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AR246966A1 - Procedimiento para obtener nuevos derivados del cromano;nuevos compuestos intermedios para la obtencion de los nuevos compuestos iniciales para dicho procedimiento,y dichos compuestos iniciales. - Google Patents

Procedimiento para obtener nuevos derivados del cromano;nuevos compuestos intermedios para la obtencion de los nuevos compuestos iniciales para dicho procedimiento,y dichos compuestos iniciales.

Info

Publication number
AR246966A1
AR246966A1 AR89313845A AR31384589A AR246966A1 AR 246966 A1 AR246966 A1 AR 246966A1 AR 89313845 A AR89313845 A AR 89313845A AR 31384589 A AR31384589 A AR 31384589A AR 246966 A1 AR246966 A1 AR 246966A1
Authority
AR
Argentina
Prior art keywords
formula
compound
ilo
alkyl
piridaziniloxi
Prior art date
Application number
AR89313845A
Other languages
English (en)
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE3815504A external-priority patent/DE3815504A1/de
Priority claimed from DE3835011A external-priority patent/DE3835011A1/de
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of AR246966A1 publication Critical patent/AR246966A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

OBTENCION DE DERIVADOS DEL CROMANO, DE FORMULA (I), DONDE R1 Y R2 SON ALQUILO, Y R1 JUNTO CON R2 SON ALQUILENO DE 3 A 6 ATOMOS DE C;R3 ES HIDROXI; R4 ES HIDROGENO, Y R3 JUNTO CON R4 ES UNA LIGADURA; R5 ES PIRIDILOXI, PIRIDAZINILOXI, OXO-DIHIDRO-PIRIDAZINILOXI,1H-2-PIRIDON-1-ILO, 1H-6-PIRIDAZINON-1-ILO O 2-PIRROLIDON-1-ILO, SUSTITUIDO O NO CON ALQUILO, HIDROXI O AMINO; R6 ES CIANO O NITRO Y R8 ES ALQUILO, EN DONDE SE HACE REACCIONAR UN 3,4-EPOXICROMANO DE FORMULA (II), CON UN COMPUESTO DE FORMULA (III), O UNO DE SUS DERIVADOS REACTIVOS, Y/O UN COMPUESTO DE FORMULA (I) EN LA QUE R3 ES HIDROXI Y R4 ES HIDROGENO, SE DESHIDRATA Y/O UN COMPUESTO DE FORMULA (I) EN LA QUE UNO O VARIOS DE LOS RESTOS R3 Y, R5 Y/O R6 SE TRANSFORMAN EN OTROS RESTOS R3, R5 Y/O R6 Y/O UN COMPUESTO DE FORMULA (I), BASICO, SE TRANSFORMA EN UNA DE SUS SALES DE ADICION DE ACIDO, TRATANDOLO CON UN ACIDO.
AR89313845A 1988-05-06 1989-05-25 Procedimiento para obtener nuevos derivados del cromano;nuevos compuestos intermedios para la obtencion de los nuevos compuestos iniciales para dicho procedimiento,y dichos compuestos iniciales. AR246966A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3815504A DE3815504A1 (de) 1988-05-06 1988-05-06 4-n-heterocyclyl-chromanderivate, verfahren sowie zwischenprodukte zu ihrer herstellung und ihre verwendung in arzneimitteln
DE3835011A DE3835011A1 (de) 1988-10-14 1988-10-14 Chromanderivate

Publications (1)

Publication Number Publication Date
AR246966A1 true AR246966A1 (es) 1994-10-31

Family

ID=25867854

Family Applications (1)

Application Number Title Priority Date Filing Date
AR89313845A AR246966A1 (es) 1988-05-06 1989-05-25 Procedimiento para obtener nuevos derivados del cromano;nuevos compuestos intermedios para la obtencion de los nuevos compuestos iniciales para dicho procedimiento,y dichos compuestos iniciales.

Country Status (17)

