[go: up one dir, main page]

AR246964A1 - Procedimiento para preparar una nueva clase de piperidinil imidazoles, utiles como agentes antiarritmicos cardiacos. - Google Patents

Procedimiento para preparar una nueva clase de piperidinil imidazoles, utiles como agentes antiarritmicos cardiacos.

Info

Publication number
AR246964A1
AR246964A1 AR89314948A AR31494889A AR246964A1 AR 246964 A1 AR246964 A1 AR 246964A1 AR 89314948 A AR89314948 A AR 89314948A AR 31494889 A AR31494889 A AR 31494889A AR 246964 A1 AR246964 A1 AR 246964A1
Authority
AR
Argentina
Prior art keywords
formula
imidazole
submitting
halogen
alkyl
Prior art date
Application number
AR89314948A
Other languages
English (en)
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of AR246964A1 publication Critical patent/AR246964A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PREPARACION DE PIPERIDINIL IMIDAZOLES, UTILES COMO AGENTES ANTIARRITMICOS CARDIACOS, DE FORMULA (I), DONDE X ES CO O CHOH; M ES 1,2,3,4 O 5; R1 ES HIDROGENO O ALQUILO E Y ES FORMULA (II), DONDE R ES ALQUILO, ALCOXI, HALOGENO O HIDROGENO, O R ES UN SUSTITUYENTE DEL TIPO 3,4-METILENDIOXI O 3,4-ETILENDIOXI; QUE COMPRENDE: A) SOMETER UN DERIVADO DE PIPERIDOILO DE FORMULA (III),DONDE A ES HALOGENO, A UNA REACCION DE N-ALQUILACION CON UN HALURO DE ARALQUILO DE FORMULA (IV), DONDE B ES HALOGENO, PARA OBTENER UN INTERMEDIO PIPERIDOILICO DE FORMULA (V); B) SOMETER ESTE INTERMEDIO PIPERIDOILICO A UNA N-ARILACION CON UN IMIDAZOL DE FORMULA (VI), CON LO QUE SE OBTIENE UN COMPUESTO DE FORMULA (I) EN EL QUE X REPRESENTA CO.
AR89314948A 1988-09-23 1989-09-18 Procedimiento para preparar una nueva clase de piperidinil imidazoles, utiles como agentes antiarritmicos cardiacos. AR246964A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/248,768 US4868194A (en) 1988-09-23 1988-09-23 Imidazole antiarrhythmics

Publications (1)

Publication Number Publication Date
AR246964A1 true AR246964A1 (es) 1994-10-31

Family

ID=22940601

Family Applications (1)

Application Number Title Priority Date Filing Date
AR89314948A AR246964A1 (es) 1988-09-23 1989-09-18 Procedimiento para preparar una nueva clase de piperidinil imidazoles, utiles como agentes antiarritmicos cardiacos.

Country Status (21)

Country Link
US (1) US4868194A (es)
EP (1) EP0360275B1 (es)
JP (1) JP2852536B2 (es)
KR (1) KR0130646B1 (es)
CN (1) CN1023702C (es)
AR (1) AR246964A1 (es)
AT (1) ATE100094T1 (es)
AU (1) AU620643B2 (es)
CA (1) CA1335594C (es)
DE (1) DE68912252T2 (es)
DK (1) DK469389A (es)
ES (1) ES2061861T3 (es)
FI (1) FI90772C (es)
HU (1) HU202860B (es)
IE (1) IE62556B1 (es)
IL (1) IL91698A0 (es)
NO (1) NO174466C (es)
NZ (1) NZ230705A (es)
PH (1) PH26029A (es)
PT (1) PT91741B (es)
ZA (1) ZA897109B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2969359B2 (ja) * 1989-01-13 1999-11-02 武田薬品工業株式会社 環状アミン化合物
US5189036A (en) * 1990-06-20 1993-02-23 Schering Ag Imidazolylbenzoyl substituted heterocycles
KR20040012851A (ko) * 2001-05-22 2004-02-11 뉴로젠 코포레이션 멜라닌 농축성 호르몬 수용체 리간드: 치환된1-벤질-4-아릴 피페라진 유사체
WO2005110982A2 (en) * 2004-04-07 2005-11-24 Neurogen Corporation Substituted 1-benzyl-4-substituted piperazine analogues
US20050239791A1 (en) * 2004-04-07 2005-10-27 Hutchison Alan J Substituted 1-heteroaryl-4-substituted piperazine and piperidine analogues
TW200609219A (en) * 2004-06-17 2006-03-16 Neurogen Corp Aryl-substituted piperazine derivatives
KR20220154949A (ko) 2021-05-14 2022-11-22 삼성중공업 주식회사 파이프 밸브 탈부착 장치

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4556665A (en) * 1984-07-09 1985-12-03 Schering A.G. Cardiotonic 1,3-dihydro-4-[[(imidazol-1-yl)aryl]carbonyl]imidazol-2-ones
PH23283A (en) * 1986-02-26 1989-06-30 Eisai Co Ltd Piperidine derivative, pharmaceutical composition containing the same and method of use thereof
US4791121A (en) * 1987-11-02 1988-12-13 The Boc Group, Inc. 4-phenyl-4-(N-(phenyl)amido) piperidine derivatives and pharmaceutical compositions and method employing such compounds

