A1
Authority
AR
Argentina
Prior art keywords
preparing
compounds
cycloheptenes
piperidylidene
dihydrodibenzo
Prior art date
Application number
AR86303933A
Other languages
English (en)
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27419175&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR241463(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/838,974 external-priority patent/US4659716A/en
Priority claimed from US06/839,016 external-priority patent/US4731447A/en
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of AR241463A1 publication Critical patent/AR241463A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

COMPUESTO DE LA FORMULA I CON R2, R3: TRIFLUORORETIL, HALOGENO O HIDROGENO Y SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS, POR MEDIO DE UNA CONDENSACION INTRAMOLECULAR DE (II) EN UN MEDIO CONACIDEZ DE HAMMETT DE MENOS DE 12 O INFERIOR, CON R QUE ES H O UN GRUPO N-PROTECTOR, SEGUIDO POR REMOCION DE CUALQUIER GRUPO N-PROTECTOR. LOS ACIDOS UTILIZADOS PUEDEN SER: HF, METANSULFONICO Y SUS DERIVADOS HALOGENADOS, SOLOS O CONJUNTAMENTE CON TRIFLUORURO DE BORO, ACIDO SULFURICO O SUPERACIDOS.
AR86303933A 1985-05-13 1986-05-13 Procedimiento para preparar aza derivados de piperiliden cicloheptenos, y procedimiento para preparar composiciones farmaceuticas utiles. AR241463A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73342885A 1985-05-13 1985-05-13
US06/838,974 US4659716A (en) 1984-02-15 1986-03-12 Antihistaminic 8-(halo)-substituted 6,11-dihydro-11-(4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridines
US06/839,016 US4731447A (en) 1985-05-13 1986-03-12 Process for preparing piperidylidene dihydro-dibenzo(a,d)-cycloheptenes or aza-derivatives thereof

Publications (1)

Publication Number Publication Date
AR241463A1 true AR241463A1 (es) 1992-07-31

Family

ID=27419175

Family Applications (1)

Application Number Title Priority Date Filing Date
AR86303933A AR241463A1 (es) 1985-05-13 1986-05-13 Procedimiento para preparar aza derivados de piperiliden cicloheptenos, y procedimiento para preparar composiciones farmaceuticas utiles.

Country Status (15)