Country Link
US (1) US5013853A (es)
EP (1) EP0340718B1 (es)
JP (1) JPH01319481A (es)
KR (1) KR0150781B1 (es)
AR (1) AR246966A1 (es)
AT (1) ATE108786T1 (es)
AU (1) AU628331B2 (es)
DE (1) DE58908062D1 (es)
DK (1) DK223289A (es)
ES (1) ES2057010T3 (es)
FI (1) FI93358C (es)
HU (1) HU207311B (es)
IE (1) IE63794B1 (es)
IL (1) IL90198A (es)
NO (1) NO174467C (es)
NZ (1) NZ228991A (es)
PT (1) PT90471B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3835011A1 (de) * 1988-10-14 1990-04-19 Merck Patent Gmbh Chromanderivate
US5387587A (en) * 1986-12-23 1995-02-07 Merck Patent Gesellschaft Mit Beschrankter Haftung Chroman derivatives
US5284838A (en) * 1987-06-23 1994-02-08 Elf Sanofi Use of 2,2-dimethylchroman-3-ol derivatives in the treatment of asthma
AU3553489A (en) * 1988-05-09 1989-11-29 Beecham Group Plc Novel compounds and treatment
EP0346724A1 (de) * 1988-06-16 1989-12-20 MERCK PATENT GmbH Chromanderivate
DE3918041A1 (de) * 1989-06-02 1990-12-06 Merck Patent Gmbh Chromanderivate
DE3923839A1 (de) * 1989-07-19 1991-01-31 Beiersdorf Ag Benzopyran-derivate, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
US5223629A (en) * 1989-07-21 1993-06-29 Alkaloida Vegyeszeti Gyar Process for the preparation of anti-hypertensive benzopyran
DE3924417A1 (de) * 1989-07-24 1991-01-31 Merck Patent Gmbh Chromanderivate
DE3936616A1 (de) * 1989-11-03 1991-05-08 Merck Patent Gmbh Verfahren zur enantiomerentrennung von benzopyranderivaten
DE4038752A1 (de) * 1990-12-05 1992-06-11 Merck Patent Gmbh Chromanderivate
NZ240933A (en) * 1990-12-21 1993-05-26 Ortho Pharma Corp Preparing enantiomerically pure thienopyran derivatives
US5332168A (en) * 1991-04-01 1994-07-26 Fuji Photo Film Co., Ltd. Photographic film cassette with improved separator claw
JP3442815B2 (ja) * 1992-05-13 2003-09-02 第一製薬株式会社 ジアザビシクロアルケン誘導体
AU5541594A (en) * 1992-10-21 1994-05-09 Gynetech Laboratories, Inc. Vaginal sponge delivery system
GB9316111D0 (en) * 1993-08-04 1993-09-22 Pfizer Ltd Benzopyrans
US5837702A (en) * 1993-10-07 1998-11-17 Bristol-Myers Squibb Co. 4-arylamino-benzopyran and related compounds
US5719155A (en) * 1993-11-10 1998-02-17 Japan Tobacco Inc. Chroman derivative and pharmaceutical use thereof
US5612323A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phosphinic ester substituted benzopyran derivatives
US5869478A (en) * 1995-06-07 1999-02-09 Bristol-Myers Squibb Company Sulfonamido substituted benzopyran derivatives
US5629429A (en) * 1995-06-07 1997-05-13 Bristol-Myers Squibb Company Process for preparing 4-arylamino-benzopyran and related compounds
US5612370A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phenylglycine and phenylalaninen amido benzopyran derivatives
WO2001025224A1 (en) * 1999-10-05 2001-04-12 Nissan Chemical Industries, Ltd. 4-oxybenzopyran derivative
FR2820974B1 (fr) * 2001-02-21 2004-02-13 Pharmascience Lab Composition topique comprenant une solution vraie contenant un derive de chromane ou de chromene, son procede de preparation et son utilisation cosmetique et therapeutique
BRPI0519013A2 (pt) * 2004-12-13 2009-11-03 Lilly Co Eli composto ou esteroisÈmeros únicos, misturas de esteroisÈmeros, sais, tautÈmeros ou pró-drogas destes farmaceuticamente aceitáveis, composição farmacêutica, e, uso de um composto
EP3099304B1 (en) 2014-01-31 2024-07-17 Mayo Foundation for Medical Education and Research Chroman derivatives and their use in the treatment of glaucoma
CN115443132A (zh) 2019-12-12 2022-12-06 奎拉里斯生物公司 色满卡林前药的受控递送

Family Cites Families (22)

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US3467676A (en) * 1967-04-05 1969-09-16 American Home Prod 5-hydroxy-2,2,7-trialkylchroman-4-ones and derivatives
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EP0346724A1 (de) * 1988-06-16 1989-12-20 MERCK PATENT GmbH Chromanderivate

Also Published As

Publication number Publication date
NO174467C (no) 1994-05-11
DK223289A (da) 1989-11-07
HUT56094A (en) 1991-07-29
HU207311B (en) 1993-03-29
AU628331B2 (en) 1992-09-17
KR0150781B1 (ko) 1998-10-15
FI93358B (fi) 1994-12-15
NZ228991A (en) 1990-12-21
NO891866D0 (no) 1989-05-05
PT90471A (pt) 1989-11-30
PT90471B (pt) 1994-09-30
FI892182A7 (fi) 1989-11-07
FI93358C (fi) 1995-03-27
EP0340718A1 (de) 1989-11-08
DE58908062D1 (de) 1994-08-25
JPH01319481A (ja) 1989-12-25
DK223289D0 (da) 1989-05-05
US5013853A (en) 1991-05-07
IE891474L (en) 1989-11-06
IE63794B1 (en) 1995-06-14
IL90198A0 (en) 1989-12-15
NO891866L (no) 1989-11-07
KR890017246A (ko) 1989-12-15
EP0340718B1 (de) 1994-07-20
IL90198A (en) 1994-01-25
ES2057010T3 (es) 1994-10-16
FI892182A0 (fi) 1989-05-05
ATE108786T1 (de) 1994-08-15
NO174467B (no) 1994-01-31
AU3390189A (en) 1989-11-09

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