Also Published As

Publication number Publication date
ATE100094T1 (de) 1994-01-15
CN1023702C (zh) 1994-02-09
FI90772C (fi) 1994-03-25
CA1335594C (en) 1995-05-16
US4868194A (en) 1989-09-19
IL91698A0 (en) 1990-06-10
JPH02124885A (ja) 1990-05-14
IE893049L (en) 1990-03-23
FI90772B (fi) 1993-12-15
NO893784L (no) 1990-03-26
AU620643B2 (en) 1992-02-20
JP2852536B2 (ja) 1999-02-03
HUT50811A (en) 1990-03-28
DE68912252T2 (de) 1994-07-07
ZA897109B (en) 1990-06-27
NZ230705A (en) 1991-03-26
AU4152689A (en) 1990-03-29
EP0360275A3 (en) 1990-08-22
NO893784D0 (no) 1989-09-22
DK469389A (da) 1990-03-24
FI894392A7 (fi) 1990-03-24
FI894392A0 (fi) 1989-09-18
IE62556B1 (en) 1995-02-08
EP0360275A2 (en) 1990-03-28
PT91741B (pt) 1995-05-31
CN1041363A (zh) 1990-04-18
KR900004717A (ko) 1990-04-12
HU202860B (en) 1991-04-29
ES2061861T3 (es) 1994-12-16
NO174466B (no) 1994-01-31
PH26029A (en) 1992-01-29
PT91741A (pt) 1990-03-30
DK469389D0 (da) 1989-09-22
DE68912252D1 (de) 1994-02-24
KR0130646B1 (ko) 1998-04-10
EP0360275B1 (en) 1994-01-12
NO174466C (no) 1994-05-11

Similar Documents

Publication Publication Date Title
ATE40994T1 (de) L-n-n-propylpipekolsaeure-2,6-xylidid und dessen herstellung.
DK51986D0 (da) Heterocycliske forbindelser, deres fremstilling og anvendelse som insecticide midler
AR246964A1 (es) Procedimiento para preparar una nueva clase de piperidinil imidazoles, utiles como agentes antiarritmicos cardiacos.
ES2048109A1 (es) Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
ATE45745T1 (de) Ketoalkylphospholipide und ihre herstellung und verwendung.
BR8900900A (pt) Composicao de tratamento de texteis aperfeicoada bem como composto de imidazol
AR240930A2 (es) "derivados de p-clorofenil-2-furanil-metilen-triazol, intermediarios para su preparacion, procedimientos para la preparacion de dichos compuestos e intermediarios y composiciones fungicidas que contienen a dichos compuestos. "
ES8502071A1 (es) Un procedimiento mejorado para producir etilenglicol
ES2103161A1 (es) Derivados de cicloheptimidazol, metodo de fabricacion de los mismos y agentes terapeuticos que contienen estos compuestos.
ES8102096A1 (es) Procedimiento para la obtencion de derivados de 3,4,5-trihi-droxipiperidina
ES2054035T3 (es) Procedimiento para la preparacion de alquil-1 nitro-5 imidazoles.
ES2032482T3 (es) Derivados del bencilidenamino-, bencilamino- y benzoilamino-imidazol y su empleo como medicamentos. (reserva del art. 167.2 cpe).
KR870002090A (ko) 1-(2-옥시아미노 카보닐페닐설포닐)-3-헤테로아릴-우레아의 제조방법
ES8703459A1 (es) Procedimiento para la preparacion de derivados de acido 4- (isoxazolil)-tiazol-2-oxamico
IT1201481B (it) Pantotenil derivati
MX9306335A (es) Composiciones a base de copolimeros fluoroelastomericos, curablesionicamente.
ES2053576T3 (es) Compuestos con grupos triazol o imidazol y tetrahidrofurano, utilizacion de los mismos como fungicidas y procedimientos de preparacion.
AR247556A1 (es) Nuevos derivados 5-carboximidato imidazoles, un procedimiento para su preparacion y la composicion fungicida que los contiene
ES2001006A4 (es) Compuestos sustituidos de 2,6-piridina sustituida
ES468486A1 (es) Procedimiento para la preparacion de nuevos derivados de 1-(3-(3,4,5-trimetoxifenoxi)-2-hidroxi - propil)-4-aril pi- perazina
ES2052783T3 (es) Procedimiento para la preparacion de 4-alquil-1,4-dihidropiridinas.
GB1181827A (en) Epoxidized Peroxides
JPS6461462A (en) Manufacture of acylated imidazole and pyrazole
AR246514A1 (es) Nuevo derivado de imidazol util como fungicida, el procedimiento para su preparacion y una composicion fungicida que contiene dicho derivado.
ES2037037T3 (es) Metodo para producir un compuesto de 5-bromo-1-pentanal o un derivado acetal del mismo.