Country Link
EP (1) EP0208855B1 (es)
JP (2) JP2511412B2 (es)
AR (1) AR241463A1 (es)
AU (2) AU600665B2 (es)
CA (1) CA1272480A (es)
DE (1) DE3677842D1 (es)
DK (1) DK173765B1 (es)
ES (1) ES8800679A1 (es)
FI (2) FI90977C (es)
HK (1) HK75993A (es)
HU (1) HU199138B (es)
IE (1) IE59110B1 (es)
IL (1) IL78771A (es)
PT (1) PT82570B (es)
SG (1) SG69193G (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4804666A (en) * 1985-08-14 1989-02-14 Schering Corporation Antiallergic 6,11-dihydro-11-(4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
ATE108453T1 (de) * 1988-04-28 1994-07-15 Schering Corp Benzopyridopiperidin, -piperidyliden und - piperazin-verbindungen, zusammensetzungen, methoden zur herstellung und verwendung.
US4863931A (en) * 1988-09-15 1989-09-05 Schering Corporation Antihistaminic fluoro substituted benzocycloheptapyridines
AU620996B2 (en) * 1989-07-04 1992-02-27 Hokuriku Pharmaceutical Co. Ltd. 4-{(dibenzocycloheptene) or (dibenzoxepin)}-1-substituted piperidines
ES2080700B1 (es) * 1994-07-27 1996-10-16 Farmihispania S A Nuevo procedimiento para la obtencion de loratadina.
ES2080699B1 (es) * 1994-07-27 1996-10-16 Farmahispania S A Nuevos derivados de 2-(1-etoxicarbonil-4-piperidiliden)metil)piridina y un procedimiento para su obtencion.
CN1047774C (zh) * 1996-09-10 1999-12-29 上海华联制药有限公司 氮杂二苯并环庚烯酮类化合物的制备方法
EP0978281B1 (en) * 1997-04-25 2002-07-17 Schering-Plough Kabushiki Kaisha Eyedrops containing a loratidine metabolite
UA62976C2 (en) * 1997-07-02 2004-01-15 Schering Corp Polymorphs of 8-chloro-6,11-dihydro-11-(4-piperidylidene)-5h-benzo[5,6]cyclohepta[1,2-b]pyridine
AU4387699A (en) * 1998-07-24 2000-02-14 Russinsky Limited A process for preparing benzocycloheptapyridin-11-ones
US6372909B1 (en) 1998-11-20 2002-04-16 Schering Corporation Synthesis of intermediates useful in preparing tricyclic compounds
JP4663122B2 (ja) * 1998-11-20 2011-03-30 シェーリング コーポレイション 三環式化合物の調製において有用な中間体の合成
AR021715A1 (es) * 1998-12-18 2002-07-31 Schering Corp Proceso para preparar compuestos triciclicos que tienen actividad antihistaminica e intermediarios.
HU226998B1 (en) * 2000-11-23 2010-04-28 Richter Gedeon Nyrt Desloratadine hemisulphate, process for the preparation thereof and pharmaceutical compositions containing the same
TWI411451B (zh) 2006-06-01 2013-10-11 Msd Consumer Care Inc 用於結腸吸收之脫羥腎上腺素醫藥調配物及組合物
TR200806298A2 (tr) 2008-08-22 2010-03-22 Bi̇lgi̇ç Mahmut Farmasötik formülasyon
CN115141229B (zh) * 2022-07-21 2023-12-12 华创合成制药股份有限公司 抗组胺类化合物及其制备方法和用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL132137C (es) * 1963-04-24
US3717647A (en) * 1971-04-09 1973-02-20 Schering Corp Alpha-nicotinoyl phenylacetonitriles
GB1489332A (en) * 1973-10-11 1977-10-19 Beecham Group Ltd Reduced bicyclic pyridone derivatives
US4282233B1 (en) * 1980-06-19 2000-09-05 Schering Corp Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines
AU570306B2 (en) * 1984-02-15 1988-03-10 Schering Corporation 8-chloro-6, 11-dihydro-11-(4-piperidylidene)-5h-benzo (5,6) cyclohepta (1,2-b) pyridine and its salts.

Also Published As

Publication number Publication date
CA1272480A (en) 1990-08-07
ES8800679A1 (es) 1987-11-16
DK173765B1 (da) 2001-09-17
HK75993A (en) 1993-08-06
JP2519880B2 (ja) 1996-07-31
AU600665B2 (en) 1990-08-23
IL78771A (en) 1990-11-29
DK220986D0 (da) 1986-05-13
HUT41731A (en) 1987-05-28
PT82570B (pt) 1988-11-30
IE59110B1 (en) 1994-01-12
JPH0859657A (ja) 1996-03-05
IE861259L (en) 1986-11-13
SG69193G (en) 1993-08-06
FI861987L (fi) 1986-11-14
AU638019B2 (en) 1993-06-17
HU199138B (en) 1990-01-29
DE3677842D1 (de) 1991-04-11
FI90977B (fi) 1994-01-14
ES554898A0 (es) 1987-11-16
AU5702690A (en) 1990-10-04
IL78771A0 (en) 1986-08-31
PT82570A (en) 1986-06-01
AU5737486A (en) 1986-12-18
JP2511412B2 (ja) 1996-06-26
DK220986A (da) 1986-11-14
JPS61289087A (ja) 1986-12-19
EP0208855B1 (en) 1991-03-06
EP0208855A1 (en) 1987-01-21
FI90977C (fi) 1994-04-25
FI87648B (fi) 1992-10-30
FI87648C (fi) 1993-02-10
FI902315A0 (fi) 1990-05-09
FI861987A0 (fi) 1986-05-13

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