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AR245723A1 - Procedure for preparing derivatives of cephalosporanic acids. - Google Patents

Procedure for preparing derivatives of cephalosporanic acids.

Info

Publication number
AR245723A1
AR245723A1 AR30089585A AR30089585A AR245723A1 AR 245723 A1 AR245723 A1 AR 245723A1 AR 30089585 A AR30089585 A AR 30089585A AR 30089585 A AR30089585 A AR 30089585A AR 245723 A1 AR245723 A1 AR 245723A1
Authority
AR
Argentina
Prior art keywords
amino
methyl
ilo
hydrogen
formula
Prior art date
Application number
AR30089585A
Other languages
Spanish (es)
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Priority to AR30089585A priority Critical patent/AR245723A1/en
Application granted granted Critical
Publication of AR245723A1 publication Critical patent/AR245723A1/en

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Landscapes

  • Cephalosporin Compounds (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE DERIVADOS DEL ACIDO CEFALOSPORANICO DE FORMULA (I'), ISOMERO SIN, EN LA QUE R ES FENILO, TIENILO, FURILO O TIAZOLILO, SUBSTITUIDOS O NO A LO SUMO POR DOS HALOGENOS AMINO Y AMINO PROTEGIDOS; R1 ES HIDROGENO, UN GRUPO DE PROTECCION DE HIDROXILO, ALCOHILO, SUBSTITUIDO O NO POR ETOXICARBONILO O TER-BUTOXICARBONILO, CARBOXI, CARBOXI SALIFICADO, NITRILO, AMINO,ALQUIL AMINO, DIALQUIL AMINO; FENILO, AZIDO, FENILTIO, HIDROXI, HALOGENO, ACILO, ALCOXI, ALQUILTIO, ISOUREIDO, TIOCIANATO, AMINO HIDRAZINO, METILTIO, O R1 ES ACILO; R'2 ES HIDROGENO O CLORO; O ALCOHILO; O ACETOXIMETILO O CARBAMOILOXI-METILO; O -CH2-S-R5 EN EL QUE R5 ES ENTRE OTROS ACETILO, 1-METIL-TETRAZOLILO, 2-METIL-1,3,4- TIADIAZOLILO, 2-AMINO-1,3,4-TIADIAZOL-5-ILO,4-METIL-5- HIDROXICARBONILMETILO, 1,3-TIAZOL-2-ILO,1-DIMETILAMINOETIL-1,2,3,4-TETRAZOL 5-ILO, 1,3,4-TRIAZOL-5-ILO, 1-AMINO-2-TRIFLUORMETIL-1,3,4-TRIAZOL-5-ILO, 4- HIDROXICARBONIL-METIL-1,3-TIAZOL-2-ILO; O AZIDOMETILO;A' ES HIDROGENO,METAL ALCALINO, ALCALINO-TERREO, MAGNESIO, AMONIO O UNA BASE ORGANICA AMINADA O DE UN GRUPO ESTER, O EL GRUPO CO2A' ES -CO2 (-), N ES UN ENTERO DE 0 A 2, QUEDANDO ENTENDIDO QUE CUANDO R'2 ES -CH2- (+)N-CO2A'-CO2 (-), DONDE SE TRATA PRIMERAMENTE EN UN DISOLVENTE, Y EVENTUALMENTE EN PRESENCIA DE UNA BASE, UN PRODUCTO DE FORMULA (II), EN LA QUE A1 ES HIDROGENO O METAL ALCALINO, ALCALINO-TERREO, MAGNESIO, AMONIO O DE UNA BASE ORGANICA AMINADA, POR UN PRODUCTO DE FORMULA:R4SO2HAL EN LA QUE R4 ES ALCOHILO, ARILO O ARALCOHILO, SUBSTITUIDO O NO, Y SE HACE REACCIONAR, ENUN DISOLVENTE, EL PRODUCTO RESULTANTE CON UN PRODUCTO DE FORMULA (IV).PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF THE CEPHALOSPORANIC ACID OF FORMULA (I '), ISOMERO SIN, IN WHICH R IS PHENYL, TENYL, FURYL OR TIAZOLYL, SUBSTITUTED OR NOT TO THE SUM BY TWO HALOGEN AMINO AND AMINO PROTECTED; R1 IS HYDROGEN, A PROTECTION GROUP FOR HYDROXYL, ALCOHYL, SUBSTITUTED OR NOT BY ETHOXYCARBONYL OR TER-BUTOXYCARBONYL, CARBOXI, SALINATED CARBOXI, NITRILE, AMINO, ALKYL AMINO, DIALKYL AMINO; PHENYL, AZIDO, FENILTIO, HIDROXI, HALOGENO, ACILO, ALCOXI, ALQUILTIO, ISOUREIDO, TIOCIANATO, AMINO HIDRAZINO, METHYL, OR R1 IS ACILO; R'2 IS HYDROGEN OR CHLORINE; OR ALCOHYL; OR ACETOXIMETILO OR CARBAMOILOXI-METHYL; OR -CH2-S-R5 IN WHICH R5 IS AMONG OTHER OIL, 1-METHYL-TETRAZOLYL, 2-METHYL-1,3,4- TIADIAZOLYL, 2-AMINO-1,3,4-TIADIAZOL-5-ILO, 4-METHYL-5- HYDROXYCARBONYL METHYL, 1,3-TIAZOL-2-ILO, 1-DIMETHYLAMINE ETHYL-1,2,3,4-TETRAZOLE 5-ILO, 1,3,4-TRIAZOL-5-ILO, 1-AMINO -2-TRIFLUORMETHYL-1,3,4-TRIAZOL-5-ILO, 4- HYDROXYCARBONYL-METHYL-1,3-TIAZOL-2-ILO; OR AZIDOMETHYL; A 'IS HYDROGEN, ALKALINE METAL, ALKALINE-TERREO, MAGNESIUM, AMMONIUM OR AN AMINATED ORGANIC BASE OR OF AN ESTER GROUP, OR THE CO2A GROUP' IS -CO2 (-), N IS AN INTEGER OF 0 TO 2, BEING UNDERSTOOD THAT WHEN R'2 IS -CH2- (+) N-CO2A'-CO2 (-), WHERE IT IS FIRST TREATED IN A SOLVENT, AND EVENTUALLY IN THE PRESENCE OF A BASE, A PRODUCT OF FORMULA (II), IN THE THAT A1 IS HYDROGEN OR ALKALINE METAL, ALKALINE-TERREO, MAGNESIUM, AMMONIUM OR FROM AN AMINATED ORGANIC BASE, BY A PRODUCT OF FORMULA: R4SO2HAL IN WHICH R4 IS ALCOHYL, ARYL OR ARALCOHYL, SUBSTITUTED OR NOT, AND IS MADE SOLVENT, THE RESULTING PRODUCT WITH A FORMULA (IV) PRODUCT.

AR30089585A 1985-07-03 1985-07-03 Procedure for preparing derivatives of cephalosporanic acids. AR245723A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AR30089585A AR245723A1 (en) 1985-07-03 1985-07-03 Procedure for preparing derivatives of cephalosporanic acids.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AR30089585A AR245723A1 (en) 1985-07-03 1985-07-03 Procedure for preparing derivatives of cephalosporanic acids.

Publications (1)

Publication Number Publication Date
AR245723A1 true AR245723A1 (en) 1994-02-28

Family

ID=32967165

Family Applications (1)

Application Number Title Priority Date Filing Date
AR30089585A AR245723A1 (en) 1985-07-03 1985-07-03 Procedure for preparing derivatives of cephalosporanic acids.

Country Status (1)

Country Link
AR (1) AR245723A1 (en)

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